Emoxypine hmoov (2364-75-2)

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Qeb: SKU: N / A

Lub npe: Emoxypine

CAS: 2364-75-2

Cov mis mos molecular: C8H11NO

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

 

Emoxypine hmoov (2364-75-2) video

 

Emoxypine hmoov Piav Cov Ntaub Ntawv

lub npe Emoxypine hmoov
CAS 2364-75-2
purity 98%
Tshuaj lub npe Mexidol; Mexifin
Synonyms Emoxipine, Emoxypin, Epigid, 6-Methyl-2-ethyl-3-hydroxypyridine
molecular Formula C8H11NO
molecular Nyhav 137.179 g g / mol
Melting Point 170 rau 172 ° C
InChI Qhov Tseem Ceeb JPGDYIGSCHWQCC-UHFFFAOYSA-N
daim ntawv Khoom
tsos Dawb rau Off-dawb hmoov
Ib Sim Neej 2-2.6 teev
solubility Zoo heev soluble hauv dej; DMSO (Tsawg me ntsis); Methanol (Tsawg me ntsis)
cia mob 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli).
Daim ntawv thov RAD140 yog qhov kev tshawb nrhiav thiab tsis yog steroidal xaiv androgen receptor modulator (SARM) rau kev kho mob ntawm tej yam mob xws li mob leeg thiab lub mis.
Kuaj Cov Ntaub Ntawv Qhov

 

Emoxypine hmoov General Cov Lus Qhia

Emoxypine (2-ethyl-6-methyl-3-hydroxypyridine) hmoov, tseem hu ua Mexidol lossis Mexifin thaum siv los ua succinate ntsev, yog ib qho tshuaj antioxidant tsim hauv Russiaby Pharmasoft Pharmaceuticals. Nws cov qauv ua kua zoo ib yam li pyridoxine (ib hom vitamin B6).

 

Emoxypine hmoov (2364-75-2) Keeb Kwm

Emoxypine hmoov tau thawj zaug tshaj tawm los ntawm LD Smirnov thiab KM Dumayev, tom qab ntawd kawm thiab tsim nyob rau hauv lub koom haum ntawm Pharmacology, Lavxias Academy ntawm Medical Science thiab National Scientific Center ntawm Bioactive Yam Kev Nyab Xeeb.

 

Emoxypine (2364-75-2) Lub Luag Haujlwm Ntawm Kev Ua

Emoxypine qhov kev ua ntawm kev ntseeg yog ntseeg tias nws cov tshuaj antioxidant thiab membrane-tiv thaiv cov teebmeem nrog cov hauv qab:

  • Emoxypine inhibits dawb radical oxidation ntawm biomembrane lipids, hnov ​​mob rau peroxide radicals ntawm lipids thawj thiab hydroxyl radical ntawm peptides
  • Nce kev ua haujlwm ntawm cov antioxidant enzymes, tshwj xeeb hais tias ntawm superoxide dismutase, lub luag hauj lwm rau kev tsim thiab kev noj cov lipid peroxides thiab cov pa oxygen nquag.
  • Txwv tsis pub dawb radicals thaum lub sijhawm coj los ua ke ntawm prostaglandin catalyzed cyclooxygenase thiab lipoxygenase, tsub kom cov correlation prostacyclin / thromboxane A2and thaiv kev tsim leukotriene.
  • Nce cov ntsiab lus ntawm polar feem ntawm lipids (phosphatidyl serine thiab phosphatidyl inositol) thiab txo cov roj (cholesterol) / phospholipids piv uas ua pov thawj cov lipid-cov cai tswj; hloov cov qauv hloov mus rau qhov chaw tsis tshua muaj kub, uas yog pov thawj kom txo cov membrane viscosity thiab qhov nce ntawm nws qhov kev npliag siab, nce lipid-protein piv.
  • Modulates cov kev ua si ntawm daim nyias nyias-ua enzymes: phosphodiesterase, cyclicnucleotides, adenylate cyclase, aldoreductase, acetylcholinesterase.
  • Modulates receptor complexes ntawm lub hlwb puas hlwb, piv txwv li benzodiazepine, GABA, acetylcholine receptors los ntawm kev ua rau lawv muaj peev xwm khi.
  • Stabilizes biomembranes, piv txwv li cov txheej txheem membrane ntawm cov ntshav ntshav - erythrocytes thiab thrombocytes thaum lawv haemolysis lossis kev raug mob tshuab nrog tsim cov dawb radicals.
  • Hloov cov qib monoamine thiab nce dopamine cov ntsiab lus hauv lub hlwb.

Emoxypine (2364-75-2) Daim Ntawv Thov

Hauv tebchaws Russia, emoxypine muaj ntau yam kev thov hauv kev kho mob. Nws purportedly siv anxiolytic, anti-stress, anti-alcohol, anticonvulsant, nootropic, neuroprotective thiab anti-inflammatory kev txiav txim. Emoxypine tuaj yeem txhim kho cov ntshav ncig hauv lub cev, tiv thaiv kev sib koom ua ke ntawm thrombocyte, txo qis cov roj cholesterol, muaj cardioprotective thiab ua haujlwm tiv thaiv kab mob plawv.

 

Emoxypine (2364-75-2) Kev Tshawb Fawb Ntau

Ib txoj kev tshawb nrhiav tau txiav txim qhov muaj txiaj ntsig ntawm emoxypine nyob rau hauv 205 cov neeg mob uas tau soj ntsuam kev mob ntawm lumbosacral radiculopathy (LSR). Cov neeg mob tau muab faib ua ob pawg, thiab txuas ntxiv tau muab faib ua pawg neeg sib txawv nyob ntawm seb puas muaj qhov tsis sib haum ntawm lub cev. Txhua tus neeg mob tau txais ib chav kawm ntawm kev kho mob sib xws thiab kho cev nqaij daim tawv; pawg tseem ntxiv tau txais emoxypine. Tom qab ntawd, kev soj ntsuam mob-neurological ntawm kev soj ntsuam mus sij hawm ntev hauv kev kho mob hauv ib pawg neeg mob ntawm cov neeg mob tau ua. Cov txiaj ntsig tau pom tias kev siv emoxypine hauv kev kho mob sib xyaw ua ke ntawm cov neeg mob nrog LSR ua rau txo qis qhov tseem ceeb ntawm kev mob hnyav thiab kev rov ua haujlwm sai sai ntawm kev ua haujlwm ntawm tus txha caj qaum thiab cov hlab ntsha ib leeg piv nrog kev kho mob.

 

Emoxypine (2364-75-2) Kev siv

[1] Dumayev KM, Voronina TA, Smirnov LD cov tshuaj tiv thaiv kab mob hauv txoj kev tiv thaiv thiab kho CNS pathologies. Moscow, 1995

[2] Kucheryanu, VG (Lub Ib Hlis 2001). "Mexidol potentiates antiparkinsonian effectof L-DOPA hauv MPTP-induced parkinsonism model". Eksperimental'naia kuv klinicheskaia farmakologiia. 64 (1): 22-25.

[3] Likhacheva, EB; Sholomov, II (2006). "Kev kuaj mob thiab tshuaj tiv thaiv kab mob ua tau zoo ntawm mexidol hauv kev kho mob ntawm lumbosacral radiculopathy". ZhurnalNevrologii thiab Psikhiatrii Imeni SS Korsakova. 106 (10): 52–7.

 

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