Nmn hmoov (1094-61-7)

Nicotinamide mononucleotide hmoov ua yeeb yaj kiab

 

Nmn hmoov Piav Cov Ntaub Ntawv

lub npe	NMN hmoov
CAS	1094-61-7
purity	98%
Tshuaj lub npe	beta-Nicotinamide mononucleotide nicotinamide mononucleotide 1094-61-7 beta-NMN nicotinamide ribonucleotide
Synonyms	3-Carbamoyl-1- [5-O- (hydroxyphosphinato) -β-D-ribofuranosyl] pyridinium
molecular Formula	C11H15N2O8P
molecular Nyhav	334.221 g / mol
Melting Point	> 96 ° C
InChI Qhov Tseem Ceeb	DAYLJWODMCOQEW-TURQNECASA-N
daim ntawv	Khoom
tsos	dawb hmoov
Ib Sim Neej
solubility	soluble hauv dej
cia mob	Hygroscopic, -20˚C Lub Freezer, Nyob Hauv Kev Tshwm Sim
Daim ntawv thov	Nicotinamide mononucleotide ("NMN", "NAMN", thiab "β-NMN") yog nucleotide muab los ntawm ribose thiab nicotinamide.
Kuaj Cov Ntaub Ntawv	Qhov

 

Nmn hmoov General Cov lus piav qhia

beta-Nicotinamide mononucleotide hmoov (1094-61-7) yog cov khoom lag luam ntawm cov tshuaj tua ntxiv ntawm Nicotinamide phosphoribosyltransferase (eNAMPT) kev cuam tshuam thiab qhov tseem ceeb NAD + nrab. Nws ameliorates qabzib tsis nkag los ntawm kev rov qab NAD + qib hauv HFD-hob T2D cov nas.

Nws tseem txhim kho qhov mob hepatic insulin rhiab thiab rov qab tso cov noob qhia ntsig txog oxidative kev nyuaj siab, kev ua kom rov ua mob, thiab lub suab circadian, ib nrab los ntawm kev ua haujlwm SIRT1.

 

Nmn hmoov (1094-61-7) Keeb Kwm

Beta-Nicotinamide mononucleotide (NMN) hmoov yog nruab nrab ntawm NAD + biosynthesis uas ua los ntawm nicotinamide los ntawm nicotinamide phosphoribosyltransferase (NAMPT) thiab kuj tseem hu ua NMN lossis nicotinamide ribotide. Hauv kev tshawb nrhiav tsis ntev los no ntawm NMN cov ntawv thov rau kev tiv thaiv thiab kuaj mob ntawm cov hnub nyoog muaj hnub nyoog xws li mob ntshav qab zib, mob neurodegenerative, mob plawv thiab lwm yam.

 

Nmn hmoov Mechanism Ntawm Kev Ua

beta-Nicotinamide mononucleotide (β-NMN) yog lub tshuab biosynthetic ua ntej ntawm nicotinamide adenine dinucleotide (NAD +) paub los txhawb nqa cellular NAD + kev tsim tawm thiab tawm tsam cov hnub nyoog ntsig txog cov kab mob uas cuam tshuam nrog poob ntawm cov ntaub so ntswg NAD + qib.

 

Nmn hmoov (1094-61-7) Daim Ntawv Thov

Laus hlwb. Tseeb, yav dhau los ua haujlwm hauv Imai lub lab tau qhia tias muab beta-Nicotinamide mononucleotide rau cov laus nas muaj cov txiaj ntsig zoo ntawm cov metabolism hauv lub cev, suav nrog cov txiaj ntsig zoo hauv cov leeg pob txha, lub siab ua haujlwm, pob txha ceev, ua haujlwm ntawm lub qhov muag, insulin rhiab heev, lub cev tsis muaj zog, lub cev qhov hnyav, thiab qib kev ua si.

 

Nmn hmoov (1094-61-7) Kev tshawb fawb ntau ntxiv

Laus hlwb. Tseeb, yav dhau los ua haujlwm hauv Imai lub lab tau qhia tias muab beta-Nicotinamide mononucleotide rau cov laus nas muaj cov txiaj ntsig zoo ntawm cov metabolism hauv lub cev, suav nrog cov txiaj ntsig zoo hauv cov leeg pob txha, lub siab ua haujlwm, pob txha ceev, ua haujlwm ntawm lub qhov muag, insulin rhiab heev, lub cev tsis muaj zog, lub cev qhov hnyav, thiab qib kev ua si.

 

Nmn hmoov (1094-61-7) Kev siv

• 1, Bogan, KL; Brenner, C (2008). "Nicotinic acid, nicotinamide, thiab nicotinamide riboside: ib qho kev soj ntsuam molecular ntawm NAD + cov kab mob sib xyaw ua ntej cov tib neeg kev noj haus". Kev Tshawb Xyuas Txhua Xyoo ntawm Khoom Noj. 28: 115–30. doi: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.
• 2, Brazill, JM; Li, C; Zhu, Y; Zhai, RG (Lub Rau Hli 2017). "NMNAT: Nws yog NAD + synthase ... Nws yog ib tus chaperone ... Nws yog ib qho neuroprotector". Cov tswv yim tam sim no hauv noob caj noob ces & Kev loj hlob. 44: 156–162. doi: 10.1016 / j.gde.2017.03.014. PMC 5515290. PMID 28445802.
• 3, "Kev Tswj Xyuas Ncua Sij Hawm Ntev ntawm Nicotinamide Mononucleotide Mitigates Hnub Nyoog-Lub Cev Kev Tshawb Fawb Lub Cev hauv cov nas tsuag". Cell Metabolism. 13 Hlis ntuj nqeg 2016.
• 4, Stipp, David (Lub Peb Hlis 11, 2015). "Dhau ntawm Resveratrol: Cov Los Tiv Thaiv Kev Laus NAD Fad". Kev paub American Blog Network.
• Txhua Yam Koj Yuav Tsum Tau Paub Txog Nicotinamide Riboside Chloride
• Nicotinamide Mononucleotide (NMN): Txiaj Ntsig, Muab, Pab Ntxiv, Tshawb Fawb