cov khoom siv

Alpha-lipoic Acid hmoov (1077-28-7)

Alpha-lipoic acid / thioctic acid hmoov yog vitamin zoo li tshuaj lom neeg hu ua antioxidant. Poov xab, nplooj siab, raum, spinach, zaub cob pob, thiab qos yaj ywm yog qhov zoo ntawm ofalpha-lipoic acid / thioctic acid. Nws tseem yog tsim hauv qhov chaw kuaj sim rau kev siv tshuaj. Alpha-lipoic acid / thioctic acid feem ntau ua rau lub qhov ncauj mob ntshav qab zib thiab cov tsos mob ntsig txog ntshav qab zib suav nrog ua kev kub taub hau, mob, thiab loog ntawm ob txhais ceg thiab caj npab. Nws kuj tseem raug muab raws li kev txhaj tshuaj rau hauv txoj leeg ntshav (los ntawm IV) rau kev siv tib yam. Kev txhaj tshuaj ntau ntawm alpha-lipoic acid / thioctic acid tau pom zoo hauv Tebchaws Yelemees rau kev kho mob ntawm cov tsos mob no.

Chaw Tsim Tshuaj: Batch Production
pob: 1KG / hnab, 25KG / nruas
Wisepowder muaj peev xwm tsim tau thiab muab khoom ntau. Txhua qhov kev tsim khoom raws li cGMP thiab kev tswj hwm nruj, tag nrho cov ntaub ntawv xeem thiab cov qauv muaj.
Qeb:

Alpha-lipoic Acid hmoov Piav Qhia Cov Lus Qhia

 

lub npe Alpha-lipoic Acid hmoov
CAS 1077-28-7
purity 98%
Tshuaj lub npe (+/-) - 1,2-Dithiolane-3-pentanoic Acid; (+/-) - 1,2-Dithiolane-3-txiaj ntsig Acid; (+/-) - Alpha-lipoic Acid / Thioctic acid; (RS) -α-Lipoic Acid
Synonyms DL-Alpha-lipoic Acid / Thioctic acid; Liposan; Lipothion; NSC 628502; NSC 90788; Protogen A; Thioctsan; Tioctacid;
molecular Formula C8H14O2S2
molecular Nyhav 206.318 g / mol
Melting Point Xyoo 60-62 ° C
InChI Qhov Tseem Ceeb AGBQKNBQESQNJD-UHFFFAOYSA-N
daim ntawv Khoom
tsos Lub Teeb Daj rau Daj
Ib Sim Neej 30 feeb txog 1 teev
solubility Soluble hauv Chloroform (Me ntsis), DMSO (Me ntsis), Methanol (Me ntsis)
cia mob Qhuav, tsaus thiab nyob rau hauv 0 - 4 C rau lub sij hawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sij hawm ntev (hli txog xyoo).
Daim ntawv thov Ib tug rog-metabolism stimulator.
Kuaj Cov Ntaub Ntawv Qhov
Alpha-lipoic acid
Hmoov daim duab
Lub teeb daj

 

Alpha-lipoic Acid yog dab tsi?

Alpha-lipoic acid yog antioxidant muab tau los ntawm caprylic acid. Nws lwm lub npe yog ALA, lipoic acid, Biletan, Lipoicin, Thioctan, thiab lwm yam Nws lub npe tshuaj yog 1,2-dithiolane-3-pentanoic acid lossis thioctic acid. Nws yog cov tshuaj organosulfur thiab tsim tawm hauv tib neeg thiab tsiaj lub cev. Nws cov khoom tsim tawm los ntawm octanoic acid thiab cysteine ​​ua cov tshuaj sulfur. Nws yog ib yam khoom tseem ceeb rau cov metabolism hauv aerobic hauv lub cev. Nws muaj nyob hauv txhua lub cell thiab pab tsim lub zog los ntawm cov piam thaj.

Nws muaj ntau lub xov tooj ntawm tes thiab molecular, vim nws muaj peev xwm tiv thaiv kab mob antioxidant. Qhov tshuaj tiv thaiv kab mob antioxidant ntawm alpha-lipoic acid tau nce nws qhov kev txaus siab rau siv los ua khoom noj ntxiv. Nws kuj tseem siv los ua tus neeg sawv cev kho mob. Nws tuaj yeem yog kev kho mob ntshav qab zib, poob phaus, mob neuropathy tshwm sim los ntawm ntshav qab zib, kho qhov txhab, txhim kho cov tawv nqaij, thiab lwm yam.

Cov hmoov alpha-lipoic acid muaj ib nrab-lub neej ntawm 30 feeb mus rau ib teev. Nws yog me ntsis soluble hauv chloroform, dimethyl sulfoxide (DMSO), thiab methanol. Nws tuaj yeem tau txais los ntawm zaub ntsuab, poov xab, zaub paj zaub, qos yaj ywm, nqaij zoo li daim siab thiab raum.

Qhov siab tshaj plaws uas ib tus neeg laus tuaj yeem noj hauv ib hnub yog 2400mg.

 

Alpha-lipoic Acid Ua Haujlwm Li Cas?

Alpha-lipoic acid muaj cov tshuaj antioxidant. Nws txhais tau tias nws tuaj yeem nquag tawm tsam cov dawb radicals hauv lub cev thiab ua rau qeeb qhov xwm txheej xws li xov tooj ntawm tes laus thiab pab tswj kev noj qab haus huv ntawm tes.

Nws tau tsim tawm hauv mitochondria thiab ua raws li cov cofactor tseem ceeb rau kev zom cov enzymes thiab cov as -ham. Nws tseem chelates cov hlau ions thiab txo cov ntawv oxidized ntawm lwm cov tshuaj tiv thaiv kab mob xws li vitamin C, Vitamin E, thiab glutathione. Nws kuj tseem tuaj yeem rov tsim dua tshiab.Alpha-lipoic acid yog qhov tsim nyog rau kev tswj hwm hom pa oxygen.

Alpha-lipoic acid kuj txhawb kev tiv thaiv kab mob antioxidant. Nws ua qhov no ntawm Nrf-2-mediated antioxidant noob qhia. Nws kuj tseem hloov pauv cov noob uas xav tau peroxisome proliferator los qhib lawv.

Alpha-lipoic acid kuj tseem cuam tshuam txog nuclear yam kappa B. Nws ua rau AMP-activated protein kinase (AMPK) hauv cov leeg pob txha thiab ua rau ntau yam kev ua haujlwm hauv metabolic.

Muaj ob hom alpha-lipoic acid. Lawv yog oxidized lipoic acid (LA) thiab txo dihydrolipoic acid (DHLA). DHLA yog tsim tawm hauv mitochondria uas muaj cov cell hauv lub cev. Qhov no ua tau nrog nicotinamide adenine dinucleotide hydrogen (NADH) thiab lipoamide dehydrogenase. Ob yam tshuaj no pab hauv qhov kev hloov pauv no.

Hauv cov hlwb uas tsis muaj mitochondria, alpha-lipoic acid tuaj yeem txo qis rau DHLA los ntawm nicotinamide adenine dinucleotide phosphate (NADPH). Qhov kev nqis tes no yog pab los ntawm glutathione thiab thioredoxin reductases.

Alpha-lipoic acid muaj qhov tshwj xeeb uas ua rau nws txawv ntawm glutathione. Thaum tsuas yog daim ntawv txo qis ntawm glutathione yog cov tshuaj tiv thaiv kab mob, ob qho tib si txo thiab tsis txo qis ntawm alpha-lipoic acid yog cov tshuaj tua kab mob muaj zog.

Alpha-lipoic acid kuj tseem koom nrog kho cov protein oxidized thiab tuaj yeem pab tswj hwm kev hloov pauv cov noob.

Alpha-lipoic acid muaj cov tshuaj tiv thaiv kab mob ib yam. Nws nres kappa B kinase, ib qho enzyme uas ua kom NF-kB, qhov cuam tshuam uas hloov pauv kev mob cytokines [1].

 

Keeb kwm ntawm Alpha-lipoic Acid

Alpha-lipoic acid tau tshawb pom xyoo 1937 los ntawm Snell. Lub sijhawm ntawd, cov kws tshawb fawb tau kawm txog ib hom kab mob uas siv cov kua txiv hmab txiv ntoo los ua noob. 1n 1951, nws tau raug cais los ntawm Reed. Thawj qhov kev siv tshuaj kho mob tau pib hauv Tebchaws Yelemees xyoo 1959 rau kev kho tshuaj lom tuag vim yog lub kaus mom tuag.

Cov ntaub ntawv hais txog kev siv alpha-lipoic acid thiab nws cov txiaj ntsig tseem tsis tau tiav. Nws siv hauv kev kho mob tseem tsis tau lees paub los ntawm FDA tseem tsis tau paub. Tab sis ntau xyoo, nws tau txais koob meej raws li qhov ntxiv.

 

Dab tsi yog qhov tshwm sim ntawm Alpha-lipoic Acid?

Zoo li feem ntau lwm cov tshuaj, alpha-lipoic acid kuj muaj qee cov kev mob tshwm sim.

Qee qhov tshwm sim tshwm sim feem ntau ntawm alpha-lipoic acid yog:

  • Mob taub hau
  • kub siab
  • xeev siab
  • Ntuav
  • Kev ua haujlwm tsis zoo
  • Lub teeb-hau
  • Cov ntshav qab zib tsawg
  • Cov tawv nqaij ua pob liab liab
  • Intoxication

Alpha-lipoic acid hmoov cov teebmeem rau cev xeeb tub thiab pub niam mis tsis paub. Yog li nws tau pom zoo kom tsis txhob siv qhov no thaum cev xeeb tub lossis pub niam mis.

 

Cov txiaj ntsig ntawm Alpha-lipoic Acid yog dab tsi?

Muaj ntau qhov txiaj ntsig ntawm alpha-lipoic acid. Lawv yog:

 

Kev cuam tshuam rau Alzheimer's Disease

Cov hmoov alpha-lipoic acid muaj peev xwm ncua kev pib lossis qeeb qeeb ntawm kev mob ntawm cov kab mob neurodegenerative. Ib txoj kev tshawb fawb tau ua rau cuaj tus neeg mob Alzheimer's disease. 600mg ntawm Alpha-lipoic acid tau muab txhua hnub rau 12 lub hlis [2]. Nws muaj peev xwm ruaj khov kev paub hauv cov neeg mob no. Nws cov cuab yeej antioxidant tuaj yeem ua rau qeeb tus mob thiab tseem tuaj yeem ua tus neeg sawv cev tiv thaiv kab mob.

 

Ua rau Ntshav Qab Zib

Alpha-lipoic acid tuaj yeem pab txo qis cov ntshav qab zib hauv cov neeg mob ntshav qab zib. Txij li nws cov tshuaj tiv thaiv kab mob tuaj yeem tshem tawm cov dawb radicals hauv lub cev, nws tuaj yeem pab kho kev puas tsuaj rau cov cell los ntawm ntshav qab zib. Nws kuj tseem tuaj yeem txhim kho insulin tsis kam hauv cov neeg mob ntshav qab zib. Nws tuaj yeem tiv thaiv kev tuag ntawm beta cells thiab tseem tuaj yeem txhim kho kev nqus cov piam thaj thiab ua kom qeeb ntawm cov teeb meem ntshav qab zib, tshwj xeeb yog mob ntshav qab zib neuropathy [3].

 

Cov nyhuv ntawm Stroke

Alpha-lipoic acid muaj peev xwm tiv thaiv kab mob. Nws cov tshuaj tiv thaiv kab mob kuj tseem tuaj yeem pab txhawb kev loj hlob ntawm neuron hauv lub hlwb uas tau raug mob stroke. Ib txoj kev tshawb fawb tau ua tiav ntawm cov nas uas muaj ischemic stroke uas tau muab alpha-lipoic acid qhia pom kev txhim kho hauv lawv tus mob [4]. Yog li, nws tuaj yeem pab txhim kho cov neeg mob stroke.

 

Nyuaj rau Kev Laus

Cov hmoov alpha-lipoic acid kuj tseem tuaj yeem pab ua kom qeeb ntawm daim tawv nqaij. Alpha-lipoic acid tuaj yeem muab ib lub tshuab hluav taws xob rau ntawm daim tawv nqaij ua rau lub cev puas tsuaj thiab ua rau cov laus ua rau muaj cov tshuaj nquag thiab ua rau nws tus kheej. Txoj kev no nws tuaj yeem nres kev laus thiab tseem tuaj yeem ua lub luag haujlwm ntawm cov tshuaj tiv thaiv kab mob tsis txaus [5]. Qhov no kuj tseem tuaj yeem pab tiv thaiv kev puas tsuaj los ntawm ntau yam tshuaj.

 

Kev cuam tshuam ntawm Mercury Poisoning thiab Autism

Alpha-lipoic acid tuaj yeem hla cov ntshav-hlwb teeb meem. Nws kuj tseem tuaj yeem siv los tshem tawm cov tshuaj mercury txuas rau lub hlwb thaum muaj tshuaj lom lom lom [6]. Nws tuaj yeem sib sau cov kab mob mercury mus rau hauv cov ntshav los ntawm qhov chaw uas lwm tus neeg sawv cev chelator zoo li dimercaptosuccinic acid (DMSA) lossis methylsulfonylmethane (MSM) tuaj yeem xa cov tshuaj mercury mus rau hauv lub raum thiab tom qab ntawd tso tawm hauv cov zis. Raws li tsis yog DMSA lossis MSM tuaj yeem hla txoj hlab ntshav-lub hlwb, siv alpha-lipoic acid nrog DMSA tuaj yeem pab tshem tawm cov tshuaj mercury. Qhov no kuj tseem tuaj yeem pab kho tus mob autism raws li cov menyuam yaus uas muaj kev puas hlwb muaj qib siab ntawm mercury hauv lawv lub hlwb piv rau ib txwm muaj. Txawm li cas los xij, kev tshawb fawb txog qhov no muaj tsawg.

 

Cov teebmeem ntawm Anemia

Ib txoj kev tshawb nrhiav tau ua rau cov neeg mob uas muaj kab mob hauv lub raum kawg nrog ntshav tsis txaus uas tau muab alpha-lipoic acid rau cov neeg mob [7]. Nws pom tias muaj peev xwm zoo li erythropoietin hauv kev nce qib hemoglobin yam tsis muaj kev phom sij. Li no, nws tuaj yeem pab kho ntshav tsis txaus los ntawm qhov kawg ntawm lub raum tsis ua haujlwm. Nws kuj tseem yuav muaj txiaj ntsig kev lag luam.

 

Cov nyhuv ua Antioxidant

Txij li alpha-lipoic acid hmoov yog cov tshuaj tua kab mob antioxidant, nws muaj ntau cov txiaj ntsig thiab tuaj yeem pab nrog ntau yam xwm txheej hauv lub cev.

 

Cov nyhuv ntawm Neurotoxicity Vim Alcoholism

Dej cawv tuaj yeem ua rau lub paj hlwb puas vim yog kev nyuab siab oxidative. Alpha-lipoic acid tuaj yeem pab kho tus mob neurotoxicity vim cawv. Nws tuaj yeem tiv thaiv cov protein oxidation uas tshwm sim hauv kev noj tshuaj ethanol [8].

 

Cov txiaj ntsig ntawm Kev Poob Haujlwm

Alpha-lipoic acid kuj tseem yog qhov zoo tshaj ntxiv rau kev pab poob phaus rau cov neeg rog thiab rog [9]. Nws muaj cov kev mob tshwm sim tsawg dua piv rau lwm cov tshuaj poob phaus thiab muaj cov tshuaj antioxidants uas tuaj yeem pab ua kom tus neeg noj qab nyob zoo.

 

Contraindications

Tsis muaj ntau txoj kev tshawb fawb txog qhov contraindications ntawm alpha-lipoic acid. Txawm li cas los xij, qee tus neeg mob uas muaj qee yam yuav tsum tau ceev faj ua ntej siv cov tshuaj no thiab sab laj nrog kws kho mob ua ntej lawv siv.

Qee qhov xwm txheej no yog:

  • Kab mob siab
  • Kev haus cawv ntau dhau
  • Mob qog noj ntshav
  • Thiamine tsis muaj peev xwm

 

Kev Sib Tham Tshuaj Nrog Alpha-lipoic Acid

Tsis muaj xov xwm ntau txog alpha-lipoic acid kev cuam tshuam nrog lwm cov tshuaj. Tab sis qee cov tshuaj yog qhov zoo tshaj kom zam nrog cov tshuaj ntxiv no.

Qee yam tshuaj no yog:

Cov tshuaj hypoglycemic -Alpha-lipoic tau txais ntshav qab zib muaj peev xwm txo qis. Qee qhov xwm txheej nws tuaj yeem ua rau cov tshuaj insulin autoimmune syndrome, ua rau muaj ntshav qab zib tsawg. Yog li siv nws nrog cov tshuaj hypoglycemic tuaj yeem ua rau mob ntshav qab zib sai sai uas yuav txaus ntshai.

Cov tshuaj kho cov thyroid -Alpha-lipoic acid tuaj yeem txo qis qib cov thyroid hormones. Yog li kev saib xyuas kom raug yog xav tau thaum siv nrog levothyroxine.

 

Koj tuaj yeem Yuav Alpha-lipoic Acid nyob qhov twg xyoo 2021?

Koj tuaj yeem yuav alpha-lipoic acid hmoov ncaj qha los ntawm lub tuam txhab tsim khoom lag luam alpha-lipoic acid. Nws muaj nyob rau hauv cov khoom tawv daj rau daj daj. Nws tau ntim rau hauv ib pob ntawm 1 kg ntawm pob ntawv thiab 25kg rau ib lub nruas. Txawm li cas los xij, qhov no tuaj yeem hloov pauv raws li qhov xav tau ntawm tus neeg yuav khoom.

Nws yuav tsum tau khaws cia ntawm qhov kub ntawm 0 txog 4 ° C rau lub sijhawm luv thiab -20 ° C rau lub sijhawm ntev. Nws xav tau qhov txias, qhov tsaus ntuj, thiab qhov chaw qhuav rau khaws cia kom tiv thaiv nws los ntawm kev cuam tshuam nrog lwm cov tshuaj hauv ib puag ncig. Cov khoom no yog tsim los ntawm cov khoom xyaw zoo tshaj hauv qab cov txheej txheem tsim nyog.

 

Cov ntaub ntawv hais txog

  1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). Alpha-lipoic acid exerts anti-inflammatory teebmeem ntawm lipopolysaccharide-stimulated nas mesangial cells ntawm inhibition ntawm nuclear factor kappa B (NF-κB) qhia txoj hauv kev. o, 38(2), 510-519.
  2. Hager, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. (2007). α-lipoic acid ua qhov kev kho mob tshiab rau Alzheimer's tus kab mob-Ib qho kev tshuaj xyuas tom qab 48 lub hlis. Hauv Neuropsychiatric Disorders Kev Sib Koom Tes(phab. 189-193). Springer, Vienna, Tebchaws Asmeskas
  3. Laher, I. (2011). Ntshav qab zib thiab alpha-lipoic acid. Cov hauv chaw muag tshuaj, 2, 69.
  4. Choi, KH, Park, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). Kev kho Alpha-lipoic acid yog neurorestorative thiab txhawb kev rov ua haujlwm tom qab mob stroke hauv nas. Molecular hlwb, 8(1), 1-16.
  5. Kim, K., Kim, J., Kim, H., & Sung, GY (2021). Cov nyhuv ntawm α-Lipoic Acid ntawm Kev Txhim Kho Tib Neeg Cov tawv nqaij sib npaug siv Cov Pumpless Skin-on-a-Chip Model. International Journal of Molecular Sciences, 22(4), 2160.
  6. Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Kev nkag siab ntawm alpha-lipoic thiab dihydrolipoic acids raws li kev cog lus cog tseg ntawm oxidative kev nyuab siab thiab ua tau chelators hauv mercury toxicology. Phau ntawv Journal ntawm inorganic biochemistry, 195, 111-119.
  7. El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Lub luag haujlwm ntawm alpha-lipoic acid hauv kev tswj ntshav tsis zoo hauv cov neeg mob uas lub raum tsis ua haujlwm tom qab hemodialysis. International Journal of nephrology thiab Renovascular Disease, 6, 161.
  8. Pirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). Alpha-lipoic acid tiv thaiv ethanol-induced protein oxidation hauv nas hippocampal HT22 hlwb. Neuroscience Ntawv, 328(2), 93-96.
  9. Kucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). Alpha -lipoic acid (ALA) raws li kev ntxiv rau kev poob phaus: tshwm sim los ntawm kev tshuaj xyuas meta ntawm kev sim tswj kev sim. Kev Taw Qhia Kev pham, 18(5), 594-601.

 

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