Oleoylethanolamide (OEA): Cov Tshuaj Pab Kom Qhov Rog Kom Txog Ntawm Lub Cev Uas Pab Ceeb Toom

Oleoylethanolamide (OEA) Yog Dab Tsi?

Oleoylethanolamide (OEA) yog lub ntuj tswj cov kev hnyav, roj (cholesterol) thiab qab los. Lub cev metabolite tau muab tso ua ke hauv cov khoom hauv cov hnyuv me. Lub ntuj molecule yog lub luag haujlwm rau qhov kev xav ntawm tag nrho tom qab koj noj zaub mov. Oleoylethanolamide pabcuam hauv kev tswj hwm lub cev muaj roj los ntawm kev khi rau Peroxisome proliferator-activated receptor alpha (PPAR-Alpha). Qhov ntuj tsim ntuj tsim kho lub cev ua kom lub cev metabolism hauv lub cev thiab qhia koj lub hlwb tias koj tau noj zaub mov txaus thiab koj yuav tsum tsis noj mov. Oleoylethanolamide tseem nce ntxiv rau kev siv nyiaj tsis muaj kev cuam tshuam txog kev siv nyiaj hauv calorie.

Oleoylethanolamide (OEA) Ua Haujlwm Li Cas?

Oleoylethanolamide (OEA) Cov kev siv ntawm kev ua

Oleoylethanolamide (covOEA) ua haujlwm ib qab los noj mov regulatorCov. Oleoylethanolamide tswj hwm koj cov khoom noj kom tsawg los ntawm xa cov cim rau lub hlwb hais rau nws tias koj tau tag nrho, thiab nws yog lub sijhawm txwv tsis pub noj mov. Raws li qhov tshwm sim, koj noj zaub mov tsawg dua nyob rau txhua hnub, thiab koj lub cev nres ntim ntau qhov hnyav hauv lub sijhawm ntev.

Oleoylethanolamide (OEA) (111-58-0) yog tsim thiab yaum hauv plab hnyuv me me los ntawm oleic acid muab los ntawm kev noj haus. Cov khoom noj uas muaj cov roj ntsha muaj roj ntau tuaj yeem tiv thaiv kev tsim tawm ntawm Oleoylethanolamide nyob rau ntawm txoj hnyuv me.

Oleoylethanolamide qis qis kev noj zaub mov kom tsawg los ntawm kev txhawb cov tshuaj histamine lub hlwb ncig, cov evostatic oxytocin, thiab cov kab mob dopamine. Nws yog qhov tseeb tias Oleoylethanolamide tseem tuaj yeem attenuate CB1R kev taw qhia, uas yog tias qhov kev txhawb nqa yuav ua rau nce khoom noj kom tsawg. Oleoylethanolamide txo qis lipid thauj mus rau hauv adipocytes kom txo cov rog rog.

OEA tseem ua haujlwm los txhawb qee yam hu ua PPAR thiab tib lub sijhawm ua kom cov rog rog tsawg thiab ua kom muaj roj ntau ntxiv. Thaum twg koj noj ib pluas mov, qib ntawm OEA nce siab thiab koj lub siab poob. Qhov no tshwm sim vim tias cov khoom sib txuam ntxig txuas nrog rau koj lub hlwb qhia nws tias koj tau ua tsaug rau PPAR-α. PPAR-α yog ligand-activated nuclear receptor uas koom nrog rau lub zog homeostasis txoj thiab cov noob qhia ntawm lipid metabolism.

Oleoylethanolamide (OEA) qhia txog txhua tus yam ntxwv uas txhais tau qhov txaus siab uas muaj xws li:

• Kev txwv tsis pub pub mis los ntawm kev ncua sijhawm hauv nruab nrab ntawm ib pluag mov rau pluas mov tom ntej;
• Nws cov khoom lag luam raug tswj los ntawm muaj kev pab khoom noj khoom haus
• Nws qib raug circadian fluctuations.

Cov Nyiaj Pab Oleoylethanolamide (OEA)

Cov txiaj ntsig Oleoylethanolamide thiab cov kev poob phaus xws li;

i. Txo cov qab los noj mov stimulating hormone paub Ghrelin

Peripheral kev txhaj tshuaj ntawm OEA muab rau cov nas uas tau yoo ib hnub tsis cuam tshuam rau ghrelin hormone li ntawm 120 feeb, tab sis tom qab 6 teev dhau los nws tau txo qis hauv cov tshuaj no los ntawm 40 txog 50 feem pua. Txawm li cas los xij, Oleoylethanolamide tsis muaj kev cuam tshuam los ntawm cov ntsiab lus ntawm qhov qab los txhawb cov tshuaj hormones hauv cov nas. Qhov no qhia tias OEA ntxiv ua haujlwm zoo tshaj plaws hauv kev txo qis ghrelin yog tias noj ua ntej noj mov.

ii. Nce tus nqi ntawm lub cev rog poob

Βeta-adrenergic receptors ua hauj lwm pab txhawb lub cev kom yuag thiab lub zog ntawm βeta3-adrenergic receptor txo cov khoom noj kom tsawg thiab nce cov rog rog hauv cov nas. Cov khoom yuav ua li ntawd los ntawm kev txhawb nqa cov nqaij tsis ua haujlwm nrog rau UCP1.

Raws li qhov tshwm sim, kev sib koom tes ntawm ag3 agonist thiab oleoylethanolamide peripheral txhaj tshuaj zoo li muaj txiaj ntsig hauv kev txo qis kev noj zaub mov kom muaj txiaj ntsig thiab muaj txiaj ntsig hauv kev txo cov rog rog uas cuam tshuam nrog kev nce nqi ntawm lub zog. Qhov nce ntawm theem ntawm UCP1 thiab PPARα (xav tias pom kev cuam tshuam kev siv lub zog siv hluav taws xob) tau tshwm sim hauv ob qho tib si xim av thiab dawb adipose cov nqaij ua ke nrog kev txhim kho hauv mitochondrial biomarkers.

OEA yog li ntawd txhim kho kev cuam tshuam ntawm cov kab mob mitochondrial metabolism thiab cov thermogenic ua yeeb yam hauv cov nas hauv ob qho tib si xim av thiab dawb adipose cov ntaub so ntswg, ntawm tib oleoylethanolamide ntau npaum li uas siv los tswj kev qab los noj mov.

iii. Txo Cov Qib Peptide YY (Kev Ntsuam Xyuas Hlav Hormone)

Kev txhaj tshuaj 5mg / kg Oleoylethanolamide rau cov nas ua rau cov sij hawm tos me ntsis ntawm cov tshuaj peptide YY uas yog ua rau hauv lub plab hauv ob qho kev pub thiab cov zaub mov tsis pub lub xeev.

Oleoylethanolamide (OEA) puas pab tswj tau Appetite?

Yog lawm. Oleoylethanolamide poob phaus ntxiv pab rau tswj kev qab los noj mov los ntawm kev ua kom raug PPAR yog li txo qis kev khaws cia ntawm cov rog thiab ua kom hlawv cov rog ntau. Thaum koj noj koj cov zaub mov, Oleoylethanolamide theem nce thiab koj lub qab los noj mov qis thaum cov cim xa mus rau koj lub hlwb qhia rau lub hlwb tias koj txaus siab.

Muaj ntau ntau txoj kev tshawb fawb los ua pov thawj uas ua pov thawj cov nyhuv no. Xyoo 2004, piv txwv li, cov kws tshawb fawb Danish kawm txog cov nas uas tau ua tsis zoo rau ib hnub. Lawv muab OEA rau lawv thiab pom tias cov khoom noj lawv coj mus txo 15.5%. Hauv cov ntsiab lus yooj yooj yim, Oleoylethanolamide (OEA) tua lub pob nyem rau kev tshaib kev nqhis hauv CNS (Central Nervous System).

Oleoylethanolamide (OEA) Kev Noj Tshuaj

Cov tshuaj oleoylethanolamide pom zoo yog ib cov tshuaj ntsiav 200mg thaum noj tsis muaj kev sib xyaw. Thaum ua ke nrog lwm cov kev pabcuam poob phaus, OEA koob tshuaj yuav tsum tau txo qis kom txog ntawm 100mg thiab 150mg.

Nws raug nquahu tias koj yuav tsum noj oleoylethanolamide ntxiv 30 feeb ua ntej noj hmo lossis noj tshais; koj yuav muaj kev txaus siab ntau dua rau lub sijhawm noj mov thiab noj tsawg dua.

Kev tshawb nrhiav qhia tias koj tuaj yeem tso qis dua lossis nce ntau ntxiv rau niaj hnub noj raws li koj lub cev hnyav. Piv txwv li, yog tias koj hnyav 150lb, koj yuav noj 100mg. 200lb tus neeg yuav siv 150mg thiab ib tus neeg 250lb yuav noj 180mg ntawm qhov ntxiv.

Oleoylethanolamide (OEA) Sab Sij Huam

Oleoylethanolamide phiv tuaj yeem yog qhov kev txhawj xeeb tseem ceeb ntawm cov neeg tsim khoom lag luam ntxiv uas xav kom suav nrog qhov muaj hwj chim loj hauv lawv cov tshuaj ntxiv kom poob phaus.

Tom qab kev txheeb xyuas txhua qhov ntawm txhua cov ntaub ntawv tshawb fawb, US FDA (Khoom Noj thiab Tshuaj Siv Tshuaj) tsis muaj teeb meem ntsig txog kev nyab xeeb ntawm cov lwg me me no. RiduZone yog thawj OEA hmoov yuav tsum muaj npe hauv 2015.

OEA yog oleic acid metabolite thiab yog ib feem ntawm kev noj zaub mov zoo rau lub cev txhua hnub. Nws zoo nyab xeeb los siv Oleoylethanolamide ntxiv vim tias tsis muaj kev mob tshwm sim loj heev uas tau hais txog tam sim no.

Oleoylethanolamide (OEA) Yuav

Koj tuaj yeem tau txais oleoylethanolamide yuav ntawm cov khw muag tshuaj online thiab tshuaj lub cev. Koj yuav tsum yog li yuav tau ceev faj vim tias tsis yog txhua tus xa khoom yog cov tseem. Nco ntsoov tias koj nyeem lawv cov oleoylethanolamide tshuaj xyuas kom paub dab tsi cov kev paub ntawm lawv cov neeg yuav khoom yav dhau los.

Puas yog koj xav paub txog qhov twg tau oleoylethanolamide muag rau? Txhob txhawj; koj tuaj yeem yuav oleoylethanolamide online ntawm peb lub vev xaib. Peb yog lub suab npe nrov thiab kev paub OEA tsum thiab peb muaj lub peev xwm xa Oleoylethanolamide (OEA) hauv Asmeskas thiab ob peb lwm lub teb chaws thoob ntiaj teb. Peb cov txheej txheem xaj yog yooj yim tab sis ua tiav kev nyab xeeb thiab nyab xeeb. Peb tseem xa peb cov khoom hauv cov ntawv kaw ntom ntom thiab zoo nkauj kom ntseeg tau tias muaj kev nyab xeeb thiab zam kev ua paug.

Tshooj ntawm:

Dr. Liang

Co-founder, lub tuam txhab qhov kev tswj hwm qhov tseem ceeb ua haujlwm; PhD tau txais los ntawm Fudan University hauv organic chemistry. Ntau tshaj li cuaj xyoo ntawm cov kev paub hauv cov organic synthesis teb cov kws tshuaj. Kev nplua nuj dhau los hauv kev sib xyaw ua ke, kev siv tshuaj lom neeg thiab cov khoom siv tshuaj lom neeg thiab kev ua kom zoo nkauj kev tswj hwm.

References:

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• Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). “Kev nce qib kev nthuav dav ntawm oleoylethanolamine mobilization nyob rau hauv txoj hnyuv me me ntawm Burmese python (Python molurus)”. Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412.
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