cov khoom siv

Glutathione hmoov (70-18-8)

Glutathione (CAS 70-18-8) yog qhov suav nrog γ-amide daim ntawv cog lus thiab thiol tripeptide. Nws yog tsuas yog tsim nrog glutamic acid, cysteine ​​thiab glycine. Nws muaj nyob hauv txhua lub cell ntawm lub cev txhawm rau kom muaj kev ua haujlwm ntawm lub cev ntawm lub cev. Glutathione muaj qhov ua rau pom dav-ua kom pom tseeb, thiab tuaj yeem siv tsis yog tshuaj, tab sis kuj yog lub hauv paus ntawm kev ua zaub mov, thiab siv dav hauv cov zaub mov ua haujlwm xws li kev tiv thaiv kev laus, txhim kho kev tiv thaiv, thiab tiv thaiv qog.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.

Glutathione hmoov (70-18-8) video

 

 

Glutathione hmoov (70-18-8) Cov Lus Qhia Puag Qhia

lub npe Glutathione hmoov
CAS 70-18-8
purity 98%
Tshuaj lub npe Glutathione; Glutathione Txo
Synonyms GSI; GSH; copren; glutide; tathion; panaron; neuthion; isethion; glutinal; tathione
molecular Formula C20H32N6O12S2
molecular Nyhav 307.32
Melting Point 192-195 ° C (dec.) (Lit.)
InChI Qhov Tseem Ceeb RWSXRVCMGQZWBV-WDSKDSINSA-N
daim ntawv hmoov
tsos Dawb los yog yuav luag dawb crystalline hmoov
Ib Sim Neej
solubility Soluble hauv DMF, ethanol, dej (20 mg / ml) ntawm 25 ° C, PBS (pH7.2) (~ 10 mg / ml), haus dej cawv, kua ammonia, thiab DMSO.
cia mob -20 ° C
Daim ntawv thov L-Glutathione (GSH) txo tau siv nyob rau hauv theelution buffer rau elute GST (glutathione S-transferase) -fused cov protein siv cov hlaws glutathione-agarose. [1] [2] Nws tau siv coj los npaj ua nkhaus txheem rau GSH kev tshuaj ntsuam.

Yuav siv tau rau ntawm 5-10 mM rau elute glutathione S-transferase (GST) los ntawm glutathione agarose.

Kuaj Cov Ntaub Ntawv Qhov

 

Glutathione yog dab tsi?

Glutathione yog ib qho muaj zog tshaj plaws antioxidants hauv lub cev. Nws yog tsim tawm hauv lub siab. Nws yog tripeptide ua los ntawm cov amino acids cysteine, glycine, thiab glutamic acid. Nws pab txhawm rau tshem tawm cov kev nyuab siab oxidative los ntawm cov dawb radicals thiab tiv thaiv kev puas tsuaj rau cov khoom siv tseem ceeb ntawm tes uas tshwm sim los ntawm kev cuam tshuam ntawm cov pa oxygen. Nws kuj tseem koom nrog tsim cov ntaub so ntswg thiab kho cov khoom puas.

 

Glutathione Ua Haujlwm Li Cas?

Glutathione yog cov tshuaj tiv thaiv kab mob qis molecular hnyav uas tau muab coj los ua ke hauv cov cell. Nws yog ib qho muaj zog antioxidant. Nws tau tsim los ntawm kev ntxiv cysteine ​​rau glutamate thiab tom qab ntawd ntxiv glycine. Cov sulfhydryl los yog thiol pawg (-SH) ntawm cysteine ​​yog ib qho uas tau koom nrog hauv kev txo qis thiab kev sib koom ua ke. Cov tshuaj tiv thaiv no yog lub luag haujlwm tshem tawm cov peroxidases thiab xenobiotic sib txuas. Glutathione tseem ua haujlwm los tswj lub voj voog ntawm tes.

Glutathione tshem tawm ntau hom kab mob reactive. Feem ntau cov lwg me me hauv lub cev ua rau muaj kev cuam tshuam redox thiab tsim cov pa oxygen zoo li superoxide (O2−) thiab hydrogen peroxide (H2O2). Glutathione koom nrog hauv nruab nrab cov H2O2 molecules.

Nws tshem tawm cov tshuaj lom, co toxins, thiab cov pa phem hauv lub cev. Nws kuj tseem tuaj yeem sib txuas nrog cov tshuaj, ua rau lawv ntau dua, yooj yim dua rau cov metabolism, thiab tom qab ntawd tshem tawm ntawm lub cev.

H2O2 cov lwg me me yog cov metabolism hauv cov cell uas tau tsim hauv peroxisomes thiab tau txais catalyzed los ntawm catalase enzymes. Sab nraum peroxisomes, H2O2 yog nruab nrab los ntawm glutathione peroxidase enzyme. Tom qab ntawd nws hloov H202 rau hauv cov dej molecule (H20). Glutathione peroxidase enzyme xav tau selenium los ua haujlwm hauv lub cev. Yog li nws yog qhov yuav tsum tau noj zaub mov tseem ceeb.

Qib glutathione tuaj yeem tswj tau los ntawm kev siv cysteine ​​thiab methylene los ntawm kev noj zaub mov. Feem ntau, qib methylene txo qis thaum cov txheej txheem kev tshem tawm lub cev. Muaj ob txoj hauv kev tshem tawm cov tshuaj lom: theem I thiab theem II.

Theem I yog txheej txheem tshem tawm cov tshuaj uas hloov cov tshuaj hydrophobic toxin molecules (RH) mus rau hydrophilic molecules (ROH). Glutathione ua haujlwm raws li kev koom tes hauv qhov no ib yam. Qhov kev hloov pauv no ua rau nws yooj yim rau cov tshuaj kom ua tiav hauv theem II kev tshem tawm cov tshuaj lom.

Phase II txheej txheem kev tshem tawm cov tshuaj muaj cov tshuaj xws li sulfation, methylation, conjugation, thiab lwm yam. Qhov kev hloov pauv no ua rau nws yooj yim dua rau lub cev tshem tawm cov co toxins.

Thaum lub sijhawm txheej txheem sulfation, yog tias sulfate tsis txaus, lub cev tawg cysteine, cov amino acid xav tau los ua glutathione. Qhov kev nqis tes no ua rau txo qis hauv qib glutathione, ua rau txo qis nruab nrab ntawm H2O2. Nws tom qab ntawd ua rau muaj qhov nce ntawm cov hydroxyl radical, uas tuaj yeem ua rau daim nyias nyias los ntawm lipid peroxidation. Cov txiaj ntsig tuaj yeem ua rau muaj kev puas tsuaj, nrog rau kev puas tsuaj ntawm cov cell sai, ua rau muaj kab mob xws li mob qog noj ntshav, mob ntshav qab zib, thiab lwm yam.

Glutathione tseem koom nrog hauv kev sib txuas ntawm DNA thiab cov protein. Nws kuj tseem tuaj yeem pab thauj cov amino acid, ua kom muaj enzyme, thiab txhim kho thiab tswj kev tiv thaiv kab mob.

Glutathione kuj koom nrog hauv leukotriene synthesis. Nws kuj tseem pab tshem tawm cov tshuaj lom hu ua methylglyoxal, cov tshuaj lom los ntawm cov khoom ntawm cov metabolism. Cov glyoxalase enzymes tswj cov haujlwm no. Lub glyoxylate I thiab II hloov methylglyoxal nrog kev pab ntawm glutathione rau hauv SD-Lactoyl-glutathione. Tom qab ntawd nws hloov pauv mus rau glutathione thiab D-lactate.

Glutathione tseem tuaj yeem ua rau nruab nrab cuam tshuam ntawm acetaminophen ntau dhau. Nws ua qhov no los ntawm kev sib txuas nrog n-acetyl-p-benzoquinone imine (NAPQI), reactive cytochrome P450 metabolite tsim tom qab cov tshuaj lom ntau dhau ntawm acetaminophen. Glutathione khi rau NAPQI thiab tshem tawm nws.

Yog li, cov tshuaj tiv thaiv kab mob antioxidant no tau siv ntau hauv tib neeg lub cev. Nws qib tuaj yeem txo qis vim ntau yam, xws li co toxins, kev ntxhov siab, kev noj zaub mov tsis zoo, hnub nyoog laus, kev ua neej nyob tsis tu ncua, thiab kev noj zaub mov tsis zoo.

L-Glutathione (GSH) kuj tau siv los laij tawm GST (glutathione S-transferase) -fused cov protein. Nws ua tiav los ntawm kev siv cov hlaws glutathione-agarose. Nws kuj tseem tau siv los npaj tus qauv nkhaus rau GSH kev tshuaj xyuas.

Khoom cua glutathione muaj raws li glutathione hmoov uas yog dawb lossis yuav luag dawb crystalline hmoov.

 

Keeb kwm ntawm Glutathione

Glutathione tau tshawb pom hauv 1998 los ntawm J.de Rey-Paihade. Nws yog thawj zaug muab rho tawm los ntawm cov tshuaj ntuj tsim los ntawm cov poov xab, qe dawb, thiab tsiaj cov nqaij. Nws yog thawj lub npe Philothion. Xyoo 1921, Hopkins tau qhia tias kev siab dawb yog dipeptide uas muaj cysteine ​​thiab glutamate, tab sis qhov tseeb no tau raug hla mus.

Cov tshuaj no tau hu ua 'glutathione'. Tom qab xyoo 1927, nws tau pom tias glutathione tsis yog dipeptide, tab sis hloov pauv, tripeptide muaj glutamate-cysteine ​​nrog rau cov amino acid ntxiv, glycine. Cov yam ntxwv zoo no tau lees paub los ntawm Harington thiab Mead xyoo 1935. Lub sijhawm ntawd, glutathione tau ua los ntawm kev sib xyaw N-carbobenzoxy cysteine ​​thiab glycine ethyl ester.

 

Cov txiaj ntsig ntawm Glutathione

Raws li nws yog ib qho tseem ceeb tshaj plaws thiab muaj zog tiv thaiv kab mob hauv lub cev, Glutathione hmoov muaj ntau yam siv.

Qee qhov kev siv no yog:

 

Txo Oxidative Stress

Qhov tsis sib xws ntawm cov dawb radicals thiab lub cev lub peev xwm los nruab nrab lawv tuaj yeem ua rau muaj ntau yam kab mob thiab kev tsis zoo. Qhov no suav nrog cov mob xws li ntshav qab zib, mob qog noj ntshav, thiab lwm yam. Nws tau pom tias tsis muaj glutathione tsis muaj txiaj ntsig hauv cov neeg mob uas muaj cov kab mob no [1]. Li no, ntxiv nrog glutathione hmoov tuaj yeem pab txo cov tsos mob ntawm cov kab mob no thiab txawm tias tiv thaiv lawv qhov tshwm sim.

 

Txhim Kho Cov tsos mob ntawm Cawv Cawv thiab Tsis Zoo Cawv Cawv Kab Mob

Cov kab mob hauv daim siab tuaj yeem ua rau hnyav dua los ntawm kev tsis muaj cov tshuaj antioxidants zoo li glutathione. Qhov no tuaj yeem ua rau mob hnyav rau cov kab mob rog rog hauv cov neeg mob, tshwj xeeb yog cov uas haus cawv. Glutathione tau pom tias ua tau zoo rau cov neeg mob rog rog. Ib txoj kev tshawb fawb pom tias glutathione txo qis hauv cov neeg mob uas muaj kab mob siab, haus cawv lossis tsis haus cawv. Kev tswj hwm kev txhaj tshuaj ntau ntawm cov tshuaj glutathione tau qhia pom kev txhim kho hauv kev kuaj lub siab [2]. Yog li glutathione hmoov yuav pab kho tus mob ntawm daim siab.

 

Txhim kho cov tshuaj insulin

Kev tsim cov glutathione tsawg zuj zus nrog lub hnub nyoog. Cov kev tshawb fawb tau qhia tias qib qis glutathione cuam tshuam nrog kev hlawv roj tsawg dua thiab qib siab ntawm cov rog khaws cia hauv lub cev [3]. Qhov no tseem ua rau txo qis insulin tsis kam. Ntxiv cysteine ​​thiab glycine rau kev noj zaub mov tuaj yeem pab nce qib glutathione, uas txhim kho insulin tsis kam thiab hlawv roj.

 

Txhim kho cov tsos mob hauv Parkinson's Disease

Tus kab mob Parkinson yog tus kab mob degenerative ntawm lub hauv paus paj hlwb thiab yog tus yam ntxwv ntawm kev puas tsuaj ntawm lub paj hlwb. Feem ntau nws tshwm sim raws li tus neeg muaj hnub nyoog thiab tsis muaj kev kho tau. Glutathione qib qis hauv Parkinson tus kab mob. Ib txoj kev tshawb fawb tau qhia tias glutathione hmoov yuav tuaj yeem txo qhov cuam tshuam ntawm Parkinson tus kab mob thiab txhim kho kev ua haujlwm ntawm lub paj hlwb [4]. Txawm li cas los xij, yuav tsum muaj kev tshawb fawb ntxiv los qhia nws qhov ua tiav.

 

Txhim Kho Cov Neeg Mob

Glutathione tau pom tias muaj kev tiv thaiv kev laus thiab tiv thaiv melanogenic teebmeem. Ib txoj kev tshawb nrhiav xyoo 2017 pom tias txo qis glutathione, txog li 500mg ib hnub, muaj qhov ua kom tawv nqaij ua rau tib neeg tawv nqaij. Hauv txoj kev tshawb fawb no, ib pab pawg ntawm poj niam noj qab haus huv tau muab 250 mg glutathione ib hnub, lwm qhov muab oxidized glutathione (GSSG), thiab pab pawg thib peb tau muab cov placebo rau 12 lub lis piam. Qhov kawg ntawm lub sijhawm, nws tau pom tias cov poj niam muaj qhov sib piv tsawg dua cov tawv nqaij dua li cov uas tau siv cov placebo. Li no, glutathione tuaj yeem pab ua kom cov xim nyob hauv daim tawv nqaij, txo qis thiab txhim kho cov tawv nqaij [5].

 

Teeb meem tiv thaiv kab mob autoimmune

Kev nyuab siab oxidative tuaj yeem nce ntxiv vim mob ntev thiab mob autoimmune. Cov no suav nrog mob caj dab rheumatoid, kab mob celiac, lupus, thiab lwm yam Glutathione qib tsawg dua hauv cov xwm txheej no [6]. Yog li ntxiv nrog glutathione hmoov tuaj yeem pab txo qis kev ntxhov siab thiab txo cov tsos mob ntawm tus kab mob autoimmune.

 

Kev cuam tshuam rau ntxiv lawm tshob

Kev tsim ntau dhau ntawm cov pa oxygen reactive los ntawm spermatozoa txawv txav yog ib qho laj thawj rau kev muaj menyuam tsis taus. Yog li muab cov tshuaj tiv thaiv kab mob zoo li glutathione tuaj yeem tuaj yeem txo qis qhov xwm txheej no thiab pab txiv neej muaj menyuam [7]. Ib yam li ntawd, nws tuaj yeem pab txo qis kev nyuab siab oxidative hauv poj niam kev ua me nyuam thiab tawm tsam kev tsim cov dawb radicals [8]. Yog li, nws yuav muaj txiaj ntsig zoo rau txiv neej thiab poj niam fertility.

 

Kev cuam tshuam rau kev puas siab ntsws

Nws tau pom tias cov menyuam yaus uas muaj kev puas hlwb muaj ntau qib kev puas tsuaj oxidative thiab qib qis ntawm glutathione hauv lub hlwb. Kev soj ntsuam kuaj mob tau ua rau menyuam yaus hnub nyoog 3 txog 13 xyoos tau ua tiav qhov uas lawv tau muab qhov ncauj lossis transdermal glutathione [9]. Cov menyuam pom pom kev txhim kho cysteine, glutathione, thiab plasma sulfate qib. Yog li nws yuav pab txhim kho cov tsos mob ntawm kev puas hlwb ib yam nkaus.

 

Cov nyhuv ntawm Tshuaj Kho Mob Tshuaj Yeeb Tshuaj Neuropathy

Glutathione tau pom tias txo qis cov hlab ntsha hauv cov hlab ntsha hauv cov nas kho nrog tshuaj tiv thaiv qog noj ntshav. Ib txoj kev tshawb fawb tau tshawb fawb ntawm cov nas nrog mob ntshav qab zib neuropathy uas tshwm sim los ntawm kev kho nrog oxaliplatin, tshuaj platinum-based cancer tshuaj [10]. Muab lawv glutathione zoo li txo cov tsos mob tshwm sim los ntawm kev mob ntshav qab zib. Yog li, nws tuaj yeem pab daws qhov tsos mob neuropathy thiab.

 

Cov Teeb Meem Ntawm Glutathione

  • Mob plab.
  • Ua pa nyuaj vim yog cov hlab ntsws txhaws.
  • Kev ua xua, xws li pob khaus.

Daim ntawv nqus tau yog contraindicated nyob rau hauv mob hawb pob. Tsis muaj kev paub tshuaj sib cuam tshuam ntawm glutathione nrog lwm cov tshuaj txog hnub.

 

Dosage ntawm Glutathione

Glutathione yog siv hauv kev kho mob ntawm ntau yam mob. Qhov ncauj qhov ncauj dav yog 250mg txog 500mg ib hnub.

 

Koj Yuav Yuav Glutathione Qhov Twg?

Glutathione tuaj yeem yuav ncaj qha los ntawm Glutathione hmoov chaw tsim tshuaj paus tuam txhab. Nws los hauv pob khoom ntawm 1kg rau pob ntawv lossis 25kg rau ib lub nruas. Txawm li cas los xij, qhov no tuaj yeem kho raws li koj xav tau. Cov khoom no yog ua nrog cov khoom xyaw zoo tshaj plaws. Nws tau tsim tawm raws li cov lus qhia nruj thiab siv kev ntsuas kev nyab xeeb kom raug. Cov tshuaj no yuav tsum tau khaws cia ntawm qhov kub ntawm -20 ° C. Qhov no yog txhawm rau tiv thaiv nws los ntawm kev cuam tshuam nrog lwm cov tshuaj hauv ib puag ncig.

 

Cov ntaub ntawv hais txog:

  1. Lutchmansingh, FK, Hsu, JW, Bennett, FI, Badaloo, AV, McFarlane-Anderson, N., Gordon-Strachan, GM,… & Boyne, MS (2018). Glutathione metabolism hauv hom 2 mob ntshav qab zib thiab nws kev sib raug zoo nrog microvascular teeb meem thiab glycemia. PloS ib, 13(6), e0198626.
  2. Dentico, P., Volpe, A., Buongiorno, R., Grattagliano, I., Altomare, E., Tantimonaco, G.,… & Schiraldi, O. (1995). Glutathione hauv kev kho cov kab mob rog rog ntev. Tsis ntev los no kev nce qib hauv tshuaj, 86(7-8), 290-293.
  3. El-Hafidi, M., Franco, M., Ramírez, AR, Sosa, JS, Flores, JAP, Acosta, OL,… & Cardoso-Saldaña, G. (2018). Glycine nce insulin rhiab heev thiab glutathione biosynthesis thiab tiv thaiv oxidative kev nyuaj siab hauv tus qauv ntawm sucrose-induced insulin kuj. Cov tshuaj oxidative thiab qib phom ntev, 2018.
  4. Wang, HL, Zhang, J., Li, YP, Dong, L., & Chen, YZ (2021). Muaj peev xwm siv glutathione ua kev kho mob Parkinson tus kab mob. Sim thiab kho tshuaj kho mob, 21(2), 1-1.
  5. Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P. (2017). Glutathione thiab nws cov antiaging thiab antimelanogenic teebmeem. Kev kho mob, tshuaj pleev ib ce thiab tshuaj kho kab mob dermatology, 10, 147.
  6. Perricone, C., De Carolis, C., & Perricone, R. (2009). Glutathione: tus neeg tseem ceeb hauv kev tiv thaiv kab mob autoimmunity. Txoj Kev Ntsuam Xyuas Lub Zeem Muag, 8(8), 697-701.
  7. Irvine, DS (1996). Glutathione ua kev kho rau txiv neej ntxiv lawm tshob. Kev txheeb xyuas ntawm Kev Luam, 1(1), 6-12.
  8. Adeoye, O., Olawumi, J., Opeyemi, A., & Christiania, O. (2018). Txheeb xyuas lub luag haujlwm ntawm glutathione ntawm kev ntxhov siab oxidative thiab ntxiv lawm tshob. JBRA tau pab txhawb kev luam tawm, 22(1), 61.
  9. Rose, S., Melnyk, S., Pavliv, O., Bai, S., Nick, TG, Frye, RE, & James, SJ (2012). Pov thawj ntawm kev puas tsuaj oxidative thiab mob cuam tshuam nrog qis glutathione redox xwm txheej hauv lub hlwb puas hlwb. Kev txhais lus kho lub hlwb, 2(7), e134-e134.
  10. Lee, M., Cho, S., Roh, K., Chae, J., Park, JH, Park, J.,… & Lee, S. (2017). Glutathione txo qis cov hlab ntsha peripheral neuropathy hauv oxaliplatin kho cov nas los ntawm kev tshem aluminium los ntawm dorsal paus ganglia. American phau ntawv txhais lus ntawm kev tshawb fawb txhais lus, 9(3), 926.

 

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