cov khoom siv

Aniracetam hmoov (72432-10-1)

Aniracetam hmoov (hom tshuaj npe Draganon, Sarpul, Ampamet, Memodrin, Referan), tseem hu ua N-anisoyl-2-pyrrolidinone, yog pyrrolidinone-hom kev txhim kho kev paub tab uas tau siv hauv kev kho mob hauv kev coj tus cwj pwm thiab kev mob hlwb ntawm dementia hauv qab no mob stroke thiab hauv Alzheimer tus kab mob.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.

Aniracetam hmoov (72432-10-1) video

 

Aniracetam hmoov Piav Cov Ntaub Ntawv

lub npe Aniracetam hmoov
CAS 72432-10-1
purity 98%
Tshuaj lub npe 1- (4-methoxybenzoyl) pyrrolidin-2-ib
Synonyms Aniracetam; Ampamet; Ro-13-5057; Ro 13 5057; Ro135057; Draganon; Sarpul
molecular Formula C12H13NO3
molecular Nyhav 219.237 g / mol
Melting Point 121-122 ° C
InChI Qhov Tseem Ceeb ZXNRTKGTQJPIJK-UHFFFAOYSA-N
daim ntawv Khoom
tsos Dawb rau Off-dawb hmoov
Ib Sim Neej 1-2.5 teev
solubility Aniracetam hmoov yog cov roj ua kom tsis muaj roj thiab zoo dua nrog kev noj mov lossis cov rog zoo li cov roj ntses. Thaum lub sijhawm peb kuaj, aniracetam tsis yog soluble hauv kev daws teeb meem thaum sov sov. Txawm li cas los xij, thaum rhuab mus rau 85 ° C, aniracetam qhia siab solubility hauv roj.
cia mob 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli).
Daim ntawv thov Aniracetam siv nyob rau hauv kev kho mob ntawm kev coj cwj pwm thiab kev mob hlwb ntawm dementia tom qab mob hlab ntsha tawg thiab hauv Alzheimer tus kab mob.
Kuaj Cov Ntaub Ntawv Qhov

 

Aniracetam: Nws yog dab tsi? Nws cov txiaj ntsig yog dab tsi?

Aniracetam yog tshuaj siv hauv kev kho mob ntawm kev nco thiab mloog tsis meej. Cov no feem ntau yog los ntawm cov kab mob degenerative lossis cerebrovascular. Nws yog cov khoom siv hluavtaws muab los ntawm nootropic los ntawm tsev neeg racetam. Nws yuav muaj txiaj ntsig los kho kev paub tsis meej, dementia, Alzheimer's disease, ADHD, thiab kev nyuaj siab.

 

Aniracetam yog dab tsi?

Aniracetam yog tshuaj ntawm tsev neeg racetam. Nws yog cov tshuaj muaj roj-soluble nootropic. Nws ua haujlwm raws li kev txhawb nqa ntxiv rau kev txhim kho lub hlwb.

Aniracetam tuaj yeem txhim kho kev nco, kev muaj tswv yim, kev txhawb siab, thiab kev ntse ntawm lub siab. Nws kuj muaj cov yam ntxwv anxiolytic. Nws muaj nyob rau hauv daim ntawv ntawm cov xim dawb lossis xim dawb-dawb.

Aniracetam tau ua thawj zaug los ntawm Hoffmann-La Roche hauv 1970s. Nws tau txais daim ntawv pov thawj los ntawm Swiss-based kws tshuaj tuam txhab F. Hoffmann-La Roche AG xyoo 1978.

Aniracetam cov tub ntxhais muaj cov pyrrolidine nucleus. Cov tshuaj no tuaj yeem tsim los ntawm kev sib xyaw 2-pyrrolidone nrog anisoyl chloride thaum muaj triethylamine. Los yog lwm txoj hauv kev, los ntawm kev sib xyaw gamma-aminobutyric acid nrog anisoyl chloride. Aniracetam yog cholinergic compound, yog li cuam tshuam rau qib acetylcholine hauv lub hlwb.

Nws tsis pom zoo siv hauv Asmeskas los ntawm FDA, txawm hais tias nws muaj raws li kev noj haus ntxiv. Nws muaj nyob raws li cov tshuaj muaj nyob hauv Europe.

 

Aniracetam Ua Dab Tsi?

Txhawm rau nkag siab txog kev ua haujlwm ntawm aniracetam, peb yuav tsum xub tham txog nws niam txiv chav kawm nootropics.

Nootropics hu ua 'cov tshuaj ntse' thiab tuaj yeem ua rau lub hlwb ua haujlwm zoo. Lawv kuj tuaj yeem ua kom lub cim xeeb zoo dua thiab txhim kho kev paub. Lawv feem ntau muaj cov txiaj ntsig zoo ib yam, zoo ib yam li kas fes. Nootropics kuj tseem tuaj yeem ua rau muaj kev ceeb toom kev xav thiab kev xav. Lawv suav nrog ob qho tib si ntuj thiab khoom siv hluavtaws.

Aniracetam ua haujlwm ntawm ib feem ntawm cov neuron hauv lub hlwb hu ua alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA). AMPA receptors yog ionotropic glutamate receptor channels.

AMPA cov neeg txais kev tso cai sib kis sai ntawm cov neurons hauv lub hauv paus paj hlwb. Lawv muaj peev xwm tswj hwm kev txaus siab ntawm tes. AMPA ua qhov no los ntawm kev tso cai tswj kev txav ntawm cov calcium thiab sodium ions rau hauv xovtooj ntawm tes. Lawv kuj pab cov cim kom txav nrawm ntawm cov neurons.

Qhov tseeb ntawm kev ua ntawm Aniracetam tseem tsis paub. Ib txoj hauv kev yuav ua li cas aniracetam ua haujlwm hauv lub hlwb yog los ntawm kev hloov pauv cov AMPA receptors hauv lub hlwb. Lub ntsiab metabolite tseem ceeb ntawm aniracetam yog N-anisoyl-GABA. Cov metabolite no muaj ntau yam cuam tshuam.

Aniracetam tuaj yeem ua rau qeeb tus nqi ntawm kev kaw ntawm cov chaw txais. Nws kuj tseem ua rau qee qhov qis qis liganded receptors [1]. Aniracetam tau qhia kom muaj peev xwm deactivating receptors txawm tias qis dua. Nws txhais tau tias cov tshuaj no txo ​​qis qhov ua rau glutamate (AMPA) receptors hauv lub hlwb. Yog li, nws ua rau muaj kev txhawb nqa lub paj hlwb. Nws yog vim qhov ua tau zoo ntxiv ntawm glutamate. Thaum kawg, nws ua rau glutamate muaj ntau hauv lub hlwb, yog li tso cai rau kev paub zoo thiab nco.

Aniracetam tuaj yeem nce qib dopamine thiab serotonin hauv prefrontal cortex, zoo ib yam li GABA. Qhov kev nqis tes no ua rau muaj kev xav zoo dua thiab tuaj yeem txo kev nyuaj siab.

Aniracetam kuj muaj cov khoom ua kom muaj zog. Cov cuab yeej no tuaj yeem suav nrog nws cov kev ua ntawm cholinergic, dopaminergic, thiab serotonergic systems.

Aniracetam yog rog-soluble. Nws txhais tau tias nws tuaj yeem hla cov ntshav-lub hlwb teeb meem yooj yim dua li cov dej-soluble molecules zoo li piracetam, lwm nootropic. Vim li no, nws ua haujlwm sai hauv lub hlwb thiab nqus tau sai dua. Nws cov kev mob tshwm sim tsis kav ntev li lwm cov tshuaj nootropics. Nws kuj tseem tuaj yeem txo kev ntxhov siab thiab kev nyuaj siab.

Nws tuaj yeem siv los kho kev nyuaj siab mob nkeeg, Alzheimer's tus kab mob, tsis meej pem tsis meej pem tsis meej pem (ADHD), pw tsis tsaug zog, thiab mob lub cev tsis muaj zog.

 

Kev siv ntawm Aniracetam

Muaj ntau qhov txiaj ntsig ntawm Aniracetam hmoov. Txawm li cas los xij, kev kawm thiab tshawb fawb tib neeg tseem muaj qhov txwv thiab xav tau ntau. Feem ntau ntawm kev tshawb fawb txog cov tshuaj no yog los ntawm kev tshawb fawb tsiaj thiab kev sim.

Qee qhov txiaj ntsig ntawm cov tshuaj no yog:

 

Teeb meem ntawm Kev Paub

Aniracetam tuaj yeem ua rau lub peev xwm txawj ntse ntawm lub hlwb, tshwj xeeb yog cov neeg hnub nyoog uas muaj kev nco qab. Dementia yog teeb meem kev paub uas tshwm sim rau ntau tus neeg thaum lawv hnub nyoog. Nws tuaj yeem ua rau lub cim xeeb poob, uas tuaj yeem cuam tshuam rau lub neej niaj hnub ntawm tus neeg.

Ib txoj kev tshawb fawb tau ua hauv 2011 uas Aniracetam tau muab rau 276 tus neeg mob uas muaj kev paub tsis meej. Nws tau muab ua ob qho tib si kho tshuaj lossis ua ke nrog cholinesterase inhibitors (ChEIs). Tom qab lub hlis ntawm kev kho mob, nws tau pom tias lub peev xwm kev paub, lub siab, thiab kev ua haujlwm ntawm cov neeg mob tau txhim kho zoo [2].

Yog li ntawd, Aniracetam hmoov yuav yog qhov kev xaiv zoo los kho cov tsos mob hauv cov neeg uas muaj kev paub tsis meej.

 

Nyuaj rau Kev Nyuaj Siab

Aniracetam yuav muaj txiaj ntsig zoo los kho cov tsos mob ntawm kev nyuaj siab. Aniracetam tuaj yeem txhim kho qib dopamine thiab serotonin hauv prefrontal cortex, amygdala, thiab thaj tsam hippocampus ntawm cov nas nrog ntshav siab thiab nquag mob stroke [3]. Cov peev xwm zoo ib yam no tau qhia los ntawm N-anisoyl-gamma-aminobutyric acid (N-anisoyl-GABA), cov tshuaj metabolite ntawm aniracetam. Qhov no txhais tau tias nws tuaj yeem ua tau rau nws kom ua tau zoo hauv kev kho kev nyuaj siab ib yam.

Ua rau pw tsaug zog

Aniracetam, zoo li lwm yam nootropics, tuaj yeem pab kho kev pw tsaug zog sib txawv thiab pw tsis tsaug zog. Ib txoj kev tshawb fawb ntawm cov nas uas ua rau mob stroke uas muaj ntshav siab tau qhia tias muab aniracetam rau tsib hnub sib law liag tau nce lawv qhov REM pw tsaug zog [4]. Yog li, nws yuav muaj txiaj ntsig zoo hauv kev pw tsaug zog tsis zoo los ntawm vascular dementia.

 

Teeb meem ntawm Nco

Aniracetam qhov cuam tshuam ntawm kev txhim kho kev nco tseem nyob hauv kev xav. Nws tuaj yeem thim rov qab tsis nco hauv nas [5]. Muab cov tshuaj aniracetam rau cov poj niam nas nrog ameliorated scopolamine-induced amnesia ua rau cov tsiaj no qhia kev nco zoo dua. Yog li nws yuav tuaj yeem txhim kho kev nco hauv tib neeg ib yam.

 

Kev cuam tshuam rau Dementia

Aniracetam muaj txiaj ntsig zoo hauv kev txo qis kev cuam tshuam ntawm dementia. Hauv txoj kev tshawb fawb cuam tshuam nrog 109 tus neeg laus laus nrog kev tsis nco qab, aniracetam tau muab rau rau lub hlis tom qab faib cov neeg mob ua ob pawg [6]. Qhov kawg ntawm qhov kev sim, nws tau pom tias cov uas tau txais aniracetam qhia pom kev txhim kho hauv tus cwj pwm kev coj cwj pwm. Nws kuj tau qhia pom qhov qeeb ntawm qhov tsis zoo. Li no, nws tuaj yeem ua tau rau aniracetam kom txo qis kev coj tus cwj pwm tsis zoo thiab poob kev paub uas tuaj yeem tshwm sim nrog kev dementia hauv cov neeg laus.

 

Kev cuam tshuam rau Lub Hlwb Rov Qab

Aniracetam muaj txiaj ntsig zoo hauv kev rov qab kho lub hlwb tom qab raug mob los ntawm kev raug mob. Ib txoj kev tshawb fawb tau ua los ntawm nas nrog kev raug mob hauv lub hlwb tau qhia tias aniracetam pab tau hauv kev kho mob ntawm kev paub tsis meej los ntawm kev raug mob hauv lub hlwb [7].

 

Qhov cuam tshuam rau Kev Ceeb Toom thiab Ua Kom Pom Zoo

Aniracetam tuaj yeem pab tus neeg siv kom mob siab rau thiab ceeb toom rau lawv ib puag ncig lossis ua haujlwm ntawm tes. Yog li nws yuav muaj txiaj ntsig zoo rau cov tub ntxhais kawm thiab cov neeg siv nrog ADHD.

 

Cov nyhuv ua Neuroprotective Agent

Aniracetam tau pom tias yog tus neeg sawv cev tiv thaiv kab mob zoo. Nws muaj peev xwm khaws cia cov kab mob neuropsychological ntawm cov neeg mob dementia. Yog li nws yuav muaj txiaj ntsig zoo rau cov neeg mob uas tsis nco qab.

 

Kev phiv los ntawm Aniracetam

Aniracetam hmoov, zoo li feem ntau lwm cov tshuaj, nws muaj nws cov teeb meem tshwm sim. Feem ntau ntawm cov no yuav yog vim tsis raug lossis siv tshuaj ntau dhau. Thaum feem ntau ntawm cov kev mob tshwm sim tsis loj heev, lwm tus tuaj yeem ua rau txaus ntshai. Yog li nws tau qhia kom ceev faj thaum noj cov tshuaj no.

Feem ntau qhia cov kev mob tshwm sim ntawm aniracetam yog:

  • Ntxhov siab vim
  • Ntxiv plawv dhia
  • poob phaus
  • tuskheej
  • Kev plees kev yi
  • insomnia
  • mob taub hau
  • Tsis phom sij
  • kiv tauv hau
  • xeev siab
  • Zawv plab
  • Ua xua lossis ua xua

 

Kev sib cuam tshuam ntawm Aniracetam Nrog Lwm Yam Tshuaj

Muaj ntau cov tshuaj uas aniracetam tuaj yeem cuam tshuam nrog. Feem ntau, nws tuaj yeem nthuav dav qhov cuam tshuam ntawm lwm cov tshuaj. Nws kuj tseem tuaj yeem ua rau qee yam ntawm cov tshuaj no nyob hauv cov kab ke ntev dua.

Qee yam tshuaj uas tuaj yeem cuam tshuam nrog Aniracetam yog:

  • Anticoagulants zoo li warfarin
  • Anticonvulsants zoo li gabapentin
  • Antidepressants zoo li bupropion
  • Tshuaj loog zoo li propofol
  • Benzodiazepines xws li diazepam, alprazolam
  • Opiates zoo li oxycodone

 

Dosage ntawm Aniracetam

Qhov pom zoo ntau npaum ntawm aniracetam hmoov yog 1500mg ib hnub, noj tshuaj 750mg thaum sawv ntxov thiab 750mg thaum yav tsaus ntuj.

 

Koj Yuav Yuav Aniracetam Qhov Twg?

Yog tias koj xav yuav Aniracetam hmoov qhov kev xaiv zoo tshaj plaws yog kom tau ncaj qha los ntawm Aniracetam hmoov chaw tsim tshuaj paus tuam txhab. Txij li cov tshuaj no tau tsim nrog cov khoom xyaw zoo tshaj plaws los ntawm pab pawg tsim khoom zoo tshaj plaws, koj yuav tau txais cov khoom lag luam zoo tshaj plaws. Aniracetam hmoov tuaj hauv pob ntawm 1kg ib pob ntawv lossis 25kg rau ib lub nruas, tab sis nws tuaj yeem kho raws li koj xav tau. Cov tshuaj yuav tsum tau khaws cia thiab thauj hauv qhov chaw qhuav thiab txias. Nws tuaj yeem khaws cia ntawm 0 txog 4 ° C rau lub sijhawm luv thiab -20 ° C rau lub sijhawm ntev. Qhov no yog txhawm rau tiv thaiv kev puas tsuaj ntawm cov tshuaj thiab ua kom nws tsis txhob cuam tshuam nrog cov tshuaj hauv ib puag ncig.

 

References

  1. Lawrence, JJ, Brenowitz, S., & Trussell, LO (2003). Cov txheej txheem ntawm kev ua ntawm aniracetam ntawm synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors: tsis ncaj thiab cuam tshuam ncaj qha rau desensitization. Molecular Pharmacology, 64(2), 269-278. https://molpharm.aspetjournals.org/content/64/2/269
  2. Koliaki, CC, Messini, C., & Tsolaki, M. (2012). Kev ua haujlwm tau zoo ntawm aniracetam, xws li kev kho mob monotherapy lossis ua ke nrog cholinesterase inhibitors, hauv cov neeg mob uas muaj kev paub tsis meej: kev sib piv qhib kev kawm. CNS neuroscience & kho, 18(4), 302-312. https://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2010.00244.x
  3. Shirane, M., & Nakamura, K. (2001). Aniracetam txhim kho cortical dopamine thiab serotonin tso tawm ntawm cholinergic thiab glutamatergic cov txheej txheem hauv SHRSP. Lub paj hlwb tshawb fawb, 916(1-2), 211-221. https://pubmed.ncbi.nlm.nih.gov/11597608/
  4. Kimura, M., Okano, S., & InouÉ, S. (2000). Cov teebmeem ntawm aniracetam rau cov qauv kev pw tsaug zog tsis zoo nyob rau hauv mob hlab ntsha tawg tuaj yeem ua rau tus mob ntshav siab tas li. Psychiatry thiab soj ntsuam neurosciences, 54(3), 314-316. https://pubmed.ncbi.nlm.nih.gov/11186092/
  5. Martin, JR, Moreau, JL, & Jenck, F. (1995). Aniracetam thim rov qab kev nco tsis zoo hauv nas. Pharmacological Research, 31(2), 133-136. https://pubmed.ncbi.nlm.nih.gov/7596957/
  6. Senin, U., Abate, G., Fieschi, C., Gori, G., Guala, A., Marini, G.,… & Parnetti, L. (1991). Aniracetam (Ro 13-5057) hauv kev kho mob senile dementia ntawm Alzheimer yam (SDAT): cov txiaj ntsig ntawm kev tshawb fawb tshuaj kho mob ntau yam hauv tsev kho mob. European Neuropsychopharmacology, 1(4), 511-517. https://pubmed.ncbi.nlm.nih.gov/1822317/
  7. Baranova, AI, Whiting, MD, & Hamm, RJ (2006). Kev ncua, kev kho tom qab raug mob nrog aniracetam txhim kho kev paub zoo tom qab raug mob lub hlwb raug mob hauv nas. Phau ntawv Journal ntawm neurotrauma, 23(8), 1233-1240. https://pubmed.ncbi.nlm.nih.gov/16928181/

 

 

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