Unifiram (DM232) hmoov (272786-64-8)

Unifiram (DM232) hmoov (272786-64-8) video

Unifiram (DM232) hmoov Piav Cov Ntaub Ntawv

Unifiram (DM232) Cov General hauj lwm

Unifiram yog ib cov tshuaj tshiab nootropic uas tej zaum tsuas yog ib qho ntawm cov muaj zog tshaj plaws los pab lub hlwb tau tsim.

Raws li tsab xov xwm hauv Kev Tshawb Fawb Kev Txhim Kho Tshuaj, qhov sib xyaw no muaj lub zog kwv yees li 1,000 npaug ntau dua li tam sim no muaj nootropics zoo li Piracetam thiab Aniracetam.

Cov kev tshawb fawb pom tau tias Unifiram muaj qhov cuam tshuam zoo rau kev nco qab thiab ua haujlwm zoo ib yam li cov khoom pov thawj los ntawm cov Racetams nrov dua.

Unifiram yog ze rau Sunifiram thiab ua haujlwm ntawm lub hlwb zoo sib xws rau qib kev txiav txim siab tib yam. Vim tias muaj kev txwv rau Unifiram, cov neeg feem coob yuav coj Sunifiram ua qhov tsim nyog hloov rau cov khoom sib txuas kim dua no.

Unifiram (DM232) hmoov Keeb kwm

Unifiram (CAS # 272786-64-8) yog cov tshuaj uas tau qhia nyob rau xyoo 2000 kom muaj cov khoom zoo sib xws rau piracetam tab sis ntau zog hauv nas dhau ntawm kev kuaj pom kev zam. Unifiram (kev loj hlob code npe DM-232) yog ib qho tshuaj sim. uas muaj antiamnesic thiab lwm yam cuam tshuam hauv kev tshawb fawb tsiaj nrog deb tshaj potency dua li piracetam. Ib tug xov tooj ntawm cov sib txuas sib txuas tau paub, xws li sunifiram (DM-235) thiab sapunifiram (MN-19). [4] [5] [6] Unifiram muaj ob lub enantiomers, nrog dextro daim ntawv ua cov isomer nquag dua. Nws tau qhia rau txo qis lub sijhawm ntawm hypnosis ntxias los ntawm pentobarbital, tsis muaj qhov cuam tshuam nrog lub cev muaj zog. Raws li ntawm 2015, tsis muaj kev tshawb fawb txog tib neeg cov ntaub ntawv nrog unifiram tau ua tiav.

Hauv xyoo 2006, cov kws tshawb nrhiav tau kawm txog tus neeg ua yeeb yam ntawm ob lub Sunifiram thiab Unifiram, pom tias ob lub tebchaw yog qhov kev txiav txim ntawm plaub lub zog ntau dua li Pircatem. Unifiram, lawv pom, muaj peev xwm tiv thaiv amnesia los ntawm cov kev hloov kho ntawm ob peb lub neurotransmitter.

Unifiram (DM232) Kev Tshawb Fawb Txog Kev Ua

Unifiram yog lub zog zoo rau txhua tus ntawm koj cov AMPA receptors. Raws li Ampakine, Unifiram cuam tshuam glutamate uptake hauv lub hlwb ua rau zoo dua synaptic kis ntawm neurons.

Unifiram kuj yuav ua rau cov acetylcholin ntau lawm ua nws cov tswv yim ntawm kev ua haujlwm zoo li Noopept, Pramiraceta, Oxiracetam thiab lwm yam kev pabcuam tsis muaj pobzeb.

Muaj ntau txoj kev tshawb fawb hauv Unifiram dua nws cov neeg ua haujlwm Sunipiram, tab sis cov tshuaj no muaj ze ze thiab ntseeg tias yuav ua hauj lwm zoo ib yam.

Qhov tshwm sim ntawm cov kev tshawb fawb txog AMPA-receptor ua kom muaj kev koom tes hauv cov nyhuv antiamnesic ntawm Unifiram qhia, tias Unifiram ua lub zog ua kom paub txog kev txhim kho los ntawm kev ua haujlwm ntawm AMPA-mediated neurotransmission system. Qhov kev sib xyaw no, txawm hais tias tsis qhia sib raug zoo hauv txoj kev tshawb fawb rau qhov tseem ceeb tshaj plaws hauv lub hauv paus receptors lossis cov channel, muaj peev xwm tiv thaiv amnesia ntxias los ntawm kev hloov kho ntawm ob peb lub neurotransmission systems thiab muaj peev xwm nce kev tso tawm ntawm acetylcholine los ntawm cerebral cortex, tsawg kawg hauv kev tshawb fawb ntawm nas Cov.

Unifiram (DM232) Daim Ntawv Thov

DM232 (unifiram) yog AMPAkine-zoo li nootropic peb xaj ntawm qhov ntau ntau dua li piracetam hauv kev tshawb nrhiav tsiaj.

Hauv kev tshawb nrhiav, nws tau pom tias unifiram muaj qhov zoo li hauv qab no; anti-sedative thiab anti-hypnotic zoo, anti-amnesia thiab acetylcholine agonism. Hauv ib txoj kev tshawb nrhiav, nws tau pom tias unifiram tuaj yeem txo cov txiaj ntsig ntawm barbiturates uas yog hypnosis thiab kev ua kom loog. Txij li thaum acetylcholine yog sib raug zoo rau kev txhim kho kev nco thiab kev kawm, unifiram tuaj yeem, yog li ntawd, muaj txiaj ntsig zoo hauv kev tsim kho lub hlwb.

Unifiram (DM232) Kev Tshawb Fawb Ntau

Unifiram yog yeeb tshuaj hauv tsev neeg racetam. Nws cov qauv zoo li ampakine, thiab nws yog ze rau Sunifiram. Unifiram yog ib qho tseem ceeb tshaj plaws ntawm lub hlwb pab. Cov ntaub ntawv pov thawj tau pom tias nws yog ib txhiab zaus muaj zog tshaj li aniracetam. Cov kev sim tshuaj rau ib lub xyoo dhau los pom tias unifiram tuaj yeem txhawb kev nco thiab txhim kho kev txawj ntse zoo ib yam li lwm cov kev qhia uas yog racetam. Cov kev tshawb fawb pom tau tias unifiram yog ib qho zoo allosteric AMPA receptor modulator.

Nws ua kom txo tau cov txiaj ntsig ntawm kev tawm tsam ntawm NMDA, muscarinic thiab AMPA. AMPA thiab NMDA antagonist luam qhov ua haujlwm ntawm glutamate, thiab vim li ntawd, lawv ncaj qha cuam tshuam nrog kev nco thiab kawm hauv lub hlwb. Nws kuj tseem muaj peev xwm tswj tau glutamate kev nkag siab hauv lub hlwb li no txhim kho cov neuronal synaptic kis tau tus mob. Zoo li piracetam, oxiracetam, pramiracetam thiab Noopept, nws txhawb cov tshuaj acetylcholine ntau lawm.

Unifiram (DM232) Kev siv

• Cov Ntsiab Lus Ntxiv rau CID 9861054. (2018). PubChem: Qhib Ntaub Ntawv Txog Tshuaj, Teb Chaws Asmeskas Tuam Tsev Qiv Ntawv Tshuaj (online). Muaj los ntawm: https://pubchem.ncbi.nlm.nih.gov/compound/9861054 [Muaj Cai Siv Lub Xya Hli 19, 2018]
• Enantioselective synthesis thiab kev soj ntsuam ua ntej pharmacological ntawm tus enantiomers ntawm unifiram (DM232), lub zog ua kom muaj kev paub zoo-txhim kho tus neeg sawv cev -
• Galeotti, N .; Ghelardini, C .; Pittaluga, A .; Pugliese, A .; Bartolini, A .; Manetti, D .; Romanelli, M .; Gualtieri, F. (2003). "Ua kom AMPA-receptor ua kom muaj kev koom tes hauv cov txiaj ntsig antiamnesic ntawm DM 232 (unifiram) thiab DM 235 (sunifiram)". Naunyn-Schmiedeberg Cov Ntawv ntawm Cov Tshuaj Kho Mob. 368 (6): 538– doi: 10.1007 / s00210-003-0812-6. PMID 14600801.
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