Diosmetin hmoov

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5-10 teev (hauv hnub ua haujlwm) ceev shipping
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Tsuas yog 6 sab lauj! 79 tus neeg tab tom saib qhov no thiab 58 tus neeg muaj nws hauv lawv lub laub.

Tsis paub Yuav Ua Li Cas Qhov Kev Txiav Txim?

Nyem qhov no
[1]. Xaiv qhov koj xav tau, tom qab ntawd ntxiv rau lub laub

[2]. Txuas mus xyuas

[3]. Sau koj cov ntaub ntawv nthuav dav, qhov * yuav tsum tau, xaiv koj txoj kev them nyiaj. Muaj ntau txoj kev them nyiaj sib txawv suav nrog:
-Direct Bank Transfer
- Kev them nyiaj npib: Bitcoin, Ether, USDT
Ces nyem "Place order"
Lub tswv yim: email chaw nyob yuav tsum tau kho, cov ntaub ntawv taug qab yuav hloov tshiab los ntawm email ceeb toom

[4]. Yog tias xaiv "Coinpayment", tom qab nyem "Place order", ces yuav qhia raws li hauv qab no them

[5]. Yog tias Xaiv "Direct Bank Transfer", tom qab nias "Place order", ces yuav qhia raws li hauv qab no, yuav tshwm sim cov ntsiab lus ntawm tus account hauv txhab nyiaj, tom qab hloov lub txhab nyiaj (thov siv koj tus lej xaj raws li qhov siv), xa daim ntawv hauv txhab nyiaj rau peb.

[6]. Kev them nyiaj lees paub
[7]. Parcel xa tawm li 5-10 teev (hauv hnub ua haujlwm)
[8]. Tus lej taug qab tau muab
[9]. Parcel tuaj txog
[10]. Rov xaj dua
Tsis muaj koj qhov ntau? Nyem no
Ceeb toom: Yog tias koj cev xeeb tub, saib xyuas neeg mob, noj cov tshuaj los yog muaj kev mob nkeeg nrog koj tus kws kho mob ua ntej siv. Khaws kom deb ntawm cov menyuam yaus.
Qeb: SKU: N / A

Dab tsi yog cov txiaj ntsig ntawm diosmetin hmoov?

  1. Siv ua tshuaj tiv thaiv kab mob
  2. Siv ua antioxidant
  3. Txo cov teebmeem ntawm hyperlipidemia
  4. Txo kev txawj ntse thiab kev nco tsis zoo
  5. Ua tau zoo hauv Alzheimer's disease
  6. Ua tau zoo hauv kev txo cov teebmeem ntawm atopic dermatitis
  7. Ua kom muaj zog ntawm cov pob txha
  8. Tej zaum yuav pab kho ntau yam kab mob plawv

Diosmetin hmoov (520-34-3) video

 

 

Cov Ntaub Ntawv Tso Rau Diosmetin

lub npe Diosmetin
CAS 520-34-3
purity 98%
Tshuaj lub npe benzopyran-4-ib
Synonyms Cyanidenon-4′-methyl ether 1479, Luteolin-4′-methyl ether
molecular Formula C16H12O6
molecular Nyhav 300.26 g / mol
Melting Point 257-259 ° C
InChI Qhov Tseem Ceeb MBNGWHIJMBWFHU-UHFFFAOYSA-N
daim ntawv Khoom
tsos lub teeb daj rau daj hmoov
Ib Sim Neej 22.9 rau 40.1 teev
solubility Sparingly soluble hauv dej (<1 mg / ml). Soluble hauv acetonitrile, DMSO (60 mg / ml), thiab ethanol (17 mg / ml).
cia mob 2-8 ° C
Daim ntawv thov kev noj zaub mov pab cuam, ntxiv cov zaub mov
Kuaj Cov Ntaub Ntawv Qhov

 

Diosmetin hmoov yog dab tsi?

Diosmetin hmoov yog ib hom flavone. Nws belongs rau O-methylated flavonoids chav kawm. Nws yog ib txwm pom nyob rau hauv citrus txiv hmab txiv ntoo. Nws lub npe IUPAC yog 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl) chromen-4-one. Diosmetin tau pib txheeb xyuas los ntawm cov nroj tsuag Amphilophium crucigerum.

Diosmetin tau siv ua tshuaj anticancer. Nws kuj tseem muaj cov tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob. Nws kuj tseem tuaj yeem pab khaws kev paub thiab nco hauv cov xwm txheej neurodegenerative.

Lub hauv paus ntawm diosmetin yog txiv hmab txiv ntoo zoo li txiv kab ntxwv, mandarins, txiv qaub, txiv kab ntxwv qaub, thiab lwm yam.

 

Diosmetin ua haujlwm li cas?

Diosmetin yog tsim thaum lub compound hu ua diosmin tau hydrolyzed rau daim ntawv aglycone los ntawm txoj hnyuv flora. Qhov kev ua no tshwm sim los ua kom nws yooj yim dua rau nws nqus hauv lub cev. Nws kuj ua haujlwm ua tus tsis muaj zog TrkB receptor agonist.

Yog li, diosmin yog flavone glycoside ntawm diosmetin. Nws yog siv los kho cov hlab ntsha sib txawv xws li hemorrhoids, varicose veins, venous stasis, hemorrhage, thiab lwm yam.

Ib qho ntawm diosmetin cov khoom yog nws lub peev xwm ua haujlwm tawm tsam cov qog nqaij hlav cancer. Cov qog nqaij hlav sib txawv tau paub los nthuav qhia ntau tshaj ntawm CYP1 tsev neeg enzymes ntawm cytochrome P450. Diosmetin tau hloov mus rau luteolin hauv HepG2 hlwb tom qab 12 thiab 30hr ntawm incubation nyob rau hauv lub xub ntiag ntawm CYP1A inhibitor alpha-naphthoflavone. Luteolin muaj txiaj ntsig zoo dua vim nws yog cytotoxic. Cov nyhuv antiproliferative ntawm diosmetin hauv HepG2 hlwb tuaj yeem thaiv G2 / M theem ntawm lub voj voog ntawm tes. Nrog rau qhov no, kuj tseem muaj kev tswj hwm ntawm phospho-extracellular-signal-regulated kinase (p-ERK), phospho-c-jun N-terminal kinase, p53, thiab p21 proteins. Yog li, diosmetin muaj peev xwm ua kom pom cov peev xwm tiv thaiv kab mob.

Diosmetin muaj peev xwm tiv thaiv CYP1A1 thiab CYP1B1. Ob qho tshuaj tiv thaiv kab mob tshwj xeeb no yog carcinogenic thiab ua rau mob qog noj ntshav.

Diosmetin kuj tseem tuaj yeem ua haujlwm hauv kev kho pob txha pob txha los ntawm kev cuam tshuam kev ciaj sia ntawm osteoblasts. Diosmetin tuaj yeem ua rau muaj kev sib txawv ntawm cov pob txha osteoblasts, thiab qhov no tuaj yeem pab kho tus mob osteoporosis.

 

Keeb kwm ntawm Diosmetin

Diosmetin txoj kev tshawb fawb tau pib tom qab nws qhov precursor diosmin raug cais tawm ntawm figwort hauv xyoo 1920. Diosmin tau qhia ua tshuaj hauv xyoo 1969. Tom qab ntawd xyoo 1960, nws tau pom tias qhov flavone glycoside tuaj yeem pab kho cov kab mob vascular. Tam sim no, muaj kev txaus siab rau kev kho mob ntawm cov tshuaj no. Tej zaum nws yuav yog ib txoj kev kho mob rau qee yam qog nqaij hlav.

Diosmetin tsis tau txais kev pom zoo los ntawm FDA. Txawm li cas los xij, nws muaj nyob rau hauv cov khoom noj khoom haus thiab tshuaj ntxiv. Nws tuaj yeem yuav los ntawm khw muag khoom ntxiv yam tsis muaj tshuaj.

 

Cov txiaj ntsig ntawm Diosmetin

Muaj ntau qhov kev siv tshuaj diosmetin ntxiv. Feem ntau ntawm cov kev siv no tseem tab tom kawm thiab tseem tsis tau tiav. Txawm li cas los xij, diosmetin tau qhia ntau lub peev xwm los ua tus qauv kev kho mob hauv kev cuam tshuam nrog ntau yam mob thiab kab mob.

Cov txiaj ntsig ntawm diosmetin hmoov yog:

Qhov cuam tshuam rau Cancer

Diosmetin muaj peev xwm txwv tsis pub kev loj hlob ntawm tes thiab kev loj hlob tshwj xeeb tshaj yog cov qog nqaij hlav cancer. Nws muaj txiaj ntsig zoo los tiv thaiv kev loj hlob thiab kev loj hlob ntawm cov qog nqaij hlav cancer [1]. Nws tuaj yeem hloov cov enzymes CYP1A1 thiab CYP1B1 rau hauv flavone luteolin. Cov no yog cov enzymes uas tuaj yeem pab txhawb kev loj hlob ntawm qog noj ntshav. Los ntawm kev tso tseg cov enzymes uas xav tau rau cov qog nqaij hlav cancer kom loj hlob thiab loj hlob, diosmetin tuaj yeem nres qhov kev loj hlob ntawm mob qog noj ntshav. Yog li, diosmetin muaj peev xwm siv tau los ua tshuaj tiv thaiv kab mob.

 

Cov nyhuv li Antioxidant

Diosmetin kuj muaj cov tshuaj tiv thaiv kab mob.Oxidation thiab kev ua ntawm ntau yam radicals hauv lub cev yog lub luag haujlwm rau kev laus thiab kev txhim kho ntawm ntau yam kab mob. Diosmetin tau pom tias muaj cov tshuaj tua kab mob, yog li ua rau cov pa oxygen tsis pub dawb uas tshwm sim hauv cov txheej txheem oxidation hauv lub cev [2]. Nws kuj tseem muaj kev cuam tshuam los ua tus neeg sawv cev chelating, tshwj xeeb tshaj yog ua tus neeg sawv cev hlau chelating. Nws kuj tau pom tias muaj cov khoom cytoprotective. Li no, diosmetin muaj txoj hauv kev raug siv los ua tshuaj tiv thaiv kab mob hauv kev kho mob.

 

Cov nyhuv ntawm Dyslipidemia

Diosmetin thiab diosmin tuaj yeem txo qhov cuam tshuam ntawm hyperlipidemia. Ib txoj kev tshawb nrhiav tau ua nyob qhov twg cov nas tsuag noj zaub mov sucrose siab tau kho nrog diosmetin thiab diosmin [3]. Cov txiaj ntsig tau qhia tias muaj qhov txo qis hauv lub cev qhov hnyav ntawm cov ntawv xeem. Diosmetin txawm txo cov qib lipid hauv cov nas no nrog hyperlipidemia. Yog li, lawv muaj peev xwm txo qis cov rog hauv daim siab thiab cov ntaub so ntswg epididymal. Lawv kuj muaj peev xwm txhim kho cov piam thaj tsis haum los ntawm kev txo qis cov piam thaj. Lawv muaj txiaj ntsig zoo dua thaum noj ua ke, nrog diosmin muaj peev xwm zoo dua li cov tshuaj tiv thaiv dyslipidemic.

 

Teeb meem ntawm kev paub thiab nco tsis zoo

Diosmetin tuaj yeem txo qis kev paub thiab kev nco. Ib txoj kev tshawb fawb tau ua rau cov nas uas tsis muaj kev ntxhov siab [4]. Lawv tau muab cov tshuaj diosmetin thiab tshuaj xyuas tom qab 28 hnub. Nws pom tias kev siv diosmetin tau pab txhim kho qib serum corticosterone thiab muab cov tshuaj tiv thaiv kab mob ntau ntxiv rau lub hlwb. Qhov no txhais tau hais tias diosmetin tuaj yeem pab ua ib qho kev nco-txhim kho cov tshuaj.

 

Teeb meem ntawm Alzheimer's disease

Diosmetin thiab diosmin muaj txiaj ntsig zoo hauv Alzheimer's disease. Diosmetin tau pom tias tuaj yeem txo cov kab mob tshwm sim los ntawm amyloid-beta (Aβ) hauv cov nas nrog Alzheimer's disease [5]. Diosmetin tuaj yeem txo cov qib ntawm cerebral amyloid-beta ntau ntau, tau-hyperphosphorylation, thiab kev paub tsis meej. Yog li nws tuaj yeem ua rau qeeb cov teebmeem ntawm Alzheimer's disease.

 

Teeb meem ntawm daim tawv nqaij teeb meem

Diosmetin tau pom tias muaj txiaj ntsig zoo hauv kev txo qis cov teebmeem ntawm atopic dermatitis. Nws cov khoom tiv thaiv kab mob tuaj yeem pab txo qis cytokines uas tau tsa hauv qhov xwm txheej no [6]. Yog li ntawd, nws yuav yog ib qho kev kho mob zoo rau cov kab mob ntawm daim tawv nqaij.

 

Cov nyhuv ntawm pob txha

Diosmetin muaj txiaj ntsig zoo hauv kev ntxiv dag zog rau cov pob txha. Nws muaj peev xwm tiv thaiv kev txhim kho pob txha los ntawm kev txhawb nqa kev sib txawv ntawm pob txha pob txha [7]. Qhov kev sib txawv no tshwm sim hauv MG-63 thiab hFOB hlwb. Nws kuj ua rau kom cov kua qaub ntawm osteocalcin. Nws kuj pab nyob rau hauv lub synthesis ntawm hom I collagen. Yog li diosmetin tuaj yeem pab tiv thaiv pob txha poob thiab osteoclastogenesis.

 

Qhov cuam tshuam rau Cardiovascular System

Diosmetin kuj qhia tau hais tias muaj peev xwm tiv thaiv platelet. Nws tuaj yeem tshem tawm cov platelet ua haujlwm thiab tuaj yeem pab kho ntau yam kab mob plawv [8].

 

Dab tsi yog Cov Teeb Meem ntawm Diosmetin

Lub plab chim siab

Zawv plab

Kauj taub hau

Mob taub hau

Daim tawv nqaij liab

Khaus

Hypersensitivity rau Diosmetin

Nqaij ua mob

Lub plawv dhia txawv txav

 

Cov tshuaj sib cuam tshuam nrog Diosmetin

Tsis muaj cov ntaub ntawv paub txog kev cuam tshuam nrog tshuaj nrog diosmetin rau hnub tim.

Cov teebmeem ntawm diosmetin rau cov neeg siv nrog cov xwm txheej tshwj xeeb thiab kab mob tsis paub.

Hauv cev xeeb tub thiab pub niam mis rau poj niam, nws yog qhov zoo tshaj kom tsis txhob siv cov tshuaj ntxiv no vim tias tsis muaj kev tshawb fawb txog diosmetin qhov cuam tshuam rau cev xeeb tub thiab pub niam mis.

 

Kev noj tshuaj Diosmetin

Qhov ntau npaum ntawm diosmetin hmoov yog kwv yees li 1000mg ib hnub twg. Txawm li cas los xij, nws tuaj yeem ncav cuag qhov ntau npaum li cas ntawm 3000mg ib hnub, nyob ntawm qhov xwm txheej.

 

Qhov twg yuav Diosmetin Bulk Powder

Wisepowder muaj CAD-031 bulk hmoov hauv 40g pob, thiab muaj cov lag luam wholesale sib txawv raws li koj xav tau. Wisepowder's Diosmetin hmoov tau raug kuaj thiab kuaj xyuas rau ob qho tib si khoom purity thiab tus kheej.

 

Diosmetin hmoov siv

Androutsopoulos, VP, Mahale, S., Arroo, RR, & Potter, G. (2009). Anticancer cov teebmeem ntawm flavonoid diosmetin ntawm lub voj voog ntawm tes thiab kev loj hlob ntawm MDA-MB 468 lub mis mob qog noj ntshav vim CYP1 ua kom. Oncology reports, 21(6), 1525-1528.

Morel, I., Lescoat, G., Cogrel, P., Sergent, O., Pasdeloup, N., Brissot, P., … & Cillard, J. (1993). Antioxidant thiab hlau-chelating kev ua ub no ntawm flavonoids catechin, quercetin, thiab diosmetin ntawm hlau-loaded nas hepatocyte kab lis kev cai. Biochemical pharmacology, 45(1), 13-19.

Chung, S., Kim, HJ, Choi, HK, Park, JH, & Hwang, JT (2020). Kev tshawb fawb sib piv ntawm cov teebmeem ntawm diosmin thiab diosmetin ntawm cov rog tsub zuj zuj, dyslipidemia, thiab qabzib intolerance hauv cov nas tau noj cov zaub mov muaj roj ntau-sucrose. Food Science & Nutrition, 8(11), 5976-5984.

Saghei, E., Nasiri Boroujeni, S., Safavi, P., Borjian Boroujeni, Z., & Bijad, E. (2020). Diosmetin Mitigates kev paub thiab kev nco tsis zoo Provoked los ntawm kev nyuaj siab me ntsis hauv nas. Cov ntaub ntawv pov thawj-based Complementary thiab Alternative Medicine, 2020.

Sawmiller, D., Habib, A., Li, S., Darlington, D., Hou, H., Tian, ​​J., … & Tan, J. (2016). Diosmin txo qis cerebral Aβ qib, tau hyperphosphorylation, neuroinflammation, thiab kev paub tsis meej hauv 3xTg-AD nas. Phau ntawv Journal of neuroimmunology, 299, 98-106.

Lee, DH, Park, JK, Choi, J., Jang, H., & Seol, JW (2020). Anti-inflammatory teebmeem ntawm ntuj flavonoid diosmetin hauv IL-4 thiab LPS-induced macrophage activation thiab atopic dermatitis qauv. International Immunopharmacology, 89, 107046.

Hsu, YL, & Kuo, PL (2008). Diosmetin induces tib neeg osteoblastic sib txawv los ntawm cov protein kinase C / p38 thiab extracellular teeb liab tswj kinase 1/2 txoj kev. Phau ntawv Journal of Bone and Mineral Research, 23(6), 949-960.

Zaragozá, C., Monserrat, J., Mantecón, C., Villaescusa, L., Álvarez-Mon, M. Á., Zaragozá, F., & Álvarez-Mon, M. (2021). Kev khi thiab kev ua haujlwm antiplatelet ntawm quercetin, rutin, diosmetin, thiab diosmin flavonoids. Biomedicine & Pharmacotherapy, 141, 111867.

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