PQQ hmoov (72909-34-3)

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Tsuas yog 14 sab lauj! 125 tus neeg tab tom saib qhov no thiab 31 tus neeg muaj nws hauv lawv lub laub.

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Nyem qhov no
[1]. Xaiv qhov koj xav tau, tom qab ntawd ntxiv rau lub laub

[2]. Txuas mus xyuas

[3]. Sau koj cov ntaub ntawv nthuav dav, qhov * yuav tsum tau, xaiv koj txoj kev them nyiaj. Muaj ntau txoj kev them nyiaj sib txawv suav nrog:
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Lub tswv yim: email chaw nyob yuav tsum tau kho, cov ntaub ntawv taug qab yuav hloov tshiab los ntawm email ceeb toom

[4]. Yog tias xaiv "Coinpayment", tom qab nyem "Place order", ces yuav qhia raws li hauv qab no them

[5]. Yog tias Xaiv "Direct Bank Transfer", tom qab nias "Place order", ces yuav qhia raws li hauv qab no, yuav tshwm sim cov ntsiab lus ntawm tus account hauv txhab nyiaj, tom qab hloov lub txhab nyiaj (thov siv koj tus lej xaj raws li qhov siv), xa daim ntawv hauv txhab nyiaj rau peb.

[6]. Kev them nyiaj lees paub
[7]. Parcel xa tawm li 5-10 teev (hauv hnub ua haujlwm)
[8]. Tus lej taug qab tau muab
[9]. Parcel tuaj txog
[10]. Rov xaj dua
Tsis muaj koj qhov ntau? Nyem no
Ceeb toom: Yog tias koj cev xeeb tub, saib xyuas neeg mob, noj cov tshuaj los yog muaj kev mob nkeeg nrog koj tus kws kho mob ua ntej siv. Khaws kom deb ntawm cov menyuam yaus.
Qeb: SKU: N / A

Lub npe: Pyrroloquinoline quinone

CAS: 72909-34-3

Cov roj formula: C14H6N2O8

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

Pyrroloquinoline quinone hmoov hmoov yeeb yaj kiab

Pyrroloquinoline quinone hmoov (72909-34-3) Cov Ntaub Ntawv Tseem Ceeb

lub npe Pyrroloquinoline quinone hmoov
CAS 72909-34-3
purity > 98%
Tshuaj lub npe 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid
Synonyms Qibxijxij PQQ

Xis khoom, PQQ

Cofactor, PQQ

Methoxatin

PQQ Coenzyme

molecular Formula C14H6N2O8
molecular Nyhav 330.208 g / mol
Melting Point 200 ° C
InChI Qhov Tseem Ceeb MMXZSJMASHPLLR-UHFFFAOYSA-N
daim ntawv Crystalline khoom
tsos liab xim av hmoov
Ib Sim Neej 3 – 5 h
solubility Soluble hauv Methanol thiab Dej
cia mob -20 ° C
Daim ntawv thov Ib qho redox / cofactor pom nyob rau hauv chav kawm ntawm enzymes hu ua quinoproteins

noj tshuaj pab txhawb nqa, pub khoom noj, tshuaj, tshuaj

Kuaj Cov Ntaub Ntawv Qhov

 

General hauj lwm

Pyrroloquinoline quinone (covPQQ) hmoov, tseem hu ua methoxatin, yog redox cofactor. Nws tau pom hauv av thiab khoom noj xws li kiwifruit, ntxiv rau tib neeg cov kua mis. Enzymes muaj Pyrroloquinoline quinone hmoov hu ua quinoproteins. Glucose dehydrogenase, ib qho ntawm quinoproteins, yog siv ua lub ntsuas ntshav qab zib. Pyrroloquinoline quinone hmoov txhawb kev loj hlob ntawm cov kab mob.

Pyrroloquinoline quinone hmoov tau pom tias txhim kho tsis tsuas yog kev nco qab tam sim ntawd, tab sis kuj tseem muaj lwm lub zog ntawm lub hlwb ntau dua xws li kev paub txog qhov loj me. Qhov cuam tshuam ntawm Pyrroloquinoline quinone hmoov tau txhim kho thaum cov tshuaj yeeb dej caw nrog CoQ10. Qhov tseem ceeb benfits ntawm Pyrroloquinoline quinone hmoov muaj xws li kev noj qab haus huv mitochondrial, kev txhawb nqa lub hlwb, thiab cov kab mob plawv.

 

Keeb kwm

Pyrroloquinoline quinone hmoov tau pom los ntawm JG Hauge ua tus thib peb lub npe redox cofactor tom qab nicotinamide thiab flavin hauv cov kab mob (txawm hais tias nws tau kwv yees tias nws yog naphthoquinone). Anthony thiab Zatman kuj tseem pom qhov tsis paub qhov tseeb reof cofactor hauv cawv dehydrogenase. Xyoo 1979, Salisbury thiab cov npoj yaig nrog rau Duine thiab cov npoj yaig tau ua tawm pawg pab pawg no los ntawm methanol dehydrogenase ntawm methylotrophs thiab txheeb xyuas nws cov qauv molecular. Adachi thiab cov npoj yaig nrhiav tau tias Pyrroloquinoline quinone kuj tseem pom hauv Acetobacter.

 

Mechanism Ntawm Kev Ua

Pyrroloquinoline quinone ua haujlwm li cas? Cov kev tshawb fawb qhia Pyrroloquinoline quinone hmoov txhawb kev noj qab haus huv cov qauv mitochondrial thiab ua haujlwm los pab tswj kev noj qab haus huv kev ua haujlwm zoo li rov nco qab, nco thiab kev paub thaum peb hnub nyoog.

Kev tshawb fawb tau qhia Pyrroloquinoline quinone hmoov:

  • Cuam tshuam rau cov phiajcim ntawm tes ua haujlwm koom nrog hauv kev loj hlob ntawm tes, kev sib txawv thiab kev ciaj sia
  • Tiv thaiv mitochondria uas twb muaj lawm los ntawm kev puas tsuaj
  • Pab tsim cov mitochondria tshiab
  • Tiv thaiv cov leeg hlwb

Cov txiaj ntsig ntawm kev noj Pyrroloquinoline quinone hmoov los ntawm ob peb cov txheej txheem sib txawv, txhua tus muaj feem cuam tshuam rau cov protein. Ua ntej, PQQ ua kom lub receptor nyob hauv lub nucleus ntawm cov hlwb hu ua NR1C3. Qhov lees txais nuclear no yog lub luag haujlwm rau cov kev ua kom dav dav, suav nrog kev loj hlob ntawm tes thiab kev ua pa ntawm mitochondrial.

Zoo sib xws rau cov kev ua ntawm CILTEP pawg, Pyrroloquinoline quinone hmoov ua kom cov CREB cov paib ua haujlwm, uas ua rau ncaj qha kev loj hlob ntawm cov mitochondria tshiab thiab txhawb kom muaj kev tsim cov hlab ntsha tshiab, hauv cov ntsiab lus ntawm lub hlwb. Tsis tas li ntawd, Pyrroloquinoline quinone hmoov sib cuam tshuam nrog ib tug xov tooj ntawm cov paib sab hauv ua qauv uas pab hauv kev tiv thaiv los ntawm kev nyuaj siab oxidative. Qhov no yog qhov tshwj xeeb rau lub hlwb hlwb, uas siv ntau lub zog thiab tsim ntau cov radicals dawb raws li qhov txiaj ntsig.

 

Daim ntawv thov

  • Raws li cov tshuaj tua kab mob muaj zog, Pyrroloquinoline quinone powderprotects thiab nce kev ua haujlwm ntawm mitochondria uas twb muaj lawm

-Zoo mitochondrial kev laus.

  • Pyrroloquinoline quinone powderalso txhawb nqa lub cim mitochondria tshiab (Mitochondrial Biogenesis).

-Zoo mitochondria = muaj zog ntau lawm.

  • PQQ stimulates kev tsim khoom ntawm Nerv Growth Factor (NGF).

-NGF ua rau kev loj hlob ntawm cov hlab hlwb kom kho cov leeg puas tsuaj los ntawm mob stroke lossis lwm qhov raug mob.

 

Tshawb nrhiav ntxiv

Ischemic mob stroke

Pyrroloquinoline quinone hmoov tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv lub hlwb los ntawm kev puas tsuaj ntawm mob stroke.

Kev mob hlab ntsha hauv ischemic tshwm sim thaum qhov kev poob ntawm cov ntshav mus rau thaj chaw tshwj xeeb ntawm lub hlwb yuav ua rau lub hlwb ntawm cov as-ham tseem ceeb / oxygen nws xav tau. Cov txiaj ntsig yog lub hlwb ntawm lub hlwb tuag thiab qhov ua haujlwm poob ntawm thaj tsam ntawm lub hlwb uas kev puas tsuaj tshwm sim. Raws li cov cheeb tsam cuam tshuam, qhov no tuaj yeem ua rau tuag tes tuag taw, tsis nco qab, thiab tseem muaj kev tuag.

Hauv kev kawm tshawb fawb, Pyrroloquinoline quinone hmoov txo ischemic kev puas tsuaj, muaj peev xwm txhim kho lub neej muaj txiaj ntsig tom qab mob stroke.

Qhov no tau pom meej meej hauv tus qauv tsiaj ntawm ischemic stroke. Thaum PQQ cov tshuaj tau muab ua ntej ischemia raug tsim tawm, nws tau txo qhov loj me ntawm lub cheeb tsam lub hlwb ua kom puas. Kuj ceeb tias, PQQ muaj cov txiaj ntsig zoo ib yam li ntawd txawm tias tau siv los tom qab siv ischemia tau tsim tawm tau.26

Lwm qhov kev tshawb nrhiav pom cov teebmeem neuroprotective zoo sib xws. Nws kuj tau qhia tias PQQ coj ua rau cov qhab nia nce neurobehavioral zoo dua tom qab mob stroke.27 Cov kev tshawb pom no zoo siab rau cov neeg ua haujlwm thaj tsam tib neeg tiv thaiv thiab kho mob stroke. Qhov kev cuam tshuam yog tias cov neeg mob stroke tuaj yeem muab PQQ hauv chav haujlwm xwm txheej ceev thiab txo qhov ua kom lub hlwb puas.

 

reference

  • Kim, J., Kobayashi, M., Fukuda, M., li al. Pyrroloquinoline quinone inhibits lub fibrillation ntawm amyloid proteins Prion 4 (1), 26-31 (2010).
  • Guan, S., Xu, J., Guo, Y., li al. Pyrroloquinoline quinone tawm tsam glutamate-ua rau neurotoxicity nyob rau hauv cov kab mob hauv cov leeg neural thiab cov hlwb progenitor Int. J. Dev. Neurosci. 42, 37-45 (2015).
  • Rucker R, Chowanadisai W, Nakano M. Peev xwm ntawm lub cev tseem ceeb ntawm pyrroloquinoline quinone. Lwm Txoj Kev Noj Qab Haus Huv Rev. 2009; 14 (3): 268-77.
  • Klinman JP, Bonnot F. Kev nkag siab thiab lub zog ntawm cov biosynthetic txoj hauv kev rau cov enzymatic quinocofactors: PQQ, TTQ, CTQ, TPQ, thiab LTQ. Chem Rev. 2014; 114 (8): 4343-65.
  • Cov txiaj ntsig sab saum toj ntawm Kev Noj Pyrroloquinoline Quinone (PQQ).

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