cov khoom siv

Diosmetin hmoov

Diosmetin hmoov yog lub flavone uas zwm rau hauv chav kawm ntawm O-methylated flavonoids. Cov chaw sib xyaw yog ib qho aglycone ntawm diosmin (diosmetin 7-o-rutinoside), uas nthuav tawm ib txwm muaj rau hauv cov txiv ntoo txiv ntoo xws li txiv qaub.

Diosmetin nthuav tawm cov tshuaj tiv thaiv kab mob qog noj ntshav, tiv thaiv kab mob, tiv thaiv kab mob, thiab antioxidant khoom. Hauv txoj kev tshawb nrhiav txoj hauv kev, cov kws tshawb fawb txheeb xyuas nws li 3 ', 5,7-trihydroxy-4'-methoxyflavone. Ob Diosmetin thiab chrysoeriol yog methylated metabolites ntawm luteolin. Diosmetin solubility hauv dej yog 0.075 g/L.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

Diosmetin hmoov (520-34-3) video

 

 

Cov Ntaub Ntawv Tso Rau Diosmetin

lub npe Diosmetin
CAS 520-34-3
purity 98%
Tshuaj lub npe benzopyran-4-ib
Synonyms Cyanidenon-4′-methyl ether 1479, Luteolin-4′-methyl ether
molecular Formula C16H12O6
molecular Nyhav 300.26 g / mol
Melting Point 257-259 ° C
InChI Qhov Tseem Ceeb MBNGWHIJMBWFHU-UHFFFAOYSA-N
daim ntawv Khoom
tsos lub teeb daj rau daj hmoov
Ib Sim Neej 22.9 rau 40.1 teev
solubility Sparingly soluble hauv dej (<1 mg / ml). Soluble hauv acetonitrile, DMSO (60 mg / ml), thiab ethanol (17 mg / ml).
cia mob 2-8 ° C
Daim ntawv thov kev noj zaub mov pab cuam, ntxiv cov zaub mov
Kuaj Cov Ntaub Ntawv Qhov

 

Diosmetin yog dab tsi?

Diosmetin yog ib hom flavone. Nws yog rau chav kawm O-methylated flavonoids. Nws yog ib txwm pom nyob rau hauv citrus txiv hmab txiv ntoo. Nws lub npe IUPAC yog 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl) chromen-4-one. Diosmetin tau xub txheeb xyuas los ntawm cov nroj tsuag Amphilophium crucigerum.

Diosmetin tau siv ua tshuaj anticancer. Nws kuj tseem muaj cov tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob. Nws kuj tseem tuaj yeem pab khaws kev paub thiab nco hauv cov xwm txheej neurodegenerative.

Lub hauv paus ntawm diosmetin yog txiv hmab txiv ntoo zoo li txiv kab ntxwv, mandarins, txiv qaub, txiv kab ntxwv qaub, thiab lwm yam.

 

Diosmetin ua haujlwm li cas?

Diosmetin yog tsim thaum lub compound hu ua diosmin tau hydrolyzed rau daim ntawv aglycone los ntawm txoj hnyuv flora. Qhov kev ua no tshwm sim los ua kom nws yooj yim dua rau nws nqus hauv lub cev. Nws kuj ua haujlwm ua tus tsis muaj zog TrkB receptor agonist.

Yog li, diosmin yog flavone glycoside ntawm diosmetin. Nws yog siv los kho cov hlab ntsha sib txawv xws li hemorrhoids, varicose veins, venous stasis, hemorrhage, thiab lwm yam.

Ib qho ntawm diosmetin cov khoom yog nws lub peev xwm ua haujlwm tawm tsam cov qog nqaij hlav cancer. Cov qog nqaij hlav sib txawv tau paub los nthuav qhia ntau tshaj ntawm CYP1 tsev neeg enzymes ntawm cytochrome P450. Diosmetin tau hloov mus rau luteolin hauv HepG2 hlwb tom qab 12 thiab 30hr ntawm incubation nyob rau hauv lub xub ntiag ntawm CYP1A inhibitor alpha-naphthoflavone. Luteolin muaj txiaj ntsig zoo dua vim nws yog cytotoxic. Cov nyhuv antiproliferative ntawm diosmetin hauv HepG2 hlwb tuaj yeem thaiv G2 / M theem ntawm lub voj voog ntawm tes. Nrog rau qhov no, kuj tseem muaj kev tswj hwm ntawm phospho-extracellular-signal-regulated kinase (p-ERK), phospho-c-jun N-terminal kinase, p53, thiab p21 proteins. Yog li, diosmetin muaj peev xwm ua kom pom cov peev xwm tiv thaiv kab mob.

Diosmetin muaj peev xwm tiv thaiv CYP1A1 thiab CYP1B1. Ob qho tshuaj tiv thaiv kab mob tshwj xeeb no yog carcinogenic thiab ua rau mob qog noj ntshav.

Diosmetin kuj tseem tuaj yeem ua haujlwm hauv kev kho pob txha pob txha los ntawm kev cuam tshuam kev ciaj sia ntawm osteoblasts. Diosmetin tuaj yeem ua rau muaj kev sib txawv ntawm cov pob txha osteoblasts, thiab qhov no tuaj yeem pab kho tus mob osteoporosis.

 

Keeb kwm ntawm Diosmetin

Diosmetin txoj kev tshawb fawb tau pib tom qab nws qhov precursor diosmin raug cais tawm ntawm figwort hauv xyoo 1920. Diosmin tau qhia ua tshuaj hauv xyoo 1969. Tom qab ntawd xyoo 1960, nws tau pom tias qhov flavone glycoside tuaj yeem pab kho cov kab mob vascular. Tam sim no, muaj kev txaus siab rau kev kho mob ntawm cov tshuaj no. Tej zaum nws yuav yog ib txoj kev kho mob rau qee yam qog nqaij hlav.

Diosmetin tsis tau txais kev pom zoo los ntawm FDA. Txawm li cas los xij, nws muaj nyob rau hauv cov khoom noj khoom haus thiab tshuaj ntxiv. Nws tuaj yeem yuav los ntawm khw muag khoom ntxiv yam tsis muaj tshuaj.

 

Cov txiaj ntsig ntawm Diosmetin

Muaj ntau txoj kev siv diosmetin. Feem ntau ntawm cov kev siv no tseem tab tom kawm thiab tseem tsis tau ua tiav. Txawm li cas los xij, diosmetin tau qhia ntau lub peev xwm los ua tus qauv kev kho mob hauv kev cuam tshuam nrog ntau yam mob thiab kab mob.

Cov txiaj ntsig ntawm diosmetin yog:

 

Qhov cuam tshuam rau Cancer

Diosmetin muaj peev xwm txwv tsis pub kev loj hlob ntawm tes thiab kev loj hlob tshwj xeeb tshaj yog cov qog nqaij hlav cancer. Nws muaj txiaj ntsig zoo los tiv thaiv kev loj hlob thiab kev loj hlob ntawm cov qog nqaij hlav cancer [1]. Nws tuaj yeem hloov cov enzymes CYP1A1 thiab CYP1B1 rau hauv flavone luteolin. Cov no yog cov enzymes uas tuaj yeem pab txhawb kev loj hlob ntawm qog noj ntshav. Los ntawm kev tso tseg cov enzymes uas xav tau rau cov qog nqaij hlav cancer kom loj hlob thiab loj hlob, diosmetin tuaj yeem nres qhov kev loj hlob ntawm mob qog noj ntshav. Yog li, diosmetin muaj peev xwm siv tau los ua tshuaj tiv thaiv kab mob.

 

Cov nyhuv li Antioxidant

Diosmetin kuj muaj cov tshuaj tiv thaiv kab mob.Oxidation thiab kev ua ntawm ntau yam radicals hauv lub cev yog lub luag haujlwm rau kev laus thiab kev txhim kho ntawm ntau yam kab mob. Diosmetin tau pom tias muaj cov tshuaj tua kab mob, yog li ua rau cov pa oxygen tsis pub dawb uas tshwm sim hauv cov txheej txheem oxidation hauv lub cev [2]. Nws kuj tseem muaj kev cuam tshuam los ua tus neeg sawv cev chelating, tshwj xeeb tshaj yog ua tus neeg sawv cev hlau chelating. Nws kuj tau pom tias muaj cov khoom cytoprotective. Li no, diosmetin muaj txoj hauv kev raug siv los ua tshuaj tiv thaiv kab mob hauv kev kho mob.

 

Cov nyhuv ntawm Dyslipidemia

Diosmetin thiab diosmin tuaj yeem txo qhov cuam tshuam ntawm hyperlipidemia. Ib txoj kev tshawb nrhiav tau ua nyob qhov twg cov nas tsuag noj zaub mov sucrose siab tau kho nrog diosmetin thiab diosmin [3]. Cov txiaj ntsig tau qhia tias muaj qhov txo qis hauv lub cev qhov hnyav ntawm cov ntawv xeem. Diosmetin txawm txo cov qib lipid hauv cov nas no nrog hyperlipidemia. Yog li, lawv muaj peev xwm txo qis cov rog hauv daim siab thiab cov ntaub so ntswg epididymal. Lawv kuj muaj peev xwm txhim kho cov piam thaj tsis haum los ntawm kev txo qis cov piam thaj. Lawv muaj txiaj ntsig zoo dua thaum noj ua ke, nrog diosmin muaj peev xwm zoo dua li cov tshuaj tiv thaiv dyslipidemic.

 

Teeb meem ntawm kev paub thiab nco tsis zoo

Diosmetin tuaj yeem txo qis kev paub thiab kev nco. Ib txoj kev tshawb fawb tau ua rau cov nas uas tsis muaj kev ntxhov siab [4]. Lawv tau muab cov tshuaj diosmetin thiab tshuaj xyuas tom qab 28 hnub. Nws pom tias kev siv diosmetin tau pab txhim kho qib serum corticosterone thiab muab cov tshuaj tiv thaiv kab mob ntau ntxiv rau lub hlwb. Qhov no txhais tau hais tias diosmetin tuaj yeem pab ua ib qho kev nco-txhim kho cov tshuaj.

 

Teeb meem ntawm Alzheimer's disease

Diosmetin thiab diosmin muaj txiaj ntsig zoo hauv Alzheimer's disease. Diosmetin tau pom tias tuaj yeem txo cov kab mob tshwm sim los ntawm amyloid-beta (Aβ) hauv cov nas nrog Alzheimer's disease [5]. Diosmetin tuaj yeem txo cov qib ntawm cerebral amyloid-beta ntau ntau, tau-hyperphosphorylation, thiab kev paub tsis meej. Yog li nws tuaj yeem ua rau qeeb cov teebmeem ntawm Alzheimer's disease.

 

Teeb meem ntawm daim tawv nqaij teeb meem

Diosmetin tau pom tias muaj txiaj ntsig zoo hauv kev txo qis cov teebmeem ntawm atopic dermatitis. Nws cov khoom tiv thaiv kab mob tuaj yeem pab txo qis cytokines uas tau tsa hauv qhov xwm txheej no [6]. Yog li ntawd, nws yuav yog ib qho kev kho mob zoo rau cov kab mob ntawm daim tawv nqaij.

 

Cov nyhuv ntawm pob txha

Diosmetin muaj txiaj ntsig zoo hauv kev ntxiv dag zog rau cov pob txha. Nws muaj peev xwm tiv thaiv kev txhim kho pob txha los ntawm kev txhawb nqa kev sib txawv ntawm pob txha pob txha [7]. Qhov kev sib txawv no tshwm sim hauv MG-63 thiab hFOB hlwb. Nws kuj ua rau kom cov kua qaub ntawm osteocalcin. Nws kuj pab nyob rau hauv lub synthesis ntawm hom I collagen. Yog li diosmetin tuaj yeem pab tiv thaiv pob txha poob thiab osteoclastogenesis.

 

Qhov cuam tshuam rau Cardiovascular System

Diosmetin kuj qhia tau hais tias muaj peev xwm tiv thaiv platelet. Nws tuaj yeem tshem tawm cov platelet ua haujlwm thiab tuaj yeem pab kho ntau yam kab mob plawv [8].

 

Cov teebmeem ntawm Diosmetin

  • Lub plab chim siab
  • Zawv plab
  • Kauj taub hau
  • Mob taub hau
  • Daim tawv nqaij liab
  • Khaus
  • Hypersensitivity rau Diosmetin
  • Nqaij ua mob
  • Lub plawv dhia txawv txav

 

Cov tshuaj sib cuam tshuam nrog Diosmetin

Tsis muaj cov ntaub ntawv paub txog kev cuam tshuam nrog tshuaj nrog diosmetin rau hnub tim.

Cov teebmeem ntawm diosmetin rau cov neeg siv nrog cov xwm txheej tshwj xeeb thiab kab mob tsis paub.

Hauv cev xeeb tub thiab pub niam mis rau poj niam, nws yog qhov zoo tshaj kom tsis txhob siv cov tshuaj ntxiv no vim tias tsis muaj kev tshawb fawb txog diosmetin qhov cuam tshuam rau cev xeeb tub thiab pub niam mis.

 

Kev noj tshuaj Diosmetin

Qhov ntau npaum ntawm diosmetin hmoov yog kwv yees li 1000mg ib hnub twg. Txawm li cas los xij, nws tuaj yeem ncav cuag qhov ntau npaum li cas ntawm 3000mg ib hnub, nyob ntawm qhov xwm txheej.

 

Qhov twg yuav Diosmetin hauv 2021?

Koj tuaj yeem yuav diosmetin hmoov ncaj qha los ntawm diosmetin hmoov manufacturers tuam txhab. Nws muaj nyob rau hauv ib daim ntawv zoo li lub teeb daj mus rau daj xim hmoov. Nws tau ntim rau hauv ib pob ntawm 1 kg ib pob ntawv thiab 25kg ib nruas. Txawm li cas los xij, qhov no tuaj yeem kho tau raws li qhov xav tau ntawm tus neeg yuav khoom.

Nws yuav tsum tau khaws cia ntawm qhov kub ntawm 2 txog 8 ° C. Nws xav tau qhov chaw txias, tsaus, thiab qhuav qhov chaw cia. Qhov no yog los tiv thaiv nws los ntawm reacting nrog lwm yam tshuaj nyob rau hauv ib puag ncig. Cov khoom no yog tsim los ntawm cov khoom xyaw zoo tshaj tom qab cov txheej txheem raug raws li kev soj ntsuam nruj.

 

Cov ntaub ntawv hais txog

  1. Androutsopoulos, VP, Mahale, S., Arroo, RR, & Potter, G. (2009). Anticancer cuam tshuam ntawm flavonoid diosmetin ntawm kev hloov pauv ntawm tes thiab nthuav dav ntawm MDA-MB 468 cov qog nqaij hlav cancer mis vim CYP1 ua kom. Oncology qhia, 21(6), 1525-1528.
  2. Morel, I., Lescoat, G., Cogrel, P., Sergent, O., Pasdeloup, N., Brissot, P.,… & Cillard, J. (1993). Cov tshuaj tiv thaiv kab mob antioxidant thiab hlau-chelating ntawm flavonoids catechin, quercetin, thiab diosmetin ntawm cov hlau thauj cov nas hepatocyte kab lis kev cai. Biochemical tshuaj, 45(1), 13-19.
  3. Chung, S., Kim, HJ, Choi, HK, Park, JH, & Hwang, JT (2020). Kev tshawb fawb sib piv ntawm cov teebmeem ntawm diosmin thiab diosmetin ntawm cov rog tsub zuj zuj, dyslipidemia, thiab qabzib intolerance hauv cov nas noj cov zaub mov muaj roj ntau-sucrose. Zaub Mov Kev Tshawb Fawb & Khoom Noj Khoom Haus, 8(11), 5976-5984.
  4. Saghei, E., Nasiri Boroujeni, S., Safavi, P., Borjian Boroujeni, Z., & Bijad, E. (2020). Diosmetin Mitigates kev paub thiab kev nco tsis zoo uas tshwm sim los ntawm kev nyuaj siab me ntsis hauv cov nas. Pov Thawj Pom Raws Li Txheej Txheem Qhia thiab Lwm Yam Tshuaj, 2020.
  5. Sawmiller, D., Habib, A., Li, S., Darlington, D., Hou, H., Tian, ​​J., … & Tan, J. (2016). Diosmin txo qib cerebral Aβ, tau hyperphosphorylation, neuroinflammation, thiab kev paub tsis meej hauv 3xTg-AD nas. Phau ntawv Journal ntawm neuroimmunology, 299, 98-106.
  6. Lee, DH, Park, JK, Choi, J., Jang, H., & Seol, JW (2020). Anti-inflammatory teebmeem ntawm ntuj flavonoid diosmetin hauv IL-4 thiab LPS-induced macrophage activation thiab atopic dermatitis qauv. International Immunopharmacology, 89, 107046.
  7. Hsu, YL, & Kuo, PL (2008). Diosmetin induces tib neeg osteoblastic sib txawv los ntawm cov protein kinase C/p38 thiab extracellular teeb liab tswj kinase 1/2 txoj kev. Phau ntawv Journal ntawm Pob Txha thiab Mineral Tshawb Fawb, 23(6), 949-960.
  8. Zaragozá, C., Monserrat, J., Mantecón, C., Villaescusa, L., Álvarez-Mon, M. Á., Zaragozá, F., & Álvarez-Mon, M. (2021). Kev khi thiab kev ua haujlwm antiplatelet ntawm quercetin, rutin, diosmetin, thiab diosmin flavonoids. Kev Kho Mob Biomedicine & Pharmacotherapy, 141, 111867.

 

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