Phenethyl Caffeate hmoov (104594-70-9)

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Lub npe: Phenethyl Caffeate

CAS: 104594-70-9

Cov roj formula: C17H16O4

KHOOM: Khaws rau hauv qhov chaw txias thiab qhuav. Khaws kom deb ntawm tshav ntuj ncaj qha thiab cua sov.

Phenethyl Caffeate hmoov (104594-70-9) video

 

Phenethyl Caffeate hmoov Piav Qhia Cov Ntaub Ntawv

lub npe Phenethyl caffeate hmoov
CAS 104594-70-9
purity > 98.0% (HPLC)
Tshuaj lub npe Caffeic acid phenethyl ester
Phenethyl caffeate hmoov
104594-70-9
CAPE
Phenylethyl caffeate hmoov
Synonyms 3- (3,4-Dihydroxyphenyl) -2-propenoic acid phenylethyl ester
molecular Formula C17H16O4
molecular Nyhav 284.311 g / mol
Melting Point 127.0-131.0 ° C
InChI Qhov Tseem Ceeb SWUARLUWKZWEBQ-VQHVLOKHSA-N
daim ntawv Khoom
tsos Lub teeb daj hmoov
Ib Sim Neej 21.2 rau 26.7 feeb
solubility Soluble hauv DMSO (10 mg / ml), ethanol (100 mM), ethyl acetate (50 mg / ml), methanol, acetone, thiab acetonitrile. Insoluble hauv dej.
cia mob -20 ° C
Daim ntawv thov Antineoplastic tus neeg sawv cev

Ib yam khoom uas txwv tsis pub los yog tiv thaiv kom loj hlob ntawm cov neoplasms.

neuroprotective tus neeg sawv cev

Ib qho sib xyaw twg uas tuaj yeem siv los kho neurodegenerative ntshawv siab.

anti-inflammatory tus neeg sawv cev

Ib qho sib txuas twg uas muaj cov tshuaj tiv thaiv.

tshuaj tiv thaiv kab mob

Cov khoom siv roj ntsha uas lub cev ua rau muaj kev cuam tshuam lossis ua lub luag haujlwm hauv kev ua haujlwm ntawm lub cev tiv thaiv kab mob.

Kuaj Cov Ntaub Ntawv Qhov

 

Phenethyl Caffeate hmoov General Cov Lus Qhia

Phenethyl Caffeate hmoov (104594-70-9) yog alkyl caffeate ester uas 2-phenylethyl yog cov tshuaj tiv thaiv alkyl. Nws muaj lub luag haujlwm ua haujlwm ua tus kabmob antineoplastic, tiv thaiv kabmob, ua haujlwm tiv thaiv kab mob, tiv thaiv kabmob, ua rau cov kabmob tiv thaiv kabmob, ua rau tus kabmob ua haujlwm, tus kabmob ua haujlwm thiab tus kabmob tua kabmob ua haujlwm.

Phenethyl caffeate hmoov yog phenethyl cawv ester ntawm caffeic acid thiab bioactive tivthaiv ntawm honeybee hive propolis, nrog antineoplastic, cytoprotective thiab immunomodulating cov haujlwm. Raws li kev tswj hwm, Phenethyl caffeate inhibits kev ua kom lub zog ntawm nuclear transposition NF-kappa B thiab tuaj yeem txwv p70S6K thiab Akt-tsav cov phiajcim. Tsis tas li ntawd, Phenethyl caffeate inhibits PDGF-hle lub cev loj hlob ntawm vascular du leeg cov leeg nqaij los ntawm kev ua kom muaj p38 mitogen-activated protein kinase (MAPK) thiab hypoxia-inducible factor (HIF) -1alpha thiab tom qab qhov induction ntawm heme oxygenase-1 (HO-1 )).

 

Phenethyl Caffeate hmoov Keeb Kwm

Phenethyl caffeate yog qhov sib xyaw ua ke nyob hauv propolis, qhov sib xyaw ua ke los ntawm cov ntab. Phenethyl caffeate pom cov khoom siv tshuaj tua kab mob, tiv thaiv atherosclerotic, tshuaj tiv thaiv kab mob, cardioprotective, tiv thaiv kev rog, thiab anticancer chemotherapeutic cov haujlwm. Hauv cov tshuaj vitro, phenethyl caffeate inhibits IL-1duced-kev tsim tawm ntawm IL-6, MCP-1, thiab ICAM-1, thiab suppresses phosphorylation ntawm Akt thiab NF-κB. Hauv vivo, phenethyl caffeate txo ntau ntawm AST thiab lactate dehydrogenase thiab suppresses lipid peroxidation.

 

Phenethyl Caffeate Txheej Txheem Ntawm Kev Ua

Phenethyl caffeate yog ib qho pov thawj ntawm cov propolis ntawm cov ntab muv thiab tau pom tias muaj qhov cuam tshuam los ntawm qhov kev xav tawm papilloma hauv cov nas. Cov kev tshawb fawb pom tau tias Phenethyl caffeate ua los tiv thaiv kev loj hlob ntawm cov kab mob loj hlob ntawm tes. Nws kuj tseem pom tias Phenethyl caffeate tuaj yeem ua rau DNA tawg thiab apoptosis uas tuaj yeem muaj cov tshuaj lom lom rau ntawm cov pob qog rub tawm embryo fibroblast (CREF). Tsis tas li ntawd, CREF cov hlwb depleted ntawm cellular glutathione (GSH) zoo li nkag siab ntau rau Phenethyl caffeate-vim raug ploj tuag ntawm tes.

Phenethyl caffeate tau tshaj tawm tias muaj anti-carcinogenic, anti-inflammatory, thiab immunomodulatory zog. Phenethyl caffeate kuj inhibits HIV-1 integrase. Cov yam ntxwv los tiv thaiv kev xav tau xav tias yog vim kev thim cov lipoxygenase txoj hauv kev ntawm arachidonic acid metabolism los ntawm Phenethyl caffeate. Cov kev tshawb fawb kuj tau qhia Phenethyl caffeate los ua ib qho tshwj xeeb thiab muaj zog hauv kev cuam tshuam ntawm kev ua kom muaj zog ntawm nuclear transaction factor NF kappa B, uas yog cov txheej txheem protein uas tswj cov kev sib hloov ntawm DNA. Phenethyl caffeate yog ib qho inhibitor ntawm ODC thiab Tyrosine Kinase.

 

Phenethyl Caffeate Daim Ntawv Thov

Phenethyl caffeate kuj txo qis lub cev qhov hnyav nce thiab cov rog lub cev hauv cov tsiaj cov tsiaj pub rau cov zaub mov muaj roj ntau, uas yog los ntawm inhibiting adipogenesis. Hauv lwm cov tsiaj qauv, qhov kev sib xyaw no ua rau 5-lipoxygenase thiab txo cov ntshav siab, collagen deposition, thiab lwm yam atherosclerotic biomarkers. Hauv cov tsiaj thiab cellular qauv ntawm cov mob hnyuv tuv, phenethyl caffeate induces apoptosis thiab inhibits kev loj hlob ntawm tes thiab qog.

Antineoplastic tus neeg sawv cev

Ib yam khoom uas txwv tsis pub los yog tiv thaiv kom loj hlob ntawm cov neoplasms.

neuroprotective tus neeg sawv cev

Ib qho sib xyaw twg uas tuaj yeem siv los kho neurodegenerative ntshawv siab.

anti-inflammatory tus neeg sawv cev

Ib qho sib txuas twg uas muaj cov tshuaj tiv thaiv.

tshuaj tiv thaiv kab mob

Cov khoom siv roj ntsha uas lub cev ua rau muaj kev cuam tshuam lossis ua lub luag haujlwm hauv kev ua haujlwm ntawm lub cev tiv thaiv kab mob.

 

Phenethyl Caffeate Kev tshawb fawb ntau ntxiv

Phenethyl caffeate yog lub ntuj qub phenolic tshuaj ua ke. Nws yog ester ntawm caffeineic acid thiab phenethyl cawv.

Ntau yam nyob hauv vitro cov chaw muag tshuaj thiab cov teebmeem hauv cov tsiaj ua qauv tau tshaj tawm txog Phenethyl caffeate, tab sis lawv qhov tseem ceeb hauv chaw kho mob tsis paub. Nws muaj cov tshuaj antimitogenic, anticarcinogenic, tiv thaiv mob, thiab tiv thaiv kab mob hauv cov tshuaj vitro. Lwm txoj kev tshawb nrhiav kuj pom tias Phenethyl caffeate txhawb kev tiv thaiv kab mob hauv lub cev thiab cov lus teb hauv vitro. Qhov no los tiv thaiv mob qog noj ntshav kuj tau pom thaum nas cov tawv nqaij tau raug kho nrog muv propolis thiab raug rau TPA, cov tshuaj uas ntxias cov tawv nqaij papillomas. Phenethyl caffeate txo tus naj npawb ntawm papillomas.

 

Phenethyl Caffeate Siv

Yang JW, Jung WK, Lee CM, li al. Caffeic acid phenethyl ester cuam tshuam rau kev cuam tshuam kev cuam tshuam ntawm interleukin-1 human nyob rau hauv tib neeg lub pob txha caj qaum fibroblasts. Immunopharmacol Immunotoxicol. 2014 Lub Kaum Hlis; 36 (5): 371-7. PMID: 25151996.

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