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9-Kuv-BC (2521-07-5)

9-Methyl-β-carboline (9-Me-BC) hmoov yog cov tshuaj tshawb xyuas, uas yog heterocyclic amine. Kuj tseem hu ua 9-Me-BC, cov tshuaj yuav raug coj los ua haujlwm los ntawm kev ua haujlwm hauv Eschweiler - Clarke cov tshuaj tiv thaiv ntawm qhov khov ntawm beta-carboline. Tam sim no, 9-methyl-car-carboline raug suav hais tias yog ib qhov zoo tshaj plaws hauv chav Nootropics, tsim kom muaj kev cuam tshuam ntev ntawm cov kab mob dopamine hauv lub hlwb. Cov kev tshawb fawb tsis ntev los no qhia tias 9-me-bc hmoov tej zaum yuav muaj kev cuam tshuam hauv lub hlwb uas tuaj yeem tiv thaiv tus kab mob pathogenesis ntawm Parkinson tus kab mob. Cov tshuaj kuj tseem yuav pab txhawb cov neuron thiab neurite kev loj hlob, ua rau nws muaj kev cog lus zoo uas yuav raug siv los cuam tshuam nrog lub hlwb tsis zoo ntawm lub hlwb. Lwm qhov kev tshawb fawb tseem qhia tau tias 9-me-bc kuj tseem tuaj yeem tiv thaiv lub hlwb los ntawm kev puas tsuaj ntawm kev taug taug toxin. Dab tsi tiag tiag teev 9-methyl-bol-carboline sib nrug yog nws lub zog dopaminergic. Cov khoom no tuaj yeem txhim kho ntau yam ntawm kev paub hauv kev ua haujlwm hauv lub hlwb.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.

9-Me-BC hmoov (2521-07-5) video

 

9-Me-BC hmoov (2521-07-5) Cov Ntaub Ntawv Qhia Npe

lub npe 9-Me-BC / 9-methyl-9H-pyrido [3,4-b] hmoov indole
CAS 2521-07-5
purity 98%
Tshuaj lub npe 9-Methyl-9H-pyrido [3,4-b] indole
Synonyms Synonyms9-me-bc;9-Methyl-9H-β-carboline;9-Methyl-9H-beta-carboline;9-methyl-9H-pyrido[3,4-b]indole;9-Me-BC/9-methyl-9H-pyrido[3,4-b]indole;9-Methyl-9H-pyrido[3,4-b]indole
molecular Formula C12H10N2
molecular Nyhav 182.226 g / mol
Melting Point 105.0 - 109.0 ° C
InChI Qhov Tseem Ceeb MABOIYXDALNSES-UHFFFAOYSA-N
daim ntawv Khoom
tsos Dawb Hmoov
Ib Sim Neej Tsis paub
solubility Tsis paub
cia mob Tsis paub
Daim ntawv thov 9-Methyl-9H-pyrido [3,4-b] indole (cas # 2521-07-5) yog cov tshuaj tshawb nrhiav muaj txiaj ntsig.
Kuaj Cov Ntaub Ntawv Qhov

 

9-Methyl-β-Carboline yog dab tsi (9-Me-BC)?

Raws li twb tau hais los saum toj no, 9-Methyl-β-carboline yog ib qho tshuaj tshawb fawb uas tau pom ntau yam ntawm Nootropic. Cov tshuaj yuav tau coj los ua ke hauv cov lab siv cov tshuaj Eschweiler - Clarke cov tshuaj tiv thaiv.

Qhov no yog ib qho tshuaj lom neeg qhov twg cov tshuaj amine yog methylated siv cov txiaj ntsig ntawm cov formic acid thiab formaldehyde. Raws li 9-me-bc tshuaj xyuas cov lus tshaj tawm, cov tshuaj lom neeg yog ib feem ntawm tsev neeg beta-carboline thiab tau pom tias muaj ntau yam muaj zog dopaminergic cov khoom hauv ntau yam hauv kev tshawb fawb hauv vitro.

Hauv qee qhov kev tshawb nrhiav nas, 9-Methyl-β-carboline kuj tau pom tias yuav ua rau muaj kev nce siab ntawm hippocampal dopamine. Qhov no coj los txhim kho ntsig txog qhov kev kawm tau zoo los ntawm cov nas ntsuas hauv qhov kev ntsuas lub radial tshawb. Qhov no yog qhov laj thawj tseem ceeb vim li cas 9-Methyl-β-carboline pom tau tias yog Nootropic muaj txiaj ntsig zoo.

Tab sis hais tias tsis yog txhua txhua. Qee qhov kev tshawb fawb kuj tau qhia tias 9-Methyl-β-carboline tuaj yeem ua kom rov qab los ntawm tyrosine hydroxylase piav qhia cov neurons uas tuaj yeem pab tiv thaiv kab mob pathogenesis ntawm kev puas hlwb ntawm lub hlwb tsis zoo xws li Parkinson.

 

9-Methyl-β-Carboline Ua Haujlwm Li Cas?

Txij li 9-Methyl-β-carboline yog ib qho tshuaj lom neeg hauv kev sim, muaj cov ntaub ntawv me me tawm ntawm qhov ntawd seb nws ua haujlwm li cas. Tsuas yog qhov peb paub yog qhov tseeb tias cov khoom muaj Nootropic zog thiab qee qhov muaj zog dopaminergic stimulatory peev xwm. Tab sis tus mechanism ntawm kev txiav txim cuam tshuam nrog cov tshuaj tseem tsis tau meej. Nws tseem ceeb heev uas yuav tsum nco ntsoov tias tseem tsis tau muaj kev tshawb nrhiav tib neeg tiag tiag rau qhov cuam tshuam ntawm 9-Methyl-β-carboline.

Txog tam sim no, cov kws tshawb nrhiav tau ua cov kev tshawb fawb hauv vitro. Cov no yog ib txwm sim kev sim ua rau txheeb raws roj ntsha molecules sab nraum lub cev. Peb tseem tau pom cov kev tshawb fawb qws thiab zoo saib yuav ua li cas 9-Methyl-β-carboline cuam tshuam rau lub hlwb ua haujlwm. Txog tam sim no cov kev tshawb fawb no qhia tau ntau yam kev cog lus. Hauv cov kev tshawb fawb txog nas, tshwj xeeb, kev tshawb fawb qhia tias kev qhia ntawm 9-Methyl-bol-carboline tuaj yeem ua rau cov qib dopamine zoo dua hauv cov hippocampus, uas ua rau kev kawm paub thiab nco qab ntawm cov nas koom nrog txoj kev tshawb no.

Qhov kev cia siab rau tam sim no yog tias peb yuav pib pom cov kev tshawb fawb txog tib neeg hauv kev kawm ze yav tom ntej. Tab sis txog rau thaum ntawd, nws tseem nyuaj heev rau nkag siab txog cov haujlwm ua haujlwm ntawm 9-Methyl-β-carboline thiab cov txiaj ntsig zoo uas nws yuav muaj rau lub hlwb.

 

9-Methyl-β-Carboline (9-Me-BC) Cov txiaj ntsig / cuam tshuam

9-Methyl-β-carboline tuaj nrog cov txiaj ntsig. Muaj tej zaum cov tshuaj kuj yuav raug siv los ua kev tiv thaiv kev tiv thaiv rau kev puas hlwb hauv lub hlwb tab sis kev tshawb fawb ntawm qhov ntawd tseem tab tom ua.

Txawm li cas los xij, ntawm no yog qee qhov tseem ceeb tshaj plaws 9-me-bc teebmeem thiab cov txiaj ntsig:

  • Qee qhov kev tshawb fawb qhia tias 9-Methyl-β-carboline tuaj yeem ua rau muaj kev tsim cov tshuaj dopamine ntau ntxiv hauv hippocampus. Qhov no yuav ua rau txhim kho kev kawm thiab kev txawj ntse. Kev soj ntsuam soj ntsuam ntawm cov nas pom tias cov ntawv xeem tau muaj peev xwm sau tau qhov kev txhim kho zoo hauv kev kawm tom qab tau kho nrog 9-Methyl-β-carboline.
  • Kuj tseem muaj qee qhov kev tshawb fawb uas qhia txog kev qhia txog 9-Methyl-β-carboline tuaj yeem nce tus nqi uas cov neurotrophins tau tsim hauv lub hlwb. Qhov nce qib ntawm neurotrophins tau paub rau txhim kho kev nco thiab kev kawm hauv feem ntau cov neeg mob.
  • Peb kuj tau pom qee qhov kev tshawb fawb hauv cov vitro qhia tias 9-Methyl-β-carboline kuj yuav raug siv los ua kev tiv thaiv kab mob hauv cov kab mob kev sib deev ntawm Parkinson tus kab mob. Tab sis li cas qhov no ua haujlwm tseem tsis meej. Tseem muaj lus hais tias 9-Methyl-β-carboline kuj tseem siv tau los ua cov tshuaj tiv thaiv kev tiv thaiv hauv kev daws cov teeb meem ntawm lub hlwb yav tom ntej. Qhov no yog vim tias cov tshuaj muaj qee yam ntxwv uas yuav txo qis lipopolysaccharide lom hauv lub hlwb.
  • 9-Methyl-β-carboline kuj tseem tuaj yeem ua rau kom muaj zog ntau ntxiv ntawm ATP lossis Adenosine Triphosphate hauv lub hlwb. Qhov no yuav ua rau kev paub ntau dua ntawm cov haujlwm cov neeg mob.

 

9-Methyl-β-Carboline (9-Me-BC) Ntau npaum li cas

Txij li thaum tsis muaj tib neeg kev tshawb fawb kom deb li deb ntawm kev siv 9-Methyl-β-carboline, pinning hauv txoj kev muab tshuaj yog tsis yooj yim. Txawm li cas los xij, cov tuam ntxhab ntawm cov khoom no pom zoo kom ntau npaum ntawm 15mg ib hnub rau cov neeg laus.

Qhov no ntxig txhais rau ib qho tshuaj ntsiav ib hnub, uas yuav tsum tau noj thaum sawv ntxov. 9-Methyl-β-carboline raug nqos los ntawm lub qhov ncauj. Thaum koj twb tau noj lwm yam tshuaj lawm, sab laj nrog koj tus kws kho mob ua ntej siv cov tshuaj no. Txawm li cas los xij, cov ntaub ntawv hais txog 9-me-bc ib nrab-lub neej tsis muaj tseeb.

 

9-Methyl-β-Carboline (9-Me-BC) Sab Cuam Tshuam

Tsawg me ntsis yog paub txog cov kev pheej hmoo tshwm sim ntawm 9-Methyl-β-carboline. Txawm li cas los xij, qhov no suav hais tias yog kev nyab xeeb zoo siv tshuaj kom ntev li ntev tau koj nyob hauv qhov ntau npaum li cas. Ib qho khaws cia rau hauv siab txawm tias yog dopamine neurotoxicity.

Raws li koj paub, 9-Methyl-β-carboline ua rau cov khoom tsim cov dopamine ntau hauv lub hlwb. Yog tias cov qib no tau siab dhau, nws muaj kev pheej hmoo lawv yuav cuam tshuam rau kev ua haujlwm mitochondrial. Tab sis qhov no yog qee yam tsis tshua muaj thiab yuav tsum tsis muaj teeb meem rau cov neeg uas siv txoj kev siv tshuaj.

 

9-Methyl-β-Carboline (9-Me-BC) Hmoov Yuav

9-me-bc nootropic tuaj yeem muas tau ua hmoov hauv online. Muaj ntau cov neeg muag khoom hnub no uas nqa cov khoom tab sis tsis yog txhua tus yuav luag muaj txiaj ntsig uas koj xav tau. Nws yog feem ntau zoo dua rau qhov yuav tsum tau ceev faj ntxiv kom tsuas yog kom koj tau yuav khoom los ntawm cov khoom uas raug cai. Ib qho uas koj tuaj yeem ua yog kom paub tseeb tias koj tau yuav los ntawm cov neeg muag khoom nrog qee qhov kev paub hauv qhov no.

Txheeb xyuas cov kev txheeb xyuas kom zoo, cov neeg muag khoom uas muaj keeb kwm xa cov khoom lag luam zoo rau cov neeg siv khoom tau pom zoo. Tsis txhob hnov ​​qab txog tias pheej yig tuaj yeem yuav kim. Txawm hais tias Methyl-β-carboline tsis yog ib yam khoom kim, koj tseem yuav tsum tau siv cov nyiaj tsim nyog kom tau nws. Tab sis nws yuav tsim nyog.

 

9-Me-BC hmoov (2521-07-5) Kev siv

  1. Polanski, W; Enzensperger, C; Reichmann, H; Gille, G (2010). "Cov yam ntxwv tshwj xeeb ntawm 9-methyl-beta-carboline: kev txhawb nqa, tiv thaiv thiab tsim dua tshiab ntawm dopaminergic neurons txuas nrog cov tshuaj tiv thaiv zoo". J Neurochem. 113 (6): 1659– doi: 10.1111 / j.1471-4159.2010.06725.x. PMID 20374418.
  2. Hamann, J; Wernicke, C; Lehmann, J; Reichmann, H; Rommelspacher, H; Gille, G (2008). "9-Methyl-beta-carboline txhim kho-tswj hwm cov tsos ntawm txawv dopaminergic neurones hauv thawj cov cai mesencephalic". Neurochem. Rau cov menyuam. 52 (4–5): 688– doi: 10.1016 / j.neuint.2007.08.018. PMID 17913302.
  3. Herraiz, T; Guillén, H (2011). "Kev txwv tsis pub cov neeg ua haujlwm ntawm cov neurotoxin MPTP los ntawm cov tshuaj tua kab mob, cov tshuaj tiv thaiv redox thiab monoamine oxidase inhibitors". Khoom noj khoom haus Chem. Toxicol. 49 (8): 1773– doi: 10.1016 / j.fct.2011.04.026. hdl: 10261/63126. PMID 21554916.

 

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