Alpha-lipoic Acid (ALA) hmoov (1077-28-7)

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Dab tsi yog cov txiaj ntsig ntawm Alpha Lipoic Acid (ALA) hmoov?

  1. Txo cov ntshav qab zib
  2. Txo qhov mob
  3. Slowed tawv nqaij laus
  4. Txhim kho cov paj hlwb
  5. Pab kom poob phaus

Alpha-lipoic Acid hmoov Piav Qhia Cov Lus Qhia

lub npe Alpha-lipoic Acid hmoov
CAS 1077-28-7
purity 98%
Tshuaj lub npe (+/-) - 1,2-Dithiolane-3-pentanoic Acid; (+/-) - 1,2-Dithiolane-3-txiaj ntsig Acid; (+/-) - Alpha-lipoic Acid / Thioctic acid; (RS) -α-Lipoic Acid
Synonyms DL-Alpha-lipoic Acid / Thioctic acid; Liposan; Lipothion; NSC 628502; NSC 90788; Protogen A; Thioctsan; Tioctacid;
molecular Formula C8H14O2S2
molecular Nyhav 206.318 g / mol
Melting Point Xyoo 60-62 ° C
InChI Qhov Tseem Ceeb AGBQKNBQESQNJD-UHFFFAOYSA-N
daim ntawv Khoom
tsos Lub Teeb Daj rau Daj
Ib Sim Neej 30 feeb txog 1 teev
solubility Soluble hauv Chloroform (Me ntsis), DMSO (Me ntsis), Methanol (Me ntsis)
cia mob Qhuav, tsaus thiab nyob rau hauv 0 - 4 C rau lub sij hawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sij hawm ntev (hli txog xyoo).
Daim ntawv thov Ib tug rog-metabolism stimulator.
Kuaj Cov Ntaub Ntawv Qhov

 

Alpha lipoic Acid (ALA) hmoov yog dab tsi?

Alpha lipoic acid (ALA) hmoov yog ib qho antioxidant muab tau los ntawm caprylic acid. Nws lwm lub npe yog ALA, lipoic acid, Biletan, Lipoicin, Thioctan, thiab lwm yam. Nws lub npe tshuaj yog 1,2-dithiolane-3-pentanoic acid lossis thioctic acid. Nws yog ib qho organosulfur compound thiab tsim nyob rau hauv lub cev ntawm tib neeg thiab tsiaj txhu. Nws cov khoom tsim tau tshwm sim los ntawm octanoic acid thiab cysteine ​​raws li ib qho sulfur. Nws yog ib qho tseem ceeb heev rau aerobic metabolism hauv lub cev. Nws muaj nyob hauv txhua lub cell thiab pab tsim lub zog los ntawm cov piam thaj.

Nws muaj ntau lub zog ntawm tes thiab molecular, vim nws muaj peev xwm antioxidant. Qhov kev tiv thaiv oxidative ntawm alpha lipoic acid hmoov tau tsa nws txoj kev txaus siab rau kev siv los ua cov khoom noj ntxiv. Nws kuj yog siv los ua tus neeg sawv cev kho mob. Nws tuaj yeem yog kev kho mob ntshav qab zib, poob phaus, neuropathy tshwm sim vim ntshav qab zib, kho qhov txhab, txhim kho daim tawv nqaij, thiab lwm yam.

alpha lipoic acid (ALA) hmoov muaj ib nrab-lub neej ntawm 30 feeb mus rau ib teev. Nws yog me ntsis soluble hauv chloroform, dimethyl sulfoxide (DMSO), thiab methanol. Nws tuaj yeem tau txais los ntawm spinach, poov xab, broccoli, qos yaj ywm, nqaij zoo li daim siab thiab raum.

 

Alpha lipoic acid ua haujlwm li cas?

Alpha lipoic acid hmoov bulk lag luam wholesale muaj antioxidant zog. Nws txhais tau hais tias nws tuaj yeem tawm tsam cov dawb radicals hauv lub cev thiab ua kom qeeb cov xwm txheej xws li kev laus ntawm tes thiab pab tswj cov hlwb noj qab haus huv.

Nws yog tsim nyob rau hauv mitochondria thiab ua raws li ib qho tseem ceeb cofactor rau rhuav tshem cov enzymes thiab cov as-ham. Nws kuj chelates cov hlau ions thiab txo cov oxidized daim ntawv ntawm lwm yam antioxidants xws li vitamin C, Vitamin E, thiab glutathione. Nws kuj tseem tuaj yeem tsim kho lawv.Alpha lipoic acid yog qhov tsim nyog rau kev tswj cov pa oxygen reactive.

Alpha lipoic acid kuj txhawb kev tiv thaiv antioxidant. Nws ua qhov no ntawm Nrf-2-mediated antioxidant gene qhia. Nws kuj tseem hloov cov noob uas xav tau lub peroxisome proliferator los qhib lawv.

Alpha lipoic acid kuj inhibits nuclear kappa B. Nws activates AMP-activated protein kinase (AMPK) nyob rau hauv cov leeg pob txha thiab ua rau ntau yam metabolic ua.

Muaj ob hom alpha lipoic acid. Lawv yog oxidized lipoic acid (LA) thiab txo dihydrolipoic acid (DHLA). DHLA yog tsim nyob rau hauv mitochondria uas muaj cov hlwb hauv lub cev. Qhov no ua tau nrog nicotinamide adenine dinucleotide hydrogen (NADH) thiab lipoamide dehydrogenase. Ob yam khoom no pab rau qhov kev hloov pauv no.

Hauv cov hlwb uas tsis muaj mitochondria, alpha lipoic acid tuaj yeem txo qis rau DHLA los ntawm nicotinamide adenine dinucleotide phosphate (NADPH). Qhov kev txiav txim no yog pab los ntawm glutathione thiab thioredoxin reductases.

Alpha lipoic acid ntxiv muaj cov khoom tshwj xeeb uas ua rau nws txawv ntawm glutathione. Thaum tsuas yog daim ntawv txo qis ntawm glutathione yog ib qho antioxidant, ob qho tib si txo thiab tsis txo cov ntaub ntawv ntawm alpha lipoic acid yog cov muaj zog antioxidants.

Alpha lipoic acid tseem koom nrog hauv kev kho cov oxidized proteins thiab tuaj yeem pab hauv kev tswj cov noob qoob loo.

Alpha lipoic acid muaj cov tshuaj tiv thaiv kab mob thiab. Nws nres cov kappa B kinase, ib qho enzyme uas ua rau NF-kB, qhov tseem ceeb uas hloov kho cov kab mob cytokines [1].

 

Keeb kwm ntawm Alpha-lipoic Acid hmoov

Alpha lipoic acid tau tshawb pom hauv xyoo 1937 los ntawm Snell. Lub sijhawm ntawd, cov kws tshawb fawb tau kawm txog ib hom kab mob uas siv cov kua txiv hmab txiv ntoo rau kev loj hlob. 1n 1951, nws raug cais los ntawm Reed. Thawj qhov kev siv tshuaj tau pib hauv lub teb chaws Yelemees xyoo 1959 rau kev kho tshuaj lom vim yog nceb nceb tuag.

Cov ntaub ntawv hais txog kev siv alpha lipoic acid thiab nws cov txiaj ntsig tseem tsis tiav. Nws siv hauv kev kho mob tseem tsis tau lees paub los ntawm FDA tseem. Tab sis xyoo dhau los, nws tau txais koob meej raws li kev ntxiv.

 

Dab tsi yog qhov txiaj ntsig ntawm Alpha lipoic Acid?

Muaj ntau cov txiaj ntsig ntawm alpha lipoic acid. Lawv yog:

 

Kev cuam tshuam rau Alzheimer's Disease

Cov alpha lipoic acid hmoov muaj peev xwm ncua kev pib lossis qeeb qeeb ntawm cov kab mob neurodegenerative. Ib txoj kev tshawb fawb tau ua rau cuaj tus neeg mob Alzheimer's disease. 600mg koob tshuaj ntawm Alpha-lipoic acid tau muab txhua hnub rau 12 lub hlis [2]. Nws muaj peev xwm stabilizing kev paub hauv cov neeg mob no. Nws cov cuab yeej antioxidant tuaj yeem ua rau tus mob qeeb thiab tseem tuaj yeem ua tus neeg saib xyuas neuroprotective.

 

Ua rau Ntshav Qab Zib

Alpha lipoic acid tuaj yeem pab txo cov ntshav qab zib hauv cov neeg mob ntshav qab zib. Txij li thaum nws cov khoom antioxidant tuaj yeem tshem tawm cov dawb radicals hauv lub cev, nws tuaj yeem pab kho qhov kev puas tsuaj rau cov hlwb uas tshwm sim los ntawm ntshav qab zib. Nws kuj tseem tuaj yeem txhim kho cov tshuaj insulin hauv cov neeg mob ntshav qab zib. Nws tuaj yeem tiv thaiv kev tuag ntawm beta hlwb thiab tseem tuaj yeem txhim kho cov piam thaj thiab txo qis cov teeb meem ntawm ntshav qab zib, tshwj xeeb tshaj yog mob ntshav qab zib neuropathy [3].

 

Cov nyhuv ntawm Stroke

Alpha lipoic acid muaj peev xwm tiv thaiv neuroprotective. Nws cov tshuaj tiv thaiv antioxidant kuj tseem tuaj yeem pab txhawb kev loj hlob ntawm neuron hauv lub hlwb uas tau raug mob stroke. Ib txoj kev tshawb fawb ua rau nas nrog ischemic stroke uas tau muab alpha lipoic acid tau pom tias muaj kev txhim kho hauv lawv cov mob [4]. Yog li, nws tuaj yeem pab txhim kho tus mob ntawm cov neeg mob stroke.

 

Nyuaj rau Kev Laus

Cov alpha lipoic acid hmoov kuj tseem tuaj yeem pab txo qis kev laus ntawm daim tawv nqaij. Alpha lipoic acid ntxiv tuaj yeem muab ib qho hluav taws xob rau ntawm daim tawv nqaij-ua puas thiab laus-ua rau cov khoom xyaw nquag thiab oxidize nws tus kheej. Txoj kev no nws tuaj yeem nres kev laus thiab tuaj yeem ua tiav lub luag haujlwm ntawm cov tshuaj tiv thaiv antioxidant tsis txaus [5]. Qhov no kuj tseem tuaj yeem pab tiv thaiv kev puas tsuaj los ntawm ntau yam tshuaj.

 

Kev cuam tshuam ntawm Mercury Poisoning thiab Autism

Alpha lipoic acid tuaj yeem hla cov hlab ntsha-hlwb barrier. Nws kuj tseem siv tau los tshem tawm cov tshuaj mercury txuas rau lub hlwb hauv cov ntaub ntawv mercury lom [6]. Nws tuaj yeem txav cov mercury khi rau hauv cov hlab ntsha los ntawm qhov chaw uas lwm tus neeg ua haujlwm chelator xws li dimercaptosuccinic acid (DMSA) lossis methylsulfonylmethane (MSM) tuaj yeem hloov cov mercury yam xyuam xim rau hauv lub raum thiab tom qab ntawd tawm hauv cov zis. Raws li tsis muaj DMSA lossis MSM tuaj yeem hla cov hlab ntsha-hlwb, kev siv alpha-lipoic acid nrog DMSA tuaj yeem pab tshem tawm cov mercury kom zoo. Qhov no kuj tseem tuaj yeem pab kho tus mob autism vim cov me nyuam autistic muaj qib mercury ntau dua hauv lawv lub hlwb piv rau qhov qub. Txawm li cas los xij, kev tshawb fawb txog qhov no tsuas yog txwv.

 

Cov teebmeem ntawm Anemia

Ib txoj kev tshawb nrhiav tau ua rau cov neeg mob uas muaj kab mob hauv lub raum kawg nrog ntshav tsis txaus uas tau muab alpha-lipoic acid rau cov neeg mob [7]. Nws pom tias muaj peev xwm zoo li erythropoietin hauv kev nce qib hemoglobin yam tsis muaj kev phom sij. Li no, nws tuaj yeem pab kho ntshav tsis txaus los ntawm qhov kawg ntawm lub raum tsis ua haujlwm. Nws kuj tseem yuav muaj txiaj ntsig kev lag luam.

 

Cov nyhuv ua Antioxidant

Txij li thaum alpha lipoic acid hmoov yog ib qho antioxidant, nws muaj ntau yam txiaj ntsig thiab tuaj yeem pab nrog ntau yam mob hauv lub cev.

 

Cov nyhuv ntawm Neurotoxicity Vim Alcoholism

Dej cawv tuaj yeem ua rau lub paj hlwb puas vim yog kev nyuab siab oxidative. Alpha-lipoic acid tuaj yeem pab kho tus mob neurotoxicity vim cawv. Nws tuaj yeem tiv thaiv cov protein oxidation uas tshwm sim hauv kev noj tshuaj ethanol [8].

 

Cov txiaj ntsig ntawm Kev Poob Haujlwm

Alpha lipoic acid kuj tseem yog ib qho zoo tshaj plaws ntxiv rau kev pab poob phaus rau cov neeg rog rog thiab rog [9]. Nws muaj kev phiv tsawg dua piv rau lwm cov tshuaj poob phaus thiab muaj cov tshuaj antioxidants uas tuaj yeem pab ua kom tus neeg noj qab nyob zoo.

 

Alpha Lipoic Acid hmoov ntau npaum

Raws li kev noj haus ntxiv, noj 600 mg (kwv yees li 1/4 tsp) ib zaug lossis ob zaug ib hnub, lossis raws li tus kws kho mob qhia.

 

Dab tsi yog qhov cuam tshuam ntawm Alpha lipoic Acid?

Zoo li feem ntau lwm cov tshuaj, alpha lipoic acid kuj muaj qee qhov kev phiv.

Qee qhov kev mob tshwm sim feem ntau ntawm alpha lipoic acid yog:

Mob taub hau

kub siab

xeev siab

Ntuav

Kev ua haujlwm tsis zoo

Lub teeb-hau

Cov ntshav qab zib tsawg

Cov tawv nqaij ua pob liab liab

Intoxication

Alpha lipoic acid hmoov cov teebmeem rau cov poj niam cev xeeb tub thiab pub niam mis tsis paub. Yog li nws raug pom zoo kom tsis txhob siv qhov no thaum cev xeeb tub lossis pub niam mis.

 

Contraindications

Tsis muaj ntau cov kev tshawb fawb txog contraindications ntawm alpha lipoic acid. Txawm li cas los xij, qee cov neeg mob uas muaj qee yam mob yuav tsum ceev faj ua ntej siv cov tshuaj no thiab sab laj nrog kws kho mob ua ntej lawv siv.

Qee qhov xwm txheej no yog:

Kab mob siab

Kev haus cawv ntau dhau

Mob qog noj ntshav

Thiamine tsis muaj peev xwm

 

Kev Sib Tham Tshuaj Nrog Alpha-lipoic Acid

Tsis muaj xov xwm ntau txog alpha-lipoic acid kev cuam tshuam nrog lwm cov tshuaj. Tab sis qee cov tshuaj yog qhov zoo tshaj kom zam nrog cov tshuaj ntxiv no.

Qee yam tshuaj no yog:

Cov tshuaj hypoglycemic - Alpha lipoic tau txais cov ntshav qab zib txo qis. Qee zaum nws tuaj yeem ua rau insulin autoimmune syndrome, ua rau hypoglycemia. Yog li kev siv nws nrog cov tshuaj hypoglycemic yuav ua rau mob ntshav qab zib sai sai uas yuav ua rau muaj kev phom sij.

Cov tshuaj thyroid - Alpha lipoic acid yuav txo qis cov thyroid hormones. Yog li yuav tsum tau saib xyuas kom raug thaum siv nrog levothyroxine.

 

Qhov twg yuav Alpha Lipoic Acid Bulk Powder

Wisepowder muaj Alpha Lipoic Acid (ALA) bulk hmoov nyob rau hauv 40g pob, thiab muab cov lag luam wholesale sib txawv raws li koj xav tau. Wisepowder's Alpha Lipoic Acid (ALA) hmoov tau raug kuaj thiab kuaj xyuas rau ob qho tib si khoom purity thiab tus kheej.

 

Alpha Lipoic Acid (ALA) hmoov siv

Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). Alpha-lipoic acid exerts anti-inflammatory teebmeem ntawm lipopolysaccharide-stimulated nas mesangial hlwb ntawm inhibition ntawm lub nuclear factor kappa B (NF-κB) signaling txoj kev. Kab mob, 38(2), 510-519.

Hager, K., Kenklies, M., McAfoose, J., Engel, J., & Munch, G. (2007). α-lipoic acid raws li kev xaiv kho tshiab rau Alzheimer's disease-A 48 lub hlis kev soj ntsuam xyuas. Nyob rau hauv Neuropsychiatric Disorders Ib txoj hauv kev sib koom ua ke (pp. 189-193). Springer, Vienna.

Laher, I. (2011). Mob ntshav qab zib thiab alpha-lipoic acid. Frontiers nyob rau hauv pharmacology, 2, 69.

Choi, KH, Park, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT, … & Cho, KH (2015). Alpha-lipoic acid kev kho mob yog neurorestorative thiab txhawb kev ua haujlwm zoo tom qab mob stroke hauv nas. Molecular hlwb, 8(1), 1-16.

Kim, K., Kim, J., Kim, H., Sung, J. (2021). Cov nyhuv ntawm α-Lipoic Acid rau kev txhim kho ntawm tib neeg daim tawv nqaij sib npaug siv Pumpless Skin-on-a-Chip Model. International Journal of Molecular Sciences, 22(4), 2160.

Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Kev nkag siab ntawm alpha-lipoic thiab dihydrolipoic acids tau cog lus tseg ntawm oxidative kev nyuaj siab thiab ua tau chelators hauv mercury toxicology. Phau ntawv Journal of inorganic biochemistry, 195, 111-119.

El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Lub luag haujlwm ntawm alpha-lipoic acid hauv kev tswj cov ntshav qab zib hauv cov neeg mob uas lub raum tsis ua haujlwm nyob rau hauv hemodialysis. International Journal of nephrology thiab Renovascular Disease, 6, 161.

Pirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). Alpha-lipoic acid tiv thaiv ethanol-induced protein oxidation nyob rau hauv nas hippocampal HT22 hlwb. Neuroscience Letters, 328(2), 93-96.

Kucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). Alpha-lipoic acid (ALA) ua ib qho ntxiv rau kev poob phaus: tshwm sim los ntawm kev tshuaj xyuas meta-kev soj ntsuam ntawm kev sim ntsuas randomized. Obesity Reviews, 18(5), 594-601.

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