Nicotinamide adenine dinucleotide (NAD) hmoov (53-84-9)

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5-10 teev (hauv hnub ua haujlwm) ceev shipping
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Tsuas yog 15 sab lauj! 143 tus neeg tab tom saib qhov no thiab 17 tus neeg muaj nws hauv lawv lub laub.

Tsis paub Yuav Ua Li Cas Qhov Kev Txiav Txim?

Nyem qhov no
[1]. Xaiv qhov koj xav tau, tom qab ntawd ntxiv rau lub laub

[2]. Txuas mus xyuas

[3]. Sau koj cov ntaub ntawv nthuav dav, qhov * yuav tsum tau, xaiv koj txoj kev them nyiaj. Muaj ntau txoj kev them nyiaj sib txawv suav nrog:
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Lub tswv yim: email chaw nyob yuav tsum tau kho, cov ntaub ntawv taug qab yuav hloov tshiab los ntawm email ceeb toom

[4]. Yog tias xaiv "Coinpayment", tom qab nyem "Place order", ces yuav qhia raws li hauv qab no them

[5]. Yog tias Xaiv "Direct Bank Transfer", tom qab nias "Place order", ces yuav qhia raws li hauv qab no, yuav tshwm sim cov ntsiab lus ntawm tus account hauv txhab nyiaj, tom qab hloov lub txhab nyiaj (thov siv koj tus lej xaj raws li qhov siv), xa daim ntawv hauv txhab nyiaj rau peb.

[6]. Kev them nyiaj lees paub
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[9]. Parcel tuaj txog
[10]. Rov xaj dua
Tsis muaj koj qhov ntau? Nyem no
Ceeb toom: Yog tias koj cev xeeb tub, saib xyuas neeg mob, noj cov tshuaj los yog muaj kev mob nkeeg nrog koj tus kws kho mob ua ntej siv. Khaws kom deb ntawm cov menyuam yaus.
Qeb: SKU: N / A

Dab tsi yog cov txiaj ntsig ntawm NAD + hmoov?

  1. Anti-aging
  2. Ua kom cov hlwb tiv taus kev ntxhov siab
  3. Tiv thaiv lub hlwb
  4. Pab kho DNA
  5. Pab koj tsaug zog thiab noj thaum lub sijhawm
  6. Txhim kho cov leeg nqaij
  7. Txhim kho lub siab ua haujlwm

Nicotinamide adenine dinucleotide hmoov yees duab

 

 

NAD hmoov (53-84-9) Cov Ntaub Ntawv Sau Npe

lub npe Nicotinamide adenine dinucleotide (NAD) hmoov
CAS 53-84-9
purity 99%
Tshuaj lub npe beta-Diphosphopyridine nucleotide
Synonyms Beta-NAD

NAD

NAD+

molecular Formula C21H27N7O14P2
molecular Nyhav 663.4 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
InChI Qhov Tseem Ceeb BAWFJGJZGIEFAR-NNYOXOHSSA-N
daim ntawv Khoom
tsos Dawb hmoov
Ib Sim Neej /
solubility Dej Dej Cev 2.14 mg / mL
cia mob nyob rau hauv lub thawv ntim ruaj ruaj, khaws cia huab cua tawm, tiv thaiv los ntawm kub, lub teeb thiab av noo.
Daim ntawv thov tej zaum yuav pab ua rau cov tsos mob rov qab thiab txo qis ntau yam mob
Kuaj Cov Ntaub Ntawv Qhov

 

NAD + hmoov (53-84-9) yog dab tsi?

NAD + hmoov, luv luv rau nicotinamide adenine dinucleotide. Ib coenzyme uas tshwm sim nyob rau hauv ntau lub hlwb muaj sia thiab ua haujlwm ua tus txais hluav taws xob. NAD hmoov yog siv ua ke nrog NADH ua oxidizing lossis txo tus neeg sawv cev hauv cov tshuaj tiv thaiv metabolic.

Koj cov qib NAD + ib txwm poob qis thaum koj loj tuaj. Tab sis qhov ntawd tsis tas txhais tau tias koj ua tsis tau dab tsi los tawm tsam nws. NAD + cov tshuaj ntxiv tuaj yeem yog ib qho cuab yeej zoo los pab txhawb kev laus noj qab haus huv, nrog rau lwm cov txheej txheem lom neeg tseem ceeb.

 

NAD + hmoov keeb kwm

Lub coenzyme NAD + (nicotinamide adenine dinucleotide) tau pom thawj zaug los ntawm British biochemists Arthur Harden thiab William John Young nyob rau hauv 1906.Lawv pom tias ntxiv boiled thiab lim cov poov xab extract zoo heev accelerated cawv fermentation nyob rau hauv unboiled poov xab rho tawm. Lawv hu ua qhov tsis paub qhov tseem ceeb ntawm lub luag haujlwm rau qhov cuam tshuam no yog kev sib koom ua ke. Los ntawm kev ua kom huv si ntev thiab nyuaj los ntawm cov poov xab rho tawm, qhov ntsuas kub ruaj khov no tau pom tias yog nucleotide qab zib phosphate los ntawm Hans von Euler-Chelpin. Xyoo 1936, tus kws tshawb fawb German Otto Heinrich Warburg tau qhia txog kev ua haujlwm ntawm nucleotide coenzyme hauv hydride hloov thiab txheeb xyuas qhov nicotinamide feem ua qhov chaw ntawm cov tshuaj tiv thaiv redox.

Vitamin cov txheej txheem ua ntej ntawm NAD + tau raug txheeb xyuas thawj zaug hauv xyoo 1938, thaum Conrad Elvehjem qhia tias daim siab muaj qhov "tiv thaiv qhov ncauj dub" kev ua haujlwm los ntawm kev ua nicotinamide. Tom qab ntawd, xyoo 1939, nws tau muab thawj qhov pov thawj tias niacin raug siv los ua ke nrog NAD + .Nyob rau xyoo 1940, Arthur Kornberg yog thawj zaug los tshawb pom ib qho enzyme nyob rau hauv biosynthetic pathway.Hauv xyoo 1949, Asmeskas biochemists Morris Friedkin thiab Albert L. Lehninger ua pov thawj tias NADH sib txuas metabolic txoj hauv kev xws li lub voj voog citric acid nrog cov synthesis ntawm ATP hauv oxidative phosphorylation.In 1958, Jack Preiss thiab Philip Handler nrhiav cov tshuaj nruab nrab thiab cov enzymes koom nrog hauv biosynthesis ntawm NAD +; khaws cia cov hluavtaws los ntawm nicotinic acid yog lub npe hu ua Preiss-Handler pathway. Xyoo 2004, Charles Brenner thiab cov neeg ua haujlwm sib koom ua haujlwm pom cov nicotinamide riboside kinase txoj hauv kev mus rau NAD +

 

NAD + hmoov (53-84-9) Mechanism Of Action

Nicotinamide adenine dinucleotide (NAD +) hmoov yog koom nrog hauv cov tshuaj tiv thaiv redox, nqa electrons los ntawm ib qho tshuaj tiv thaiv mus rau lwm qhov. Cov cofactor yog, yog li ntawd, pom nyob rau hauv ob daim ntawv nyob rau hauv lub hlwb: NAD + yog ib tug oxidizing tus neeg sawv cev - nws txais electrons los ntawm lwm yam molecules thiab ua txo. Cov tshuaj tiv thaiv no ua rau NADH, uas tuaj yeem siv los ua tus neeg saib xyuas kom pub dawb electrons. Cov kev hloov pauv hluav taws xob no yog lub luag haujlwm tseem ceeb ntawm NAD. Txawm li cas los xij, nws kuj tseem siv rau hauv lwm cov txheej txheem ntawm tes, tshwj xeeb tshaj yog cov substrate ntawm enzymes uas ntxiv lossis tshem tawm cov tshuaj lom neeg los ntawm cov protein, hauv kev hloov pauv tom qab. Vim tias qhov tseem ceeb ntawm cov haujlwm no, cov enzymes koom nrog hauv NAD metabolism yog lub hom phiaj rau kev tshawb nrhiav tshuaj.

 

NAD + hmoov cov txiaj ntsig

Nicotinamide adenine dinucleotide (NAD +) hmoov ua cov roj rau ntau cov txheej txheem lom neeg tseem ceeb, xws li:

(1) Hloov cov khoom noj rau hauv lub zog

(2) Kho DNA puas lawm

(3) Fortifying hlwb tiv thaiv kab mob

(4) Teem koj lub cev lub moos sab hauv lossis circadian atherosclerosis

 

Vim tias feem ntau cov kev tshawb fawb ntawm Nicotinamide adenine dinucleotide (NAD) hmoov los ntawm kev tshawb fawb tsiaj, tsis muaj kev txiav txim siab meej txog nws cov txiaj ntsig rau tib neeg. Nov yog qee qhov txiaj ntsig kev noj qab haus huv ntawm Nicotinamide adenine dinucleotide (NAD) hmoov:

 

Ua kom muaj Enzymes uas tuaj yeem pab txhawb kev laus

Tuaj Yeem Pab Tiv Thaiv Lub Hlwb Hlwb

NAD + lub luag haujlwm tseem ceeb hauv kev pab koj lub hlwb hlwb hnub nyoog zoo.

Hauv cov hlwb hlwb, NAD + pab tswj kev tsim cov PGC-1-alpha, cov protein uas zoo li pab tiv thaiv cov hlwb tiv thaiv oxidative kev nyuaj siab thiab kev ua haujlwm tsis zoo ntawm mitochondrial. Cov kws tshawb fawb ntseeg tias ob qho tib si oxidative kev nyuaj siab thiab kev ua haujlwm tsis zoo ntawm mitochondrial yog txuas rau hnub nyoog txog kev mob hlwb xws li Alzheimer's thiab Parkinson's disease.

 

Lub Tsib Hlis Uas Yuav Muaj Kab Mob Hauv Lub Siab Tsawg

Kev laus yog qhov tseem ceeb ntawm kev pheej hmoo rau kab mob plawv, uas yog lub ntiaj teb ua rau tuag taus. Nws tuaj yeem ua rau cov hlab ntsha zoo li koj lub aorta ua tuab, tawv thiab tsis hloov pauv. Cov kev hloov no tuaj yeem nce ntshav siab thiab ua rau koj lub plawv ua haujlwm hnyav dua.

Hauv tsiaj, nce NAD + pab thim rov qab muaj hnub nyoog hloov pauv hloov rau cov hlab ntsha

 

Tej zaum yuav txo tau kev mob qog noj ntshav

Qib NAD + Qib siab pab tiv thaiv DNA ua kom puas thiab oxidative kev nyuaj siab, uas txuas nrog rau kev mob qog noj ntshav

 

Yuav txhawb txoj kev laus ua kom cov leeg noj qab haus huv

Kev nce qib NAD + qib pab txhim kho cov leeg ua haujlwm, lub zog thiab thev naus laus zis hauv nas ntev

 

Puas yog NAD + hmoov tiag tiag ua haujlwm?

Cov kev tshawb fawb qhia tau hais tias kev txhawb nqa NAD + qib tuaj yeem txuas lub neej ntev hauv cov poov xab, kab txaij thiab nas. Kev tshawb fawb tsiaj kuj qhia txog NAD + cov lus cog tseg rau kev txhim kho ntau yam ntawm kev noj qab haus huv. Kev nce qib ntawm cov molecule nyob rau hauv cov nas qub zoo li rejuvenate mitochondria - lub cell lub zog factories, uas ua rau lub sij hawm poob. Lwm cov kev tshawb fawb nas tau pom cov txiaj ntsig xws li kev txhim kho cov hlab plawv, txhim kho cov leeg nqaij thiab cov metabolism hauv qabzib zoo dua nrog NAD + supplementation.

 

Yuav ua li cas nce NAD + qib?

NAD + qib tuaj yeem nce ntxiv los ntawm kev txhawb nqa nws cov synthesis - txhim kho cov enzymes koom nrog NAD + biosynthesis lossis noj NAD + precursor molecules.

 

Kev yoo mov thiab qoj ib ce

Kev coj noj coj ua hauv kev noj qab haus huv los ntawm kev noj zaub mov kom zoo thiab kev tawm dag zog tsis zoo tsuas yog ua rau koj lub hlwb noj qab haus huv xwb, tab sis nws tseem tuaj yeem txhawb koj qib NAD +.

Kev ntxhov siab me me rau lub cev xws li kev yoo mov thiab kev tawm dag zog tuaj yeem txhawb kev tsim NAD +. Hauv cov poov xab, txwv tsis pub calorie ua rau NAD + cov noob caj ces, sirtuins, thiab txuas ntxiv lawv txoj sia. Kev txwv calories kuj tseem txhim kho kev noj qab haus huv thoob plaws cov nas sib txawv thiab poj niam txiv neej.

Ntau qhov kev tshawb fawb tsiaj qhia tias tsiaj kuj tuaj yeem txhawb nqa lawv qib NAD + los ntawm kev tawm dag zog. Ib txoj kev tshawb fawb tsis ntev los no hauv tib neeg pom tias aerobic thiab kev tawm dag zog tuaj yeem rov qab muaj hnub nyoog enzymes koom nrog hauv NAD + synthesis hauv cov leeg.

 

NAD + precursor supplementation

Tib neeg siv NMN thiab NR ua cov tshuaj ntxiv los txhawb NAD + qib. NMN thiab NR yog biosynthesis precursors ntawm NAD +. Qhov zoo sib xws ntawm cov precursors no suav nrog lawv kev siv "txoj kev cawm seej" ntawm NAD + biosynthesis. Ob lub molecules muaj kev nyab xeeb rau tib neeg noj, ib yam nkaus.

Cov kws tshawb fawb tau ua cov kev tshawb fawb hauv tib neeg ua qauv qhia NR tuaj yeem txhawb NAD + qib. Kev tshawb fawb ntawm NMN kuj qhia nws lub peev xwm los txhawb NAD + qib hauv cov nas.

Kev tshawb fawb qhia tias nas muaj NMN thauj khoom hauv lawv lub plab. Cov noob rau tib lub thauj khoom muaj nyob hauv tib neeg. Yog tias tus neeg thauj khoom NMN muaj cov lus qhia zoo sib xws hauv tib neeg, lub cev tuaj yeem siv NMN.

 

Qhov twg yuav NAD + Bulk Powder

Wisepowder muaj NAD + bulk hmoov hauv 40g pob, thiab muab cov khoom lag luam sib txawv raws li koj xav tau. Wisepowder's NAD + hmoov tau raug kuaj thiab kuaj xyuas rau ob qho tib si khoom purity thiab tus kheej.

 

 

Nicotinamide adenine dinucleotide (NAD +) Kev siv

[1] Sakuraba H, Kawakami R, Ohshima T (2005). "Thawj Archaeal Inorganic Polyphosphate / ATP-Dependent NAD Kinase, los ntawm Hyperthermophilic Archaeon Pyrococcus horikoshii: Cloning, nthuav qhia, thiab tus cwj pwm". Appl. Ib puag ncig. Microbiol. 71 (8): 4352–8. doi: 10.1128/AEM.71.8.4352-4358.2005. PMC 1183369. PIB 16085824.

[2] Katoh A, Uenohara K, Akita M, Hashimoto T (2006). "Cov kauj ruam thaum ntxov hauv Biosynthesis ntawm NAD hauv Arabidopsis Pib nrog Aspartate thiab tshwm sim hauv Plastid". Nroj Physiol. 141 (3): 851–7. doi: 10.1104/pp.106.081091. PMC 1489895. PIB 16698895.

[3] Chen YG, Kowtoniuk WE, Agarwal I, Shen Y, Liu DR (December 2009). "LC / MS tsom xam ntawm cellular RNA qhia NAD-txuas RNA". Nat Chem Biol. 5 (12): 879–881. doi: 10.1038/nchembio.235. PMC 2842606. PIB 19820715.

[4] Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Tswb EL, Sinclair DA (19 Kaum Ob Hlis 2013). "Kev Txom Nyem NAD + Induces Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication thaum laus". Cell. 155 (7): 1624–1638. doi: 10.1016/j.cell.2013.11.037. PMC 4076149. PMID 24360282.Txhua yam Koj Yuav Tsum Paub Txog Nicotinamide Riboside Chloride

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