cov khoom siv

Tianeptine hmoov (66981-73-5)

Tianeptine, tricyclic compound, yog tus xaiv kev coj ua ntawm 5-HT (serotonin; sc-201146) uptake hauv vitro thiab hauv vivo. Tsis tas li ntawd, Tianeptine raug tshaj tawm ua haujlwm los ua cov tshuaj tiv thaiv dopamine uptake thiab zoo ib yam li amineptine. Tianeptine tsis muaj kev cuam tshuam dab tsi ntawm kev saib xyuas monoamine. Hauv kev tshawb fawb uas siv cov synaptosomes ua kom huv los ntawm cov nas hlwb, Tianeptine tau tshaj tawm los txhim kho serotonin uptake hauv cheeb tsam xaiv lub hlwb. Purified synaptosomes tau los ntawm nas thiab tsim tawm nrog tritium-sau npe 5-H thiab Tianeptine hauv vitro. Lub synaptosomes tau tshawb rau qhov kev khaws tseg thiab tso 5-HT ntawm kev ua kua hluav taws.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.

Tianeptine hmoov (66981-73-5) video

 

 

Tianeptine hmoov (66981-73-5) Cov Ntaub Ntawv Sau Npe

lub npe Tianeptine hmoov
CAS 66981-73-5
purity 98%
Tshuaj lub npe 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid
Synonyms S-1574; JNJ-39823277; TPI-1062
molecular Formula C21H25ClN2O4S
molecular Nyhav 436.95
Melting Point 129-131 ° C
InChI Qhov Tseem Ceeb JICJBGPOMZQUBB-UHFFFAOYSA-N
daim ntawv hmoov
tsos Dawb Xim
Ib Sim Neej 4 rau 9 teev
solubility Dawb do rau hauv dej, hauv methanol thiab methylene chloride.
cia mob Khw ntawm 4 ° C
Daim ntawv thov Tricyclic compound nrog psychostimulant, tiv thaiv mob rau sab hauv thiab tiv thaiv emetic zog. Cov tshuaj tiv thaiv kab mob
Kuaj Cov Ntaub Ntawv Qhov

 

Tianeptine hmoov (66981-73-5) Cov Lus Qhia dav dav

Tianeptine yog ib qho tshuaj siv rau kev kho mob ntawm kev kho mob siab tshaj plaws thiab tau kawm hauv kev kho mob ntawm txoj hlab ntaws hauv plab (IBS) .Qhov kev cuam tshuam, Tianeptine, yog ib qho tshuaj tiv thaiv kab mob atypical uas siv feem ntau kho kev nyuaj siab tsis zoo, txawm hais tias nws kuj tseem siv tau los kho kev ntxhov siab, hawb pob, thiab chim siab mob plab hnyuv.

Tianeptine muaj cov tshuaj tiv thaiv kev ntxhov siab thiab ntxhov siab nrog ib tus neeg txheeb ze tsis muaj qhov tshuaj loog, tshuaj anticholinergic, thiab mob plawv. Nws tau pom tias ua raws li atypical agonist ntawm recept-opioid receptor nrog qhov chaw kuaj mob tsis zoo ntawm the- thiab io-opioid receptors uas ua feem ntau tricyclic antidepressants (TCA).

 

Tianeptine hmoov (66981-73-5) Keeb Kwm

Tianeptine tau tshawb pom thiab sau ntawv tso cai los ntawm Fabkis Kev Koom Tes ntawm Kev Tshawb Nrhiav Kev Kho Mob hauv xyoo 1960 Tam sim no, tianeptine tau pom zoo hauv Fabkis thiab tsim thiab ua lag luam los ntawm Laboratories Servier SA; Nws kuj tseem raug muag tawm hauv ntau lub tebchaws European nyob hauv kev lag luam npe Coaxil zoo li hauv Asia (suav nrog Singapore) thiab Latin America li Stablon thiab Tatinol tab sis nws tsis muaj nyob hauv Australia, Canada, New Zealand, United Kingdom, lossis Tebchaws Meskas.

 

Tianeptine hmoov (66981-73-5) Mechanism Ntawm Kev Ua

Cov kev tshawb fawb tsis ntev los no hais tias tianeptine ua raws li agonist tag nrho ntawm mu-type opioid receptor (MOR) [A33314], [A33316]. Cov mu opioid receptors tam sim no tau kawm raws li lub hom phiaj zoo rau kev kho tshuaj tiv thaiv kab mob. Nws ntseeg tau tias qhov kev soj ntsuam los ntawm tianeptine them rau nws cov kev hloov kho ntawm cov receptors.

Ntau tus qhia tias cov txheej txheem ntawm kev ua ntawm tianeptine txawv ntawm SSRIs thiab txhawb qhov kev xav tias qhov mechanism ntawm kev ua ntawm tianeptine cuam tshuam rau kev hloov kho glutaminergic hauv amygdala thiab hippocampus [A31971, A431969, A31986]. Ntxiv nrog rau cov txheej txheem saum toj no, tianeptine yog ib qho kev tiv thaiv kev tsis haum tshuaj thiab qhov kev mob siab rau qhov ua kom muaj zog ntawm serotonin (5-hydroxytryptamine; 5-HT), thiab 5-hydroxyindoleacetic acid (5-HIAA) hauv cov ntaub so ntswg hlwb [A31971]. Txawm hais tias monoaminergic neurotransmitters serotonin (5-HT), noradrenaline (NA) thiab dopamine (DA) muaj pov thawj cuam tshuam nrog kev tshwm sim ntawm kev nyuaj siab tsis txaus, tam sim no tau lees paub tias monoamine kev tiv thaiv tsis txaus los piav txog cov txheej txheem ntawm kev txiav txim siab ntawm antidepressant. Cov.

 

Tianeptine hmoov (66981-73-5) Kev Thov

  • 1) Tianeptine Txhim Kho Cov Kev Nyuaj Siab
  • 2) Tianeptine Tsawg Kev Ntshai, Kev Nyuaj Siab, thiab PTSD thiab Cov tsos mob los ntawm Kev Nyuaj Siab.
  • 3) Tianeptine Txiaj Ntsig thiab Kev Kawm
  • 4) Tianeptine yog tshuaj tiv thaiv
  • 5) Tianeptine txo qis qhov mob
  • 6) Tianeptine Pab kho kho mob voos plab txoj hnyuv
  • 7) Tianeptine Txo hawb pob

 

Tianeptine hmoov (66981-73-5) Kev tshawb fawb ntxiv

Kev soj ntsuam kab mob sib piv nws txoj kev ua tau zoo thiab lub siab ntev nrog amitriptyline hauv kev kho tus mob chim siab plob tsis so tswj pom tau hais tias tianeptine tau muaj txiaj ntsig zoo li amitriptyline thiab ua rau muaj txiaj ntsig tsis zoo xws li lub qhov ncauj qhuav thiab cem quav.Tianeptine tau tshaj tawm tias nws muaj txiaj ntsig zoo rau mob hawb pob. Cov. Thaum Lub Yim Hli 1998, Dr. Fuad Lechin thiab cov npoj yaig ntawm Central University of Venezuela Lub Tsev Haujlwm ntawm Kev Tshawb Fawb hauv tshuaj hauv Caracas luam tawm cov txiaj ntsig ntawm 52-lub limtiam randomized tswj kev sim ntawm cov menyuam asthmatic; cov menyuam yaus hauv cov pab pawg uas tau txais tianeptine tau txo qis hauv kev kuaj mob ntau ntxiv thiab nce ntxiv hauv lub ntsws. Ob xyoos dhau los, lawv tau pom qhov sib ze, zoo koom tes ntawm kev pub dawb serotonin hauv plasma thiab mob hnyav ntawm hawb pob hauv cov neeg mob. Raws li tianeptine tsuas yog tus neeg sawv cev tsuas yog paub txog kev txo qis dawb serotonin hauv plasma thiab txhim kho kev sib txuam hauv platelets, lawv tau txiav txim siab siv nws los saib seb puas txo qis ntau serotonin hauv plasma yuav pab tau. Txog thaum Lub Kaum Ib Hlis 2004, tau muaj ob lub qhov muag dig muag ob qho kev sim tshuaj ntsuam thiab muaj> 25,000 tus neeg qhib daim ntawv lo kawm ntev tshaj xya xyoo, uas qhia tag li. Tianeptine tseem muaj cov tshuaj anticonvulsant thiab analgesic, thiab cov kev sim tshuaj hauv Spain uas xaus rau Lub Ib Hlis 2007 tau pom tias tianeptine siv tau los kho mob vim mob fibromyalgia. Tianeptine tau pom tias muaj kev ua tau zoo nrog kev mob tshwm sim tsawg kawg hauv kev kho mob ntawm kev saib xyuas kev tiv thaiv kev tsis haum hyperactivity tsis meej.

 

Tianeptine hmoov (66981-73-5) Kev siv

  • Mennini, T., li al. 1987. Naunyn Schmiedebergs Koov. Kws tshuaj. 336: 478-482. PMID: 3437921
  • Kato, G. thiab Weitsch, AF 1988. Clin Neuropharmacol. 11: S43-S50. PMID: 3052825
  • Tianeptine Sodium. Martindale: Ua tiav Kev Siv Tshuaj. London, UK: Xovxwm Siv Tshuaj. 5 Hlis ntuj nqeg 2011. Muab rov qab 2 Hlis ntuj nqeg 2013.
  • J. Elks (14 Kaum Ib Hlis Ntuj 2014). Cov Lus Txhais ntawm Cov Tshuaj: Cov Ntaub Ntawv Tshuaj: Cov Ntaub Ntawv Tshuaj, Cov Qauv thiab Cov Lus Teev. Caij nplooj ntoos hlav. pp. 1195–. ISBN 978-1-4757-2085-3.

 

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