Chrysin hmoov (Los ntawm zymotechnics)

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Tsuas yog 12 sab lauj! 155 tus neeg tab tom saib qhov no thiab 34 tus neeg muaj nws hauv lawv lub laub.

Tsis paub Yuav Ua Li Cas Qhov Kev Txiav Txim?

Nyem qhov no
[1]. Xaiv qhov koj xav tau, tom qab ntawd ntxiv rau lub laub

[2]. Txuas mus xyuas

[3]. Sau koj cov ntaub ntawv nthuav dav, qhov * yuav tsum tau, xaiv koj txoj kev them nyiaj. Muaj ntau txoj kev them nyiaj sib txawv suav nrog:
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- Kev them nyiaj npib: Bitcoin, Ether, USDT
Ces nyem "Place order"
Lub tswv yim: email chaw nyob yuav tsum tau kho, cov ntaub ntawv taug qab yuav hloov tshiab los ntawm email ceeb toom

[4]. Yog tias xaiv "Coinpayment", tom qab nyem "Place order", ces yuav qhia raws li hauv qab no them

[5]. Yog tias Xaiv "Direct Bank Transfer", tom qab nias "Place order", ces yuav qhia raws li hauv qab no, yuav tshwm sim cov ntsiab lus ntawm tus account hauv txhab nyiaj, tom qab hloov lub txhab nyiaj (thov siv koj tus lej xaj raws li qhov siv), xa daim ntawv hauv txhab nyiaj rau peb.

[6]. Kev them nyiaj lees paub
[7]. Parcel xa tawm li 5-10 teev (hauv hnub ua haujlwm)
[8]. Tus lej taug qab tau muab
[9]. Parcel tuaj txog
[10]. Rov xaj dua
Tsis muaj koj qhov ntau? Nyem no
Ceeb toom: Yog tias koj cev xeeb tub, saib xyuas neeg mob, noj cov tshuaj los yog muaj kev mob nkeeg nrog koj tus kws kho mob ua ntej siv. Khaws kom deb ntawm cov menyuam yaus.
Qeb: SKU: N / A

Lub npe: Chrysin

CAS: 480-40-0

Cov roj formula: C15H10O4

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

Chrysin hmoov (480-40-0) video

 

Chrysin hmoov Pob Lus Qhia

lub npe Chrysin
CAS 480-40-0
purity 98%
Tshuaj lub npe Chrysine

Crysin

Synonyms 5,7-dihydroxy-2-phenylchromen-4-ib, 5, 7-Chrysin, 5, 7-Dihydroxyflavone, Chrysine, Flavone X, Flavonoid, Flavonoïde, Galangin Flavanone, Galangine Flavanone
molecular Formula C15H10O4
molecular Nyhav 254.24 g / mol
Melting Point 285.5 ° C
InChI Qhov Tseem Ceeb RTIXKCRFFJGDFG-UHFFFAOYSA-N
daim ntawv khoom
tsos Daj rau grey
Ib Sim Neej /
solubility Chrysin yog soluble hauv cov kuab tshuaj organic xws li DMSO thiab dimethyl formamide, uas yuav tsum tau ua kom huv nrog cov roj sab hauv. Kev daws teeb meem ntawm chrysin hauv cov kuab tshuaj no yog kwv yees li 30 mg / ml
cia mob Khaws nyob rau hauv chav tsev kub, nyob rau hauv lub thawv ntim airtight kaw, ua pa tawm, tiv thaiv los ntawm tshav kub, lub teeb thiab av noo.
Daim ntawv thov Chrysin yog siv rau kev tawm dag zog; txhawm rau kho kev ntxhov siab, o, mob gout, HIV / AIDS, mob erectile kawg (ED), thiab mas thiab rau kev tiv thaiv mob qog noj ntshav
Kuaj Cov Ntaub Ntawv Qhov

 

Chrysin yog dab tsi?

Chrysin, tseem hu ua 5,7-dihydroxyflavone, yog flavonoid pom hauv zib ntab, propolis, thiab ob peb hom paj nyiam paj. Nws kuj tseem pom muaj hauv carrots, nyiaj linden, qee hom geranium, thiab chamomile. Chrysin muaj ntau yam kev kho mob thiab ua haujlwm ua cov tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob. Nws kuj muaj cov tshuaj tua kab mob thiab tshuaj tua kab mob. Nws tau muab rho tawm los ntawm ntau yam nroj tsuag, tshwj xeeb yog paj paj tawg paj xiav (Passiflora caerulea).

Chrysin, txawm li cas los xij, muaj tsawg bioavailability thiab muaj feem ntawm kev tshem tawm sai hauv tib neeg lub cev. Yog li nws tsis zoo nqus los ntawm lub cev. Chrysin yuav tsum tau txhaj tshuaj ntau dua kom tau txais txiaj ntsig zoo tshaj plaws.

 

Chrysin Ua Haujlwm Li Cas?

Chrysin yog hom flavonoid. Flavonoids yog cov xim ntuj pom hauv cov nroj tsuag, txiv hmab txiv ntoo, zaub, thiab zib ntab. Lawv pab tswj hwm kev ua haujlwm ntawm tes thiab pab tshem tawm cov radicals uas tuaj yeem ua rau muaj kev ntxhov siab hauv lub cev. Lawv kuj tseem tuaj yeem muaj cov tshuaj tua kab mob.

Chrysin tau txais cov tshuaj tiv thaiv kab mob thiab antioxidant. Chrysin feem ntau txo qis kev nthuav dav ntawm tes, ua rau cov cell tuag los ntawm apoptosis hauv cov qog nqaij hlav cancer, thiab txo qhov mob.

Nws cov tshuaj tiv thaiv kab mob tau txuas nrog kev tswj hwm cytokine, feem ntau yuav yog vim muaj kev txwv ntawm cytokines xws li IFN-c thiab TNF-α. Nws ua qhov no los ntawm kev qhib macrophages ntawm NF-κB txoj hauv kev. Chrysin kuj tseem tuaj yeem txwv qib ntawm cytokines loj xws li prostaglandin-E2, COX-2, thiab kev ua haujlwm ntawm NO thiab qib iNOS ntshav.

Chrysin kuj muaj cov tshuaj tiv thaiv kab mob. Antioxidants yog cov tshuaj uas tuaj yeem tiv thaiv kev puas tsuaj rau cov cell los ntawm ntau yam dawb radicals. Chrysin tiv thaiv kev puas tsuaj los ntawm cov dawb radicals hauv lub cev [1].

Nws kuj tau pom los txhim kho cov xwm txheej ntawm lipid peroxidases thiab cov tshuaj tiv thaiv kab mob, tshwj xeeb tshaj yog thaum lub sijhawm mob qog noj ntshav. Nws tuaj yeem tiv thaiv kev loj hlob ntawm cov qog nqaij hlav ntawm apoptosis los ntawm kev ua kom pom txoj hauv kev taw qhia Notch1 [2].

Chrysin lub peev xwm los nce qib testosterone hauv tib neeg lub cev zoo li yog qhov ua yuam kev raws li nws tau pom tias nws tsis muaj qhov cuam tshuam zoo li no. Li no nws siv los ua cov tshuaj testosterone txhim kho cov khoom hauv lub cev yuav tsum tau tshuaj xyuas [3].

Cov khoom siv ntuj tsim los ntawm chrysin yog tsob ntoo mint, zib ntab nplaum lossis propolis, zib ntab, paj noob hlis, thiab cov nceb oyster.

 

Cov txiaj ntsig ntawm Chrysin

Chrysin tsis muaj pov thawj txaus los qhia nws qhov ua tiav ntawm lub cev. Txawm li cas los xij, ntau txoj kev tshawb fawb tau qhia tias chrysin muaj peev xwm noj qab haus huv.

Qee qhov txiaj ntsig kev noj qab haus huv ntawm Chrysin yog:

 

Cov nyhuv Neuroprotective

Chrysin tuaj yeem pab tiv thaiv lub paj hlwb los ntawm kev puas tsuaj vim lub hnub nyoog laus thiab cov co toxins. Qhov no feem ntau yog vim nws cov tshuaj tiv thaiv antioxidant [4]. Nws tau pom tias muaj txiaj ntsig zoo hauv kev kho mob ntawm cov hlab ntsha los ntawm hyperammonemia.

 

Cov nyhuv ntawm Prostate Cancer

Chrysin tuaj yeem txo qis kev loj hlob thiab ua rau cov cell tuag hauv cov qog nqaij hlav cancer hauv qog noj ntshav prostate [5]. Li no, nws yuav yog ib qho kev ntsuas muaj txiaj ntsig los kho tus mob no.

 

Teeb meem plawv

Chrysin tuaj yeem txo qis lipid synthesis thiab tuaj yeem ua rau muaj kev noj qab haus huv zoo ntawm nitric oxide (NO). Yog li nws tuaj yeem pab kho qhov ua haujlwm ntawm cov hlab ntshav. Nws kuj tseem tuaj yeem tiv thaiv kev txhim kho ntawm atherosclerosis los ntawm kev txo qhov mob hauv cov hlab ntsha. Yog li, nws yuav pab tiv thaiv thiab kho kab mob plawv [6].

 

Cov nyhuv ntawm ob lub raum

Chrysin tau pom los txo lub raum puas tsuaj vim tshuaj thiab tshuaj lom. Ib txoj kev tshawb fawb tshawb fawb ntawm cisplatin-induced nephrotoxicity hauv nas pom tias siv chrysin hauv cov kev xeem no tau pab ua kom lawv lub raum ua haujlwm zoo [7]. Yog li, chrysin tej zaum yuav muaj kev ua haujlwm nephroprotective ib yam.

 

Hepatoprotective nyhuv

Ib txoj kev tshawb fawb tshawb fawb ntawm cov nas nrog lub siab puas los ntawm carbon tetrachloride (CCl4) qhia pom tias siv chrysin ntawm cov kev xeem no txhim kho lawv lub siab ua haujlwm thiab txo qis lub siab enzymes uas yog biomarkers ntawm lub siab ua haujlwm [8]. Yog li, chrysin tau txais lub peev xwm hepatoprotective.

 

Teeb meem ntawm mob hawb pob

Chrysin tau pom tias muaj txiaj ntsig zoo hauv kev kho mob bronchoalveolar hyperresponsiveness hauv ovalbumin (OVA) vim nas [9]. Nws muaj peev xwm txo qhov mob hauv lub ntsws thiab txo cov tsos mob. Qhov no tej zaum yuav yog vim kev hloov pauv ntawm Th1/Th2 polarization vim yog kev txwv tsis pub ua kom muaj nitric oxide synthase, nuclear factor-κB, thiab ua kom muaj protein ntau. Li no, chrysin kuj tseem tuaj yeem pab kho mob hawb pob ib yam.

 

Teeb meem ntawm Ntshav Qab Zib

Chrysin tuaj yeem txo qis cov ntshav qab zib. Nws kuj tseem tuaj yeem pab kho qhov teeb meem vim ntshav qab zib [10].

 

Cov teebmeem ua Antioxidant

Chrysin cov tshuaj tiv thaiv kab mob tuaj yeem pab tiv thaiv kev cuam tshuam ntawm kev laus, kev puas tsuaj ntawm tes vim tshuaj lom thiab cov pa phem, thiab lwm yam. Qhov no tuaj yeem pab kho cov tawv nqaij thiab plaub hau.

 

Kev Nyuaj Siab

Chrysin tuaj yeem tuaj yeem kho kev ntxhov siab vim nws muaj kev cuam tshuam zoo li anxiolytic. Ib txoj kev tshawb fawb pom tias muab chrysin rau cov nas tom qab phais tas nrog cov tsos mob zoo li tuaj yeem pab txo lawv cov tsos mob [11]. Qhov no yuav yog vim nws cuam tshuam rau GABAA receptors.

 

Cov nyhuv ntawm Estrogen

Ib qho ntawm cov khoom ntawm chrysin yog tias nws tuaj yeem txo qis qib cov tshuaj estrogen hauv lub cev los ntawm kev tshem tawm cov enzyme aromatase (CYP19) [12]. Qhov no txhais tau tias nws tuaj yeem pab tiv thaiv aromatase enzyme thiab yog li pab tiv thaiv thiab kho cov tshuaj hormone-vam khom mob qog noj ntshav. Nws kuj tseem tuaj yeem ua haujlwm kho cov tshuaj estrogen-dependent.

 

Cov Teeb Meem Ntawm Chrysin

Tsis tau tshaj tawm cov xwm txheej txog kev phiv los ntawm kev siv chrysin hmoov txog tam sim no.

 

Leej twg yuav tsum zam Chrysin?

Muaj qee qhov xwm txheej uas yuav tsum zam chrysin. Qhov no yog vim qhov cuam tshuam ntawm cov tshuaj no rau cov neeg mob nrog cov xwm txheej no tsis tau tsim los zoo.

Qee qhov xwm txheej no yog:

Hauv cev xeeb tub thiab niam pub niam mis - Txij li thaum tsis muaj cov ntaub ntawv txaus txog qhov cuam tshuam ntawm Chrysin hauv cev xeeb tub thiab leej niam pub niam mis, nws yog qhov zoo tshaj kom zam kev siv lub sijhawm no.

Los ntshav tsis zoo - Muaj qee qhov kev txhawj xeeb tias chrysin tuaj yeem ua rau cov ntshav loj tuaj rau cov uas muaj ntshav tsis zoo.

Kev phais - Muaj qhov ua tau tias chrysin tuaj yeem ua rau cov ntshav khov hauv lub cev. Yog li nws yuav yog qhov zoo kom zam nws tsawg kawg 2 lub lis piam ua ntej yuav phais.

 

Cov Tshuaj Uas Muaj Kev Sib Tham Nrog Chrysin

Muaj qee cov tshuaj uas tuaj yeem cuam tshuam nrog chrysin.

Lawv yog:

 

Aromatase Inhibitors

Cov tshuaj no suav nrog aminoglutethimide, anastrozole, exemestane, letrozole, thiab lwm yam. Aromatase inhibitors txo qib tshuaj estrogen hauv lub cev. Qhov khoom qub no tau nthuav tawm los ntawm chrysin hmoov ib yam. Yog li, noj cov tshuaj no nrog chrysin tuaj yeem ua rau lub cev qib ntawm cov tshuaj estrogen tsawg zuj zus, ua rau muaj kev phiv ntau yam.

 

Tshuaj Glucuronidated

Cov no yog cov tshuaj uas tau metabolized los ntawm daim siab. Chrysin hmoov tuaj yeem ua kom nrawm cov txheej txheem ntawm cov tshuaj no, ua rau lawv nyob ntev dua hauv lub cev. Qhov kev nqis tes no tuaj yeem ua rau muaj txiaj ntsig tsawg dua ntawm cov tshuaj no. Cov tshuaj Glucuronidated suav nrog acetaminophen, atorvastatin, diazepam, digoxin, entacapone, estrogen, irinotecan, lamotrigine, lorazepam, lovastatin, meprobamate, morphine, oxazepam, thiab lwm yam.

 

Cytochrome P450 1A2 (CYP1A2) Substrates

Chrysin tuaj yeem txo qis cov txheej txheem metabolic ntawm cov tshuaj no, ua rau lawv nyob ntev dua hauv lub cev. Qhov kev nqis tes ua no tuaj yeem ua rau theem ntawm cov tshuaj no hauv cov ntshav nce thiab nyob li ntawd ntev dua, ua rau muaj kev phiv ntau dua. Cov tshuaj no suav nrog clozapine, cyclobenzaprine, fluvoxamine, haloperidol, imipramine, mexiletine, olanzapine, propranolol, theophylline, thiab lwm yam.

 

Dosage ntawm Chrysin

Kev noj tshuaj txhua hnub ntawm 0.5 txog 3g chrysin hmoov yog suav tias nyab xeeb. Txawm li cas los xij, qhov no tuaj yeem hloov pauv raws li qhov xwm txheej thiab xav tau ntawm tus neeg siv.

 

Koj Yuav Yuav Chrysin Qhov Twg?

Koj tuaj yeem yuav chrysin ncaj qha los ntawm chrysin hmoov chaw tsim tshuaj paus tuam txhab. Nws los hauv pob khoom ntawm 1kg ib pob ntawv lossis 25kg rau ib lub nruas. Txawm li cas los xij, kev kho kom haum ntawm qhov kev xaj yog ua tau raws li koj xav tau. Cov khoom no yog ua nrog cov khoom xyaw zoo tshaj plaws. Nws tau tsim tawm raws li cov lus qhia nruj thiab siv kev ntsuas kev nyab xeeb kom raug. Cov tshuaj no yuav tsum tau khaws cia ntawm chav sov, kom deb ntawm tshav ntuj ncaj qha thiab av noo, hauv lub thawv cua txias. Qhov no yog txhawm rau tiv thaiv nws los ntawm kev cuam tshuam nrog lwm cov tshuaj hauv ib puag ncig.

 

References

  1. Mani, R., & Natesan, V. (2018). Chrysin: Cov peev txheej, cov txiaj ntsig zoo ntawm kev siv tshuaj tua kab mob, thiab cov txheej txheem molecular ntawm kev nqis tes ua. Phytochemistry, 145, 187-196, ib. https://pubmed.ncbi.nlm.nih.gov/29161583/
  2. Yu, XM, Phan, T., Patel, PN, Jaskula -Sztul, R., & Chen, H. (2013). Chrysin ua rau Notch1 teeb tsa thiab tiv thaiv qog kev loj hlob ntawm anaplastic thyroid carcinoma hauv vitro thiab hauv vivo. cancer, 119(4), 774-781. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528831/
  3. Gambelunghe, C., Rossi, R., Sommavilla, M., Ferranti, C., Rossi, R., Ciculi, C.,… & Rufini, S. (2003). Cov teebmeem ntawm chrysin ntawm cov zis testosterone qib hauv tib neeg txiv neej. Phau ntawv teev npe tshuaj noj, 6(4), 387-390. https://pubmed.ncbi.nlm.nih.gov/14977449/
  4. Mani, R., Natesan, V., & Arumugam, R. (2017). Neuroprotective effect ntawm chrysin ntawm hyperammonemia kho cov lus teb neuroinflammatory thiab hloov pauv qhia ntawm cov protein astrocytic hauv hippocampus. Kev Kho Mob Biomedicine & Pharmacotherapy, 88, 762-769: kuv. https://www.sciencedirect.com/science/article/abs/pii/S0753332216320480
  5. Samarghandian, S., Afshari, JT, & Davoodi, S. (2011). Chrysin txo qis kev loj hlob thiab ua rau apoptosis hauv tib neeg cov qog nqaij hlav cancer qog noj ntshav pc-3. Cov Chaw Kho Mob, 66, 1073-1079 ib. https://www.scielo.br/j/clin/a/KKS4gNtfLkMdT9RZzbwRkJF/?lang=en
  6. Farkhondeh, T., Samarghandian, S., & Bafandeh, F. (2019). Kev tiv thaiv kab mob plawv ntawm chrysin: kev tshuaj xyuas piav qhia ntawm kev tshawb fawb tshawb fawb. Cov Kab Mob Hauv Plawv & Cov Tshuaj Hematological hauv Tshuaj Kho Mob (Yav Dhau Los Tam Sim No Cov Tshuaj Kho Mob-Cardiovascular & Cov Tshuaj Hematological), 17(1), 17-27. https://pubmed.ncbi.nlm.nih.gov/30648526/
  7. Sultana, S., Verma, K., & Khan, R. (2012). Nephroprotective kev ua tau zoo ntawm chrysin tiv thaiv cisplatin-induced toxicity los ntawm kev txo qis ntawm oxidative kev nyuab siab. Phau ntawv Journal of Pharmacy and Pharmacology, 64(6), 872-881.
  8. Hermenean, A., Mariasiu, T., Navarro -González, I., Vegara -Meseguer, J., Miuțescu, E., Chakraborty, S., & Pérez ‑ Sánchez, H. (2017). Hepatoprotective kev ua ntawm chrysin yog kho nruab nrab los ntawm TNF-α hauv kev tsim cov tshuaj lom ua rau lub siab puas: Kev kawm hauv vivo thiab kev ua qauv qauv. Kev sim thiab tshuaj kho mob, 13(5), 1671-1680. https://www.spandidos-publications.com/10.3892/etm.2017.4181
  9. Wadibhasme, PG, Ghaisas, MM, & Thakurdesai, PA (2011). Muaj peev xwm tiv thaiv hawb pob ntawm chrysin ntawm ovalbumin-induced bronchoalveolar hyperresponsiveness hauv nas. Tshuaj lom neeg, 49(5), 508-515. https://www.tandfonline.com/doi/full/10.3109/13880209.2010.521754
  10. Samarghandian, S., Azimi-Nezhad, M., Samini, F., & Farkhondeh, T. (2016). Kev kho Chrysin txhim kho cov ntshav qab zib thiab nws cov teeb meem hauv lub siab, lub paj hlwb, thiab cov txiav txiav hauv cov nas mob ntshav qab zib streptozotocin. Canadian phau ntawv journal physiology thiab tshuaj, 94(4), 388-393. https://pubmed.ncbi.nlm.nih.gov/26863330/
  11. Rodríguez-Landa, JF, Hernández-López, F., Cueto-Escobedo, J., Herrera-Huerta, EV, Rivadeneyra-Domínguez, E., Bernal-Morales, B., & Romero-Avendaño, E. (2019) . Chrysin (5, 7-dihydroxyflavone) ua rau muaj kev cuam tshuam zoo li kev ntxhov siab los ntawm GABAA cov neeg txais khoom hauv kev phais lub cev ntas qauv hauv nas. Kev Kho Mob Biomedicine & Pharmacotherapy, 109, 2387-2395, ib. https://pubmed.ncbi.nlm.nih.gov/30551498/
  12. Balam, FH, Ahmadi, ZS, & Ghorbani, A. (2020). Kev cuam tshuam ntawm chrysin ntawm cov tshuaj estrogen biosynthesis los ntawm kev txwv ntawm enzyme aromatase (CYP19): Kev tshuaj xyuas tas li. Heliyon, 6(3), e03557. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063143/

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