cov khoom siv

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6

N-AcetylneuraminiC ACID (Sialic acids) yog tsev neeg ntawm cuaj-carbon acidic monosaccharides uas tshwm sim ib txwm muaj qhov kawg ntawm cov suab thaj txuas rau ntawm thaj chaw ntawm cov hlwb thiab cov tshuaj tiv thaiv soluble. Hauv tib neeg lub cev, qhov siab tshaj plaws ntawm sialic acid (raws li N-acetylneuraminic acid) tshwm sim hauv lub hlwb uas nws koom nrog ua ib feem tseem ceeb ntawm ganglioside qauv hauv synaptogenesis thiab neural kis.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Cov Ntaub Ntawv Los Ua Ntej

lub npe N-AcetylneuraminiC ACID (SIALIC ACID)
CAS 131-48-6
purity 98%
Tshuaj lub npe N-AcetylneuraminiC ACID
Synonyms Neuraminic acid
molecular Formula C11H19NO9
molecular Nyhav 309.27 g / mol
Melting Point 185 ℃
InChI Qhov Tseem Ceeb SQVRNKJHWKZAKO-UHFFFAOYSA-N
daim ntawv hmoov
tsos Dawb Crystal hmoov
Ib Sim Neej /
solubility /
cia mob Khaws nyob rau hauv chav tsev kub, nyob rau hauv lub thawv ntim airtight kaw, ua pa tawm, tiv thaiv los ntawm tshav kub, lub teeb thiab av noo.
Daim ntawv thov Kev tiv thaiv kev laus , kev noj haus ntxiv
Kuaj Cov Ntaub Ntawv Qhov

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 General hauj lwm

Sialic acid yog cov lus siv dav dav rau tsev neeg ntawm derivatives ntawm neuraminic acid, muaj suab thaj acid nrog cuaj-carbon rov qab. Nws tseem yog lub npe rau cov tswvcuab feem ntau ntawm pawg no, N-acetylneuraminic acid (Neu5Ac lossis NANA).

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Keeb Kwm

N-AcetylneuraminiC ACID Sialic kua qaub tau pom dav dav hauv cov tsiaj cov nqaij thiab kom tsawg dua lwm qhov muaj sia, suav txij li kab mob fungi mus rau cov poov xab thiab cov kab mob, feem ntau nyob hauv glycoproteins thiab gangliosides (lawv tshwm sim thaum kawg ntawm cov suab thaj txuas txuas nrog cov nplaim ntawm cov hlwb. thiab cov soluble protein). Qhov ntawd vim tias nws zoo li tau tshwm sim lig hauv kev hloov pauv [[yuav tsum tau] Txawm li cas los xij, nws tau pom nyob hauv Drosophila embryos thiab lwm yam kab thiab hauv cov hlab hauv polysaccharides ntawm qee hom kab mob. Feem ntau, cov nroj tsuag tsis muaj lossis tso cov sialic acids.

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Mechanism OAction

Hauv tib neeg lub hlwb muaj lub siab sialic acid siab, qhov twg cov kua qaub no ua lub luag haujlwm tseem ceeb hauv kev sib txuas lus neural thiab ganglioside qauv hauv synaptogenesis. Ntau tshaj 50 hom sialic acid tau paub, txhua tus tuaj yeem tau txais los ntawm cov kua roj ntawm cov kua qaub neuraminic acid los ntawm kev hloov cov amino pawg ntawm ib qho ntawm nws cov pawg hydroxil. Feem ntau, cov pab pawg amino muaj cov acetyl lossis glycolyl pawg, tab sis lwm qhov kev hloov kho tau piav qhia. Cov kev hloov kho no nrog rau cov kev sib txuas tau pom tias yog cov ntaub so ntswg tshwj xeeb thiab kev nthuav dav hauv kev loj hlob, yog li qee qhov ntawm lawv tsuas pom qee yam ntawm glycoconjugates hauv cov hlwb tshwj xeeb. [3] Cov hloov pauv hydroxyl tuaj yeem sib txawv ntau; Cov tshuaj acetyl, lactyl, methyl, sulfate, thiab phosphate tau pom.

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Daim Ntawv Thov

  1. Qhov "lub hlwb kub" ntawm kev nthuav dav

Hauv cov tsiaj yug menyuam, N-AcetylneuraminiC ACID (SIALIC ACID) muab tshuaj ua ke ua lub siab. Nws yog cov zaub mov tseem ceeb hauv cov kua mis, uas tuaj yeem txhawb txoj kev loj hlob ntawm lub hlwb thiab cov hlab nqaij hauv cov menyuam mos thiab menyuam yaus, txhim kho lub cim xeeb thiab kev txawj ntse, txhim kho kev tiv thaiv ntawm cov menyuam mos thiab leej niam;

  1. Detox tua, txhim kho lub cev tiv thaiv kab mob.

 N-AcetylneuraminiC ACID (SIALIC ACID) tsis raug puas tsuaj los ntawm cov enzymes hauv cov zom zaub mov, nws tsim cov glycoproteins uas thaiv kev ua ke ntawm pathogens (kab mob, kab mob thiab kab mob toxins) mus rau endocrine cov hlwb, thiab tuaj yeem txhim kho cell txheeb, detoxify cholera toxins, tiv thaiv kev kis kab mob pathological E. coli, tswj cov roj ntsha muaj sia ib nrab, thiab ua li no hloov kho tib neeg lub cev tsis ua haujlwm. Tib lub sijhawm, N-AcetylneuraminiC ACID (SIALIC ACID) tuaj yeem txhim kho lub plab hnyuv nqus ntawm cov vitamins thiab cov zaub mov. Txhim kho qhov kev tiv thaiv ntawm tus menyuam thiab leej niam; N-AcetylneuraminiC ACID (SIALIC ACID) nws tus kheej tseem ua rau muaj txiaj ntsig ntawm kev yug menyuam ruaj khov, pab cov poj niam cev xeeb tub kom yug tau yooj yim, thiab ua kom sai tom qab yug me nyuam.

  1. Ncua kev laus ntawm tes thiab ncua lub neej.

 Qhov chaw ntawm tib neeg lub hlwb muaj txheej tuab ntawm N-AcetylneuraminiC ACID (SIALIC ACID), tswj kev ua neej nyob ntawm tes thiab xov tooj sib txuas lus, N-AcetylneuraminiC ACID (SIALIC ACID) tsis muaj peev xwm ua rau lub cev ntshav metabolism hauv lub neej thiab cov protein protein tsawg. Thiab qhov ncauj N-AcetylneuraminiC ACID (SIALIC ACID) tuaj yeem txhim kho qhov tsis haum ntawm N-AcetylneuraminiC ACID (SIALIC ACID) nyob rau hauv lub cev, tiv thaiv lub ntsej muag ntawm tes N-AcetylneuraminiC ACID (SIALIC ACID) los tu, ncua lub hnub nyoog ntawm lub cev, muaj lub luag haujlwm ntev. Cov.

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Kev tshawb fawb ntxiv

Sialic acid-nplua nuj glycoproteins (sialoglycoproteins) khi xaiv hauv tib neeg thiab lwm yam muaj sia. Cov kab mob qog nqaij hlav hlwb feem ntau qhia qhov siab ceev ntawm sialic acid-glycoproteins ntau. Qhov overexpression ntawm sialic acid ntawm thaj chaw tsim lub txim tsis zoo rau ntawm cov cell ua huv si. Qhov no tsim qhov rov ua haujlwm ntawm cov hlwb (lub cell tawm tsam) thiab pab cov hlwb qog nqaij hlav hlwb lig nkag mus rau cov ntshav. Cov kev sim tshiab tsis ntev los no tau pom tias muaj cov sialic acid nyob rau hauv cov kabmob zais cia cov kabmob muaj kabmob loj ntxiv.

 

N-AcetylneuraminiC ACID (SIALIC ACID) 131-48-6 Kev Qhia Tawm

[1] Severi E .; Hood DW; Thomas GH (2007). "Kev siv kua qaub Sialic acid los ntawm cov kab mob pathogens". Microbiology. 153 (9): 2817–2822. doi: 10.1099 / mic.0.2007 / 009480-0. PMID 17768226

[2] Schauer R. (2000). "Kev ua tiav thiab kev sib tw ntawm kev tshawb fawb sialic acid". Glycoconj. J. 17 (7–9): 485–499. doi: 10.1023 / A: 1011062223612. PMC 7087979. PMID 11421344

[3] Racaniello, Vincent (5 Tsib Hlis 2009). “Kab mob ua npaws rau lub hlwb: lub luag hauj lwm ntawm cov sib txawv sialic acids”. Vav vwm. Txais lawm 10 Tim 2019.

[4] Warren, Leonard; Felsenfeld, Herbert (1962). “Lub Biosynthesis ntawm Sialic Acids” (PDF). Cov phau ntawv Journal ntawm lom Chemistry. 237 (5): 1421.

 

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