Cannabidiol (CBD)

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Qeb: SKU: N / A

Lub npe: Cannabidiol (CBD)

CAS: 13956-29-1

Cov mis mos molecular: C21H30O2

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

Cov Ntaub Ntawv Qhia Txog Tshuaj Hauv Paus

lub npe Cannabidiol (CBD)
CAS 13956-29-1
purity 99% Cais / Extrapure Isolate (CBD≥99.5%)
Tshuaj lub npe CANNABIDIOL
Synonyms CBD; C07578; Roj CBD; Siv lead ua CBD; CANNABIDIOL; CBD Cais; (1r-trans) -; CBD hmoov 99%; CBD, CANNABIDIOL; (-) - CANNABIDIOL
molecular Formula C21H30O2
molecular Nyhav 314.46
Melting Point 62-63 ° C
InChI Qhov Tseem Ceeb QHMBSVQNZZTUGM-ZWKOTPCHSA-N
daim ntawv Khoom
tsos Dawb rau lub teeb daj crystalline hmoov
Ib Sim Neej 18-32 teev
solubility Soluble nyob rau hauv roj, tsis tshua muaj soluble hauv ethanol thiab methanol, insoluble hauv dej
cia mob Chav sov, ua kom qhuav thiab deb ntawm lub teeb
Daim ntawv thov Rau kev tshawb fawb lub hom phiaj nkaus xwb, los yog raws li cov khoom siv rau kev tsim khoom hauv qab, los yog coj mus muag rau cov teb chaws thiab cheeb tsam raug cai sab nrauv. Thov nco ntsoov cov khoom no yuav tsum tsis txhob siv ncaj qha lossis siv rau kev kho mob hauv Suav teb cov av loj
Kuaj Cov Ntaub Ntawv Qhov

 

Cannabidiol (CBD) hmoov 13956-29-1 General Description

Cannabidiol [CBD] yog lub hauv paus tseem ceeb uas tsis yog psychotropic ntawm cov qog plaub hau ntawm Cannabis sativa. Nws qhia txog ntau yam kev ua nrog rau anticonvulsive, sedative, hypnotic, antipsychotic, thiab anti-inflammatory thiab cov khoom tiv thaiv neuroprotective. Nws yog phyto-cannabinoid loj, suav txog 40% ntawm Cannabis cog cov extract, uas khi rau ntau yam ntawm lub cev lub hom phiaj ntawm endocannabinoid system hauv lub cev. Txawm hais tias qhov tseeb cuam tshuam txog kev kho mob tam sim no tab tom tshawb fawb, CBD tau qhia pom kev cog lus tias yog lub hom phiaj kho tshuaj thiab tshuaj. Tshwj xeeb, CBD tau qhia kev cog lus tias yog tshuaj loog, tshuaj tiv thaiv kab mob, nqaij leeg, anxiolytic, antipsychotic thiab tau qhia txog kev tiv thaiv kab mob, tiv thaiv kev mob, thiab tshuaj tiv thaiv kab mob, ntawm lwm qhov kev tshawb nrhiav tam sim no.

CBD muaj feem cuam tshuam nrog lwm qhov tseem ceeb medicinally active phytocannabinoid: tetrahydrocannabinol (THC), cov sib txuas uas ua rau muaj qhov siab ntawm cannabis yog lub npe nrov rau. Cov no yog ob qho kev sib txuas ntawm cov kab mob cannabis uas tau kawm ntau los ntawm cov kws tshawb fawb.

Ob CBD thiab THC muaj cov kev coj ua uas tseem ceeb. Tab sis tsis zoo li THC, CBD tsis ua rau ib tus neeg "hnov pob zeb" los yog qaug. Tias vim tias CBD thiab THC ua txoj hauv kev sib txawv ntawm cov sib txawv receptors hauv lub hlwb thiab lub cev.

CBD muaj peev xwm ua tau kom tsawg dua los yog nruab nrab ntawm qhov kev xav zoo hauv THC, nyob ntawm seb siv ntau npaum li cas ntawm ib qho kev sib xyaw. Ntau tus neeg xav tau cov txiaj ntsig kev noj qab haus huv ntawm cannabis yam tsis muaj qhov siab - lossis nrog tsawg dua ntawm ib qho siab. Qhov tseeb tias CBD yog kev kho mob kom muaj txiaj ntsig zoo li tsis muaj tshuaj lom, thiab yooj yim los noj raws li roj CBD, ua rau nws muaj kev xaiv txaus rau cov neeg uas ceev faj txog kev sim cannabis thawj zaug.

 

Keeb kwm

Kev siv zog cais cov khoom xyaw nquag hauv cannabis tau ua nyob rau xyoo pua puv 19. Cannabidiol tau kawm nyob rau xyoo 1940 los ntawm Minnesota cov tsiaj nyaum hemp thiab Egyptian Cannabis indica cob. Tus qauv tshuaj lom neeg ntawm CBD tau npaj siab los ntawm ib txoj hauv kev rau nws cais tawm los ntawm hemp qus. Nws cov qauv thiab stereochemistry tau txiav txim siab hauv 1963.

 

Mechanism Ntawm Kev Ua

Cannabidiol muaj cov txiaj ntsig rau lub hlwb. Qhov tseeb yog vim li cas rau cov teebmeem no tsis paub meej. Txawm li cas los xij, cannabidiol zoo li tiv thaiv kev puas tsuaj ntawm tshuaj hauv lub hlwb uas cuam tshuam rau qhov mob, lub siab lub ntsws thiab lub hlwb kev ua haujlwm. Tiv thaiv kev puas tsuaj ntawm cov tshuaj no thiab nce hauv theem hauv cov ntshav zoo li txo cov tsos mob psychotic cuam tshuam nrog cov mob xws li mob schizophrenia. Cannabidiol tseem tuaj yeem thaiv qee qhov kev puas siab ntsws ntawm delta-9-tetrahydrocannabinol (THC). Tsis tas li ntawd, cannabidiol zoo li txo qhov mob thiab ntxhov siab.

 

Daim ntawv thov

Daim ntaub ntawv kho mob:

Analgesic thiab anti-inflammatory: Cannabidiol tuaj yeem tsim cov teebmeem analgesic. Cov txheej txheem tshuaj ntawm cov tshuaj analgesia feem ntau cuam tshuam nrog CB1 thiab CB2 receptors.CB1 receptors ua tiav cov txiaj ntsig analgesic los ntawm kev cuam tshuam ncaj qha txwv tsis pub tso tawm gamma-aminobutyric acid, teeb meem grey thiab RVM (GABA), thiab glutamate hauv tus txha caj qaum hauv periaquapular.

Kev Siv Tshuaj Tiv Thaiv Kab Mob:

GABA neurotransmitters hauv tib neeg lub hlwb muaj qhov ua kom zoo, txwv tsis pub muaj kev cuam tshuam nyob rau hauv lub hlwb cov chaw.

Kev ntxhov siab:

Endocannabinoids yog ib qho tseem ceeb hauv lub cev uas pab cov neeg mob kev nyuab siab txo kev ntxhov siab. Cannabidiol pab ua kom cov tshuaj endocannabinoids tsim nyog, ua rau cov neeg mob zoo siab thiab zoo siab, tab sis cov neeg mob yuav tsis teb rau ntawm CBD hmoov.

 

Cannabidiol (CBD) hmoov 13956-29-1 Kev tshawb fawb ntxiv

Kev tshawb nrhiav ntawm lwm qhov kev siv rau cannabidiol suav nrog ntau qhov kev puas siab puas ntsws, tab sis qhov kev tshawb pom tsis tau lees tias tsim kev siv li ntawd hauv kev coj ua. Thaum Lub Kaum Hli 2019, FDA tau tawm lus ceeb toom tias cov teebmeem ntawm CBD thaum cev xeeb tub lossis pub niam mis tsis paub txog, qhia tias muaj kev nyab xeeb, koob tshuaj, cuam tshuam nrog lwm cov tshuaj lossis khoom noj, thiab phiv CBD tsis yog cov kws kho mob tau hais tseg, thiab yuav ua rau muaj teeb meem txaus ntshai rau leej niam thiab tus me nyuam.

Ntau cov lus thov yog ua rau kev kho mob tau txais txiaj ntsig ntawm cannabidiol uas tsis tau thim rov qab los ntawm cov pov thawj suab. Qee qhov kev thov - piv txwv tias cannabidiol tuaj yeem siv los kho mob qog nqaij hlav - poob rau hauv lub cev qhov tseeb ntawm pseudoscience.

Hauv xyoo 2020, daim ntawv lo rau Epidiolex hauv Asmeskas tau nthuav dav suav nrog kev kho mob qaug dab peg txuam nrog cov hlab ntsws txhaws txhaws.

 

reference

  1. "Kev tswj hwm FDA ntawm Cannabis thiab Cannabis-Cov khoom lag luam, suav nrog Cannabidiol (CBD) (General)". Meskas cov Khoom Noj thiab Tshuaj (FDA). Lub Ib Hlis 22, 2021. Rov tuaj dua lub Plaub Hlis 14, 2021.
  2. Campos AC, Moreira FA, Gomes FV, ​​Del Bel EA, Guimarães FS (Kaum Ob Hlis 2012). "Ntau cov txheej txheem koom nrog rau hauv qhov loj-spectrum kho cov peev xwm ntawm cannabidiol hauv kev puas siab puas ntsws". Lub Neej Kev Lag Luam ntawm Royal Society of London. Series B, Kev Tshawb Fawb Txog Tshuaj Txheeb Ze (Biology) (Tshawb Xyuas). 367 (1607): 3364–
  3. Izgelov D, Davidson E, Barasch D, Regev A, Domb AJ, Hoffman A. Pharmacokinetic tshawb ntawm hluavtaws cannabidiol qhov ncauj tsim nyob rau hauv kev noj qab haus huv tuaj pab dawb. Eur J Pharm Biopharm. 2020; 154: 108-115.
  4. Gurley BJ, Murphy TP, Gul W, Walker LA, ElSohly M. Cov ntsiab lus tsis sib xws ntawm Daim Ntawv Thov Nyiaj hauv Cannabidiol (CBD) -Txoj Khoom Lag Luam Tau los ntawm Cov Chaw Muag Khoom hauv Lub Xeev Mississippi. J Cov Khoom Noj Noj Haus. 2020; 17: 599-607.

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