NSI-189 phosphate hmoov (1270138-41-4)

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5-10 teev (hauv hnub ua haujlwm) ceev shipping
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Tsuas yog 7 sab lauj! 65 tus neeg tab tom saib qhov no thiab 65 tus neeg muaj nws hauv lawv lub laub.

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[1]. Xaiv qhov koj xav tau, tom qab ntawd ntxiv rau lub laub

[2]. Txuas mus xyuas

[3]. Sau koj cov ntaub ntawv nthuav dav, qhov * yuav tsum tau, xaiv koj txoj kev them nyiaj. Muaj ntau txoj kev them nyiaj sib txawv suav nrog:
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[4]. Yog tias xaiv "Coinpayment", tom qab nyem "Place order", ces yuav qhia raws li hauv qab no them

[5]. Yog tias Xaiv "Direct Bank Transfer", tom qab nias "Place order", ces yuav qhia raws li hauv qab no, yuav tshwm sim cov ntsiab lus ntawm tus account hauv txhab nyiaj, tom qab hloov lub txhab nyiaj (thov siv koj tus lej xaj raws li qhov siv), xa daim ntawv hauv txhab nyiaj rau peb.

[6]. Kev them nyiaj lees paub
[7]. Parcel xa tawm li 5-10 teev (hauv hnub ua haujlwm)
[8]. Tus lej taug qab tau muab
[9]. Parcel tuaj txog
[10]. Rov xaj dua
Tsis muaj koj qhov ntau? Nyem no
Ceeb toom: Yog tias koj cev xeeb tub, saib xyuas neeg mob, noj cov tshuaj los yog muaj kev mob nkeeg nrog koj tus kws kho mob ua ntej siv. Khaws kom deb ntawm cov menyuam yaus.
Qeb: SKU: N / A

Lub npe: NSI-189 phosphate

CAS: 1270138-41-4

Cov mis mos molecular: C22H33N4O5P

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

NSI-189 phosphate hmoov (1270138-41-4) video

 

 

NSI-189 phosphate Pob Lus Qhia

lub npe NSI-189 phosphate hmoov
CAS 1270138-41-4
purity 98%
Tshuaj lub npe (2-((3-Methylbutyl)amino)-3-pyridinyl)(4-(phenylmethyl)-1-piperazinyl)-methanone phosphate
Synonyms NSI189 Phosphate; NSI 189 Phosphate; NSI-189 Phosphate
molecular Formula C22H33N4O5P
molecular Nyhav 464.5
Melting Point
InChI Qhov Tseem Ceeb LWHMGALTTIYPJU-UHFFFAOYSA-N
daim ntawv hmoov
tsos dawb hmoov
Ib Sim Neej Tsis paub
solubility Tsis paub
cia mob Khw rau ntawm 4-8 ° C
Daim ntawv thov kev siv nootropic
Kuaj Cov Ntaub Ntawv Qhov

 

NSI-189 phosphate Cov Lus Qhia dav dav

NSI-189 phosphate yog neurogenic thiab nootropic tshawb nrhiav tus neeg sawv cev uas tau tsim los ntawm nicotinamide thiab pyrazine.

Kev tshawb fawb pom kev tsis tu ncua tau pom tias nws nkoos neurogenesis lossis neuronal cell ntau lawm hauv lub hlwb. Hauv cov kev tshawb fawb tsiaj, nws tseem tau pom tias nce hippocampus ntau npaum li ntawm 20% dhau los ua kom rov qab ua tus cwj pwm mob tshwm sim ntawm kev nyuaj siab. Cov kev tshawb nrhiav pom tau hais tias nws yuav yog txoj kev kho zoo rau kev mob siab ntsws.

Nws tseem xav tias yuav muaj kev cog lus rau kev kho mob rau lwm yam mob nrog rau cov kev mob siab tom qab (PTSD), Kab mob Alzheimer thiab teeb meem rau lub hnub nyoog txog cov kev txawj ntse.

 

NSI-189 phosphate Mechanism Ntawm Kev Ua

Cov kws tshawb nrhiav tau tshawb pom tias tus kabmob-loj qhov cuam tshuam tsis sib haum (MDD) -leads kom txo qis hippocampal ntim. Nco ntsoov tias lub hippocampus noj qab haus huv yog qhov zoo tshaj plaws ntawm cov hlwb ua haujlwm hauv hlwb uas ua rau cov khoom tsim cov neurons. Neurons ntawm qhov tod tes yog qhov tseem ceeb rau kev tsim cov kev sib txuas tshiab tseem ceeb hauv lub hlwb. Los ntawm kev tsim cov khoom tsim hluav taws xob tshiab hauv thaj chaw hippocampal, kev kho kev nyuaj siab tuaj yeem kho tau.

NSI-189 phosphate tau tsim los hais txog peb yam tseem ceeb ntawm kev nyuaj siab muaj xws li ntim hippocampal, neurogenesis thiab neurotransmission. NSI-189 nce qhov ntim hauv qhov hippocampus. Hauv kev ua li no, hippocampal ntim thiab lub paj hlwb hlwb zoo yog nce ntxiv txhim kho mod thiab kev txawj ntse. Ib cag los ntawm nce hippocampal ntim, cov tshuaj kuj txhim kho neuronal cell ua haujlwm. Nws ua haujlwm nws txhawb kev noj qab haus huv neuronal cell loj hlob thaum kho cov chaw puas hauv lub hlwb.

 

NSI-189 phosphate hmoov (1270138-41-4) Daim Ntawv Thov

  1. Kev txhim kho hauv kev coj tus cwj pwm cuam tshuam nrog kev nyuaj siab.
  2. Rov qab ntawm hippocampal atrophy.
  3. Tej zaum yuav txhim kho kev nco thiab kev paub los ntawm kev nce neurogenesis, tshwj xeeb hauv cov kev nyuaj siab.
  4. Qhov zoo tshwm sim tuaj yeem txuas ntxiv tom qab kho tas.

 

NSI-189 phosphate hmoov (1270138-41-4) Kev tshawb fawb ntxiv

Kev tshawb nrhiav los soj ntsuam txog kev cuam tshuam ntawm NSI-189 phosphate tau qhia tias 40 txog 80 mg txhua hnub zoo rau kev kho kev nyuaj siab thiab kev paub txog ntawm cov neeg mob zoo. Hauv cov kev sim no, tsis muaj qhov tshwm sim tsis zoo uas tau teev tseg. Feem ntau, NSI-189 phosphate tau pom zoo zoo thiab nyab xeeb rau tib neeg siv.

 

NSI-189 phosphate hmoov Siv Khoom

  • 1: Papakostas GI, Johe K, Tes H, Drouillard A, Russo P, Kay G, Kashambwa R, Hoeppner B, Flynn M, Yeung A, Martinson MA, Fava M. Ib qib 2, ob qhov muag dig, qhov chaw kawm tshuaj ntawm NSI-189 phosphate, ib qho neurogenic compound, ntawm cov neeg mob sab nrauv uas muaj qhov cuam tshuam loj tsis txaus ntseeg. Mol Lub Siab Ntsws. 2019 Jan 9. doi: 10.1038 / s41380-018-0334-8. [Epub ua ntej sau] PubMed PMID: 30626911.
  • 2: Liu Y, Johe K, Sun J, Hao X, Wang Y, Bi X, Baudry M. Kev txhim kho ntawm synaptic plasticity thiab thim rov qab ntawm kev puas nyob rau hauv lub cev muaj zog thiab lub zog ua haujlwm hauv cov nas tus qauv ntawm Angelman Syndrome los ntawm cov me me neurogenic molecule, NSI -189. Neuropharmacology. 2019 Jan; 144: 337-344. doi: 10.1016 / j.neuropharm.2018.10.038. Epub 2018 Nov 5. PubMed PMID: 30408487.
  • 3: Allen BD, Acharya MM, Lu C, Giedzinski E, Chmielewski NN, Quach D, Hefferan M, Johe KK, Limoli CL. Kev Kho Mob Ua Hluav Taws Xob-Induced Nkag Siab Kev Ua Haujlwm dhau los ntawm Kev Ua Haujlwm ntawm ncauj ntawm Neuroprotective Compound NSI-189. Radiat Res. 2018 Lub Plaub Hlis; 189 (4): 345-353. doi: 10.1667 / RR14879.1. Epub 2018 Jan 19. PubMed PMID: 29351056; PubMed Central PMCID: PMC5910029.

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