cov khoom siv

Astragaloside IV

Astragaloside IV yog ib tus neeg hu ua bioactive saponin ua ntej cais los ntawm cov nroj tsuag qhuav ntawm lub genus Astragalus, uas yog siv hauv cov tshuaj hauv Suav teb.1 Nws siv tshuaj tiv thaiv kab mob tib neeg adenovirus hom 3 (HAdV-3) hauv A549 hlwb (IC50 = 23 µM; LC50 = 865 µM) .2 Nws inhibits replication ntawm HAdV-3 thiab txo qis HAdV-3-induced apoptosis. Nws muaj ntau hom kev tiv thaiv rau cov hlab plawv, lub cev tsis muaj zog, lub plab zom mov, thiab cov hlab hlwb.1,3 Hauv kev tshwj xeeb, nws txo qis myocardial infarct loj hauv cov dev thaum muab ua ntej ua mob caj dab thiab txo cov kev rov ua haujlwm.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

Astragaloside IV Powder Base Cov Lus Qhia

lub npe Astragaloside IV Hmoov
CAS 84687-43-4
purity 50%, 98% yog '
Tshuaj lub npe Astragaloside IV
Synonyms Astrasieversianin XIV;

kev voj voog F;

ASTRAGALOSIDE;

cyclosiversioside F;

Astragalus Polysaccharides;

Astragalus extract;

molecular Formula C41H68O14
molecular Nyhav 784.97
Melting Point 295-296 ° C (lit.)
InChI Qhov Tseem Ceeb QMNWISYXSJWHRY-YLNUDOOFSA-N
daim ntawv Khoom
tsos Dawb rau daj ntseg daj hmoov
Ib Sim Neej /
solubility Soluble hauv methanol, ethanol, acetone; Insoluble inchloroform, ethyl acetate thiab lwm yam tsis muaj zog polar organic solvents.
cia mob Khw tom-20 ° C
Daim ntawv thov vasodilator, antihypertensive, tshuaj tiv thaiv
Kuaj Cov Ntaub Ntawv Qhov

 

Astragaloside IV Hmoov 84687-43-4 General hauj lwm

Astragaloside IV yog pentacyclic triterpenoid uas yog cycloastragenol muaj beta-D-xylopyranosyl thiab beta-D-glucopyranosyl seem txuas ntawm cov haujlwm O-3 thiab O-6 feem. Nws yog cais tawm ntawm Astragalus membranaceus var mongholicus. Nws muaj lub luag haujlwm ua haujlwm EC 4.2.1.1 (carbonic anhydrase) inhibitor, tiv thaiv kab mob, tus kab mob neuroprotective, tus kab mob antioxidant, tus kab mob pro-angiogenic thiab cov nroj tsuag metabolite. Nws yog tus triterpenoid saponin thiab pentacyclic triterpenoid. Nws txais los ntawm cycloastragenol.

 

Astragaloside IV Hmoov 84687-43-4 Keeb kwm

Astragaloside IV yog cov tsoos suav tshuaj ntsuab, thiab cov txiaj ntsig tseem ceeb suav nrog kev tiv thaiv kev laus, kev ua kom lub cev tsis muaj zog, pw tsaug zog zoo dua thiab tob tob, plaub hau kev loj hlob, libido txhim kho, thiab tiv thaiv.

 

Astragaloside IV Hmoov 84687-43-4 Mechanism OAction

Astragaloside IV yog cycloartane-type triterpene glycosides, nws yog ib qho ntawm cov khoom xyaw tseem ceeb ntawm cov tshuaj suav ib txwm Astragalus membranaceus, uas nws cov ntsiab lus yog lub hauv paus tseem ceeb rau kev tshuaj xyuas qhov txiaj ntsig zoo ntawm Astragalus membranaceus. Astragaloside IV muaj cov teebmeem hauv kev tiv thaiv qog, anti-inflammatoryantioxidant, hypoglycemic, tiv thaiv myocardial, tiv thaiv kab mob myocarditis, tiv thaiv cov ntaub so ntswg hauv lub cev thiab tiv thaiv kab mob siab B, thiab lwm yam, thiab nws muaj ntau yam tshuaj muaj txiaj ntsig zoo thiab siv tau zoo heev.

 

Astragaloside IV Hmoov 84687-43-4 Kev tshawb fawb ntxiv

Cov chaw muag tshuaj :

  1. Kev siv tshuaj tiv thaiv kab mob: Astragaloside IV, nas peritoneal macrophages thiab Mycobacterium tuberculosis tau sib koom ua ke los kuaj qhov muaj peev xwm phagocytic rau Mycobacterium tuberculosis ntawm nas peritoneal macrophages, thiab cov ntsiab lus ntawm γ-interferon (IFN-γ) thiab interleukin-1β (IL-1β) hauv kab lis kev cai nruab nrab raug kuaj pom ib yam nkaus.
  2. Lub cev tiv thaiv cov nyhuv, uas suav nrog Kev Tiv Thaiv Lub Hlwb, Raum tiv thaiv, Lub ntsws tiv thaiv, myocardial tiv thaiv, tiv thaiv daim siab
  3. Cov Hypoglycemic effect: Noj nas nrog cov ntshav qab zib hom 2 ua cov khoom tshawb fawb los kawm cov kev cai ntawm astragaloside IV rau cov ntshav qabzib ntshav qabzib hauv cov nas nrog cov ntshav ntawd streptomycin thiab cov zaub mov muaj roj ntau hauv cov ntshav qab zib.
  4. Cov tshuaj tiv thaiv apoptotic: astragaloside IV tuaj yeem txo cov apoptosis index ntawm myocardial hlwb nrog CVB3 kab mob myocarditis.
  5. Anti-inflammatory thiab cov tshuaj tiv thaiv kab mob: astragaloside IV ua rau muaj kev cuam tshuam xylene-induced pob ntseg pob ntseg hauv nas, nrog rau muaj zog tiv thaiv kev cuam tshuam.
  6. Los tiv thaiv kev laus ua hauj lwm zoo: kev tiv thaiv kev laus ntawm astragaloside IV cuam tshuam nrog nws lub luag haujlwm hauv kev tshem tawm cov dawb radical thiab tiv thaiv lipid peroxidation, txhawb kev hloov pauv protein, tshem tawm cov nucleic acid metabolic teeb meem thiab txhawb kev loj hlob thiab apoptosis ntawm tib neeg cov tawv nqaij fibroblasts.
  7. Txhawb txoj kev loj hlob ntawm tes: tsim nyog cov ntsiab lus ntawm astragaloside IV tuaj yeem txhawb kev nthuav dav sai ntawm chondrocytes thiab tuav cov kev ua haujlwm ntawm chondrocytes, muab txoj hauv kev tshiab rau pob txha mos cov ntaub so ntswg engineering kom tau txais ntau cov noob hlwb thiab tswj cov haujlwm chondrocyte hauv lub sijhawm luv.

 

Astragaloside IV Hmoov 84687-43-4 Kev Siv

  1. Zhang, Wei-Jian., Li al., 2003. Antiinflammatory kev ua ntawm astragaloside IV yog kev kho kom haum xeeb los ntawm inhibition ntawm NF-kappaB ua kom thiab adhesion molecule qhia. Thrombosis thiab haemostasis. 90 (5): 904-14. PMID: 14597987
  2. Li M, li al. Astragaloside IV ua rau kev nkag siab tsis meej pem los ntawm kev hloov chaw mus rau isrebia thiab ua kom rov zoo hauv cov nas ntawm cov txheej txheem los tiv thaiv. Neurosci Lett. 2016 Dec 20.
  3. Nws CS, li al. Astragaloside IV Txhim Kho Cisplatin Chemosensitivity hauv Cov Kab Mob Ntshav Tsis Muaj Cov Qog Hlawv Me Los Ntawm Kev Txwv B7-H3. Cell Physiol Biochem. 2016; 40 (5): 1221-1229. Epub 2016 Dec 14.

 

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