Nicotinamide Riboside Chloride hmoov (23111-00-4)

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Lub npe: Nicotinamide Riboside Chloride

CAS: 23111-00-4

Cov roj formula: C11H15ClN2O5

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

Nicotinamide Riboside Chloride hmoov ua yeeb yaj kiab

 

Nicotinamide Riboside Chloride hmoov (23111-00-4) Cov Ntaub Ntawv Cov Lus Qhia

lub npe Nicotinamide Riboside Chloride hmoov
CAS 23111-00-4
purity 98%
Tshuaj lub npe 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Synonyms Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, β / β sib xyaw
molecular Formula C11H15ClN2O5
molecular Nyhav 290.7 g / mol
Melting Point 115 ℃-125 ℃
InChI Qhov Tseem Ceeb YABIFCKURFRPPO-FSDYPCQHSA-N
daim ntawv Khoom
tsos Tawm Dawb rau Tawv daj hmoov
Ib Sim Neej 2.7 teev
solubility Soluble hauv DMSO
cia mob Qhuav, tsaus thiab nyob rau hauv 0 - 4 C rau lub sij hawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sij hawm ntev (hli txog xyoo).
Daim ntawv thov Nicotinamide riboside yog ib hom pyridine-nucleoside ntawm cov vitamins B3 .Nws Nootropics
Kuaj Cov Ntaub Ntawv Qhov

 

Nicotinamide Riboside Chloride hmoov (23111-00-4) Cov Lus Qhia dav dav

Nicotinamide Riboside Chloride hmoov nucleosides yog qhov ua ntej ntawm nicotinamide adenine dinucleotide (NAD) thiab sawv cev rau cov khoom siv ntawm vitamin B3. Cov kev tshawb fawb tsis ntev los no tau pom tias kev noj ntau npaum li cas ntawm nicotinamide nucleosides ib txwm muaj hauv cov zaub mov tuaj yeem muab cov txiaj ntsig kev noj qab haus huv tshiab. Piv txwv, nicotinamide nucleosides tau txais qhov cuam tshuam hauv kev nce hauv cov nqaij mos NAD concentration thiab inulin insulin rhiab li txhim kho sirtuin muaj nuj nqi. Nws lub peev xwm los nce NAD ntau lawm qhia tias nicotinamide nucleosides kuj tseem tuaj yeem txhim kho kev noj qab haus huv mitochondrial, txhawb kev ua mitochondrial, thiab ntxias cov mitochondria tshiab. Lwm yam kev tshawb fawb uas siv nicotinamide nucleosides hauv Alzheimer tus qauv kab mob tau pom tias cov lwg me me muaj nyob rau lub hlwb thiab yuav muab cov neuroprotection los ntawm kev txhawb cov hlwb NAD synthesis.

 

Nicotinamide Riboside Chloride Keeb kwm

Nyob rau ntawm kev tshawb fawb xyoo 2012 pom tias nas tau noj cov zaub mov muaj roj ntau ntau ntxiv nrog cov nicotinamide nucleosides muaj 60% kev txo qhov hnyav nce piv rau cov nas uas noj cov tib cov zaub mov muaj roj ntau ntau yam tsis muaj nicotinamide nucleoside.

Ua ib qho tshuaj tua kab mob los tiv thaiv kab mob, doxorubicin yog ib qho zoo tshaj plaws thiab siv tshuaj kho mob hauv kev kho mob ntawm ntau yam mob qog. Hmoov tsis zoo, ntau caum xyoo, nws cov cardiotoxicity hauv kev kho mob qog noj ntshav tau txwv tsis pub siv tshuaj kho mob.

 

Nicotinamide Riboside Chloride Txheej Txheem Ntawm Kev Ua

Nicotinamide Riboside (NR) yog ib daim ntawv pom ntev los ntawm cov vitamin B3 uas tuaj yeem nce qib ntawm Nicotinamide Adenine Dinucleotide (NAD +) ntau hauv tib neeg.

NAD + yog ib qho tseem ceeb sib koom ua ke uas lub mitochondria nyob rau hauv txhua lub xov tooj ntawm peb lub cev nyob ntawm cov roj ua txhua yam haujlwm yooj yim.

NAD + qib poob zuj zus raws li peb muaj hnub nyoog thiab thaum peb lub cev muaj kev ntxhov siab los ntawm tus kab mob lossis mob mob mus ntev.

Niacinamide yog ib qho ua ke ntawm coenzyme I thiab coenzyme II, ua lub coenzyme ntawm ntau cov dehydrogenases.

Hauv kev ua zaub mov noj, nicotinamide siv nrog Vc ua cov xim qub

Niacin tseem hu ua vitamin B3, lossis vitamin PP, Niacin tseem raug hu ua nicotinic acid thiab niacin. Tib neeg lub cev tseem suav nrog nws cov derivative nicotinamide lossis nicotinamide. Nws yog ib qho ntawm 13 vitamins tsim nyog rau tib neeg lub cev, yog dej-soluble vitamin, belongs rau tsev neeg B ntawm vitamin B. Nicotinic acid hauv hloov mus rau hauv niacinamide, nicotinamide coenzyme thiab ib feem ntawm coenzyme, koom nrog cov metabolism ntawm lipids thiab nqaij. kev ua pa ntawm cov txheej txheem oxidation thiab cov txheej txheem ntawm anaerobic decomposition qab zib.

 

Nicotinamide Riboside Chloride Ua Ntawv Thov

Cov kev tshawb fawb pom tau qhia tias qhov sib ntxiv ntawm nicotinamide ribose tsis tuaj yeem tsuas yog nce NAD + qib kev nyab xeeb, tab sis kuj tseem siv qhov kev siv NAD + ntau tshaj nyob hauv tib neeg, uas tsis tau muaj nrog lwm cov vitamin B3. Cov neeg qhia tau pom tias ib zaug nicotinamide ribose tshwm hauv lub cell, lub cev hloov pauv nws mus rau hauv NAD +. Cov NAD + no tsim kho cov txheej txheem ntawm intracellular pib ntawm lub zog tsim khoom los ntawm mitochondria

Nicotinamide Riboside Chloride tuaj yeem txhim kho mitochondrial muaj nuj nqi, uas tau qhia los txhim kho kev nthuav qhia ntawm mitochondrial electron thauj cov saw hlau protein, txhim kho mitochondrial membrane muaj peev xwm, thiab nce tus nqi oxidative ua pa thiab intracellular ATP qib. Qhov no yuav suav nrog qib siab dua ntawm kev tsim kho mitochondrial. Mitochondrial muaj nuj nqi poob qis raws li peb hnub nyoog, thiab qhov no yog lub cim ntawm kev laus ntawm cov qia hlwb uas peb pom. NR tuaj yeem txhim kho kev ua haujlwm ntawm mitochondria thiab inhibit lub senescence ntawm qia hlwb.

 

Nicotinamide Riboside Chloride Kev tshawb fawb ntxiv

Nicotinamide nucleosides yog qhov ua ntej ntawm nicotinamide adenine dinucleotide (NAD) thiab sawv cev rau cov khoom siv ntawm vitamin B3. Cov kev tshawb fawb tsis ntev los no tau pom tias kev noj ntau npaum li cas ntawm nicotinamide nucleosides ib txwm muaj hauv cov zaub mov tuaj yeem muab cov txiaj ntsig kev noj qab haus huv tshiab. Piv txwv, nicotinamide nucleosides tau txais qhov cuam tshuam hauv kev nce hauv cov nqaij mos NAD concentration thiab inulin insulin rhiab li txhim kho sirtuin muaj nuj nqi. Nws lub peev xwm los nce NAD ntau lawm qhia tias nicotinamide nucleosides kuj tseem tuaj yeem txhim kho mitochondrial kev noj qab haus huv, txhawb kev ua haujlwm mitochondrial, thiab ntxias cov mitochondria tshiab. Lwm yam kev tshawb fawb siv nicotinamide nucleosides hauv Alzheimer tus qauv kab mob tau pom tias cov lwg me me muaj nyob rau hauv lub hlwb thiab tuaj yeem muab cov neuroprotection los ntawm kev txhawb cov hlwb NAD synthesis.

Nicotinamide Riboside Chloride kuj tuaj yeem txo qhov hnyav: Kev tshawb fawb pom tau tias los ntawm kev nce lub zog hauv lub cev, koj tuaj yeem txo cov khoom noj muaj roj ntau ntau hauv lub cev nyhav. Txhawm rau ntsuas lub nicotinamide ribose mechanism ntawm NR txhawb kev poob phaus, cov neeg tshawb nrhiav ntsuas lub siab mitochondrial muaj nuj nqi txuam nrog caloric kom tsawg, kev ua si, calories, lub duav ib puag ncig, so tus nqi metabolic, lub cev muaj pes tsawg, muaj siab ntev, insulin rhiab heev thiab ntau yam biochemical thiab metabolomics tsis. Cov ntaub ntawv no thiab cov ua kom poob phaus tshiab los ntawm malabsorption, kev nthuav tawm ntawm cov cim roj ntsha rau kev taug qab. Cov kws tshawb nrhiav tau tshaj tawm tias cov nas noj cov zaubmov nicotinamide muaj txiaj ntsig zoo rau kev poob phaus ntawm cov nas uas tsis ntxiv cov tshuaj nicotinamide.

 

Nicotinamide Riboside Chloride Siv

  • Chi Y, Sau AA. Nicotinamide riboside, ib txoj lw noj zaub mov hauv cov zaub mov, yog cov vitamin B3 uas muaj cov teebmeem ntawm lub zog metabolism thiab neuroprotection. Curr Opin Clin Nutr Metab Tu Neeg. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Ntsuam Xyuas. PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, thiab nicotinamide riboside: ib qho kev soj ntsuam molecular ntawm NAD + cov kab mob ua ntej cov vitamins hauv tib neeg cov khoom noj khoom haus. Annu Rev Nutr. Xyoo 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Ntsuam Xyuas. PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation ua cov cell-intrinsic, cov tsav tsheb hloov pauv ntawm cov rog cia: cov tshuaj lom thiab cov metabolism hauv kev hloov kho ntawm acetyl-lysine kev hloov kho. Ntxov Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Ntsuam Xyuas. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • Yang Y, Sau AA. NAD (+) metabolism: Bioenergetics, taw qhia thiab thev naus laus zis rau kev kho. Biochim Biophys Acta. 2016 Dec; 1864 (12): 1787-1800. doi: 10.1016 / j.bbapap.2016.06.014. Ntsuam Xyuas. PubMed PMID: 27374990.
  • Qhov Zoo tshaj Nootropic Tshooj Qhia: Txhua Yam Koj Yuav Tsum Tau Paub [5 Xyoo Kev Ua Haujlwm]
  • Txhua Yam Koj Yuav Tsum Tau Paub Txog Nicotinamide Riboside Chloride

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