cov khoom siv

Nicotinamide adenine dinucleotide (NAD) hmoov (53-84-9)

Nicotinamide adenine dinucleotide (NAD) hmoov yog cofactor uas yog qhov tseem ceeb hauv cov metabolism. Pom nyob hauv txhua lub hlwb muaj sia, NAD hmoov yog hu ua dinucleotide vim tias nws muaj ob lub nucleotides koom nrog lawv cov phosphate pawg. Ib qho nucleotide muaj adenine nucleobase thiab lwm qhov nicotinamide. NAD hmoov tshwm sim nyob rau hauv ob daim ntawv: ib qho oxidized thiab txo daim ntawv, sau ua NAD + thiab NADH feem.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

Nicotinamide adenine dinucleotide hmoov yees duab

 

 

NAD hmoov (53-84-9) Cov Ntaub Ntawv Sau Npe

lub npe Nicotinamide adenine dinucleotide (NAD) hmoov
CAS 53-84-9
purity 99%
Tshuaj lub npe beta-Diphosphopyridine nucleotide
Synonyms Beta-NAD

NAD

NAD+

molecular Formula C21H27N7O14P2
molecular Nyhav 663.4 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
InChI Qhov Tseem Ceeb BAWFJGJZGIEFAR-NNYOXOHSSA-N
daim ntawv Khoom
tsos Dawb hmoov
Ib Sim Neej /
solubility Dej Dej Cev 2.14 mg / mL
cia mob nyob rau hauv lub thawv ntim ruaj ruaj, khaws cia huab cua tawm, tiv thaiv los ntawm kub, lub teeb thiab av noo.
Daim ntawv thov tej zaum yuav pab ua rau cov tsos mob rov qab thiab txo qis ntau yam mob
Kuaj Cov Ntaub Ntawv Qhov

 

NAD hmoov (53-84-9) Cov Lus Qhia dav dav

NAD hmoov, luv rau nicotinamide adenine dinucleotide. Ib lub coenzyme uas tau tshwm sim hauv ntau lub hlwb muaj sia thiab kev ua haujlwm raws li tus xaiv hluav taws xob. NAD hmoov yog siv hloov pauv nrog NADH ua li oxidizing lossis txo tus neeg sawv cev hauv cov teeb meem metabolic.

 

Nicotinamide adenine dinucleotide Keeb Kwm

Lub coenzyme NAD + tau pom thawj zaug los ntawm British biochemists Arthur Harden thiab William John Young hauv xyoo 1906. Lawv tau pom tias ntxiv cov hau rhaub thiab lim cov poov xab cov cawv ntau heev nyob rau hauv cov poov xab tsis xyaw poov xab. Lawv hu qhov xwm txheej tsis lees paub txog qhov ua tau no coferment. Los ntawm kev ntxuav ntev thiab nyuaj ntawm cov poov xab rho tawm, qhov ntsuas kub ntawm qhov ntsuas kub tau txheeb xyuas raws li nucleotide qab zib phosphate los ntawm Hans von Euler-Chelpin. Xyoo 1936, tus kws tshawb fawb German Otto Heinrich Warburg qhia txog kev ua haujlwm ntawm nucleotide coenzyme hauv hydride hloov chaw thiab txheeb xyuas qhov feem nicotinamide yog qhov chaw ntawm kev rov ua cov tshuaj tiv thaiv.

Vitamin cov txheej txheem ua ntej ntawm NAD + tau raug txheeb xyuas thawj zaug hauv xyoo 1938, thaum Conrad Elvehjem qhia tias daim siab muaj qhov "tiv thaiv qhov ncauj dub" kev ua haujlwm los ntawm kev ua nicotinamide. Tom qab ntawd, xyoo 1939, nws tau muab thawj qhov pov thawj tias niacin raug siv los ua ke nrog NAD + .Nyob rau xyoo 1940, Arthur Kornberg yog thawj zaug los tshawb pom ib qho enzyme nyob rau hauv biosynthetic pathway.Hauv xyoo 1949, Asmeskas biochemists Morris Friedkin thiab Albert L. Lehninger ua pov thawj tias NADH sib txuas metabolic txoj hauv kev xws li lub voj voog citric acid nrog cov synthesis ntawm ATP hauv oxidative phosphorylation.In 1958, Jack Preiss thiab Philip Handler nrhiav cov tshuaj nruab nrab thiab cov enzymes koom nrog hauv biosynthesis ntawm NAD +; khaws cia cov hluavtaws los ntawm nicotinic acid yog lub npe hu ua Preiss-Handler pathway. Xyoo 2004, Charles Brenner thiab cov neeg ua haujlwm sib koom ua haujlwm pom cov nicotinamide riboside kinase txoj hauv kev mus rau NAD +

 

NAD hmoov (53-84-9) Mechanism Ntawm Kev Ua

Nicotinamide adenine dinucleotide (NAD) hmoov yog koom nrog cov tshuaj tiv thaiv kev coj ua, nqa cov khoom siv hluav taws xob los ntawm ib qho tshuaj tiv thaiv rau lwm. Lub cofactor yog, yog li ntawd, pom nyob rau hauv ob daim ntawv hauv hlwb: NAD + yog ib qho oxidizing tus neeg sawv cev - nws lees txais cov khoom siv hluav taws xob los ntawm lwm cov lwg me thiab ua kom tsawg dua. Qhov tshuaj tiv thaiv no ua NADH, uas tom qab ntawd tuaj yeem siv los ua tus neeg txo qis los pub cov khoom siv hluav taws xob. Cov hluav taws xob hloov pauv hluav taws xob yog qhov haujlwm tseem ceeb ntawm NAD. Txawm li cas los xij, nws tseem siv nyob rau hauv lwm cov txheej txheem ntawm tes, feem ntau tshwj xeeb tshaj yog cov txheej txheem ntawm cov enzymes uas ntxiv los yog tshem tawm cov pab pawg tshuaj los ntawm cov protein, hauv kev hloov kho kev ua haujlwm. Vim tias qhov tseem ceeb ntawm cov haujlwm no, cov enzymes koom nrog NAD metabolism yog qhov hom phiaj rau kev tshawb pom yeeb tshuaj.

 

Nicotinamide adenine dinucleotide Daim Ntawv Thov

Nicotinamide adenine dinucleotide (NAD) hmoov ua roj rau ntau yam txheej txheem kev lom neeg tseem ceeb, xws li:

1) Kev hloov pauv khoom noj rau lub zog

2) Kho cov DNA uas puas lawm

3) Fortifying cell 'tiv thaiv lub zog

4) Teem koj lub cev lub sijhawm sab hauv lossis lub suab circadian

 

NAD hmoov (53-84-9) Kev tshawb fawb ntau ntxiv

Vim tias kev tshawb fawb feem ntau ntawm Nicotinamide adenine dinucleotide (NAD) hmoov los ntawm cov kev tshawb fawb txog tsiaj, tsis muaj kev txiav txim siab meej meej tuaj yeem hais txog nws cov hauj lwm zoo rau tib neeg. Nov yog qee cov txiaj ntsig kev noj qab haus huv muaj txiaj ntsig ntawm Nicotinamide adenine dinucleotide (NAD) hmoov:

  1. Ua kom muaj Enzymes uas tuaj yeem pab txhawb kev laus
  1. Tuaj Yeem Pab Tiv Thaiv Lub Hlwb Hlwb

NAD + lub luag haujlwm tseem ceeb hauv kev pab koj lub hlwb hlwb hnub nyoog zoo.

Tsis pub dhau lub hlwb hlwb, NAD + pab tswj kev tsim PGC-1-alpha, cov protein uas zoo li los pab tiv thaiv cov hlwb tiv thaiv oxidative kev nyuaj siab thiab kev ua haujlwm tsis zoo ntawm mitochondrial. Cov kws tshawb nrhiav ntseeg hais tias ob qho tib si oxidative kev nyuaj siab thiab kev ua tsis tau zoo mitochondrial yog txuas rau lub hnub nyoog muaj feem cuam tshuam rau lub hlwb xws li Alzheimer thiab Parkinson tus kab mob.

  1. Lub Tsib Hlis Uas Yuav Muaj Kab Mob Hauv Lub Siab Tsawg

Kev laus yog qhov pheej hmoo ua rau mob plawv, uas yog lub ntiaj teb ua rau ploj tuag. Nws tuaj yeem ua rau cov hlab ntshav zoo li koj lub aorta ua tuab dua, stiffer thiab hloov pauv yooj. Cov kev hloov pauv no tuaj yeem nce qib ntshav siab thiab ua rau koj lub siab ua haujlwm hnyav.

Hauv tsiaj, nce NAD + pab thim rov qab muaj hnub nyoog hloov pauv hloov rau cov hlab ntsha

  1. Tej zaum yuav txo tau kev mob qog noj ntshav

Qib NAD + Qib siab pab tiv thaiv DNA ua kom puas thiab oxidative kev nyuaj siab, uas txuas nrog rau kev mob qog noj ntshav

  1. Yuav txhawb txoj kev laus ua kom cov leeg noj qab haus huv

Kev nce qib NAD + qib pab txhim kho cov leeg ua haujlwm, lub zog thiab thev naus laus zis hauv nas ntev

 

Nicotinamide adenine dinucleotide Siv

  • [1] Sakuraba H, Kawakami R, Ohshima T (2005). "First Archaeal Inorganic Polyphosphate / ATP-dependant NAD Kinase, los ntawm Hyperthermophilic Archaeon Pyrococcus horikoshii: Cloning, Qhia Tawm, thiab Qhov Cim". Ntsuas siv. Ib puag ncig. Microbiol. 71 (8): 4352–8. doi: 10.1128 / AEM.71.8.4352-4358.2005. PMC 1183369. PMID 16085824.
  • [2] Katoh A, Uenohara K, Akita M, Hashimoto T (2006). "Cov Kauj Ruam Thaum Ntxov nyob hauv Biosynthesis ntawm NAD hauv Arabidopsis Pib nrog Aspartate thiab tshwm sim hauv Plastid". Nroj Physiol. 141 (3): 851–7. doi: 10.1104 / pp.106.081091. PMC 1489895. PMID 16698895.
  • [3] Chen YG, Kowtoniuk WE, Agarwal I, Shen Y, Liu DR (Kaum Ob Hlis 2009). "LC / MS tsom xam ntawm cellular RNA qhia NAD-txuas RNA". Nat Chem Biol. 5 (12): 879–881. doi: 10.1038 / nchembio.235. PMC 2842606. PMID 19820715.
  • [4] Gomes AP, Nqe NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, Dawb JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Tswb EL, Sinclair DA (19 Kaum Ob Hlis 2013). "Tsis kam NAD + Induces Pseudohypoxic Lub Xeev Cuam Tshuam Cuam Tshuam Nuclear-Mitochondrial thaum muaj hnub nyoog". Ntawm tes. 155 (7): 1624–1638. doi: 10.1016 / j.cell.2013.11.037. PMC 4076149. PMID 24360282.
  • Txhua Yam Koj Yuav Tsum Tau Paub Txog Nicotinamide Riboside Chloride

 

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