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Cycloastragenol (CAG) hmoov 78574-94-4

Cycloastragenol hmoov yog molecule cais tawm los ntawm ntau hom tsiaj nyob rau hauv lub genus Astragalus uas tau lees tias muaj telomerase ua kom cov haujlwm. Ib qho kev tshawb fawb hauv vitro ua tiav hauv 2009 tau ua rau cov neeg pab leg ntaubntawv hais tias cycloastragenol tuaj yeem qhib telomerase, ua rau muaj kev tsis txaus siab thov rau nws lub luag haujlwm hauv kev txo cov teebmeem kev laus.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
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Cycloastragenol (CAG) hmoov (78574-94-4) video

 

 

Cycloastragenol (CAG) hmoov Cov ntaub ntawv

lub npe Cycloastragenol (CAG) hmoov
CAS 78574-94-4
purity 50% , 98%
Tshuaj lub npe CYCLOASTRAGENOL
Synonyms Cyclosieversigenin; Cyclosiversigenin; Astramembrangenin; (3β,6α,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;
molecular Formula C30H50O5
molecular Nyhav 490.72
Melting Point 241-245 ° C
InChI Qhov Tseem Ceeb WENNXORDXYGDTP-UOUUCMYEWSA-N
daim ntawv Khoom
tsos Dawb hmoov
Ib Sim Neej /
solubility Soluble Hauv Methanol, Ethanol
cia mob 4 ℃ Cov tub yees, kaw, tsaus
Daim ntawv thov Cycloastragenol yog lub zog ua haujlwm ntawm telomerase. Tsis tas li, nws yog qhov muaj feem cuam tshuam nrog los tiv thaiv kev laus hauv tshuaj suav uas yog tshuaj Hmoob.
Kuaj Cov Ntaub Ntawv Qhov

 

Cycloastragenol (CAG) hmoov General Description

Cycloastragenol hmoov muaj cov qauv tshuaj zoo ib yam li cov qauv Astragaloside IV, tab sis nws tseem me dua thiab muaj ntau dua bioavailable, ua rau cov tshuaj txhaj qis dua. Nws twb siv los ua tshuaj tiv thaiv kab mob vim tias nws muaj peev xwm nce T lymphocyte proliferation. Txawm li cas los xij, nws yog nws qhov tshwj xeeb los tiv thaiv kev laus lub zog uas yog kev nyiam ua kom lub zej zog science.

Cycloastragenol hmoov stimulates kho qhov hloov kho DNA los ntawm kev ua kom telomerase, nucleoprotein enzyme uas catalyses synthesis thiab kev loj hlob ntawm telomeric DNA. Telomeres yog ua los ntawm cov ntxaij lim dej nyias thiab yog pom ntawm cov lus qhia ntawm cov chromosomes. Tswj lawv qhov kev nyob ruaj khov ua rau cov hlwb ua kom zam dhau qhov ua rov ua kom zoo thiab tsis paub kawg mus dhau qhov 'Hayflick txwv'. Telomeres kom luv nrog txhua lub voj voog ntawm kev faib tawm ntawm tes, lossis thaum raug mob oxidative kev nyuaj siab. Txog tam sim no, qhov no tau dhau los ua qhov kev zam tsis muaj kev cuam tshuam ntawm kev laus.

 

Cycloastragenol (CAG) hmoov (78574-94-4) Keeb kwm

Cycloastragenol hmoov tau thawj muag nyob rau hauv kev noj zaubmov noj nyob rau tebchaws Asmeskas xyoo 2007 raws li lub npe TA-65, qhov no yog vim li cas TA 65 lossis TA65 tseem yog lub npe tshaj plaws rau cycloastragenol. CAS 84605-18-5 thiab CAS 78574-94-4 yog cov ntawv pov thawj tsis tu ncua rau cov kws tshaj lij cov khoom lag luam thiab cov kws tshawb nrhiav.

Cycloastragenol yog triterpene aglycone ntawm 9,19-cyclolanostane-hom muab los thiab ua kom huv los ntawm lub hauv paus ntawm Astragalus membranaceus cog, uas tau siv nyob rau hauv tsoos suav pharmacopoeia rau ntau tshaj ob txhiab xyoo, tshwj xeeb rau nws lub peev xwm los txo qis hnub nyoog muaj feem cuam tshuam degenerative kev. Triterpene glycosides ua rau cov chav kawm ntawm theem pib ntawm cov nroj tsuag metabolites hu ua saponins thiab yog muaj cov polycyclic aglycone txuas ntawm C3 thiab ib qho kev sib txuas ether rau cov qab zib muaj suab thaj. 

 

Cycloastragenol (CAG) hmoov Mechanism Of Action

Cov kws tshawb nrhiav tau pom tias Cycloastragenol ua tau zoo heev ntawm kev rov ua cov txheej txheem los ntawm kev loj hlob ntawm qhov ntev ntawm telomeres, uas yog qhov ua rau cov laus qeeb qeeb. Qhov no tau ua tiav los ntawm kev ua rau kev ua ntawm lub enzyme xa mus rau hauv telomerase uas kho cov xov tawg / luv luv. Txog tam sim no cycloastragenol yuav yog tib tug neeg ua haujlwm hauv telomerase los ntawm kev loj hlob ntawm telomerase.

Cycloastragenol rub tawm T cell loj hlob los ntawm kev ua haujlwm ntawm telomerase uas yuav pab tau ntau lub hlwb ua rau lawv cov telomeres ntev dua, ntxiv rau ntau xyoo ntawm kev ua tiav kev ua haujlwm ntawm tes uas ib txhia ntseeg tias yuav pab tau tib neeg lub neej ntev dua.

 

Cycloastragenol (CAG) hmoov (78574-94-4) Daim ntawv thov

  1. Siv rau hauv cov khoom lag luam kev noj qab haus huv teb, cycloastreganol 50% thiab 98% hmoov yuav siv tau raws li cov khoom xyaw noj haus ntxiv;
  2. Siv rau hauv daim teb kws tshaj lij, 98% cycloastragenol hmoov tuaj yeem siv, raws li nruj thiab kev tshawb pom los ntawm tsev kho mob tshawb pom.

 

Cycloastragenol (CAG) (78574-94-4) Kev tshawb fawb ntxiv

Ua haujlwm ntawm Cycloastragenol hmoov

1.Astragalus Extract Cycloastragenol tuaj yeem ua kom muaj zog thiab ua siab ntev, txhim kho lub zog tiv thaiv kab mob thiab pab ua kom rov zoo los ntawm kev mob siab lossis mob ntev.

2. Cov ntawv sau cia tau sau tseg tias Astragalus Extract Cycloastragenol txhawb kev ua haujlwm ntawm ntau hom qe ntshav dawb thiab nce tsim ntau cov tshuaj tiv thaiv thiab cuam tshuam kev cuam tshuam, lub cev muaj tshuaj tua kab mob ntuj.

3.Cycloastragenol muaj cov txiaj ntsig ntawm kev txo kev ntxhov siab thiab tiv thaiv lub cev tiv thaiv ntau yam kev ntxhov siab,nrog rau lub cev, lub paj hlwb, lossis kev nyuaj siab;

4.Astragalus Extract muaj cov haujlwm ua kom muaj zog tiv thaiv kab mob, tiv thaiv lub cev los ntawm cov kab mob xws li mob cancer thiab ntshav qab zib;

5.muaj cov tshuaj antioxidants, uas tiv thaiv cov cell tiv thaiv kev puas tsuaj los ntawm cov dawb radicals;

6. siv los tiv thaiv thiab txhawb kev tiv thaiv kab mob, tiv thaiv kab mob, thiab tiv thaiv kab mob, txhawm rau tiv thaiv khaub thuas thiab kab mob ua pa sab saud;

7.Cycloastragenol muaj cov txiaj ntsig txo qis ntshav siab, kho ntshav qab zib thiab tiv thaiv lub siab.

 

Cycloastragenol (CAG) hmoov (78574-94-4) Siv

  • Ma, P., li al .: Xenobiotica, 47, 526-537 (2017); Shen, C., li al.: Br. J. Pharmacol., 174, 1395-1425 (2017)
  • Le Saux CJ, Davy P, Brampton C, li al. Tus tshiab telomerase activator txwv kev mob ntsws kev puas tsuaj hauv tus qauv murine ntawm idiopathic pulmonary fibrosis. PLOS Ib. 2013; 8 (3): e58423. PMID: 23516479.
  • Caliş I, Koyunoğlu S, Yeşilada A, li al. Antitrypanosomal cycloartane glycosides los ntawm Astragalus baibutensis. Chem Biodivers. 2006 Lub Yim Hli; 3 (8): 923-9.
  • Cycloastragenol (CAG): Muaj txiaj ntsig, noj ntau npaum li cas, Phiv nyhuv

 

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