IDRA-21 - tshiab

IDRA-21-lable-tshiab

IDRA-21 hmoov (22503-72-6)

$14.99

Kev xa khoom pub dawb rau kev txiav txim ntau dua US $ 249 (USA thiab Asia)
Kev xa khoom pub dawb rau kev txiav txim ntau dua US $ 349 (Tebchaws Europe)
5-10 teev (hauv hnub ua haujlwm) ceev shipping

Tsuas yog 14 sab lauj! 65 tus neeg tab tom saib qhov no thiab 21 tus neeg muaj nws hauv lawv lub laub.

Tsis paub Yuav Ua Li Cas Qhov Kev Txiav Txim?

Nyem qhov no

[1]. Xaiv qhov koj xav tau, tom qab ntawd ntxiv rau lub laub

[2]. Txuas mus xyuas

[3]. Sau koj cov ntaub ntawv nthuav dav, qhov * yuav tsum tau, xaiv koj txoj kev them nyiaj. Muaj ntau txoj kev them nyiaj sib txawv suav nrog:
-Direct Bank Transfer
- Kev them nyiaj npib: Bitcoin, Ether, USDT
Ces nyem "Place order"
Lub tswv yim: email chaw nyob yuav tsum tau kho, cov ntaub ntawv taug qab yuav hloov tshiab los ntawm email ceeb toom

[4]. Yog tias xaiv "Coinpayment", tom qab nyem "Place order", ces yuav qhia raws li hauv qab no them

[5]. Yog tias Xaiv "Direct Bank Transfer", tom qab nias "Place order", ces yuav qhia raws li hauv qab no, yuav tshwm sim cov ntsiab lus ntawm tus account hauv txhab nyiaj, tom qab hloov lub txhab nyiaj (thov siv koj tus lej xaj raws li qhov siv), xa daim ntawv hauv txhab nyiaj rau peb.

[6]. Kev them nyiaj lees paub
[7]. Parcel xa tawm li 5-10 teev (hauv hnub ua haujlwm)
[8]. Tus lej taug qab tau muab
[9]. Parcel tuaj txog
[10]. Rov xaj dua

Tsis muaj koj qhov ntau? Nyem no

Ceeb toom: Yog tias koj cev xeeb tub, saib xyuas neeg mob, noj cov tshuaj los yog muaj kev mob nkeeg nrog koj tus kws kho mob ua ntej siv. Khaws kom deb ntawm cov menyuam yaus.

Qeb: Nootropics hmoovSKU: N / A

Lub npe: IDRA-21

CAS: 22503-72-6

Cov mis mos molecular: C8H9ClN2O2S

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

IDRA-21 hmoov (22503-72-6) daim video

IDRA-21 hmoov Cov Lus Qhia Yooj Yim

lub npe	IDRA-21 hmoov
CAS	22503-72-6
purity	98%
Tshuaj lub npe	7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide
Synonyms	IDRA-21; IDRA 21; IDRA 21.
molecular Formula	C8H9ClN2O2S
molecular Nyhav	232.682
Melting Point	Tsis paub
InChI Qhov Tseem Ceeb	VZRNTCHTJRLLTMU-UHFFFAOYSA-N
daim ntawv	khoom
tsos	Dawb rau hmoov av dawb
Ib Sim Neej	24/36 teev
solubility	soluble hauv DMSO (100mM)
cia mob	Khw nyob RT
Daim ntawv thov	Ib qho lus piv txwv ntawm cyclothiazide uas Inhibits AMPA receptor desensitization
Kuaj Cov Ntaub Ntawv	Qhov

IDRA-21 hmoov General Cov Lus Qhia

IDRA-21 hmoov yog cais raws li ampakine. Nws muaj peev xwm txhim kho kom pom tseeb thiab mloog zoo li txhawb kev kawm thiab nco qab. Ampakines tab tom loj hlob hauv kev muaj npe ntau vim tias lawv muab cov kev txawj ntse ntawm cov stimulants yam tsis muaj kev mob tshwm sim uas tsis xav ua.

Hauv xyoo 1995 kev tshawb fawb tau ua los ntawm cov nas, IDRA-21 txo qhov kev xav ntawm kev nkag siab los ntawm alprazolam (Xanax). Xyoo ntawd, lwm txoj kev tshawb pom pom tias qhov kev xav tsis meej pom tshwm sim los ntawm scopolamine tau rov qab rau hauv cov liab los ntawm IDRA-21. Tsis muaj kev tshawb nrhiav tib neeg li cas tau ua tiav.

IDRA-21 hmoov (22503-72-6) Keeb Kwm

IDRA-21 hmoov yog qhov zoo sib ntxiv ntawm cov tshuaj AMPA receptor thiab benzothiadiazine derivative. Nws yog cov nplauv-luav qauv, nrog (+) - IDRA-21 yog daim foos.

IDRA-21 yog cov tsiaj txhu hauv kev tshawb nrhiav tsiaj, pab txhim kho kev kawm thiab nco qab. Nws yog nyob ib ncig ntawm 10-30 lub sijhawm ntau zog tshaj li aniracetam hauv thim rov qab qhov kev xav ntawm kev nkag los ntawm alprazolam lossis scopolamine, thiab tsim cov kev mob siab ntev txog li 48 teev tom qab ib koob nkaus.Qhov mechanism rau qhov kev txiav txim no yog xav tau los ntawm kev txhawb nqa qhov induction ntawm lub sij hawm ntev potentiation ntawm synapses hauv lub hlwb.

IDRA-21 tsis tsim cov neurotoxicity nyob rau hauv ib txwm mob, txawm hais tias nws yuav ua rau cov neuronal puas tsuaj raws li ntiaj teb ischemia tom qab mob stroke lossis qaug dab peg.

Hauv kev sib piv rau cov ampakines lossis benzoylpiperidine-tau los ntawm AMPA receptor potentiators, IDRA-21 muaj hwj chim ntau dua CX-516, tab sis muaj zog tsawg dua CX-546. Cov tshuaj benzothiadiazide ntau dua nrog cov muaj zog ntau dua piv rau IDRA-21 tau tsim, tab sis cov no tsis tau tshawb nrhiav rau tib yam, nrog benzoylpiperidine thiab benzoylpyrrolidine CX-series ntawm cov tebchaw tau ua rau muaj kev pom zoo rau kev txhim kho hauv chaw kho mob, feem ntau yuav yog vim muaj cov tshuaj lom ntau dua. profiles ntawm qib siab.

IDRA-21 (22503-72-6) Mechanism Ntawm Kev Ua

IDRA-21 raws li cov tshuaj ampakine stimulant tshuaj, stimulants yog allosteric modulators ntawm AMPA receptors hauv lub hlwb. Cov AMPA receptors yog lub luag haujlwm rau kev ceev ceev synaptic kis tau tus mob thiab tau koom nrog synaptic plasticity thiab lub zog ntev. Ua ib ampakine lub IDRA-21 ua haujlwm los ntawm kev hloov kho ntawm AMPA receptors hauv lub hlwb. Nws yog lub luag haujlwm los khi rau lub vev xaib tag nrho txuas ntxiv thiab tom qab ntawd yuam kev ntsuas zoo. Qee tus neeg xa mus rau cov txheej txheem no raws li kev ua kom zoo.

IDRA-21 yog benzothiadiazine derivative nrog nootropic cov yam ntxwv. Nws yog "yuav muaj peev xwm IDRA 21 exerts nws cov cwj pwm cuam tshuam los ntawm antagonizing AMPA receptor desensitization." Ampakines txhawb nqa glutamatergic AMPA receptors. Qhov no pab tau txoj kev mloog zoo thiab nthuav dav, ua rau hauv chav kawm ntawm cov tshuaj no txaus siab rau kev kho mob ntawm kev kawm tsis taus ntxiv nrog rau kev nthuav dav dav. Ntau dhau lo glutamate tuaj yeem ua rau ntxhov siab lossis poob siab, tsawg dhau vim yog inertia thiab apathy.

IDRA-21 (TSI22503-72-6) Daim Ntawv Thov

IDRA-21 yog benzothiadiazine derivative thiab tus qauv zoo tag nrho theglutamate AMPA receptors (1,2,3,4). Nws muaj peev xwm nce excitatory synaptic zog los ntawm inhibiting AMPA receptor desensitization. IDRA 21 tej zaum yuav ua rau pom muaj kev cuam tshuam rau kev kho qhov tsis nco qab hauv cov neeg mob uas muaj kev puas hlwb xws li Alzheimer tus kab mob.

IDRA-21 kuj tseem xav ua kom muaj lub zog muaj zog ntev (LTP). LTP yog kev txhim kho ntev nyob hauv yuav ua li cas cov neurons sib txuas lus nrog hauv lub hlwb. Nws yog qhov tseem ceeb rau kev txhim kho synaptic plasticity, uas ntxiv dag zog rau synapses hauv lub hlwb. Raws li synapses feem ntau yog lub luag haujlwm rau nco, txhim kho lawv lub zog thiab kev ua haujlwm yog qhov tseem ceeb rau txhim kho kev paub tag nrho.

IDRA-21 (22503-72-6) Kev Tshawb Fawb Ntau

Hauv kev sib piv rau cov ampakines lossis benzoylpiperidine-tau los ntawm AMPA receptor potentiators, IDRA-21 muaj hwj chim ntau dua CX-516, tab sis muaj zog tsawg dua CX-546. Cov tshuaj benzothiadiazide tshiab nrog ntau dua potency piv rau IDRA-21 tau tsim, tab sis cov no tsis tau tshawb nrhiav rau tib yam, nrog benzoylpiperidine thiab benzoylpyrrolidine CX-series ntawm cov tshuaj pom zoo rau kev txhim kho hauv chaw kho mob, feem ntau yuav yog vim muaj cov tshuaj lom ntau dua. profiles ntawm qib siab.

IDRA-21 yog ib qho tshuaj tshawb fawb los siv rau kev tshawb fawb pom zoo los ntawm cov chaw tswj kev cai hauv koj thaj av.

IDRA-21 (22503-72-6) Kev siv

Malkova L, Kozikowski AP, Gale K. Qhov cuam tshuam ntawm huperzine A thiab IDRA 21 ntawm cov cim pom tau zoo nco txog cov hluas macaques. Neuropharmacology. 2011 Lub Hlis; 60 (7-8): 1262-8. doi: 10.1016 / j.neuropharm.2010.12.018. Epub 2010 Dec 23. PubMed PMID: 21185313; PubMed Central PMCID: PMC3073152.
Buccafusco JJ, Weiser T, Lub Caij Ntuj Sov K, Klinder K, Terry AV. Qhov cuam tshuam ntawm IDRA 21, qhov hloov kho zoo ntawm AMPA receptor, ntawm kev ncua kev txuam nrog kev ua yeeb yam los ntawm cov hluas thiab hnub nyoog rhesus liab. Neuropharmacology. 2004 Jan; 46 (1): 10-22. PubMed PMID: 14654093.
Losi G, Puia G, Braghiroli D, Baraldi M. IDRA-21, tus qauv zoo AMPA receptor modulator, inhibits synaptic thiab extrasynaptic NMDA receptor mediated cov xwm txheej hauv kab lis kev cai cerebellar granule hlwb. Neuropharmacology. 2004 Lub Rau Hli; 46 (8): 1105-13. PubMed PMID: 15111017.
IDRA-21 Cov Hmoov Noj Nqaij, Ib nrab ntawm lub neej, muaj txiaj ntsig, Sab Cuam Tshuam, thiab Tshuaj Xyuas.

Xyuas

Muaj cov kev xyuas tsis tau.

Ua thawj zaug tshuaj xyuas “IDRA-21 hmoov (22503-72-6)”

$0.00

✕

Laub

Koj lub tawb nqa khoom yog tam sim no tas.

Azərbaycan dili

Беларуская мова

বাংলা

Български

ქართული

Ελληνικά

ગુજરાતી

Ōlelo Hawaiʻi

עִבְרִית

हिन्दी

Bahasa Indonesia

ಕನ್ನಡ

Қазақ тілі

ភាសាខ្មែរ

Кыргызча

ພາສາລາວ

Latviešu valoda

Lietuvių kalba

Lëtzebuergesch

Македонски јазик

മലയാളം

मराठी

ဗမာစာ

नेपाली

ਪੰਜਾਬੀ

Српски језик

සිංහල

தமிழ்

తెలుగు

Українська

img.wp-smiley,img.emoji{display:inline !important;border:none !important;box-shadow:none !important;height:1em !important;width:1em !important;margin:0 .07em !important;vertical-align:-.1em !important;background:none !important;padding:0 !important;}#rs-demo-id{}.woocommerce form .form-row .required{visibility:visible;}form input.display-none{display:none !important;}.article-navigation{display:inline;}.blog-navigation{width:150px;position:fixed;left:10px;top:330px;}.floating-nav{width:100%;color:#cb6e6e !important;border:none;border-radius:0px !important;background-color:transparent !important;outline:none;text-align:left;padding:2px !important;margin:2px !important;font-size:12px !important;overflow:hidden !important;text-overflow:ellipsis !important;display:-webkit-box;-webkit-line-clamp:2;-webkit-box-orient:vertical;}.floating-nav:hover{color:#0ff !important;}.floating-nav:focus{color:#008000 !important;}@media only screen and (max-width: 1440px){.blog-navigation{display:none;}}.wise-product-title{font-size:24px;line-height:28px;font-weight:400;color:#2a3039;}.woocommerce ul.products li.product{border:1px solid #dbdfe4;text-align:center;border-radius:10px;overflow:hidden;box-sizing:border-box;}.shop_slider .shop_slider_ul li{text-align:center;}.shop_slider .shop_slider_ul li .item_wrapper .desc{background:transparent;}.computershop-monthly-specials{border-radius:10px 0 0 10px;}.computershop-discount{border-radius:0 10px 10px 0;}.sec{width:100%;margin:0 auto;overflow:hidden;box-sizing:border-box;background:#fff;}.poster{margin-bottom:.3215rem;}.poster-list img{width:100%;}.poster-list .poster-txt{position:relative;overflow:hidden;transition:height .24s;}.poster-list .poster-txt.xg:after{content:"";position:absolute;bottom:0;display:block;width:100%;height:4rem;background:-moz-linear-gradient(to bottom,rgba(255,255,255,0),#fff);background:-webkit-linear-gradient(to bottom,rgba(255,255,255,0),#fff);background:linear-gradient(to bottom,rgba(255,255,255,0),#fff);}.poster-btn{outline:none;display:block;width:50%;line-height:2;margin:.1rem auto;color:#666;font-size:.28rem;text-align:center;}.Article-author{display:-webkit-flex;flex-direction:row !important;flex-wrap:nowrap !important;justify-content:flex-start !important;border-radius:5px !important;border:1px solid #f17878 !important;border-top:6px solid #f17878 !important;padding:5px 0px 5px 0 !important;}.woocommerce-variation-add-to-cart{display:block;}.woocommerce div.product form.cart .button{vertical-align:middle;float:left;margin-top:10px;}.bundled_product_title_inner .item_title{font-size:14px;line-height:20px;}.mymsg01{clear:both;width:100%;padding:10px 0;}.mymsg01 span{color:red;}.mailpoet_hp_email_label{display:none !important;}#mailpoet_form_5 .mailpoet_form{}#mailpoet_form_5 form{margin-bottom:0;}#mailpoet_form_5 p.mailpoet_form_paragraph.last{margin-bottom:10px;}#mailpoet_form_5 .mailpoet_column_with_background{padding:10px;}#mailpoet_form_5 .mailpoet_form_column:not(:first-child){margin-left:20px;}#mailpoet_form_5 .mailpoet_paragraph{line-height:20px;margin-bottom:20px;}#mailpoet_form_5 .mailpoet_form_paragraph last{margin-bottom:0px;}#mailpoet_form_5 .mailpoet_segment_label,#mailpoet_form_5 .mailpoet_text_label,#mailpoet_form_5 .mailpoet_textarea_label,#mailpoet_form_5 .mailpoet_select_label,#mailpoet_form_5 .mailpoet_radio_label,#mailpoet_form_5 .mailpoet_checkbox_label,#mailpoet_form_5 .mailpoet_list_label,#mailpoet_form_5 .mailpoet_date_label{display:block;font-weight:normal;}#mailpoet_form_5 .mailpoet_text,#mailpoet_form_5 .mailpoet_textarea,#mailpoet_form_5 .mailpoet_select,#mailpoet_form_5 .mailpoet_date_month,#mailpoet_form_5 .mailpoet_date_day,#mailpoet_form_5 .mailpoet_date_year,#mailpoet_form_5 .mailpoet_date{display:block;}#mailpoet_form_5 .mailpoet_text,#mailpoet_form_5 .mailpoet_textarea{width:200px;}#mailpoet_form_5 .mailpoet_checkbox{}#mailpoet_form_5 .mailpoet_submit{}#mailpoet_form_5 .mailpoet_divider{}#mailpoet_form_5 .mailpoet_message{}#mailpoet_form_5 .mailpoet_form_loading{width:30px;text-align:center;line-height:normal;}#mailpoet_form_5 .mailpoet_form_loading > span{width:5px;height:5px;background-color:#5b5b5b;}#mailpoet_form_5 h2.mailpoet-heading{margin:0 0 20px 0;}#mailpoet_form_5 h1.mailpoet-heading{margin:0 0 10px;}#mailpoet_form_5{border-radius:2px;text-align:left;}#mailpoet_form_5 form.mailpoet_form{padding:30px;}#mailpoet_form_5{width:100%;}#mailpoet_form_5 .mailpoet_message{margin:0;padding:0 20px;}#mailpoet_form_5 .mailpoet_validate_success{color:#00d084;}#mailpoet_form_5 input.parsley-success{color:#00d084;}#mailpoet_form_5 select.parsley-success{color:#00d084;}#mailpoet_form_5 textarea.parsley-success{color:#00d084;}#mailpoet_form_5 .mailpoet_validate_error{color:#cf2e2e;}#mailpoet_form_5 input.parsley-error{color:#cf2e2e;}#mailpoet_form_5 select.parsley-error{color:#cf2e2e;}#mailpoet_form_5 textarea.textarea.parsley-error{color:#cf2e2e;}#mailpoet_form_5 .parsley-errors-list{color:#cf2e2e;}#mailpoet_form_5 .parsley-required{color:#cf2e2e;}#mailpoet_form_5 .parsley-custom-error-message{color:#cf2e2e;}#mailpoet_form_5 .mailpoet_paragraph.last{margin-bottom:0;}@media (max-width: 500px){#mailpoet_form_5{background-image:none;}#mailpoet_form_5.nitro-lazy{background-image:none !important;}}@media (min-width: 500px){#mailpoet_form_5 .last .mailpoet_paragraph:last-child{margin-bottom:0;}}@media (max-width: 500px){#mailpoet_form_5 .mailpoet_form_column:last-child .mailpoet_paragraph:last-child{margin-bottom:0;}}.switcher{font-family:Arial;font-size:12pt;text-align:left;cursor:pointer;overflow:hidden;width:173px;line-height:17px;}.switcher a{text-decoration:none;display:block;font-size:12pt;-webkit-box-sizing:content-box;-moz-box-sizing:content-box;box-sizing:content-box;}.switcher a img{vertical-align:middle;display:inline;border:0;padding:0;margin:0;opacity:.8;}.switcher a:hover img{opacity:1;}.switcher .selected{background:#fff linear-gradient(180deg,#efefef 0%,#fff 70%);position:relative;z-index:9999;}.switcher .selected a{border:1px solid #ccc;color:#666;padding:3px 5px;width:161px;}.switcher .selected a:after{height:24px;display:inline-block;position:absolute;right:10px;width:15px;background-position:50%;background-size:11px;background-image:url("data:image/svg+xml;utf8,<svg xmlns=\'http://www.w3.org/2000/svg\' width=\'16\' height=\'16\' viewBox=\'0 0 285 285\'><path d=\'M282 76.5l-14.2-14.3a9 9 0 0 0-13.1 0L142.5 174.4 30.3 62.2a9 9 0 0 0-13.2 0L3 76.5a9 9 0 0 0 0 13.1l133 133a9 9 0 0 0 13.1 0l133-133a9 9 0 0 0 0-13z\' style=\'fill:%23666\'/></svg>");background-repeat:no-repeat;content:"" !important;transition:all .2s;}.switcher .selected a.open:after{-webkit-transform:rotate(-180deg);transform:rotate(-180deg);}.switcher .selected a:hover{background:#fff;}.switcher .option{position:relative;z-index:9998;border-left:1px solid #ccc;border-right:1px solid #ccc;border-bottom:1px solid #ccc;background-color:#eee;display:none;width:171px;max-height:198px;-webkit-box-sizing:content-box;-moz-box-sizing:content-box;box-sizing:content-box;overflow-y:auto;overflow-x:hidden;}.switcher .option a{color:#000;padding:3px 5px;}.switcher .option a:hover{background:#fff;}.switcher .option a.selected{background:#fff;}#selected_lang_name{float:none;}.l_name{float:none !important;margin:0;}.switcher .option::-webkit-scrollbar-track{-webkit-box-shadow:inset 0 0 3px rgba(0,0,0,.3);border-radius:5px;background-color:#f5f5f5;}.switcher .option::-webkit-scrollbar{width:5px;}.switcher .option::-webkit-scrollbar-thumb{border-radius:5px;-webkit-box-shadow:inset 0 0 3px rgba(0,0,0,.3);background-color:#888;}