Berberine hydrochloride hmoov 633-65-8

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[1]. Xaiv qhov koj xav tau, tom qab ntawd ntxiv rau lub laub

[2]. Txuas mus xyuas

[3]. Sau koj cov ntaub ntawv nthuav dav, qhov * yuav tsum tau, xaiv koj txoj kev them nyiaj. Muaj ntau txoj kev them nyiaj sib txawv suav nrog:
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Lub tswv yim: email chaw nyob yuav tsum tau kho, cov ntaub ntawv taug qab yuav hloov tshiab los ntawm email ceeb toom

[4]. Yog tias xaiv "Coinpayment", tom qab nyem "Place order", ces yuav qhia raws li hauv qab no them

[5]. Yog tias Xaiv "Direct Bank Transfer", tom qab nias "Place order", ces yuav qhia raws li hauv qab no, yuav tshwm sim cov ntsiab lus ntawm tus account hauv txhab nyiaj, tom qab hloov lub txhab nyiaj (thov siv koj tus lej xaj raws li qhov siv), xa daim ntawv hauv txhab nyiaj rau peb.

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[8]. Tus lej taug qab tau muab
[9]. Parcel tuaj txog
[10]. Rov xaj dua
Tsis muaj koj qhov ntau? Nyem no
Ceeb toom: Yog tias koj cev xeeb tub, saib xyuas neeg mob, noj cov tshuaj los yog muaj kev mob nkeeg nrog koj tus kws kho mob ua ntej siv. Khaws kom deb ntawm cov menyuam yaus.
Qeb: SKU: N / A

Lub npe: Berberine hydrochloride

CAS: 633-65-8

Cov mis mos molecular: C20H18ClNO4

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

Chemical Base Information Base Information

lub npe Berberine hydrochloride hmoov
CAS 633-65-8
purity 98%
Tshuaj lub npe Berberine hydrochloride hmoov
Synonyms Berberine HCL, tshuaj

berberine tshuaj dawb,

Ntuj Daj 18,

Benzodioxide, cov

molecular Formula C20H18ClNO4
molecular Nyhav 371.8 g / mol
Melting Point 193-196 ℃
InChI Qhov Tseem Ceeb VKJGBAJNNALVAV-UHFFFAOYSA-M
daim ntawv hmoov
tsos Daj
Ib Sim Neej /
solubility Soluble hauv dej (<1 mg / ml ntawm 25 ° C)
cia mob /
Daim ntawv thov Berberine hydrochloride feem ntau noj ntawm qhov ncauj rau cov ntshav qab zib, ntshav siab los yog lwm cov rog (lipids) hauv cov ntshav (hyperlipidemia), thiab ntshav siab. Nws kuj tseem raug thov rau ntawm daim tawv nqaij los kho kho qhov mob kub nyhiab thiab canker nqaij
Kuaj Cov Ntaub Ntawv Qhov

 

Berberine Hydrochloride

Berberine yog cov tshuaj alkaloid muab los ntawm cov nroj tsuag thiab tshuaj ntsuab uas npaj tau. Qhov iab-saj, hmoov daj tau nquag siv hauv Tshuaj ib txwm rau ntau yam ntawm nws cov txiaj ntsig kev noj qab haus huv, thiab nws yog cov txiaj ntsig uas tam sim no txhawb nqa los ntawm cov pov thawj tshawb fawb. Muab rho tawm los ntawm pab pawg ntawm tsob ntoo hu ua Berberis, cov tshuaj alkaloid no tseem siv ua xim zas xim rau nws cov xim daj. Cov xim daj ntawm cov tshuaj no tseem tuaj yeem pom nyob rau hauv ultraviolet fluorescence, uas yog vim li cas nws thiaj li nquag siv hauv kev ua kom heparin hauv cov qog ua haujlwm.

Berberine yog quaternary ammonium ntsev uas belongs rau benzylisoquinoline alkaloids uas tau muab los ntawm cov nroj tsuag sib txawv ntawm Berberis tsev neeg. Txawm li cas los xij, qhov sib xyaw no tuaj yeem muab rho tawm los ntawm lwm cov nroj tsuag thiab cov nroj tsuag, tshwj xeeb tshaj yog cov hauv paus hniav, tawv ntoo, thiab stems ntawm cov nroj tsuag no.

Berberine, ib zaug noj, nkag mus rau kev sib haum xeeb faib mus rau ntau qhov chaw ntawm lub cev kom tsim tau ntau yam txiaj ntsig ntawm qhov sib xyaw. Thaum nws tau ua haujlwm rau nws lub hom phiaj, qhov sib xyaw ua ke yog metabolized hauv daim siab, los ntawm CYP2D enzyme, hauv ob qho tib si tsiaj qauv thiab tib neeg. Nws tau hloov pauv mus rau hauv berberrubine thiab berberrubine-9-O-β-D-glucuronide los ntawm kev ua ntawm cov enzymes siab, tom qab uas cov khoom sib xyaw tau tso rau hauv cov quav thiab tso zis.

Berberrubine thiab berberrubine-9-O-β-D-glucuronide raug tso tawm rau hauv quav thiab zis, raws li, txawm hais tias lub sijhawm sijhawm ntawm cov txheej txheem tseem tsis tau paub. Raws li qee qhov kev tshawb fawb, kev tshem tawm ntawm berberine los ntawm lub cev, txawm tias tom qab 84 teev ntawm kev noj tshuaj tsuas yog 41 feem pua. Qhov no ntawm cov metabolism ntawm Berberine hmoov yuav tsum tau kawm ntxiv kom nco ntsoov lub sijhawm raws nraim.

 

Khoom noj khoom haus nplua nuj nyob hauv Berberine

Berberine hydrochloride hmoov yog muab los ntawm cov khoom siv ntuj tsim, thiab kev siv cov khoom noj no tuaj yeem muab tau rau tib neeg lub cev nrog berberine, txawm hais tias tsis nyob rau hauv tib cov concentrated npaum li tsuas yog noj berberine hmoov. Cov khoom noj tseem ceeb tshaj plaws uas muaj berberine yog turmeric, cov cag ntoo uas feem ntau siv los ua cov txuj lom muaj zog hauv South Asian cuisine.

Berberine kuj muaj nyob rau hauv cov khoom noj hauv qab no:

Goldenseal,

Barberry,

Oregon txiv hmab,

Tsob ntoo turmeric.

Xov tooj,

Phellodendron,

 

Mechanism of Action ntawm Berberine Hydrochloride

Berberine hydrochloride yog khaws cia rau hauv cov hlwb ntawm lub cev, tom qab noj thiab thauj los ntawm cov hlab ntsha mus rau ntau qhov chaw ntawm lub cev. Thaum nws mus txog cov hlwb no, nws ua rau muaj kev hloov pauv rau kev noj qab haus huv zoo, los ntawm ntau yam kev ua haujlwm.

Cov txiaj ntsig muaj zog tshaj plaws ntawm cov tshuaj sib xyaw yog nws ua kom AMP qhib lub zog protein kinase enzyme hauv cov hlwb, uas yog tus tswj hwm tseem ceeb ntawm cov metabolism hauv thiab homeostasis hauv lub cev. Vim li no, tus enzyme hu ua tus tswv metabolic hloov. Nrog rau cov enzyme no, berberine tseem cuam tshuam rau lwm txoj hauv kev tswj hwm uas tuaj yeem tig los yog tawm ntawm kev qhia ntawm cov noob sib txawv.

 

Cov txiaj ntsig ntawm Berberine Hmoov

Berberine hmoov muaj ntau yam txiaj ntsig cuam tshuam nrog nws, feem ntau yog rov qab los ntawm kev tshawb fawb pov thawj. Cov txiaj ntsig no kuj yog vim li cas vim li cas qhov sib xyaw tau siv ua tiav hauv kev kho mob ntawm ntau yam kab mob hauv cov tshuaj tsoos. Cov txiaj ntsig ntawm qhov sib xyaw ua pov thawj los ntawm ntau hom kev tshawb fawb yog:

 

Kev tswj ntshav qab zib mellitus

Berberine hmoov muaj peev xwm tswj tau cov tsos mob ntawm cov ntshav qab zib thiab kho nws nrog tib lub zog zoo li ntau lwm cov tshuaj tiv thaiv ntshav qab zib, tshwj xeeb yog Metformin. Metformin yog thawj zaug kev kho mob feem ntau siv los kho ntshav qab zib. Ib qho kev sim tshuaj ntsuam randomized ua rau cov neeg mob ntshav qab zib mellitus tau kawm txog qhov muaj zog no los ntawm kev random muab kev kho mob nrog berberine lossis metformin rau ntau pawg neeg koom nrog kev kawm. Qhov kev sim tshuaj kho mob no tau mus rau peb lub hlis thiab cov txiaj ntsig tau pom tias ob qho ntawm cov tshuaj no muaj txiaj ntsig zoo hauv kev tswj ntshav qab zib, sib npaug.

Hauv txoj kev tshawb no, nws tau pom tias qib HBa1c thiab ntshav qab zib theem nrog rau qib triglycerides thiab qis lipoproteins tsawg (LDL) hauv lub cev txo qis hauv ob pawg. Cov txiaj ntsig no tau coj mus rau qhov xaus tias ob qho tib si berberine thiab Glucophage, lub npe tshuaj ntawm metformin yuav luag zoo ib yam hauv kev tswj cov tsos mob ntshav qab zib.

Tsis tas li ntawd, cov txiaj ntsig ntawm berberine ntawm kev tswj cov ntshav qab zib tau ua raws li ntau txoj hauv kev. Qhov no yog qhov tseem ceeb vim tias berberine paub tias txo cov ntshav qab zib, tab sis nws tsis paub tias nws ua haujlwm li cas. Cov kev tshawb fawb tau ua rau cov neeg mob ntshav qab zib uas tau nthuav tawm rau berberine ntxiv pom tias muaj kev txhim kho tseem ceeb rau qhov uas cov ntshav qab zib poob los ntawm cov txheej txheem ntshav qab zib mus rau qhov ib txwm muaj, noj qab nyob zoo.

Berberine nce kev ua haujlwm ntawm insulin hauv lub cev, thiab qhov no yog qhov tseem ceeb tshwj xeeb tshaj yog vim tias qhov tshwm sim ntawm cov ntshav qab zib mellitus nce ntxiv vim yog insulin tsis kam. Ntxiv nrog rau qhov sib xyaw ua kom cov lus teb ntawm cov kab mob peripheral rau insulin, ua rau cov ntshav qabzib qis qis.

Thaum cov piam thaj molecules raug coj mus rau hauv lub cell, raws li cov lus teb rau insulin ntau ntxiv, lawv tau khaws cia rau ntawd. Cov kua nplaum uas khaws cia no tau raug nce ntxiv los ntawm berberine vim nws txhawb nqa glycolysis. Kev rhuav tshem cov suab thaj hauv cov hlwb yog ib qho ntawm ntau txoj hauv kev los ntawm cov hmoov berberine pab tswj ntshav qab zib mellitus.

Cov kev tshawb fawb tseem tau qhia tias berberine txo qis cov piam thaj hauv lub siab, vim qhov ntawd yog ib qho ntawm cov txheej txheem uas cov piam thaj nce ntxiv hauv lub cev, sib nrug los ntawm kev noj cov carbohydrates. Txhawm rau tiv thaiv lwm txoj hauv kev ntawm cov piam thaj nce ntxiv, berberine txo qis kev nqus ntawm cov carbohydrates hauv lub plab. Qhov no pab txo qis cov piam thaj hauv lub cev, qhov tseem ceeb.

 

Kev kho mob ntawm kab mob

Berberine hydrochloride hmoov tau pom tias muaj cov tshuaj tua kab mob zoo heev vim nws muaj peev xwm tiv thaiv cov kab mob sib txawv, kab mob, fungi, thiab txawm tias kab mob. Cov teebmeem ntawm qhov sib xyaw no tau kawm hauv chav kuaj qhov chaw uas nws tau pom tias nws inhibits kev loj hlob ntawm Staphylococcus aureus, ib qho kab mob uas muaj feem xyuam rau ntau yam kab mob sib txawv. Ntxiv mus, nyob rau hauv ib txoj kev tshawb fawb zoo sib xws, nws tau pom tias berberine yog lub luag haujlwm rau stunted protein ntau lawm thiab DNA tsim nyob rau hauv cov kab mob.

 

Anti-inflammatory thiab Antioxidant zog

Berberine hmoov tau pom tias muaj cov tshuaj tiv thaiv kab mob uas ntseeg tau los pab tiv thaiv kev mob ntshav qab zib ntawm berberine. Oxidative stress thiab o ua lub luag haujlwm tseem ceeb hauv kev tsim cov kab mob ntshav qab zib mellitus, thiab kev tshawb fawb tau pom tias berberine cuam tshuam nrog cov kab mob inflammatory. Ntxiv mus, berberine tau pom tias muaj kev cuam tshuam rau cov dawb radicals hauv lub cev thiab txo lawv cov kev ua tau zoo.

Vim tias cov txheej txheem ntawm kev ua haujlwm no, cov kws tshawb fawb tau hu rau kev siv berberine hydrochloride hmoov hauv kev kho cov kab mob inflammatory. Tsis tas li ntawd, lawv tau hu rau nws txoj kev siv hauv kev tswj cov kab mob hauv lub plawv raws li lawv feem ntau pib nrog kev mob ntawm cov theem pib, ua ntej ua rau cov txiaj ntsig hnyav dua.

 

Kev tswj cov roj (cholesterol) siab

Thaum kawm txog qhov cuam tshuam ntawm berberine rau cov ntshav qab zib mellitus, cov kws tshawb fawb pom tau tias nws muaj peev xwm txo qis kev nqus ntawm triglycerides thiab LDL hauv lub plab. Qhov no tau coj mus rau kev tshawb fawb ntxiv ntawm cov ncauj lus uas exaggerated lub anti-hypercholesterolemic teebmeem ntawm lub compound.

Ib txoj kev tshawb fawb tsis ntev los no tau pom tias cov roj cholesterol tau txo qis nrog berberine supplementation thiab tseem ceeb tshaj, cov teebmeem no tau pom tseeb hauv txhua hom roj cholesterol. Lub caij no, cov qib ntawm cov roj cholesterol zoo lossis HDL tau nce ntau, yog li txo qhov kev pheej hmoo ntawm hypercholesterolemia thiab thaum kawg, kab mob plawv hauv cov neeg mob.

Lwm txoj kev tshawb nrhiav pom tias berberine qhov tseeb kuj tseem txo qis qib apolipoprotein B, uas yog qhov cim tseem ceeb ntawm kev mob plawv thiab hypercholesterolemia. Cov cholesterol-txo cov teebmeem ntawm berberine yog tshwj xeeb tshaj yog muaj txiaj ntsig zoo li cov roj cholesterol hauv lub cev tuaj yeem ua rau mob plawv lossis mob stroke, uas yog qhov ua rau tuag taus yog tias tsis kho kom raug thiab raws sijhawm.

Ib txoj kev tshawb fawb tau ua los ntawm tsiaj qauv qhia tias cov roj (cholesterol) ntau hauv lub cev tau hloov mus rau lub siab los ntawm berberine yog li nws tuaj yeem tso tawm thiab tshem tawm ntawm lub cev. Cov tsiaj ua qauv qhia pom qis qis triglycerides thiab qib LDL tom qab tau ntxiv nrog Berberine.

Ntxiv mus, cov kws tshawb fawb tau pom tias berberine muaj peev xwm inhibit ib qho enzyme, PCSK9, uas ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev tshem tawm ntawm LDL los ntawm cov ntshav. Cov txiaj ntsig ntawm berberine no tseem ua rau qib qis ntawm cov sib xyaw hauv cov ntshav, uas ua rau txo qis cov qib roj cholesterol hauv lub cev.

Tag nrho cov teebmeem ntawm berberine tau pom zoo ib yam, thiab muaj zog sib npaug, raws li ntau cov tshuaj tiv thaiv cholesterol. Qhov no tau coj mus rau cov kws tshawb fawb hu rau siv cov khoom sib xyaw ua kev kho rau cov roj (cholesterol) siab.

 

Cardioprotective zog

Ib txoj kev tshawb fawb ib zaug tau ua rau cov neeg muaj kev pheej hmoo siab rau kev txhim kho lub plawv tsis ua hauj lwm pom tias berberine supplementation txo cov kev pheej hmoo ntawm lub plawv tsis ua hauj lwm. Hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm, qhov sib xyaw ua ke tau pab txo qis cov tsos mob.

Cov teebmeem cardioprotective ntawm berberine yog tshwj xeeb tshaj yog nyob rau hauv cov teebmeem ntawm cov compound tiv thaiv kub siab. Hauv txoj kev tshawb fawb tau ua ntawm cov tsiaj ua qauv, nws tau pom tias berberine muaj qhov cuam tshuam rau qhov pib ntawm kev mob ntshav siab ntau, vim nws tau qhia tias lub sijhawm qeeb. Thiab thaum pib pib, cov tsiaj ua qauv pom muaj tsos mob tsawg dua li cov uas tsis noj tshuaj berberine.

Kev siv cov tshuaj sib xyaw ua ke hais txog kev kho mob ntshav siab tam sim no tab tom sib cav vim muaj ntau tus kws tshawb fawb ntseeg tias qhov sib xyaw muaj peev xwm ua tau raws li cov tshuaj tiv thaiv kab mob siab vim tias lub zog ntawm ob tus neeg ua haujlwm zoo sib xws.

 

Muaj zog yuag tus neeg sawv cev

Berberine hmoov tau ntseeg tias txo cov rog hauv lub cev los ntawm kev txo qis gat cell loj hlob, nqis mus rau qib molecular. Txawm hais tias xav tau kev tshawb fawb ntxiv ntawm qhov kev kawm, ntau qhov kev tshawb fawb sib txawv qhia tias berberine ua lub luag haujlwm tseem ceeb hauv kev tswj hwm cov tshuaj hormones xws li adiponectin thiab leptin, uas tso cai rau cov khoom sib xyaw kom nws cov khoom poob.

Ib txoj kev tshawb fawb tau ua rau cov neeg mob uas muaj BMIs siab thiab cov kab mob metabolic pom tias kev noj tshuaj berberine ntxiv rau peb lub hlis pab cov neeg koom nrog 4 cov ntsiab lus ntawm BMI nplai, qhov nruab nrab. Ntxiv mus, cov neeg koom no tau pom qhov txo qis hauv lawv lub plab rog cov ntsiab lus nrog rau kev txo qis ntawm kev rog rog ntsig txog comorbidities.

Hauv txoj kev tshawb fawb zoo sib xws, cov txiaj ntsig ntawm cov tshuaj sib xyaw tau kawm thiab nws tau pom tias berberine nce kev tsim cov nqaij adipose xim av hauv lub cev. Xyoo tshwj xeeb ntawm cov ntaub so ntswg pab hloov rog rau hauv lub cev kom sov, ua rau muaj kev noj cov khw muag roj hauv lub cev thiab muaj peev xwm, kho kev rog.

 

Cov khoom tiv thaiv qog noj ntshav

Muaj ob peb yam kev tshawb fawb txhawb nqa kev siv berberine vim nws muaj peev xwm tiv thaiv qog noj ntshav. Ib txoj kev tshawb fawb tau ua rau cov qog nqaij hlav cancer thiab berberine hmoov supplementation pom tau tias cov compound muaj cov cim qhia txog kev mob qog noj ntshav thiab kev loj hlob, raws li nyob rau hauv uas nws inhibits nws. Lwm qhov kev tshawb fawb tau ua rau qhov teeb meem pom tias berberine muaj kev cuam tshuam rau kev mob qog noj ntshav hauv tsev menyuam, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, thiab mob ntsws cancer.

 

Kev kho PCOS

Polycystic zes qe menyuam syndrome tshwm sim los ntawm insulin tsis kam thiab yog teeb meem metabolic, uas yog vim li cas berberine ntseeg tau tias muaj txiaj ntsig zoo hauv kev kho mob tsis meej pem. Raws li nws feem ntau ua rau muaj menyuam tsis taus, kev kho raws sijhawm thiab tsim nyog yog qhov tsim nyog kiag li. Ntau tus kws tshawb fawb tau pom berberine los pab tswj cov teeb meem ntawm kev rog rog, insulin tsis kam, thiab cov roj cholesterol siab uas tsis yog qhov tseem ceeb hauv cov kab mob, tab sis kuj yog kev kho mob ntawm PCOS.

 

Kev siv ntawm Berberine Powder

Berberine hmoov yog siv los ua ib qho ntxiv, feem ntau yog rau kev tswj cov ntshav qab zib thiab cov kab mob sib kis. Nws yog ib qho kev txhawb nqa kev noj qab haus huv nrog ntau yam txiaj ntsig, raws li tau hais los saum toj no, thiab cov tshuaj uas tsim los ntawm cov khoom sib xyaw tsim los ntawm peb cov tuam txhab berberine hydrochloride hmoov, tau siv dav los ntawm cov pej xeem rau cov txiaj ntsig.

Nws kuj yog siv los ua cov xim rau staining ntawm cell npaj nyob rau hauv lub chaw soj nstuam, txawm hais tias qhov kev siv ntawm cov compound no tsis yog ze li ntawm nws siv raws li ib tug ntxiv.

 

Dosage ntawm Berberine Powder

Cov hmoov berberine hydrochloride tuaj yeem siv tau zoo txhua hnub, ntawm qhov nruab nrab koob ntawm 500mg, peb zaug ib hnub twg ntxiv txog 1500mg ib hnub. Cov koob tshuaj dav dav rau ib hnub yog li ntawm 900 mg txog 1500 mg.

 

Cov Teeb Meem Ntawm Berberine Hmoov

Berberine hmoov yog ib qho kev nyab xeeb zoo uas tuaj yeem noj tau raws li nws tsis cuam tshuam nrog cov tshuaj tam sim no ntawm cov neeg siv khoom. Feem ntau cov kev mob tshwm sim ntawm qhov sib xyaw yog txwv tus kheej thiab yuav daws teeb meem yam tsis muaj kev pab kho mob. Txawm li cas los xij, cov kev mob tshwm sim me ntsis uas tshwm sim yog cuam tshuam nrog kev mob plab, thiab feem ntau tshwm sim xws li:

  • Tawg
  • Xeev thiab ntuav
  • cem quav
  • Zawv plab

 

References

  1. Yin, J., Xing, H., & Ye, J. (2008). Kev ua tau zoo ntawm berberine hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus. Metabolism: kev kho mob thiab kev sim, 57(5), 712-717. https://doi.org/10.1016/j.metabol.2008.01.013
  2. Zheng Li, Ya-Na Geng, Jian-Dong Jiang, Wei-Jia Kong, "Antioxidant thiab Anti-Inflammatory Activities ntawm Berberine hauv kev kho mob ntshav qab zib mellitus", Pov Thawj Pom Raws Li Txheej Txheem Qhia thiab Lwm Yam Tshuaj, vol. 2014, Tshooj ID 289264, 12 nplooj ntawv, 2014. https://doi.org/10.1155/2014/289264
  3. Ortiz, LM, Lombardi, P., Tillhon, M., & Scovassi, AI (2014). Berberine, ib qho epiphany tiv thaiv qog noj ntshav. Molecules (Basel, Switzerland), 19(8), 12349-12367. https://doi.org/10.3390/molecules190812349
  4. Lou, T., Zhang, Z., Xi, Z., Liu, K., Li, L., Liu, B., & Huang, F. (2011). Berberine txwv tsis pub cov tshuaj tiv thaiv kab mob thiab txhim kho insulin tsis kam hauv hepatocytes. o, 34(6), 659-667. https://doi.org/10.1007/s10753-010-9276-2
  5. Cernáková, M., & Kostálová, D. (2002). Antimicrobial kev ua ub no ntawm berberine - ib qho tseem ceeb ntawm Mahonia aquifolium. Tsob ntoo microbiologica, 47(4), 375-378. https://doi.org/10.1007/BF02818693
  6. Dong, H., Zhao, Y., Zhao, L., & Lu, F. (2013). Cov teebmeem ntawm berberine ntawm cov ntshav lipids: kev tshuaj xyuas thiab kev tshuaj xyuas meta-kev soj ntsuam ntawm randomized tswj kev sim. Planta tshuaj, 79(6), 437-446. https://doi.org/10.1055/s-0032-1328321

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