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Sulforaphane Hmoov (4478-93-7)

Sulforaphane hmoov yog qhov ua kom zaub ntsuab yog ua los ntawm isothiocyanate nrog kev cog lus rau kev tiv thaiv kab mob, tshuaj lom neeg thiab kho kev ua haujlwm, nws inhibits TPA-ntxias NF-ationB ua kom thiab COX-2 qhia hauv MCF-10A hlwb los ntawm kev thaiv ob txoj kev sib kis tshwj xeeb los ntawm ERK1 / 2-IKKα thiab NAK-IKKβ. Sulforaphane hmoov yuav ua rau muaj kev cuam tshuam loj ntawm neuroprotective rau cholinergic qhov tsis txaus ntseeg thiab lub hlwb puas, nws tseem muaj cov nyhuv tiv thaiv, tsawg kawg, ib feem, cuam tshuam nrog cuam tshuam nrog NF-κB txoj hauv kev.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

Sulforaphane Hmoov (4478-93-7) video

 

Cov Ntaub Ntawv Sulforaphane Hmoov Puag

lub npe Sulforaphane Hmoov
CAS 4478-93-7
purity 1% , 10%
Tshuaj lub npe D, L-Sulforaphane
Synonyms sulforafan; sulforaphan; sulforaphane; R-SULFORAPHANE; R, S-SULFORAPHANE; SULFORAPHANE, L-; SULFORAPHANE, DL-; SULFORAPHANE, D-
molecular Formula C6H11 NOS 2
molecular Nyhav 177.3
Melting Point 68.93 ° C (kwv yees)
InChI Qhov Tseem Ceeb SUVMJBTUFCVSAD-UHFFFAOYSA-N
daim ntawv hmoov
tsos Tsis muaj kob los daj
Ib Sim Neej /
solubility Chloroform (Sparingly), Methanol (Me ntsis)
cia mob -20 ° C
Daim ntawv thov Lub hwj chim, xaiv qhov inducer ntawm theem II detoxification enzymes nrog cov yam ntxwv anticarcinogenic. Muaj tshwm sim hauv zaub cob pob. Nws tau pom rau qhov ua rau cov leeg lub zog hloov maj mam hlav cov qog nqaij hlav hauv cov nas. Antitumor tus neeg sawv cev.
Sulforaphane yog tshaj tawm rau txoj kev tshawb nrhiav me me kom daws cov tsos mob cuam tshuam nrog mob vwm.
Kuaj Cov Ntaub Ntawv Qhov

 

sulforaphane Hmoov Cov Lus Qhia Ntxiv

Sulforaphane, uas yog cais tawm ntawm cov noob ntawm Brassica oleracea L. var. botrytis L, yog ib qho khoom noj muaj roj zoo nkauj cog qoob loo isothiocyanate nrog kev cog lus ua tshuaj lom neeg thiab kev ua kom zoo nkauj. Sulforaphane hmoov muaj antitumor cuam tshuam tiv thaiv lub hlwb mob zais zis los ntawm ROS-mediated intrinsic apoptotic pathway, thiab hais tias kev nyuaj siab ER thiab Nrf2 tuaj yeem sawv cev rau lub hom phiaj kev lag luam rau Sulforaphane-induced apoptosis. Sulforaphane tej zaum yuav muaj cov kev cuam tshuam neuroprotective tseem ceeb rau cholinergic qhov tsis txaus thiab lub hlwb puas. Cov zaub cob pob muaj ntau ntawm sulforaphane, uas kuj muaj nyob hauv lwm cov zaub zaub zoo nkauj suav nrog zaub qhwv thiab kale.

 

Sulforaphane Hmoov (4478-93-7) Keeb Kwm

Sulforaphane hmoov yog ib qho isothiocyanate tam sim no ib txwm muaj ntau yam zaub noj; tau qhia cov tshuaj anticancer thiab cardioprotective.

Hauv Vitro: Sulforaphane tsim muaj lub xov tooj ntawm lub cev mus rau hauv qhov chaw muaj tshuaj ntau dua, tom qab ntawd kev tuag ntawm tes. Qhov sulforaphane-huav lub voj voog raug ntes kaw tau cuam tshuam nrog kev nthuav dav ntawm cyclins A thiab B1. Sulforaphane induces kev tuag ntawm tes ntawm cov txheej txheem apoptotic. Sulforaphane inhibits qhov ua kom rov muaj zog ntawm kev loj hlob thiab txo qis kev muaj peev xwm ntawm tes hauv quiescent nyuv carcinoma hlwb (HT29) thiab muaj cov tshuaj lom tsawg dua ntawm cov CaCo2 hlwb sib txawv. Kev kho mob ua ntej ntawm H9c2 nas myoblasts nrog sulforaphane txo lub apoptotic cell xov tooj thiab qhov kev tshaj tawm ntawm cov pro-apoptotic protein (Bax, caspase-3 thiab cytochrome c), nrog rau doxorubicin-induced nce hauv mitochondrial membrane tej zaum. Tsis tas li ntawd, sulforaphane tsub kom mRNA thiab cov protein qhia ntawm heme oxygenase-1, uas yog li txo cov theem ntawm hom kabmob oxygen (ROS, ntsuas siv MitoSOX Red reagent) hauv mitochondria uas ntxias los ntawm doxorubicin.

Hauv Vivo: Sulforaphane tuaj yeem thaiv kev tsim cov qog ammary hauv Sprague-Dawley nas kho nrog ib zaug xwb ntawm 9,10-dimethyl-1,2-benzanthracene. Kev tswj hwm ntawm sulforaphane txo cov xwm txheej, ntau, thiab hnyav thiab qeeb ntawm kev txhim kho ntawm cov qog nqaij hlav mam evoked los ntawm ib koob tshuaj DMBA hauv cov poj niam Sprague-Dawley nas.

 

Sulforaphane Hmoov Txheej Txheem Ntawm Kev Ua

Biochem / physiol Kev Ua

Xaiv inducer ntawm theem II detoxification enzymes nrog anticarcinogenic cov yam ntxwv. Organosulfur compound pom nyob hauv cov zaub zaub zoo nkauj, suav nrog zaub cob pob.

Sulforaphane yog ib qho kev tiv thaiv kabmob kheesxaws, tiv thaiv kab mob ntshav siab thiab tshuaj tiv thaiv kab mob ntshav qab zib nyob hauv cov zaub zaub txhuv.Qhov tsim cov khoom ua rau detoxifying enzymes xws li quinone reductase thiab glutathione S-transferase uas ua rau xenobiotic hloov. Sulforaphane tseem tseem nce qhov hloov pauv ntawm cov qog ua kom hlav cov nqaijrog thiab inhibits histone deacetylases. Nws hloov cov xim teb los ntawm qhov LPS-mediated qhia ntawm iNOS, COX-2, IL-1β thiab TNF-α.

 

Sulforaphane Hmoov (4478-93-7) Daim Ntawv Thov

Sulforaphane tuaj yeem tiv thaiv kev mob qog nqaij daim tawv thaum thov ncaj qha rau ntawm daim tawv nqaij. Sulforaphane yog Hwj Chim, xaiv xim tsim ntawm theem II detoxification enzymes nrog anticarcinogenic cov yam ntxwv. Muaj tshwm sim hauv zaub cob pob. Nws tau pom rau qhov ua rau cov leeg lub zog hloov maj mam hlav cov qog nqaij hlav hauv cov nas. Antitumor tus neeg sawv cev.
Sulforaphane yog tshaj tawm rau txoj kev tshawb nrhiav me me kom daws cov tsos mob cuam tshuam nrog mob vwm.

 

Sulforaphane Hmoov (4478-93-7) Kev tshawb fawb ntxiv

Sulforaphane nthuav tawm cov tshuaj anticancer, tshuaj tiv thaiv kab mob ntshav, thiab tshuaj tua kab mob hauv cov qauv sim. Nws tau txais los ntawm zaub paj zoo li zaub cob pob, Zaub pob zaub ntsuab lossis cij zaub. Lub enzyme myrosinase hloov pauv glucoraphanin, glucosinolate, rau hauv sulforaphane raws li kev puas tsuaj rau tsob ntoo (xws li los ntawm kev zom). Cov tub ntxhais hluas tawg paj ntawm zaub cob pob thiab zaub paj yog tshwj xeeb yog nplua nuj hauv glucoraphanin.

 

Sulforaphane Hmoov (4478-93-7) Kev siv

  • Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, Tus Tshiab AMPA Receptor Potentiator nrog qis Agonistic nyhuv, Avoided Tswb-Cov Lus Teb nyob rau hauv Vitro BDNF ntau lawm. J Pharmacol Exp Ther. 2018 Mar; 364 (3): 377-389. doi: 10.1124 / jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.
  • Zhang, Y., li al .: Proc. Naj. Neeg ntxhoo. Khej. USA, 89, 2399 (1992), Shikita, M., li al .: Biochem. J., 341, 725 (1999), Wittich, S., li al .: J. Med. Chem., 45, 3296 (2002), Lee, J., li al.: Cancer Lett., 224, 171 (2005); Chem. thiab Eng. Xov Xwm, p 11, Kaum Hli 20 (2014)
  • Gamet-Payrastre L, li al. Sulforaphane, ib txwm tshwm sim isothiocyanate, ua rau lub xov tooj ntawm lub cev raug ntes thiab apoptosis nyob rau hauv HT29 tib neeg cov mob hlwb. Cancer Res. 2000 Mar 1; 60 (5): 1426-33.
  • Li B, li al. Sulforaphane tiv thaiv doxorubicin-induced oxidative kev nyuaj siab thiab kev tuag ntawm tes hauv nas H9c2 hlwb. Int J Mol Med. 2015 Lub Xya Hli; 36 (1): 53-64. [3]. Zhang Y, li al. Anticarcinogenic cov dej num ntawm sulforaphane thiab cov yam ntxwv ntawm cov khoom siv hluavtaws norbornylisothiocyanates. Proc Natl Acad Sci US A. 1994 Plaub Hlis Tim 12; 91 (8): 3147-50.
  • 2020 Glucoraphanin Vs. Sulforaphane: Qhov zoo tshaj plaws Antioxidant thiab tseem ceeb Noj hauv zaub cob pob

 

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