cov khoom siv

Urolithin Ib Hmoov

Urolithin A, lub plab-microbial metabolite ntawm ellagic acid, siv tshuaj tiv thaiv, tiv thaiv antiproliferative, thiab lub zog tiv thaiv lub zog. Urolithin A induces autophagy thiab apoptosis, txhawb kev muaj kev voj voog ntawm tes, thiab inhibits DNA synthesis. Urolithin A tsis raug pom tias muaj nyob hauv cov khoom noj khoom haus. Nws cov bioavailability feem ntau nyob ntawm tus neeg microbiota muaj pes tsawg leeg, vim tias tsuas yog qee tus kab mob tuaj yeem hloov ellagitannins rau hauv urolithins.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

Urolithin A hmoov Base Cov ntaub ntawv

lub npe Urolithin Ib Hmoov
CAS 1143-70-0
purity 98%
Tshuaj lub npe 3,8-Dihydroxybenzo [c] chromen-6-ib
Synonyms 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-ib; 3,8-DIHYDROXYDIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-ib; Castoreum xim rau kuv; Urolithin A; 6H-Dibenzo (B, D) pyran-6-ib, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-ib); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-ib
molecular Formula C13H8O4
molecular Nyhav 228.2
Melting Point > 300 ° C
InChI Qhov Tseem Ceeb RIUPLDUFZCXCHM-UHFFFAOYSA-N
daim ntawv khoom
tsos Lub teeb Daj hmoov
Ib Sim Neej
solubility Soluble hauv DMSO (3 mg / mL).
cia mob Qhuav, tsaus thiab nyob rau hauv 0 - 4 C rau lub sij hawm luv luv (hnub mus rau lub lis piam) lossis -20 C rau lub sij hawm ntev (hli txog xyoo).
Daim ntawv thov Urolithin A yog tshuaj metabolite ntawm ellagitannin; Kws Tshuaj Intermediates
Kuaj Cov Ntaub Ntawv Qhov

 

Urolithin Ib Hmoov General hauj lwm

Urolithin Ib cov hmoov yog qhov sib xyaw ua ke uas los ntawm kev hloov pauv ntawm ellagitannins los ntawm tus kab mob plab thiab nws yog qhov ua kom muaj txiaj ntsig ntawm mitophagy. Urolithin Ib qho kev hloov pauv mitochondria los ntawm CI- txog kev ua kom lub zog ua haujlwm CII-ua lub zog, txuas lub neej ntev thiab txhim kho cov leeg ua haujlwm. Nws yog rau cov chav kawm ntawm cov organic sib txuas hu ua benzo-coumarins lossis dibenzo-α-pyrones. Nws cov ua ntej - ellagic acids thiab ellagitannins - yog qhov ubiquitous hauv qhov, suav nrog cov nroj tsuag tuaj yeem, xws li pomegranates, txiv pos nphuab, raspberries, thiab walnuts. Txij li xyoo 2000, urolithin A tau raug kev tshawb fawb ua ntej txog nws qhov kev xav tau lom neeg.

Urolithin Ib cov hmoov tshuaj tuaj yeem txhim kho qhov ua tau zoo thiab ua haujlwm ntawm mitochondria, thiab ua rau lub zog thiab kev ruaj khov ntawm cov leeg laus. Nws yog lub ntuj tsuas cov khoom uas tau raug pov thawj kom rov ua dua mitochondrial autophagy thiab thim rov qab cov laus kev laus.

Urolithins yog microflora tib neeg cov metabolites ntawm kev noj haus ellagic acid derivatives , xws li ellagitannins. Lawv tau tsim hauv qhov

tib neeg lub plab, thiab pom nyob hauv cov zis hauv daim ntawv ntawm urolithin B glucuronide tom qab kev nqus ntawm ellagitannins-muaj cov zaub mov xws li

pomegranate, txiv pos nphuab, kua liab liab, Walnut los yog Oak-laus liab.

Thaum lub plab hnyuv plab zom mov los ntawm cov kab mob, ellagitannins thiab punicalagins hloov dua siab tshiab rau urolithins, uas tsis tau paub dua

kev lom neeg hauv vivo hauv tib neeg. Urolithins metabolites ntawm pomegranate kua txiv ellagitannins localize tshwj xeeb hauv

lub caj pas prostate, hnyuv, thiab cov hnyuv ntawm cov nas.

Ellagitannins ua kom pom kev siv lub cev tsis tshua muaj siab thiab hloov mus rau lub plab rau ellagic acid thiab nws cov microbiota metabolites.

Urolithins pom nyob hauv ntshav feem ntau li glucuronides thaum tsis tshua muaj ntau.

Urolithins ntau lawm yog nyob ntawm lub plab microbiome enterotype. Cov tib neeg tsim ua urolithins qhia tau ntau ntau dua

ntawm Clostridium leptum pawg ntawm Firmicutes phylum dua li Bacteroides lossis Prevotella

 

Urolithin A hmoov Keeb kwm

Hauv kev kawm tshawb nrhiav, urolithin Ib cov hmoov tau pom tias ua kom muaj teeb meem ntawm mitophagy, uas yog kev xaiv cov tshuaj rov qab los ntawm mitochondria los ntawm autophagy, tus txheej txheem uas ntxuav cov mitochondria tom qab kev puas tsuaj lossis kev ntxhov siab, thiab feem ntau ua kom tsawg dua thaum muaj hnub nyoog. [14] Qhov zoo li no tau pom nyob hauv cov tsiaj sib txawv (cov hlwb mammalian, cov nas thiab C. elegans).

 

Urolithin A hmoov Daim ntawv thov

Urolithin Ib cov hmoov yog npaj rau kev siv ua cov khoom noj hauv cov khoom noj uas xaiv los yog rau cov khoom noj tshwj xeeb hauv kev hloov cov khoom noj raws li nws cov khoom noj muaj txiaj ntsig hauv kev txhawb nqa kev noj qab haus huv mitochondrial.

 

Urolithin A hmoov Kev tshawb fawb ntxiv

Urolithin A tsis tau pom tias muaj nyob hauv cov zaub mov. Nws ua raws li qhov txiaj ntsig ntawm kev hloov ntawm ellagic acids thiab ellagitannins los ntawm lub plab microflora hauv tib neeg. Ellagic acid nws tus kheej tau los ntawm hydrolysis ntawm ellagitannins hauv lub plab hauv lub xub ntiag ntawm cov dej.

Cov peev txheej ntawm ellagitannins yog: pomegranates, noob txiv, qee yam txiv ntoo (raspberries, txiv pos nphuab, blackberries, huab), tshuaj yej, muscadine txiv hmab, ntau cov txiv hmab txiv ntoo tauj, thiab cov ntoo qhib muaj hnub nyoog (nyob hauv qab).

Kev hloov pauv ntawm ellagic acids rau hauv urolithin A yog nyob ntawm tus neeg microflora muaj pes tsawg leeg thiab tuaj yeem sib txawv.

 

Urolithin Ib Powder Reference

  1. Paller CJ, Pantuck A, Carducci MA. Kev soj ntsuam ntawm pomegranate hauv prostate mob cancer. Prostate Cancer Prostatic Dis. 2017 Plaub Hlis 25. doi: 10.1038 / pcan.2017.19. [Epub ua ntej sau] Tshawb xyuas. PubMed PMID: 28440320.
  2. Ito H. Metabolites ntawm ellagitannin geraniin thiab lawv cov haujlwm antioxidant. Planta Med. 2011 Jul; 77 (11): 1110-5. doi: 10.1055 / s-0030-1270749. Epub 2011 Feb 3. Tshab xyuas. PubMed PMID: 21294073.
  3. Ishimoto H, li al. Hauv vivo los tiv thaiv kev tiv thaiv thiab cov khoom ua si ntawm ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1; 21 (19): 5901-4.

 

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