cov khoom siv

Nefiracetam hmoov (77191-36-7)

Nefiracetam hmoov nce lub hlwb kev noj qab haus huv thiab ua haujlwm nyob rau ntau txoj hauv kev. Tab sis ob qho tshwj xeeb sawv tawm.Nefiracetam txhim kho kev nco. Nefiracetam tseem yuav pab txhawb acetylcholine (ACh) kev ua hauv koj lub hlwb. Txhawm rau zam "racetam mob taub hau" nco ntsoov teeb Nefiracetam nrog cov choline zoo xws li CDP-Choline lossis Alpha GPC. Txij li Nefiracetam yog cov roj ua kom tsis muaj roj ntau ntau, koj yuav tsum noj nrog lub pluas mov uas muaj cov rog zoo. Los yog nrog ib tug tablespoon ntawm nkauj xwb, expeller txias-nias txiv maj phaub lossis txiv roj roj. Los yog lwm qhov muaj roj muaj txiaj ntsig zoo txhawm rau kom nqus sai.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.

Nefiracetam hmoov (77191-36-7) video

 

Nefiracetam hmoov Piav Cov Ntaub Ntawv

lub npe Nefiracetam hmoov
CAS 77191-36-7
purity 98%
Tshuaj lub npe Nefiracetam 77191-36-7

N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide ,Translon ,DM 9384

Synonyms (2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384
molecular Formula C14H18N2O2
molecular Nyhav 246.3 g / mol
Melting Point 151-155 ° C
InChI Qhov Tseem Ceeb NGHTXZCKLWZPGK-UHFFFAOYSA-N
daim ntawv Khoom
tsos dawb rau off-dawb hmoov
Ib Sim Neej 3-5 teev
solubility Soluble rau 100 mM hauv DMSO thiab rau 100 mM hauv ethanol
cia mob Khw nyob RT
Daim ntawv thov Nefiracetam yog qhov sib xyaw organooxygen thiab ib qho chaw muaj npe hu ua organonitrogen. Nws keeb kwm los ntawm alpha-amino acid.Its Nootropics
Kuaj Cov Ntaub Ntawv Qhov

 

Nefiracetam hmoov General Cov Lus Qhia

Nefiracetam hmoov tau txiav txim siab ua kom muaj zog ntau dua li Piracetam. Raws li ib tug nootropic, nws pab ua kom pom kev nthuav dav, ua kom paub meej, paub, kawm thiab txhawb kev nco.Nefiracetam tau siv los ua tshuaj nyob hauv Nyij Pooj. Thiab raws li kev ntxiv hauv Tebchaws Meskas Nws zoo ib yam li Piracetam nrog pawg phenyl thiab ob pawg methyl ntxiv rau amine ntawm Piracetam. Nefiracetam, zoo li txhua racetam nootropics, muaj lub pyrrolidone nucleus ntawm nws cov tub ntxhais. Tus qauv ntawm Nefiracetam zoo ib yam li Aniracetam

 

Nefiracetam hmoov (77191-36-7) Keeb Kwm

Nefiracetam tau tsim los ntawm Daiichi Seiyaku thaum xyoo 1990 ua kev kho rau cov mob cerebrovascular. Xyoo 1999, Nefiracetam tau nyob rau theem II kev soj ntsuam hauv tebchaws Asmeskas rau kev kho cov teeb meem kev txawj ntse vim yog qhov tshwm sim ntawm mob stroke, thiab Alzheimer hom dementia.Japan-based pharmaceutical tuam txhab Daiichi Seiyaku tsim Nefiracetam nyob rau lub sijhawm xyoo 1990 los ua ib qho kev sib txuas ntawm Piracetam.Nefiracetam yog rog-soluble thaum Piracetam yog dej-soluble. Cov roj nyeem ua kom cov roj nyeem hla cov ntshav-hlwb teeb meem yooj yim dua li cov dej-soluble molecules.

Ob Nefiracetam thiab Piracetam yog qhov kev txhim kho txawj ntse. Thiab ob qho tib si muaj neuroprotective zoo. Ob tus cwj pwm sib tw ua ke tuaj yeem txhim kho kev kawm thiab cim xeeb. Thiab ob qho tib si muaj peev xwm tiv thaiv lub hlwb ua kom puas.

 

Nefiracetam (77191-36-7) Lub Tswv Yim Ntawm Kev Ua

Nefiracetam muaj cov txiaj ntsig ntxiv tsis koom nrog Piracetam. Nefiracetam tuaj yeem txo cov kev ntxhov siab thiab kev ntxhov siab. Thiab cov khoom pov thawj ob peb lwm nco kev ua kom zoo dua Piracetam.Nefiracetam tsub kom cov sij hawm calcium nyob hauv neurons tseem qhib. Khi rau cov protein kinase A (PKA) thiab Gi alpha subunit (Gi / o protein), cov paib tau ua kom zoo dua rau hauv neuroreceptor ywj siab ntawm cov lus sib dhos. Qhov calcium calcium pathway no yog qhov tseem ceeb rau lub hwj chim ntev (LTP) thiab kev tsim lub cim xeeb ntev.Nefiracetam tseem muaj hwj chim tseem ceeb protein kinase C alpha (PKCα) uas muaj kev koom tes nrog kev ua haujlwm ntev (LTP). PKCα yog nyob ntawm glutamate signaling.Thiab Nefiracetam ua haujlwm Ca2 + / calmodulin-dependant protein kinase II (CaMKII) uas yog qhov tseem ceeb hauv kev nco. Ib zaug ntxiv nyob ntawm glutamate signaling.Finally, Nefiracetam potentiates acetylcholine receptors nyob rau hauv hippocampus uas xav kom glutamate tso tawm thiab LTP. Piracetam tsis qhia txoj kev nco no txhim kho kom zoo.Qhov hauv qab yog Nefiracetam zoo li muaj kev nco ntau ntau zog uas cov thawj nootropic Piracetam.

 

Nefiracetam (77191-36-7) Kev Thov

Neuroprotection: Nefiracetam pab tswj hwm NMDA cov paib uas tiv thaiv cov qib siab glutamate ntau dhau. Glutamate yog qhov muaj zog excitatory neurotransmitter. Ntau cov glutamate ua rau cov neurons thiab lub paj hlwb tag nrho.

Neurotransmitters: Nefiracetam modulates GABA qib hauv lub hlwb. Txo GABA thaum nws siab dhau, thiab nce GABA ntau ntau yog tias lawv qes dhau. Ua cov yeeb yaj kiab zoo li kev tsom xam thiab txo kev ntxhov siab. Nefiracetam ncua sijhawm qhib cov calcium calcium. Ua kom cov neurotransmitters nquag ua haujlwm ntev. Txhim kho qhov cim xeeb tsim thiab rov qab.

Acetylcholine: Nefiracetam potentiates nicotinic acetylcholine receptors. Txhawb kev tso tawm ntawm GABA thiab glutamate. Ua rau muaj lub zog zoo thaum txhim kho neuroplasticity thiab txhim kho kev kawm thiab nco.

Nefiracetam (DM-9384, N- (2, 6-dimethylphenyl) -2- (2-oxopyrrolidine-1-yl) -acetamide) yog nyob rau hauv racetam-tsev neeg ntawm cov nootropic tebchaw. Nws yog cov roj-soluble nootropic.

Lub racetam-chav kawm ntawm nootropics muaj pyrrolidone nucleus ntawm lawv cov tub ntxhais. Ib qho Nefiracetam yog cholinergic compound, txhais tau tias nws cuam tshuam rau qib acetylcholine hauv lub hlwb.

Nefiracetam yog siv los ua cov tshuaj hauv Nyiv. Nws raug muag raws li kev tshaj tawm, suav cov tsis muaj kev sib txig sib luag hauv Tebchaws Asmeskas. Tab sis tsis raws li kev noj zaub mov ntxiv. Ib qho ntawm cov khoom sib txuas nootropic tsis ntev los no, nws yog lub npe hu ua kev txhim kho kev txawj ntse. Thiab yog paub txog nws cov anxiolytic, lossis los tiv thaiv kev ntxhov siab los.

 

Nefiracetam (77191-36-7) Kev tshawb fawb ntxiv

Nefiracetam boosts lub hlwb kev noj qab haus huv thiab muaj nuj nqi nyob rau hauv ob peb txoj kev. Tab sis ob qho tshwj xeeb sawv.

Nefiracetam txhim kho kev nco. Hauv ob peb txoj kev tshawb nrhiav thiab kev sim tshuaj, cov kws tshawb nrhiav tau sau tseg txog Nefiracetam cov teebmeem los tiv thaiv kev tsis nco qab. Thiab lawv tau tuaj txog qhov kev soj ntsuam no los ntawm kev ceeb toom Nefiracetam sib cuam tshuam nrog cov neeg muaj acetylcholine receptors hauv lub hlwb.

Ib txoj kev tshawb nrhiav thaum Albert Einstein Pawg Kho Mob Network hauv Philadelphia ua haujlwm nrog cov luav qub. Cov kws tshawb nrhiav siv cov txheej txheem hu ua "nictitating membrane (NM) / eyeblink teb" hauv luav uas tau siv hauv chav kuaj los kawm txog lub cim xeeb ntsig txog lub hnub nyoog.

Hauv qhov zoo li no, pab pawg tau siv Nefiracetam los kawm nws qhov ntxim rau kev tuav thiab rov qab tso dua. Cov kws tshawb fawb tau muab 5, 10 lossis 15 mg / kg ntawm Nefiracetam rau 34 tus "laus" luav nyob 15 hnub.

 

Nefiracetam (77191-36-7) Kev siv

  • Crespi F. “Nefiracetam. Daiichi Seiyaku. " Cov tswvyim Tam Sim No Hauv Kev Tshuaj Yeeb. 2002 Tsib Hlis; 3 (5): 788-93.
  • Malenka RC, Kauer JA, Perkel DJ, Nicoll RA "Qhov cuam tshuam ntawm postynaptic calcium ntawm synaptic kis tau - nws lub luag haujlwm hauv kev ua haujlwm ntev ntev" Kev Lag Luam hauv Neurosciences Volume 12, Qhov teeb meem 11, p444-450, 1989
  • Kim H., Han SH, Quan HY, Jung YJ, Ib J., Kang P., Park JB, Yoon BJ, Seol GH, Min SS "Bryostatin-1 txhawb nqa lub zog ntev ntev los ntawm kev ua kom PKCα thiab PKCε hauv hippocampus . ” Lub paj hlwb. 2012 Dec 13; 226: 348-55.
  • Moriguchi S., Han F., Shioda N., Yamamoto Y., Nakajima T., Nakagawasai O., Tadano T., Yeh JZ, Narahashi T., Fukunaga K. “Nefiracetam ua kom CaM kinase II thiab protein kinase C sib kho los ntawm NMDA thiab metabotropic glutamate receptors hauv olfactory bulbectomized nas. " Phau ntawv Journal ntawm Neurochemistry. 2009 Jul; 110 (1): 170-81
  • Qhov kawg sib piv ntawm kev qhia ntawm Racetam Nootropics
  • Qhov Zoo tshaj Nootropic Tshooj Qhia: Txhua Yam Koj Yuav Tsum Tau Paub [5 Xyoo Kev Ua Haujlwm]

 

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