cov khoom siv

Anandamide (AEA) hmoov (94421-68-8)

Anandamide hmoov yog qhov tshwm sim tsis txaus tshwm sim cannabinoid neurotransmitter hauv lub hlwb, uas txhais tau tias tib neeg lub hlwb muaj peev xwm ua anandamide tsis tau noj cov khoom noj uas muaj AEA. Lub plhaw ntawm cov tsiaj muaj peev xwm thiab cacao nyoos tau lees tias muaj qee qhov nyiaj ntawm anandamide.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.

Anandamide (AEA) hmoov (94421-68-8) video

 

 

Anandamide (AEA) Cov Lus Qhia Hauv Paus

lub npe Anandamide (AEA) hmoov
CAS 94421-68-8
purity 98%
Tshuaj lub npe N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Synonyms Arachidonoyl Ethanolamide, AEA, arachidonoylethanolamide, (5Z, 8Z, 11Z, 14Z) -N- (2-hydroxyethyl) icosa-5,8,11,14-tetraenamide, N-arachidonoylethanolamine
molecular Formula C22H37NO2
molecular Nyhav 347.53
Melting Point /
InChI Qhov Tseem Ceeb LGEQQWMQCRIYKG-DOFZRALJSA-N
daim ntawv roj
tsos lub teeb daj
Ib Sim Neej /
solubility Soluble hauv DMSO (~ 30 mg / ml), DMF (~ 10 mg / ml), anhydrous ethanol (5 mg / ml), PBS, pH 7.2 (~ 100 mg / ml), thiab dej (<0.1 mg / ml ntawm 25 ° C).
cia mob 80 ° C (des.)
Daim ntawv thov Ib qhov endogenous cannabinoid receptor ligand
Kuaj Cov Ntaub Ntawv Qhov

 

Anandamide (AEA) Cov Lus Qhia dav dav

Anandamide, tseem hu ua N-arachidonoylethanolamine (AEA), yog ib hom fatty acid neurotransmitter muab los ntawm qhov tsis-oxidative metabolism ntawm eicosatetraenoic acid (arachidonic acid), qhov tseem ceeb omega-6 fatty acid. Lub npe tau muab los ntawm Sanskrit lo lus ananda, uas txhais tau tias "kev zoo siab, paj tawg, zoo siab", thiab amide. Nws yog cov hluavtaws los ntawm N-arachidonoyl phosphatidylethanolamine los ntawm ntau txoj hauv kev.

Tshaj li cov neeg muaj tswv yim, anandamide muaj cov tswv pab muaj txiaj ntsig zoo ib yam, ntawm no tau hais qhia dav dav rau lawv.

Ua Hauj Lwm Nco - Nov yog ib qhov tseem ceeb ntawm kev muaj tswv yim. Raws li tau hais los saum no, anandamide pab sau ntau cov ntaub ntawv txhawm rau txhawm rau tsim cov tswv yim tshiab. Muaj ob peb txoj kev tshawb fawb txog cov neeg laus noj qab haus huv, tab sis ib tus qauv qhia tau hais tias nas cuam tshuam nrog ua haujlwm lub cim xeeb tsis txaus siab txhim kho qhov kev ntsuas no nrog lub anandamide nkaus xwb.

Los ntawm cov ntaub ntawv pov thawj no, nws yog qhov tseeb anandamide cuam tshuam nrog kev ua haujlwm nco thiab ntau yam txheej txheem. Qhov kev hloov pauv tau pom tshwm sim tiag, tab sis rau cov neeg laus noj qab haus huv ntawm qhov ntau tseem tsis tau paub.

Neurogenesis - Raws li Dr. Gary Wenk, anandamide tuaj yeem ua lub zog muaj zog txuam nrog neurogenesis tshwj xeeb tshaj yog rau cov neeg laus. Raws li kev tshawb fawb ntawm neuroscience, nws muaj kev nkag siab txog qhov tshwm sim ntawm anandamide thiab kev cuam tshuam nrog lub hlwb.

Txog thaum tsis ntev los no, cov kws tshawb fawb ntseeg tias neurogenesis (kev loj hlob ntawm cov hlwb tshiab) tsuas yog tshwm sim hauv cov hluas thiab cov hluas. Niaj hnub no nws tau paub zoo tias neurogenesis txuas ntxiv ntev mus rau hauv neeg laus thiab qhov zoo dua peb tuaj yeem tswj hwm nws, qhov tsawg dua peb muaj cov teeb meem neurodegenerative zoo li cov teeb meem nco thiab dementia.

Los tiv thaiv Kev Nyuaj Siab - Tshaj li ntawm kev txawj ntse, muaj ntau lub siab lub ntsws thiab lub neej zoo nrog anandamide zoo li. Cov kev tshawb fawb ntawm cov nas hlwb qauv qhia txog anandamide muaj cov kev tiv thaiv tsis zoo hauv lub hlwb, uas tuaj yeem pab cov uas muaj lub siab tsis zoo.

 

Anandamide (AEA) hmoov (94421-68-8) Keeb kwm

Anandamide tau piav txog thawj zaug (thiab muaj npe) xyoo 1992 los ntawm Raphael Mechoulam thiab nws cov tswv cuab (lab) WA Devane thiab Lumír Hanuš.

 

Anandamide (AEA) hmoov Daim Ntawv Thov

Anandamide yog synthesized enzymatically nyob rau thaj chaw ntawm lub hlwb uas tseem ceeb hauv kev nco, kev xav thiab tswj kev txav. Kev tshawb fawb qhia tau tias anandamide ua lub luag haujlwm hauv kev tsim thiab tawg ntawm lub sijhawm luv sib txuas ntawm cov leeg hlwb, thiab qhov no cuam tshuam nrog kev kawm thiab cim xeeb. Kev tshawb fawb tsiaj qhia tias ntau dhau lawm anandamide induces tsis nco qab. Qhov no qhia tau tias yog tias cov tshuaj yeeb dej caw tuaj yeem tsim kho uas ua rau anandamide los ntawm kev khi rau nws cov receptor, cov no yuav raug siv los kho kev nco ploj lossis tseem txhim kho kev nco!

 

Anandamide (AEA) Kev tshawb fawb ntxiv

Cov kua txob dub muaj cov alkaloid guineesine, uas yog ib qho anandamide reuptake inhibitor. Nws yuav yog li ntawd nce anandamide lub zog lub cev.

Kev noj tshuaj tsawg kawg ntawm anandamide muaj qhov mob siab ntsws, tab sis kev siv tshuaj ntau hauv cov nas qhia pom tias tus kabmob hippocampus tuag tas.

Tus pojniam Scottish nrog cov kev hloov caj ces tsis tshua muaj tsawg hauv nws cov FAAH lub cev nrog cov txiaj ntsig ntawm anandamide tau tshaj tawm tias lub cev tsis muaj zog tiv thaiv kev ntxhov siab, tsis tuaj yeem ntshai thiab tsis hnov ​​mob. Cov nquag kub hnyiab thiab txiav nws raug mob vim nws qhov mob hypoalgesia kho sai dua li qhov nruab nrab.

 

Anandamide (AEA) hmoov (94421-68-8) Kev siv

  • Devane, W .; Hanus, L; Breuer, A; Pertwee, R .; Stevenson, L .; Griffin, G; Gibson, D; Mandelbaum, A; Etinger, A; Mechoulam, R (18 Hlis ntuj nqeg 1992). "Kev rho tawm thiab kev teeb tsa ntawm lub hlwb tsim uas khi rau cannabinoid receptor". Kev Tshawb Fawb. 258 (5090): 1946–
  • Mechoulam R, Fride E (1995). "Txoj kev tsis tau tsim kho kom lub hlwb endogenous cannabinoid ligands, cov anandamides". Hauv Pertwee RG (ed.). Cannabinoid receptors. Boston: Xov Xwm Ntawm Kev Kawm. pp 233–
  • Battista, N., thiab Maccarrone, M. (2017). "Cov txheej txheem yooj yim ntawm synthesis thiab hydrolysis ntawm endocannabinoids loj," hauv Endocannabinoid System: Noob caj noob ces, Biochemistry, Lub hlwb tsis zoo, thiab Kev Kho Mob, ed. E. Murillo-Rodriguez (Amsterdam: Elsevier), 1–24.
  • Devane li al. (1992), Kev rho tawm thiab kev teeb tsa ntawm lub hlwb sib cais uas khi rau lub cannabinoid receptor; Kev Tshawb Fawb, 258 1946.
  • Anandamide (AEA): Txhua Yam Koj Yuav Tsum Tau Paub Txog

 

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