cov khoom siv

PAB (56-12-2)

acid-Aminobutyric acid (GABA) yog tus kabmob inhibitory neurotransmitter hauv lub hlwb mammalian nruab nrab lub paj hlwb. Nws ua lub luag haujlwm hauv kev tswj hwm neuronal excitability thoob plaws hauv cov leeg hlwb. Hauv tib neeg, GABA kuj yog lub luag haujlwm ncaj qha rau cov kev cai ntawm cov leeg nqaij. Txawm hais tias kev siv tshuaj yog nws cov amino acid, GABA tsis tshua tau hais txog nyob rau hauv cov zej zog scientific lossis kev kho mob, vim hais tias lo lus "amino acid," siv tsis muaj qhov muaj txiaj ntsig, conventionally hais txog alpha amino acids, uas GABA tsis yog, tsis yog nws puas tau koom rau hauv ib lub protein. Hauv tib neeg mob dasticgia rau hauv tib neeg, GABA qhov kev nqus yuav ua rau tsis muaj zog ntawm cov leeg puas los ntawm qhov mob ntawm lub cev muaj zog neuron lesion, uas ua rau hypertonia ntawm cov nqaij ntshiv tau taw los ntawm cov hlab ntsha uas tsis tuaj yeem nqus GABA.

Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

Cov Ntaub Ntawv Qhia Txog Tshuaj Hauv Paus

lub npe acid-Aminobutyric acid (GABA)
CAS 56-12-2
purity 98%
Tshuaj lub npe 4-Aminobutyric acid
Synonyms GABA; df468; gamma;(2D2); (3B7); Gammar; Immu-G; Reanal; DF 468; Gamarex
molecular Formula C4H9NO2
molecular Nyhav 103.12
Melting Point 195 ° C
InChI Qhov Tseem Ceeb BTCSSZJGUNDROE-UHFFFAOYSA-N
daim ntawv hmoov
tsos Dawb crystalline hmoov
Ib Sim Neej /
solubility H2O: 1 M ntawm 20 ° C, ntshiab, tsis muaj xim
cia mob Khw nyob RT
Daim ntawv thov Siv rau hauv kev tiv thaiv kev mob hlwb.
Kuaj Cov Ntaub Ntawv Qhov

 

General hauj lwm

Gamma Amino Butyric Acid lossis GABA, raws li nws ib txwm paub, yog nrov amino acid uas tau txais txiaj ntsig muaj cov txiaj ntsig loj rau koj cov leeg hlwb. Kev hais lus, GABA tuaj yeem pab cov hlab ntsha dhia ua ke hla cov khoob khoob hauv kev sib txuas lus thiab yog li pab lub hlwb xa cov paib hauv txoj kev zoo dua. Nyob rau hauv qhov kev txiav txim, nws ua raws li tus neurotransmitter.

Txawm li cas los xij, kev siv tseem ceeb tshaj plaws ntawm Gamma Amino Butyric Acid yog vim nws tuaj yeem ua qhov kev tiv thaiv kev hnyav kom zoo. Cov no tsis yog cov ntawv thov tsis tau raws li nws tau raug pov thawj los ntawm kev tshawb fawb ntau. GABA yog paub kom nce ntau ntxiv ntawm Kev Loj Hlob Tib Neeg Lawm (HGH). HGH yog qhov ua pov thawj metabolism ntxiv. Hauv lwm lo lus, nws tuaj yeem nce tus nqi uas lub cev hlawv cov roj lwg roj. Yog li, los ntawm kev tswj hwm kev noj qab haus huv ntawm Gamma Amino Butyric Acid, nws muaj peev xwm nce cov rog ntau ntau uas lub cev hlawv

 

Keeb kwm

Xyoo 1883, GABA tau tsim ua ntej, thiab nws tau paub ua ntej tsuas yog cog thiab microbe cov khoom lag luam metabolic.

Hauv xyoo 1950, GABA tau tshawb pom tias yog ib feem tseem ceeb ntawm txoj hlab hlwb hauv cov leeg tsiaj.

Xyoo 1959, nws tau qhia tias ntawm ib qho kev txwv tsis pub ua rau ntawm cov leeg nqaij ntses muaj zog GABA ua zoo li kev ua kom lub ntsej muag inhibitory. Ob qho tib si inhibition los ntawm kev txhawb cov hlab thiab siv GABA yog thaiv los ntawm picrotoxin.

 

acid-Aminobutyric acid (GABA) 56-12-2 Mechanism Of Action

acid-Aminobutyric acid (GABA) tej zaum sawv cev rau qhov tseem ceeb tshaj plaws cov khoom xa hluav taws xob ntawm lub mammalian CNS (kuj saib Tshooj 15). Ob hom GABAergic inhibition (pre- thiab postsynaptic) siv tib qho GABAA receptor subtype, uas ua los ntawm cov kev cai ntawm chloride channel ntawm lub neuronal membrane. Qhov thib ob GABA receptor yam, GABAB, uas yog G protein – txuas ntxiv cov khoom tsis suav tias yog qhov tseem ceeb hauv kev nkag siab txog cov txheej txheem ntawm hypnotics. Kev ua kom muaj GABAA receptor los ntawm agonist tsub kom qhov kev tiv thaiv kom zoo cov lus teb ntawm cov neurons nruab nrab rau GABA los ntawm hyperpolarization. Vim tias muaj ntau, yog tias tsis yog txhua txhua, lub hauv paus neurons tau txais qee GABAergic cov tswv yim, qhov no ua rau muaj kev coj ua uas CNS kev ua si tuaj yeem nyuaj siab Piv txwv li, yog tias GABAergic interneurons ua haujlwm los ntawm agonist uas cuam tshuam rau monoaminergic cov qauv ntawm lub paj hlwb, txoj haujlwm hypnotic yuav raug pom. Cov neuronal tshwj xeeb hauv cov cheeb tsam sib txawv paj hlwb raug cuam tshuam los ntawm GABAA agonist tseem pom zoo dua.

 

acid-Aminobutyric acid (GABA) 56-12-2 Daim ntawv thov

Siv tau ntawm GABA:

Cov ntaub ntawv zoo tshaj plaws uas kuv muaj hauv kev siv tshuaj kho mob los ntawm kev sau ntawv ntawm Eric Braverman thiab Carl Pfeiffer. Lawv phau ntawv 1987 hais txog kev siv tshuaj cov amino acids yog kev kho mob ua ntej rau kev xyaum tshuaj noj tshuaj.

Ntxhov siab vim:

Yog tias qhov ncauj GABA nce mus rau lub hlwb hauv ib qhov tseem ceeb nws yuav tsum ua qhov tshuaj tua kabmob. GABA ua tus neurotransmitter, thaiv cov hlab siab lub zog thiab qeeb qeeb ntawm cov neuronal kis. Nws yuav tsum ua rau koj xav tias qhov rov qab ntawm ob chav espresso.

Braverman thiab Pfeiffer sau cov lus tshaj tawm txog kev ua tiav ntawm kev kho mob muaj hnub nyoog plaub caug xyoo tus poj niam muaj kev txom nyem nrog kev ntxhov siab nrog 800 mg ntawm GABA ib hnub. Lawv kuj tau muab nws qhov tsis qhia paub tseeb ntawm inositol uas peb tam sim no paub yog qhov kev mob siab xav tau raug coj los siv rau kev kho qhov tsis nco qab qhov sib txawv. Puas yog GABA lossis qhov inositol uas tau pab tus neeg mob no? Tej zaum ua ke nrog.

Txawm hais tias qhov kev lees paub no tsis meej, siv GABA los kho kev ntxhov siab yog qhov feem ntau siv thiab tsim nyog siv.

Lub paj hlwb yuav hloov puas ntxiv rau GABA ntxiv? Tsis muaj lus teb rau qhov no vim tsis muaj leej twg tau qhia tseeb GABA mus txog rau lub hlwb. Saib ntawm lub hlwb lub peev xwm los hloov GABA receptor teb thiab nws txoj kev nyiam los ua siab ntev rau cov tshuaj uas hloov GABA, nws yog qhov ua tau kom nkag siab GABA qhov ncauj yuav tshwm sim thiab tshem tawm cov tsos mob yuav tshwm sim. Tsis muaj ib qho ntawv tshaj tawm hauv cov ntaub ntawv rau kuv txoj kev paub.

Lus Qhia ntxiv

GABA yog tsim nyob rau hauv tib neeg lub hlwb thiab ua haujlwm li kev ntsuas, tswj kev sib luag ntawm lub cev thiab lub siab hauv cov xeev ntawm kev lom zem. GABA pab cuam rau ntau yam teeb meem suav nrog Kev Kho Mob Hlawv Hyperactivity Disorder lossis ADHD, kub siab lossis HBP, rog dhau, pw tsis tsaug zog, haus dej cawv thiab ntau ntxiv. Nws tseem yog ib qho kev pab zoo rau kev kho cov hlwb.

Cov tshuaj GABA pab tau rau txhua tus neeg nquag, bodybuilders thiab ncaws pob. Lawv pab txhawm rau txhim kho cov leeg nqaij ntawm lub cev.

 

Tshawb nrhiav ntxiv

GABA raws li cov lus qhia ntxiv

Ib tug xov tooj ntawm cov lag luam muag muag formulations ntawm GABA rau kev siv ua khoom noj khoom haus muaj txiaj ntsig, qee zaum rau kev tswj hwm sublingual. Cov chaw no ib txwm hais tias qhov ntxiv tau muaj qhov ntsuas kom zoo. Cov kev thov no tseem tsis tau muaj pov thawj ntawm kev tshawb fawb. Piv txwv li, muaj cov pov thawj qhia tias cov teebmeem raug mob ntawm GABA tuaj yeem pom nyob rau hauv tib neeg lub hlwb tom qab kev tswj hwm ntawm GABA ua qhov ncauj ntxiv. Txawm li cas los xij, tseem muaj pov thawj tias GABA tsis hla ntshav - lub hlwb teeb meem ntawm theem tseem ceeb.

Muaj qee qhov kev yuav pem khw xws li phenylated GABA nws tus kheej, lossis Phenibut; thiab Picamilon (ob qho tib si khoom ntawm cosmonaut) - Picamilon sib xyaw niacin thiab phenylated GABA thiab hla ntshav – lub hlwb cuam tshuam uas yog cov khoom tiv thaiv uas tom qab hydrolyzes mus rau GABA thiab niacin.

 

reference

  1. Roth RJ, Cooper JR, Bloom FE (2003). Biochemical Hauv Paus ntawm Neuropharmacology. Oxford [Oxfordshire]: Oxford University Xovxwm. p. 106.
  2. Haynes, William M., ed. (2016). CRC Phau Ntawv Chemistry thiab Physics (97th ed.). CRC Xov Xwm. pp. 5–
  3. Roberts, E., thiab Frankel, S. (1950). gamma-aminobutyric acid hauv hlwb: nws tsim los ntawm cov kua qaub glutamic. J. Biol. Chem. 187, 55–
  4. Abdou, AM, Higashiguchi, S., Horie, K., Kim, M., Hatta, H., thiab Yokogoshi, H. (2006). So thiab tiv thaiv kev tiv thaiv kom muaj txiaj ntsig zoo ntawm gamma-aminobutyric acid (GABA) kev tswj hwm hauv tib neeg. Cov khoom siv roj ntsha 26, 201– 208.

 

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