cov khoom siv

L - (+) - Ergothioneine (EGT) hmoov (497-30-3)

L - (+) - Ergothioneine (EGT) yog lub ntuj chiral amino-acid antioxidant biosynthesized hauv qee yam kab mob thiab hu ua fungi. Nws yog ib qho tseem ceeb bioactive compound uas tau siv los ua cov radical scavenger, ultraviolet ray lim, lub chaw tswj hwm ntawm oxidation-txo cov tshuaj tiv thaiv thiab cellular bioenergetics, thiab lub cev cytoprotector, thiab lwm yam.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

L - (+) - Ergothioneine (EGT) (497-30-3) daim video

 

 

L - (+) - Ergothioneine Cov Ntaub Ntawv Ntaub Ntawv

lub npe L-(+)-Ergothioneine (EGT)
CAS 497-30-3
purity 98%
Tshuaj lub npe (α-S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium sab hauv ntsev
Synonyms Ergothionine; L - (+) - Ergothioneine; Erythrothioneine
molecular Formula C9H15N3O2S
molecular Nyhav 229.30
Melting Point 255-259 ° C
InChI Qhov Tseem Ceeb SSISHJJTAXXQAX-ZETCQYMHSA-N
daim ntawv khoom
tsos dawb khoom
Ib Sim Neej nyob ib ncig ntawm 30 hnub
solubility Soluble hauv dej (50 mg / ml), acetone, kub ethanol, thiab methanol.
cia mob -20 ° C (des.)
Daim ntawv thov Lub tshuaj antioxidant thiab dawb radical scavenger
Kuaj Cov Ntaub Ntawv Qhov

L - (+) - Ergothioneine (EGT) General hauj lwm

L-Ergothioneine yog cov tshuaj tua kab mob ua kom lub zog ruaj khov uas tuaj yeem pom nyob rau hauv cov xwm txheej ntawm kev kub ntxhov ntau dhau ntawm cov kab mob hauv cov nroj tsuag thiab tsiaj. L-ergothioneine muaj lub peev xwm txhaws dawb radicals thiab tiv thaiv cov hlwb los ntawm UV-ROS ua haujlwm nrog kev ua tau zoo dua li antioxidant coenzyme Q (10) lossis idebenone, yog li ua rau nws muaj kev tiv thaiv zoo antioxidant. Qhov sib xyaw ua ke tau pom tias tsis muaj tshuaj lom thiol buffering antioxidant, txhim kho lub peev xwm ntawm tes los ntawm hydrogen peroxide (H2O2), thiab inhibit DNA oxidation los ntawm peroxynitrite (ONOO-) hauv tib neeg neuronal hybridoma cell kab (N-18-RE- 105).

L - (+) - Ergothioneine (EGT) hmoov (497-30-3)

 

L-(+)-Ergothioneine (EGT)497-30-3) Keeb kwm

EGT yog tsim nyob hauv ob peb yam muaj sia, tshwj xeeb yog Actinobacteria, Cyanobacteria, thiab qee yam hu ua fungi. Ergothioneine tau tshawb pom hauv xyoo 1909 thiab muaj npe tom qab cov kab mob ergot los ntawm qhov uas nws tau ua kom huv thawj, nrog nws cov qauv raug txiav txim siab xyoo 1911.

 

L - (+) - Ergothioneine (EGT) Mechanism Kev Ua

l - (+) Ergothioneine yog ib txwm tshwm sim los ntawm thiol amino acid nrog lub zog antioxidant thiab cov txiaj ntsig zoo li kev noj zaub mov ntxiv. Txawm hais tias nws cov cim xyoo pua thiab muaj kev faib khoom dav hauv tib neeg cov zaub mov, me ntsis yog paub ntawm nws cov tshuab ntawm kev coj ua thiab kev nyab xeeb.

 

L - (+) - Ergothioneine (EGT) hmoov hmoov Kev Thov

L - (+) - Ergothioneine tau siv:

  • raws li kev tiv thaiv nruab nrab ntawm cov kom loj hlob nruab nrab rau cumulus-oocyte complexes (COCs) los kuaj tiv thaiv kev ua haujlwm ntawm lipid peroxide tsim
  • raws li cov tshuaj antioxidant compound los kuaj hom 2 cov neeg mob ntshav qab zib

L-Ergothioneine – ib yam tshiab ntawm ntuj antioxidant

EGT yog lub ntuj chiral amino-acid antioxidant biosynthesized hauv qee yam kab mob thiab hu ua fungi. Nws yog ib qho tseem ceeb bioactive compound uas tau siv los ua cov radical scavenger, ultraviolet ray lim, lub chaw tswj hwm ntawm oxidation-txo cov tshuaj tiv thaiv thiab cellular bioenergetics, thiab lub cev cytoprotector, thiab lwm yam.

L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), tseem hu ua (S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- 4-ethanaminium sab hauv ntsev, tau pib tawm los ntawm ergot los ntawm Tanret C hauv xyoo 1909, tom qab ntawd nws tseem tau tshawb pom hauv cov ntshav tsiaj. Kev ntshiab EGT yog dawb siv lead ua, soluble hauv dej, (yaj 0.9mol / L ntawm chav sov). Autoxidation tsis tuaj yeem tshwm sim ntawm physiological pH tus nqi lossis hauv cov tshuaj alkaline muaj zog. EGT tuaj yeem muaj nyob hauv ob daim isomer - ib daim thiol thiab thione form, raws li qhia hauv qab no:

Nrog rau qhov zoo ntawm cov haujlwm ntau, EGT sawv tawm ntawm ntau lwm cov tshuaj tiv thaiv antioxidant.Advantages (piv nrog glutathione, cysteine ​​thiab lwm yam.):

——EGT yog yooj yim mus rau hauv cov hlwb thiab cov concentration yog ruaj khov dua li lwm cov antioxidant.

——EGEG zoo dua rau kev txo qis kev tuag ntawm tes los ntawm pyrogallol.

——EGT tsuas yog scavenges ROS kom tiv thaiv oxidation, thaum glutathione thiab lwm tus tau scavenge dawb radicals, uas yog, lwm cov khoom siv tiv thaiv kab mob tiv thaiv cov khoom lag luam oxidation.

  • raws li kev tswj tau zoo nyob hauv solute carrier protein 22 A4 (SLC22A4) thauj khoom

L - (+) - Ergothioneine yog qhov tsim nyog rau siv nyob rau hauv kev kawm txog nws cov tshuaj tiv thaiv nrog 2,2′- thiab 4,4′-dipyridyl disulphide (2-Py-SS-2-Py thiab 4-Py-SS-4- Py), rau kev tsim tawm ntawm kev sim hauv hlwb thaum ua haujlwm hauv vitro kinase kev ua haujlwm assays rau ATM (Ataxia telangiectasia mutated) lossis ATR (ATM- thiab RAD3-cuam tshuam).

 

L - (+) - Ergothioneine (EGT) Kev tshawb fawb ntxiv

L - (+) - Ergothioneine (EGT) hmoov (497-30-3)

COMPARISON NTAWM COV TXHEEJ TXHEEM

Cov txiaj ntsig: EGT yog qhov tseem ua haujlwm qub tshaj plaws ntawm cov dawb radicals piv rau cov qub antioxidants li GSH, uric acid thiab trolox. Hauv tshwj xeeb, lub siab tshaj plaws cov tshuaj tiv thaiv antioxidant muaj peev xwm nthuav tawm los ntawm EGT vs. peroxyl radicals ua rau 25% siab dua tus nqi uas tau txais nrog kev siv antioxidant trolox. Qhov peev xwm sib xyaw ntawm EGT rau hydroxyl radicals yog 60% siab dua, piv rau cov uric acid, uas sawv cev rau kev siv tshuaj antioxidant thiab hydroxyl radicals. Thaum kawg, EGT pom tias muaj cov tshuaj tiv thaiv antioxidant ntau tshaj plaws rau peroxynitrite, nrog qhov muaj peev xwm faib 10% siab dua li ntawm uric acid.

LWM LUB LAUS

EGT tseem muaj kev cuam tshuam rau kev tswj hwm lub zog hauv lub cev,

txhim kho kev tiv thaiv,

txhim kho cov ciaj sia taus ntawm phev,

tiv thaiv daim siab los ntawm kev raug mob,

inhibiting qhov mob,

tshuaj neurodegeneration,

kev loj hlob tsis xws luag thiab mob cataract.

5-10mg ib chav rau ib tus neeg laus thiab 2-3 ib pawg tas mus li kom tau cov zaub mov rau koj noj txhua hnub.

Tau qhov twg los: Li Yiqun, Zhou Nianbo. Kev Ua Yeeb Yam Ib Ce thiab Kev Siv EGT [J]. Khoom Noj Khoom Haus Engineering , 2010,9 (3) : 26-28.

Kev nkag yog muaj npe raws li hauv qab no:

  • Cov menyuam yaus (3-11 xyoos)
  • L 0 mg / hnub
  • Cov Hluas (11-21 xyoos)
  • ≤30 mg / hnub
  • Cov Neeg Loj (21-80 xyoo)
  • ≤30 mg / hnub

Nco ntsoov:

  • Koob tshuaj rau cov me nyuam thiab cov laus (3 -80 xyoo)
  • Tsis pom zoo siv rau kev xeeb tub lossis lactating cov poj niam.

Cov ntaub ntawv peev txheej: Tetrahedron thaum thov rau Asmeskas NDI

■ Cov ntaub ntawv hais tawm: 10.5mg / g rau OXIS's ADI (Kev Txais Txais Txhua Hnub).

 

L - (+) - Ergothioneine (EGT) hmoov xa mus

  • Tanret Sur une base nouvelle retiree du seigle ergote, l'ergothioneine Compt. Rend., 149 (1909), phab 222-224
  • Akanmu D, Cecchini R, Aruoma OI, Halliwell B (Lub Xya Hli 1991). “Lub antioxidant txiav txim ntawm ergothioneine”. Arch Tsev Biochem. 288 (1): 10–
  • “Ergothioneine”. PubChem, Lub Chaw Haujlwm Hauv Tebchaws rau Cov Ntaub Ntawv Xov Xwm Biotechnology, Asmeskas Lub Tsev Haujlwm Saib Xyuas Kev Noj Tshuaj Hauv Tebchaws. 2 Lub Kaum Ib Hlis 2019. Rov Sib Tham 7 Lub Kaum Ib Hlis 2019.
  • L-Ergothioneine (EGT): Lub Luag Khoom Noj ‐ Neeg Los Ntawm Antioxidant nrog Kev Kho Nyog

 

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