cov khoom siv

IDRA-21 hmoov (22503-72-6)

IDRA-21 hmoov yog ib qho kev tshawb nrhiav cov tshuaj lom neeg cov tshuaj raws li ampakine. Ampakines cuam tshuam rau glutamatergic AMPA receptor. Nws muaj peev xwm txhim kho kom pom tseeb thiab mloog zoo li txhawb kev kawm thiab nco qab. Ampakines tab tom loj hlob hauv kev muaj npe ntau vim tias lawv muab cov kev txawj ntse ntawm cov stimulants yam tsis muaj kev mob tshwm sim uas tsis xav ua. Thiab IDRA-21 yog qhov zoo sib ntxiv ntawm cov qauv AMPA receptor thiab benzothiadiazine derivative. Nws yog cov nplauv-luav qauv, nrog (+) - IDRA-21 yog daim foos.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.

IDRA-21 hmoov (22503-72-6) daim video

 

IDRA-21 hmoov Cov Lus Qhia Yooj Yim

lub npe IDRA-21 hmoov
CAS 22503-72-6
purity 98%
Tshuaj lub npe 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide
Synonyms IDRA-21; IDRA 21; IDRA 21.
molecular Formula C8H9ClN2O2S
molecular Nyhav 232.682
Melting Point Tsis paub
InChI Qhov Tseem Ceeb VZRNTCHTJRLLTMU-UHFFFAOYSA-N
daim ntawv khoom
tsos Dawb rau hmoov av dawb
Ib Sim Neej 24/36 teev
solubility soluble hauv DMSO (100mM)
cia mob Khw nyob RT
Daim ntawv thov Ib qho lus piv txwv ntawm cyclothiazide uas Inhibits AMPA receptor desensitization
Kuaj Cov Ntaub Ntawv Qhov

 

IDRA-21 hmoov General Cov Lus Qhia

IDRA-21 hmoov yog cais raws li ampakine. Nws muaj peev xwm txhim kho kom pom tseeb thiab mloog zoo li txhawb kev kawm thiab nco qab. Ampakines tab tom loj hlob hauv kev muaj npe ntau vim tias lawv muab cov kev txawj ntse ntawm cov stimulants yam tsis muaj kev mob tshwm sim uas tsis xav ua.

Hauv xyoo 1995 kev tshawb fawb tau ua los ntawm cov nas, IDRA-21 txo qhov kev xav ntawm kev nkag siab los ntawm alprazolam (Xanax). Xyoo ntawd, lwm txoj kev tshawb pom pom tias qhov kev xav tsis meej pom tshwm sim los ntawm scopolamine tau rov qab rau hauv cov liab los ntawm IDRA-21. Tsis muaj kev tshawb nrhiav tib neeg li cas tau ua tiav.

 

IDRA-21 hmoov (22503-72-6) Keeb Kwm

IDRA-21 hmoov yog qhov zoo sib ntxiv ntawm cov tshuaj AMPA receptor thiab benzothiadiazine derivative. Nws yog cov nplauv-luav qauv, nrog (+) - IDRA-21 yog daim foos.

IDRA-21 yog cov tsiaj txhu hauv kev tshawb nrhiav tsiaj, pab txhim kho kev kawm thiab nco qab. Nws yog nyob ib ncig ntawm 10-30 lub sijhawm ntau zog tshaj li aniracetam hauv thim rov qab qhov kev xav ntawm kev nkag los ntawm alprazolam lossis scopolamine, thiab tsim cov kev mob siab ntev txog li 48 teev tom qab ib koob nkaus.Qhov mechanism rau qhov kev txiav txim no yog xav tau los ntawm kev txhawb nqa qhov induction ntawm lub sij hawm ntev potentiation ntawm synapses hauv lub hlwb.

IDRA-21 tsis tsim cov neurotoxicity nyob rau hauv ib txwm mob, txawm hais tias nws yuav ua rau cov neuronal puas tsuaj raws li ntiaj teb ischemia tom qab mob stroke lossis qaug dab peg.

Hauv kev sib piv rau cov ampakines lossis benzoylpiperidine-tau los ntawm AMPA receptor potentiators, IDRA-21 muaj hwj chim ntau dua CX-516, tab sis muaj zog tsawg dua CX-546. Cov tshuaj benzothiadiazide ntau dua nrog cov muaj zog ntau dua piv rau IDRA-21 tau tsim, tab sis cov no tsis tau tshawb nrhiav rau tib yam, nrog benzoylpiperidine thiab benzoylpyrrolidine CX-series ntawm cov tebchaw tau ua rau muaj kev pom zoo rau kev txhim kho hauv chaw kho mob, feem ntau yuav yog vim muaj cov tshuaj lom ntau dua. profiles ntawm qib siab.

 

IDRA-21 (22503-72-6) Mechanism Ntawm Kev Ua

IDRA-21 raws li cov tshuaj ampakine stimulant tshuaj, stimulants yog allosteric modulators ntawm AMPA receptors hauv lub hlwb. Cov AMPA receptors yog lub luag haujlwm rau kev ceev ceev synaptic kis tau tus mob thiab tau koom nrog synaptic plasticity thiab lub zog ntev. Ua ib ampakine lub IDRA-21 ua haujlwm los ntawm kev hloov kho ntawm AMPA receptors hauv lub hlwb. Nws yog lub luag haujlwm los khi rau lub vev xaib tag nrho txuas ntxiv thiab tom qab ntawd yuam kev ntsuas zoo. Qee tus neeg xa mus rau cov txheej txheem no raws li kev ua kom zoo.

IDRA-21 yog benzothiadiazine derivative nrog nootropic cov yam ntxwv. Nws yog "yuav muaj peev xwm IDRA 21 exerts nws cov cwj pwm cuam tshuam los ntawm antagonizing AMPA receptor desensitization." Ampakines txhawb nqa glutamatergic AMPA receptors. Qhov no pab tau txoj kev mloog zoo thiab nthuav dav, ua rau hauv chav kawm ntawm cov tshuaj no txaus siab rau kev kho mob ntawm kev kawm tsis taus ntxiv nrog rau kev nthuav dav dav. Ntau dhau lo glutamate tuaj yeem ua rau ntxhov siab lossis poob siab, tsawg dhau vim yog inertia thiab apathy.

 

IDRA-21 (TSI22503-72-6) Daim Ntawv Thov

IDRA-21 yog benzothiadiazine derivative thiab tus qauv zoo tag nrho theglutamate AMPA receptors (1,2,3,4). Nws muaj peev xwm nce excitatory synaptic zog los ntawm inhibiting AMPA receptor desensitization. IDRA 21 tej zaum yuav ua rau pom muaj kev cuam tshuam rau kev kho qhov tsis nco qab hauv cov neeg mob uas muaj kev puas hlwb xws li Alzheimer tus kab mob.

IDRA-21 kuj tseem xav ua kom muaj lub zog muaj zog ntev (LTP). LTP yog kev txhim kho ntev nyob hauv yuav ua li cas cov neurons sib txuas lus nrog hauv lub hlwb. Nws yog qhov tseem ceeb rau kev txhim kho synaptic plasticity, uas ntxiv dag zog rau synapses hauv lub hlwb. Raws li synapses feem ntau yog lub luag haujlwm rau nco, txhim kho lawv lub zog thiab kev ua haujlwm yog qhov tseem ceeb rau txhim kho kev paub tag nrho.

 

IDRA-21 (22503-72-6) Kev Tshawb Fawb Ntau

Hauv kev sib piv rau cov ampakines lossis benzoylpiperidine-tau los ntawm AMPA receptor potentiators, IDRA-21 muaj hwj chim ntau dua CX-516, tab sis muaj zog tsawg dua CX-546. Cov tshuaj benzothiadiazide tshiab nrog ntau dua potency piv rau IDRA-21 tau tsim, tab sis cov no tsis tau tshawb nrhiav rau tib yam, nrog benzoylpiperidine thiab benzoylpyrrolidine CX-series ntawm cov tshuaj pom zoo rau kev txhim kho hauv chaw kho mob, feem ntau yuav yog vim muaj cov tshuaj lom ntau dua. profiles ntawm qib siab.

IDRA-21 yog ib qho tshuaj tshawb fawb los siv rau kev tshawb fawb pom zoo los ntawm cov chaw tswj kev cai hauv koj thaj av.

 

IDRA-21 (22503-72-6) Kev siv

  • Malkova L, Kozikowski AP, Gale K. Qhov cuam tshuam ntawm huperzine A thiab IDRA 21 ntawm cov cim pom tau zoo nco txog cov hluas macaques. Neuropharmacology. 2011 Lub Hlis; 60 (7-8): 1262-8. doi: 10.1016 / j.neuropharm.2010.12.018. Epub 2010 Dec 23. PubMed PMID: 21185313; PubMed Central PMCID: PMC3073152.
  • Buccafusco JJ, Weiser T, Lub Caij Ntuj Sov K, Klinder K, Terry AV. Qhov cuam tshuam ntawm IDRA 21, qhov hloov kho zoo ntawm AMPA receptor, ntawm kev ncua kev txuam nrog kev ua yeeb yam los ntawm cov hluas thiab hnub nyoog rhesus liab. Neuropharmacology. 2004 Jan; 46 (1): 10-22. PubMed PMID: 14654093.
  • Losi G, Puia G, Braghiroli D, Baraldi M. IDRA-21, tus qauv zoo AMPA receptor modulator, inhibits synaptic thiab extrasynaptic NMDA receptor mediated cov xwm txheej hauv kab lis kev cai cerebellar granule hlwb. Neuropharmacology. 2004 Lub Rau Hli; 46 (8): 1105-13. PubMed PMID: 15111017.
  • IDRA-21 Cov Hmoov Noj Nqaij, Ib nrab ntawm lub neej, muaj txiaj ntsig, Sab Cuam Tshuam, thiab Tshuaj Xyuas.

 

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