N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6)

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Lub npe: N-Acetyl-L-cysteine ​​ethyl ester

CAS: 59587-09-6

Cov mis mos molecular: C7H13NO3S

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N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) video

 

N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) Cov Ntaub Ntawv Cov Lus Qhia

lub npe N-Acetyl-L-cysteine ​​ethyl ester
CAS 59587-09-6
purity 98%
Tshuaj lub npe N-Acetyl-L-cysteine ​​ethyl ester
NACET (R) -ethyl 2-acetamido-3-mercaptopropanoate
Synonyms N-Acetylcysteine ​​tus cwj pwm; (R) -Methyl 2-acetaMido-3-Mercaptopropanoate; -Ethyl 2-acetamido-3-mercaptopropanoate; Ethyl (2R) -2-Acetamido-3-Sulfanyl-Propanoate; (2R) -2-Acetamido-3-Mercaptopropanoic Acid Ethyl Ester; (2R) -2-Acetamido-3-Mercapto-Propionic Acid Ethyl Ester
molecular Formula C7H13NO3S
molecular Nyhav 191.25 g / mol
Melting Point 197.0 rau 202.0 ° C
InChI Qhov Tseem Ceeb MSMRAGNKRYVTCX-LURJTMIESA-N
daim ntawv Khoom
tsos Tshem tawm dawb
Ib Sim Neej N / A
solubility N / A
cia mob Khaws rau hauv qhov chaw txias; Kaw lub thawv kaw kom nruj rau hauv qhov chaw qhuav thiab zoo tso cua
Daim ntawv thov N-Acetyl-L-cysteine ​​ethyl ester hmoov siv los ua kom lub zog nco, tsom, muaj tswv yim, txawj ntse thiab lub zog.
Kuaj Cov Ntaub Ntawv Qhov

 

N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) Cov Lus Qhia dav dav

N-Acetyl-L-cysteine ​​ethyl ester hmoov (NACET): tus tshiab lipophilic cell-permeable cysteine ​​derivative nrog ib qho txawv txawv pharmacokinetic thiab qhov muaj peev xwm ua tau antioxidant.

 

N-Acetyl-L-cysteine ​​ethyl ester Ntau cov kev tshawb fawb

Tsis ntev los no hauv cov chaw kuaj mob tsis txaus ntseeg kom paub meej tias qhov txiaj ntsig zoo ntawm N-acetylcysteine ​​(NAC) hauv kev tiv thaiv kab mob oxidative kev ntxhov siab. Qhov no tuaj yeem vim nws qhov qis qis dua ntawm bioavailability. Peb xav tias esterification ntawm pab pawg carboxyl ntawm NAC los tsim N-acetylcysteine ​​ethyl ester (NACET) yuav ruaj nce lipophilicity ntawm NAC, yog li txhim kho nws cov chaw muag tshuaj zoo heev. Hauv kev ua haujlwm tam sim no, peb qhia txog cov sawv cev tshuaj lom neeg, pharmacological thiab anti-oxidant zog ntawm NACET, tshwj xeeb tshaj yog nyob rau hauv kev sib piv ncaj qha nrog nws cov neeg ua haujlwm NAC. Peb pom tias NACET tau nrawm nrawm rau nas tom qab kev tswj hwm qhov ncauj tab sis mus txog ntau qhov tsis tshua muaj nyob hauv ntshav. Qhov no yog vim muaj qhov tshwj xeeb ntawm NACET: nws nrawm rau hauv lub hlwb qhov chaw uas nws tab cuab tau hloov mus rau hauv NAC thiab cysteine. Tom qab kev kho mob ntawm qhov ncauj, NACET (tab sis tsis yog NAC) tau muaj peev xwm nce cov ntsiab lus glutathione ntawm feem ntau cov ntaub so ntswg tau tshuaj xyuas, lub hlwb suav nrog, thiab tiv thaiv los ntawm paracetamol intoxication hauv cov nas. NACET tseem muaj qhov cim tshwj xeeb kom khaws hauv tib neeg erythrocytes qhov twg nws coj los ua cov muaj zog tiv thaiv kev tiv thaiv hydroperoxide los tiv thaiv kev puas tsuaj. Peb txoj kev tshawb fawb qhia tau tias nkag mus rau hauv hlwb thiab tsim NAC thiab cysteine, NACET nce ncig cov pa tshuaj hydrogen sulfide (H (2) S), yog li sawv cev rau cov neeg sib tw zoo rau kev siv lub qhov ncauj ua H (2) S cov khoom tsim, muaj qhov zoo meej dhau NAC. NACET muaj lub peev xwm hloov NAC los ua tus mucolytic tus neeg sawv cev, ua paracetamol antidote thiab ua GSH cuam tshuam los tiv thaiv kab mob.

 

N-Acetyl-L-cysteine ​​ethyl ester Siv

  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) thiab N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cov neeg sib tw siv tshuaj yaj yeeb nrog cov cim tshuaj rau kev siv hauv qhov ncauj li TSIS, H2S thiab GSH cov neeg xa khoom thiab raws li cov tshuaj tiv thaiv antioxidant: Cov txiaj ntsig thiab kev saib xyuas. 2018 Lub Ob Hlis; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Rov Los Saib. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester ua GSH txhim kho hauv tib neeg lub hlwb endothelial: Ib txoj kev sib piv nrog lwm cov tshuaj. 2018 Lub Kaum Hli; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478
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