cov khoom siv

Urolithin B hmoov (1139-83-9)

Urolithin B yog lub ntuj zom ntawm ellagitannin tam sim no hauv pomegranates thiab lwm yam txiv hmab txiv ntoo thiab txiv ntoo. Pom tau los ntawm cov kws tshawb fawb los ua tshuaj tiv thaiv kev laus, kev tswj hwm qhov ncauj tuaj yeem rov qab mitochondria thiab rov qab cov leeg kev laus, thiab yog lub plab hnyuv metabolite.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

Urolithin B hmoov puag cov ntaub ntawv

lub npe Urolithin B Hmoov
CAS 1139-83-9
purity 98%
Tshuaj lub npe 3-Hydroxy-6H-dibenzo [b, d] pyran-6-ib
Synonyms AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR
molecular Formula C13H8O3
molecular Nyhav 212.2 g / mol
Melting Point 247 ° C
InChI Qhov Tseem Ceeb WXUQMTRHPNOXBV-UHFFFAOYSA-N
daim ntawv Khoom
tsos Lub teeb xim av lub ntsej muag
Ib Sim Neej /
solubility soluble5mg / mL, ntshiab (sov)
cia mob 2-8 ° C
Daim ntawv thov Urolithin B yog lub plab hnyuv plab zom zaub mov ntawm ellagitannis thiab ua kom pom cov khoom muaj zog tiv thaiv tua hluav taws thiab cov khoom ua kom muaj zog nyob ntawm seb cov kab mob thiab kev ua haujlwm zoo li cas. Urolithin B tseem tuaj yeem tso tawm estrogenic thiab / lossis kev ua haujlwm los tiv thaiv estrogen.
Kuaj Cov Ntaub Ntawv Qhov

 

Urolithin B hmoov General Description

Urolithin B yog urolithin, ib hom phenolic tebchaw tsim hauv tib neeg lub plab tom qab nqus cov ellagitannins-uas muaj cov zaub mov xws li pomegranate, txiv pos nphuab, liab raspberries, walnuts lossis oak-hnub nyoog liab. Urolithin B yog pom nyob hauv cov zis hauv daim ntawv ntawm urolithin B glucuronide.

Urolithin B yog ib lub plab microbial metabolites ntawm ellagitannins, thiab muaj cov anti-inflammatory thiab antioxidant cuam tshuam. Urolithin B inhibits NF-activityB kev ua haujlwm los ntawm kev txo phosphorylation thiab degradation ntawm IκBα, thiab suppresses phosphorylation ntawm JNK, ERK, thiab Akt, thiab txhim kho phosphorylation ntawm AMPK. Urolithin B kuj tseem yog tus tsim txoj cai pob txha leeg pob txha. Urolithin B tseem tuaj yeem tso tawm estrogenic thiab / lossis kev ua haujlwm los tiv thaiv estrogen.

 

Urolithin B hmoov Keeb kwm

Urolithin B tuaj yeem raug siv ua tshuaj rau tshuaj tiv thaiv antitumor thiab anticancer. Urolithin B (CAS TSIS TAU: 1139-83-9) yog urolithin, nws tseem yog tsim hauv tib neeg lub plab tom qab nqus ellagitannins los ntawm pomegranate. Urolithin B tuaj yeem txo kev puas tsuaj rau cov leeg nqaij thaum ntsib kev qoj ib ce thiab tiv thaiv cov leeg tiv thaiv kev ntxhov siab los ntawm cov zaub mov muaj roj ntau.

Urolithin B hmoov kuj tseem yog cov plab hnyuv plab zom zaub mov ntawm ellagitannis thiab muaj cov khoom siv los tiv thaiv oxidant thiab pro-oxidant kev ua haujlwm nyob ntawm seb cov txheej txheem thiab cov kev mob. Urolithin B tseem tuaj yeem tso tawm estrogenic thiab / lossis kev ua haujlwm los tiv thaiv estrogen. Nws muaj anti-inflammatory thiab antioxidant zoo. Urolithin B kuj tseem siv tau tsim kev tswj hwm cov pob txha leeg pob txha.

Thiab Urolithin B tau pom tias hla txoj hlab ntshav lub hlwb, thiab tej zaum yuav muaj neuroprotective cuam ​​tshuam rau Alzheimer's Disease.

 

Urolithin B hmoov Kev tshawb fawb ntxiv

Urolithin B tuaj yeem txo kev puas tsuaj rau cov leeg nqaij thaum ntsib kev qoj ib ce thiab tiv thaiv cov leeg tiv thaiv kev ntxhov siab los ntawm cov zaub mov muaj roj ntau. Cov kev tshawb fawb soj ntsuam ntawm Urolithin B hauv cov nas pom tias nws txhim kho myotubes kev loj hlob thiab kev sib txawv los ntawm kev ua kom muaj protein ntau ntxiv. Nws pom tias muaj peev xwm los inhibit qhov ubiquitin – proteasome pathway (UPP), lub tswv yim tseem ceeb rau protein catabolism. Nws kuj ua rau cov leeg ntshav tsis zoo thiab ua rau cov leeg mob thim.

Thaum piv rau testosterone, Urolithin B thaum noj ntawm 15 uM nce androgen receptor kev ua si los ntawm 90% thaum testosterone tsuas yog muaj peev xwm ua tiav cov kev ua kom muaj zog ntawm 50% ntawm 100uM. Qhov no txhais tau hais tias nws yuav siv ntau tsawg Urolithin B kom nce androgen kev ua haujlwm zoo dua ces tus nqi ntau dua ntawm testosteronewhich nce androgen kev ua haujlwm tsawg dua.

Ntxiv mus, tshaj 15uM ntawm Urolithin B loj dua cov leeg protein ua kom sib luag ntawm 96% thaum piv rau 100uM ntawm insulin, uas loj dua cov leeg protein synthesis ntawm kev ua tau zoo tshaj 61%. Qhov kev ntseeg tau yog tias nws yuav siv sijhawm ntev npaum li cas tsawg dua Urolithin B kom txuas cov nqaij pob txha mos ua ke nrog cov tshuaj tiv thaiv sab saud.

Cov kev tshawb fawb no qhia tau tias Urolithin B tuaj yeem inhibit protein catabolism thaum tib lub sijhawm nce cov synthesis protein, nws yog lub cev ntuj tsim los pab txhim kho cov nqaij ntshiv thaum tiv thaiv cov leeg mob.

 

Urolithin B Hmoov 1139-83-9 Kev Xa Khoom

  1. 1. Kallio, T., li al .: J. Agr. Khoom Noj Khoom Haus Chem., 61, 10720 (2013); Nealmongkol, P., li al.: Tetrahedron, 69, 9277 (2013); Larrosa, M., li al .: J. Agr. Khoom Noj Khoom Haus Chem., 54, 1611 (2006); Bialonska, D., li al.: J. Agr. Khoom Noj Khoom Haus Chem., 57, 10181 (2009)
  2. Rodriguez J, li al. Urolithin B, ib tus neeg nyuam qhuav pib lub cev muaj mob pob txha leeg pob txha. J Cachexia Sarcopenia Nqaij. 2017 Lub Yim Hli; 8 (4): 583-597.
  3. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Kaum Ib Hlis 2009). "Urolithins, plab hnyuv microbial metabolites ntawm Pomegranate ellagitannins, muaj cov antioxidant muaj zog ua nyob rau hauv kev soj raws li ntawm tes". J Agric Zaub Noj Tsuag. 57 (21): 10181–6.

 

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